Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging
Identifieur interne : 002901 ( Istex/Corpus ); précédent : 002900; suivant : 002902Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging
Auteurs : Y. Allanore ; O. Vignaux ; L. Arnaud ; X. Puéchal ; S. Pavy ; D. Duboc ; P. Legmann ; A. KahanSource :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2006-02.
English descriptors
- KwdEn :
- Teeft :
- Abnormality, Allanore, Anteroseptal, Anteroseptal wall, Antinuclear antibodies, Arnaud, Cardiac, Cardiac involvement, Cardiac sarcoidosis5, Cardiac symptoms, Cardiac troponin, Classification criteria, Cochin, Cochin hospital, Contrast enhancement, Corticosteroid, Creatine kinase, Cyclophosphamide, Daily infusions, Dermatomyositis, Diffuse cutaneous, Duboc, Dyspnoea, Echocardiography, Endomyocardial, Endomyocardial biopsy, Enhancement, Idiopathic, Immunosuppressive, Immunosuppressive therapy, Immunosuppressor, Inflammation, Inflammatory, Inflammatory myopathies, Infusion, Intravenous, Laboratory investigations, Large scale, Magnetic resonance imaging, Main prognostic factor, Methylprednisolone, Month period, Monthly infusions, Myocardial, Myocardial contrast enhancement, Myocardial infarction, Myocardial inflammation, Myocardial involvement, Myocarditis, Myopathy, Online, Oral corticosteroids, Other patients, Overlap syndrome, Patient number, Polymyositis, Powerful tool, Rare disorders, Recent onset, Regimen, Resonance imaging, Rheumatic diseases, Rheumatol, Scarring tissue, Short axis view, Systemic sclerosis, Therapeutic regimen, Treatment strategy, Troponin, Vignaux, Viral, Viral myocarditis.
Abstract
Background: Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical. Objective: To investigate the effects of corticosteroids and immunosuppressors on myocarditis in patients with inflammatory myopathies. Methods: Patients with inflammatory myositis of recent onset who had not received treatment were evaluated for associated myocarditis by magnetic resonance imaging (MRI) and reinvestigated after treatment with high dose corticosteroids and immunosuppressors. Results: Four patients with histologically proven myositis were included. Two patients with polymyositis had cardiac clinical symptoms. Two other patients with dermatomyositis and diffuse cutaneous systemic sclerosis-polymyositis overlap syndrome were asymptomatic. In three cases the usual conventional screening tests were normal. For all patients an area of contrast enhancement and hypokinesia detected by cardiac MRI was markedly reduced after treatment with corticosteroids and immunosuppressors for 6 months. Conclusion: Treatment with intravenous methylprednisolone followed by prednisone and immunosuppressive therapy seems to be effective for treating myocardial involvement in patients with idiopathic inflammatory myopathies, either alone or presenting as overlap syndromes. Cardiovascular MRI is a non-invasive technique that may be a powerful tool for diagnosis and monitoring of myocardial inflammation in this setting.
Url:
DOI: 10.1136/ard.2005.038679
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ISTEX:C974B3F249155FA7483DF912D679A73C386235E7Le document en format XML
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Arnaud</name><affiliation><mods:affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Puechal, X" sort="Puechal, X" uniqKey="Puechal X" first="X" last="Puéchal">X. Puéchal</name><affiliation><mods:affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Pavy, S" sort="Pavy, S" uniqKey="Pavy S" first="S" last="Pavy">S. Pavy</name><affiliation><mods:affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Duboc, D" sort="Duboc, D" uniqKey="Duboc D" first="D" last="Duboc">D. 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Allanore</name><affiliation><mods:affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Vignaux, O" sort="Vignaux, O" uniqKey="Vignaux O" first="O" last="Vignaux">O. Vignaux</name><affiliation><mods:affiliation>Paris-Descartes University, Radiology A Department, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Arnaud, L" sort="Arnaud, L" uniqKey="Arnaud L" first="L" last="Arnaud">L. Arnaud</name><affiliation><mods:affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Puechal, X" sort="Puechal, X" uniqKey="Puechal X" first="X" last="Puéchal">X. Puéchal</name><affiliation><mods:affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Pavy, S" sort="Pavy, S" uniqKey="Pavy S" first="S" last="Pavy">S. Pavy</name><affiliation><mods:affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Duboc, D" sort="Duboc, D" uniqKey="Duboc D" first="D" last="Duboc">D. Duboc</name><affiliation><mods:affiliation>Paris-Descartes University, Cardiology Departments, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Legmann, P" sort="Legmann, P" uniqKey="Legmann P" first="P" last="Legmann">P. Legmann</name><affiliation><mods:affiliation>Paris-Descartes University, Radiology A Department, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Kahan, A" sort="Kahan, A" uniqKey="Kahan A" first="A" last="Kahan">A. Kahan</name><affiliation><mods:affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2006-02">2006-02</date><biblScope unit="volume">65</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="249">249</biblScope></imprint><idno type="ISSN">0003-4967</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-4967</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>dermatomyositis</term><term>heart</term><term>magnetic resonance imaging</term><term>myocarditis</term><term>polymyositis</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abnormality</term><term>Allanore</term><term>Anteroseptal</term><term>Anteroseptal wall</term><term>Antinuclear antibodies</term><term>Arnaud</term><term>Cardiac</term><term>Cardiac involvement</term><term>Cardiac sarcoidosis5</term><term>Cardiac symptoms</term><term>Cardiac troponin</term><term>Classification criteria</term><term>Cochin</term><term>Cochin hospital</term><term>Contrast enhancement</term><term>Corticosteroid</term><term>Creatine kinase</term><term>Cyclophosphamide</term><term>Daily infusions</term><term>Dermatomyositis</term><term>Diffuse cutaneous</term><term>Duboc</term><term>Dyspnoea</term><term>Echocardiography</term><term>Endomyocardial</term><term>Endomyocardial biopsy</term><term>Enhancement</term><term>Idiopathic</term><term>Immunosuppressive</term><term>Immunosuppressive therapy</term><term>Immunosuppressor</term><term>Inflammation</term><term>Inflammatory</term><term>Inflammatory myopathies</term><term>Infusion</term><term>Intravenous</term><term>Laboratory investigations</term><term>Large scale</term><term>Magnetic resonance imaging</term><term>Main prognostic factor</term><term>Methylprednisolone</term><term>Month period</term><term>Monthly infusions</term><term>Myocardial</term><term>Myocardial contrast enhancement</term><term>Myocardial infarction</term><term>Myocardial inflammation</term><term>Myocardial involvement</term><term>Myocarditis</term><term>Myopathy</term><term>Online</term><term>Oral corticosteroids</term><term>Other patients</term><term>Overlap syndrome</term><term>Patient number</term><term>Polymyositis</term><term>Powerful tool</term><term>Rare disorders</term><term>Recent onset</term><term>Regimen</term><term>Resonance imaging</term><term>Rheumatic diseases</term><term>Rheumatol</term><term>Scarring tissue</term><term>Short axis view</term><term>Systemic sclerosis</term><term>Therapeutic regimen</term><term>Treatment strategy</term><term>Troponin</term><term>Vignaux</term><term>Viral</term><term>Viral myocarditis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical. Objective: To investigate the effects of corticosteroids and immunosuppressors on myocarditis in patients with inflammatory myopathies. Methods: Patients with inflammatory myositis of recent onset who had not received treatment were evaluated for associated myocarditis by magnetic resonance imaging (MRI) and reinvestigated after treatment with high dose corticosteroids and immunosuppressors. Results: Four patients with histologically proven myositis were included. Two patients with polymyositis had cardiac clinical symptoms. Two other patients with dermatomyositis and diffuse cutaneous systemic sclerosis-polymyositis overlap syndrome were asymptomatic. In three cases the usual conventional screening tests were normal. For all patients an area of contrast enhancement and hypokinesia detected by cardiac MRI was markedly reduced after treatment with corticosteroids and immunosuppressors for 6 months. Conclusion: Treatment with intravenous methylprednisolone followed by prednisone and immunosuppressive therapy seems to be effective for treating myocardial involvement in patients with idiopathic inflammatory myopathies, either alone or presenting as overlap syndromes. Cardiovascular MRI is a non-invasive technique that may be a powerful tool for diagnosis and monitoring of myocardial inflammation in this setting.</div></front></TEI><istex><corpusName>bmj</corpusName><keywords><teeft><json:string>myocarditis</json:string><json:string>myopathy</json:string><json:string>cardiac</json:string><json:string>enhancement</json:string><json:string>idiopathic</json:string><json:string>corticosteroid</json:string><json:string>methylprednisolone</json:string><json:string>immunosuppressor</json:string><json:string>vignaux</json:string><json:string>contrast enhancement</json:string><json:string>allanore</json:string><json:string>dyspnoea</json:string><json:string>intravenous</json:string><json:string>inflammatory 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view</json:string><json:string>cardiac troponin</json:string><json:string>viral myocarditis</json:string><json:string>large scale</json:string><json:string>oral corticosteroids</json:string><json:string>cardiac sarcoidosis5</json:string><json:string>patient number</json:string><json:string>therapeutic regimen</json:string><json:string>rare disorders</json:string><json:string>treatment strategy</json:string><json:string>month period</json:string><json:string>creatine kinase</json:string><json:string>inflammation</json:string></teeft></keywords><author><json:item><name>Y Allanore</name><affiliations><json:string>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</json:string></affiliations></json:item><json:item><name>O Vignaux</name><affiliations><json:string>Paris-Descartes University, Radiology A Department, Cochin Hospital, AP-HP, Paris, France</json:string></affiliations></json:item><json:item><name>L Arnaud</name><affiliations><json:string>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</json:string></affiliations></json:item><json:item><name>X Puéchal</name><affiliations><json:string>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</json:string></affiliations></json:item><json:item><name>S Pavy</name><affiliations><json:string>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</json:string></affiliations></json:item><json:item><name>D Duboc</name><affiliations><json:string>Paris-Descartes University, Cardiology Departments, Cochin Hospital, AP-HP, Paris, France</json:string></affiliations></json:item><json:item><name>P Legmann</name><affiliations><json:string>Paris-Descartes University, Radiology A Department, Cochin Hospital, AP-HP, Paris, France</json:string></affiliations></json:item><json:item><name>A Kahan</name><affiliations><json:string>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>polymyositis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dermatomyositis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>myocarditis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>heart</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>magnetic resonance imaging</value></json:item></subject><arkIstex>ark:/67375/NVC-7SB2FJF4-1</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>other</json:string></originalGenre><abstract>Background: Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical. Objective: To investigate the effects of corticosteroids and immunosuppressors on myocarditis in patients with inflammatory myopathies. Methods: Patients with inflammatory myositis of recent onset who had not received treatment were evaluated for associated myocarditis by magnetic resonance imaging (MRI) and reinvestigated after treatment with high dose corticosteroids and immunosuppressors. Results: Four patients with histologically proven myositis were included. Two patients with polymyositis had cardiac clinical symptoms. Two other patients with dermatomyositis and diffuse cutaneous systemic sclerosis-polymyositis overlap syndrome were asymptomatic. In three cases the usual conventional screening tests were normal. For all patients an area of contrast enhancement and hypokinesia detected by cardiac MRI was markedly reduced after treatment with corticosteroids and immunosuppressors for 6 months. Conclusion: Treatment with intravenous methylprednisolone followed by prednisone and immunosuppressive therapy seems to be effective for treating myocardial involvement in patients with idiopathic inflammatory myopathies, either alone or presenting as overlap syndromes. Cardiovascular MRI is a non-invasive technique that may be a powerful tool for diagnosis and monitoring of myocardial inflammation in this setting.</abstract><qualityIndicators><score>6.515</score><pdfWordCount>2247</pdfWordCount><pdfCharCount>16291</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>4</pdfPageCount><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>189</abstractWordCount><abstractCharCount>1485</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging</title><pmid><json:string>16410529</json:string></pmid><genre><json:string>other</json:string></genre><host><title>Annals of the Rheumatic Diseases</title><language><json:string>unknown</json:string></language><issn><json:string>0003-4967</json:string></issn><eissn><json:string>1468-2060</json:string></eissn><volume>65</volume><issue>2</issue><pages><first>249</first></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Immunology (including allergy)</value></json:item><json:item><value>Muscle disease</value></json:item><json:item><value>Inflammation</value></json:item><json:item><value>Radiology</value></json:item><json:item><value>Connective tissue disease</value></json:item><json:item><value>Musculoskeletal syndromes</value></json:item><json:item><value>Clinical diagnostic tests</value></json:item><json:item><value>Radiology (diagnostics)</value></json:item><json:item><value>Epidemiology</value></json:item></subject></host><namedEntities><unitex><date><json:string>1998</json:string><json:string>2006-01-12</json:string></date><geogName></geogName><orgName><json:string>France Conflict</json:string><json:string>A Department, Cochin Hospital, AP</json:string><json:string>Cochin Hospital, AP</json:string><json:string>Paris-Descartes University</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName><json:string>Faubourg</json:string><json:string>Paris</json:string><json:string>France</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Friedrich et al</json:string><json:string>Mahrholdt et al</json:string><json:string>Tanimoto et al</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/NVC-7SB2FJF4-1</json:string></ark><categories><wos><json:string>1 - 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sciences medicales</json:string><json:string>4 - sarcoidoses. granulomatoses d'etiologie indeterminee. maladies du tissu conjonctif. maladies du tissu elastique. vascularites</json:string></inist></categories><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><doi><json:string>10.1136/ard.2005.038679</json:string></doi><id>C974B3F249155FA7483DF912D679A73C386235E7</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-7SB2FJF4-1/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-7SB2FJF4-1/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/NVC-7SB2FJF4-1/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://publisher-list.data.istex.fr">BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><availability><licence><p>Copyright 2006 by Annals of the Rheumatic Diseases</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</p></availability><date>2006-01-12</date></publicationStmt><notesStmt><note type="other" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-7474895G-0">other</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Correspondence to:
Dr Y Allanore
Service de Rhumatologie A, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; yannick.allanore@cch.ap-hop-paris.fr</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging</title><author xml:id="author-0000"><persName><forename type="first">Y</forename><surname>Allanore</surname></persName><affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation></author><author xml:id="author-0001"><persName><forename type="first">O</forename><surname>Vignaux</surname></persName><affiliation>Paris-Descartes University, Radiology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation></author><author xml:id="author-0002"><persName><forename type="first">L</forename><surname>Arnaud</surname></persName><affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation></author><author xml:id="author-0003"><persName><forename type="first">X</forename><surname>Puéchal</surname></persName><affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation></author><author xml:id="author-0004"><persName><forename type="first">S</forename><surname>Pavy</surname></persName><affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation></author><author xml:id="author-0005"><persName><forename type="first">D</forename><surname>Duboc</surname></persName><affiliation>Paris-Descartes University, Cardiology Departments, Cochin Hospital, AP-HP, Paris, France</affiliation></author><author xml:id="author-0006"><persName><forename type="first">P</forename><surname>Legmann</surname></persName><affiliation>Paris-Descartes University, Radiology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation></author><author xml:id="author-0007"><persName><forename type="first">A</forename><surname>Kahan</surname></persName><affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation></author><idno type="istex">C974B3F249155FA7483DF912D679A73C386235E7</idno><idno type="ark">ark:/67375/NVC-7SB2FJF4-1</idno><idno type="DOI">10.1136/ard.2005.038679</idno><idno type="href">annrheumdis-65-249.pdf</idno><idno type="PMID">16410529</idno><idno type="local">0650249</idno></analytic><monogr><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="pISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><idno type="PublisherID-hwp">annrheumdis</idno><idno type="PublisherID-nlm-ta">Ann Rheum Dis</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2006-02"></date><biblScope unit="volume">65</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="249">249</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006-01-12</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background: Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical. Objective: To investigate the effects of corticosteroids and immunosuppressors on myocarditis in patients with inflammatory myopathies. Methods: Patients with inflammatory myositis of recent onset who had not received treatment were evaluated for associated myocarditis by magnetic resonance imaging (MRI) and reinvestigated after treatment with high dose corticosteroids and immunosuppressors. Results: Four patients with histologically proven myositis were included. Two patients with polymyositis had cardiac clinical symptoms. Two other patients with dermatomyositis and diffuse cutaneous systemic sclerosis-polymyositis overlap syndrome were asymptomatic. In three cases the usual conventional screening tests were normal. For all patients an area of contrast enhancement and hypokinesia detected by cardiac MRI was markedly reduced after treatment with corticosteroids and immunosuppressors for 6 months. Conclusion: Treatment with intravenous methylprednisolone followed by prednisone and immunosuppressive therapy seems to be effective for treating myocardial involvement in patients with idiopathic inflammatory myopathies, either alone or presenting as overlap syndromes. Cardiovascular MRI is a non-invasive technique that may be a powerful tool for diagnosis and monitoring of myocardial inflammation in this setting.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>KWD</head><item><term>polymyositis</term></item><item><term>dermatomyositis</term></item><item><term>myocarditis</term></item><item><term>heart</term></item><item><term>magnetic resonance imaging</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Immunology (including allergy)</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Muscle disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Inflammation</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Radiology</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Connective tissue disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Musculoskeletal syndromes</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Clinical diagnostic tests</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Radiology (diagnostics)</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Epidemiology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-01-12">Created</change><change when="2006-02">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-7SB2FJF4-1/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article xml:lang="en" article-type="other"><front><journal-meta><journal-id journal-id-type="hwp">annrheumdis</journal-id><journal-id journal-id-type="nlm-ta">Ann Rheum Dis</journal-id><journal-title>Annals of the Rheumatic Diseases</journal-title><abbrev-journal-title abbrev-type="publisher">Ann Rheum Dis</abbrev-journal-title><issn pub-type="ppub">0003-4967</issn><issn pub-type="epub">1468-2060</issn><publisher><publisher-name>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="other">0650249</article-id><article-id pub-id-type="doi">10.1136/ard.2005.038679</article-id><article-id pub-id-type="other">annrheumdis;65/2/249</article-id><article-id pub-id-type="pmid">16410529</article-id><article-id pub-id-type="other">249</article-id><article-id pub-id-type="other">ard.2005.038679</article-id><article-categories><subj-group subj-group-type="heading"><subject content-type="original">Concise reports</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Immunology (including allergy)</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Muscle disease</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Inflammation</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Radiology</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Connective tissue disease</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Musculoskeletal syndromes</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Clinical diagnostic tests</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Radiology (diagnostics)</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Epidemiology</subject></subj-group></article-categories><title-group><article-title>Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Allanore</surname><given-names>Y</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Vignaux</surname><given-names>O</given-names></name><xref rid="AFF2">2</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Arnaud</surname><given-names>L</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Puéchal</surname><given-names>X</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Pavy</surname><given-names>S</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Duboc</surname><given-names>D</given-names></name><xref rid="AFF3">3</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Legmann</surname><given-names>P</given-names></name><xref rid="AFF2">2</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kahan</surname><given-names>A</given-names></name><xref rid="AFF1">1</xref></contrib><aff id="AFF1"><label>1</label>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</aff><aff id="AFF2"><label>2</label>Paris-Descartes University, Radiology A Department, Cochin Hospital, AP-HP, Paris, France</aff><aff id="AFF3"><label>3</label>Paris-Descartes University, Cardiology Departments, Cochin Hospital, AP-HP, Paris, France</aff></contrib-group><author-notes><corresp>Correspondence to:
Dr Y Allanore
Service de Rhumatologie A, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; <ext-link xlink:href="yannick.allanore@cch.ap-hop-paris.fr" ext-link-type="email" xlink:type="simple">yannick.allanore@cch.ap-hop-paris.fr</ext-link></corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>12</day><month>1</month><year>2006</year></pub-date><volume>65</volume><volume-id pub-id-type="other">65</volume-id><volume-id pub-id-type="other">65</volume-id><issue>2</issue><issue-id pub-id-type="other">annrheumdis;65/2</issue-id><issue-id pub-id-type="other">2</issue-id><issue-id pub-id-type="other">65/2</issue-id><fpage>249</fpage><history><date date-type="accepted"><day>21</day><month>06</month><year>2005</year></date></history><permissions><copyright-statement>Copyright 2006 by Annals of the Rheumatic Diseases</copyright-statement><copyright-year>2006</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="annrheumdis-65-249.pdf"></self-uri><abstract xml:lang="en"><p><bold>Background:</bold> Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical.</p><p><bold>Objective:</bold> To investigate the effects of corticosteroids and immunosuppressors on myocarditis in patients with inflammatory myopathies.</p><p><bold>Methods:</bold> Patients with inflammatory myositis of recent onset who had not received treatment were evaluated for associated myocarditis by magnetic resonance imaging (MRI) and reinvestigated after treatment with high dose corticosteroids and immunosuppressors.</p><p><bold>Results:</bold> Four patients with histologically proven myositis were included. Two patients with polymyositis had cardiac clinical symptoms. Two other patients with dermatomyositis and diffuse cutaneous systemic sclerosis-polymyositis overlap syndrome were asymptomatic. In three cases the usual conventional screening tests were normal. For all patients an area of contrast enhancement and hypokinesia detected by cardiac MRI was markedly reduced after treatment with corticosteroids and immunosuppressors for 6 months.</p><p><bold>Conclusion:</bold> Treatment with intravenous methylprednisolone followed by prednisone and immunosuppressive therapy seems to be effective for treating myocardial involvement in patients with idiopathic inflammatory myopathies, either alone or presenting as overlap syndromes. Cardiovascular MRI is a non-invasive technique that may be a powerful tool for diagnosis and monitoring of myocardial inflammation in this setting.</p></abstract><kwd-group kwd-group-type="KWD" xml:lang="en"><kwd>polymyositis</kwd><kwd>dermatomyositis</kwd><kwd>myocarditis</kwd><kwd>heart</kwd><kwd>magnetic resonance imaging</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Allanore</namePart><affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Vignaux</namePart><affiliation>Paris-Descartes University, Radiology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Arnaud</namePart><affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Puéchal</namePart><affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Pavy</namePart><affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Duboc</namePart><affiliation>Paris-Descartes University, Cardiology Departments, Cochin Hospital, AP-HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Legmann</namePart><affiliation>Paris-Descartes University, Radiology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Kahan</namePart><affiliation>Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="other" displayLabel="other" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-7474895G-0">other</genre><originInfo><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><dateIssued encoding="w3cdtf">2006-02</dateIssued><dateCreated encoding="w3cdtf">2006-01-12</dateCreated><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Background: Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical. Objective: To investigate the effects of corticosteroids and immunosuppressors on myocarditis in patients with inflammatory myopathies. Methods: Patients with inflammatory myositis of recent onset who had not received treatment were evaluated for associated myocarditis by magnetic resonance imaging (MRI) and reinvestigated after treatment with high dose corticosteroids and immunosuppressors. Results: Four patients with histologically proven myositis were included. Two patients with polymyositis had cardiac clinical symptoms. Two other patients with dermatomyositis and diffuse cutaneous systemic sclerosis-polymyositis overlap syndrome were asymptomatic. In three cases the usual conventional screening tests were normal. For all patients an area of contrast enhancement and hypokinesia detected by cardiac MRI was markedly reduced after treatment with corticosteroids and immunosuppressors for 6 months. Conclusion: Treatment with intravenous methylprednisolone followed by prednisone and immunosuppressive therapy seems to be effective for treating myocardial involvement in patients with idiopathic inflammatory myopathies, either alone or presenting as overlap syndromes. Cardiovascular MRI is a non-invasive technique that may be a powerful tool for diagnosis and monitoring of myocardial inflammation in this setting.</abstract><note type="author-notes">Correspondence to:
Dr Y Allanore
Service de Rhumatologie A, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; yannick.allanore@cch.ap-hop-paris.fr</note><subject lang="en"><genre>KWD</genre><topic>polymyositis</topic><topic>dermatomyositis</topic><topic>myocarditis</topic><topic>heart</topic><topic>magnetic resonance imaging</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the Rheumatic Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Ann Rheum Dis</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>hwp-journal-coll</genre><topic>Immunology (including allergy)</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Muscle disease</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Inflammation</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Radiology</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Connective tissue disease</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Musculoskeletal syndromes</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Clinical diagnostic tests</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Radiology (diagnostics)</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Epidemiology</topic></subject><identifier type="ISSN">0003-4967</identifier><identifier type="eISSN">1468-2060</identifier><identifier type="PublisherID-hwp">annrheumdis</identifier><identifier type="PublisherID-nlm-ta">Ann Rheum Dis</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>249</start></extent></part></relatedItem><identifier type="istex">C974B3F249155FA7483DF912D679A73C386235E7</identifier><identifier type="ark">ark:/67375/NVC-7SB2FJF4-1</identifier><identifier type="DOI">10.1136/ard.2005.038679</identifier><identifier type="href">annrheumdis-65-249.pdf</identifier><identifier type="PMID">16410529</identifier><identifier type="local">0650249</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright 2006 by Annals of the Rheumatic Diseases</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</recordContentSource><recordOrigin>Copyright 2006 by Annals of the Rheumatic Diseases</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-7SB2FJF4-1/record.json</uri></json:item></metadata><annexes><json:item><extension>jpeg</extension><original>true</original><mimetype>image/jpeg</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-7SB2FJF4-1/annexes.jpeg</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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