Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging
Identifieur interne : 002901 ( Istex/Corpus ); précédent : 002900; suivant : 002902Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging
Auteurs : Y. Allanore ; O. Vignaux ; L. Arnaud ; X. Puéchal ; S. Pavy ; D. Duboc ; P. Legmann ; A. KahanSource :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2006-02.
English descriptors
- KwdEn :
- Teeft :
- Abnormality, Allanore, Anteroseptal, Anteroseptal wall, Antinuclear antibodies, Arnaud, Cardiac, Cardiac involvement, Cardiac sarcoidosis5, Cardiac symptoms, Cardiac troponin, Classification criteria, Cochin, Cochin hospital, Contrast enhancement, Corticosteroid, Creatine kinase, Cyclophosphamide, Daily infusions, Dermatomyositis, Diffuse cutaneous, Duboc, Dyspnoea, Echocardiography, Endomyocardial, Endomyocardial biopsy, Enhancement, Idiopathic, Immunosuppressive, Immunosuppressive therapy, Immunosuppressor, Inflammation, Inflammatory, Inflammatory myopathies, Infusion, Intravenous, Laboratory investigations, Large scale, Magnetic resonance imaging, Main prognostic factor, Methylprednisolone, Month period, Monthly infusions, Myocardial, Myocardial contrast enhancement, Myocardial infarction, Myocardial inflammation, Myocardial involvement, Myocarditis, Myopathy, Online, Oral corticosteroids, Other patients, Overlap syndrome, Patient number, Polymyositis, Powerful tool, Rare disorders, Recent onset, Regimen, Resonance imaging, Rheumatic diseases, Rheumatol, Scarring tissue, Short axis view, Systemic sclerosis, Therapeutic regimen, Treatment strategy, Troponin, Vignaux, Viral, Viral myocarditis.
Abstract
Background: Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical. Objective: To investigate the effects of corticosteroids and immunosuppressors on myocarditis in patients with inflammatory myopathies. Methods: Patients with inflammatory myositis of recent onset who had not received treatment were evaluated for associated myocarditis by magnetic resonance imaging (MRI) and reinvestigated after treatment with high dose corticosteroids and immunosuppressors. Results: Four patients with histologically proven myositis were included. Two patients with polymyositis had cardiac clinical symptoms. Two other patients with dermatomyositis and diffuse cutaneous systemic sclerosis-polymyositis overlap syndrome were asymptomatic. In three cases the usual conventional screening tests were normal. For all patients an area of contrast enhancement and hypokinesia detected by cardiac MRI was markedly reduced after treatment with corticosteroids and immunosuppressors for 6 months. Conclusion: Treatment with intravenous methylprednisolone followed by prednisone and immunosuppressive therapy seems to be effective for treating myocardial involvement in patients with idiopathic inflammatory myopathies, either alone or presenting as overlap syndromes. Cardiovascular MRI is a non-invasive technique that may be a powerful tool for diagnosis and monitoring of myocardial inflammation in this setting.
Url:
DOI: 10.1136/ard.2005.038679
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Background: Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical. Objective: To investigate the effects of corticosteroids and immunosuppressors on myocarditis in patients with inflammatory myopathies. Methods: Patients with inflammatory myositis of recent onset who had not received treatment were evaluated for associated myocarditis by magnetic resonance imaging (MRI) and reinvestigated after treatment with high dose corticosteroids and immunosuppressors. Results: Four patients with histologically proven myositis were included. Two patients with polymyositis had cardiac clinical symptoms. Two other patients with dermatomyositis and diffuse cutaneous systemic sclerosis-polymyositis overlap syndrome were asymptomatic. In three cases the usual conventional screening tests were normal. For all patients an area of contrast enhancement and hypokinesia detected by cardiac MRI was markedly reduced after treatment with corticosteroids and immunosuppressors for 6 months. Conclusion: Treatment with intravenous methylprednisolone followed by prednisone and immunosuppressive therapy seems to be effective for treating myocardial involvement in patients with idiopathic inflammatory myopathies, either alone or presenting as overlap syndromes. Cardiovascular MRI is a non-invasive technique that may be a powerful tool for diagnosis and monitoring of myocardial inflammation in this setting.</div>
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Dr Y Allanore
Service de Rhumatologie A, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; yannick.allanore@cch.ap-hop-paris.fr</note>
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Paris-Descartes University, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France</aff>
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Paris-Descartes University, Radiology A Department, Cochin Hospital, AP-HP, Paris, France</aff>
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Paris-Descartes University, Cardiology Departments, Cochin Hospital, AP-HP, Paris, France</aff>
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Dr Y Allanore
Service de Rhumatologie A, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; <ext-link xlink:href="yannick.allanore@cch.ap-hop-paris.fr" ext-link-type="email" xlink:type="simple">yannick.allanore@cch.ap-hop-paris.fr</ext-link>
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<abstract xml:lang="en"><p><bold>Background:</bold>
Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical.</p>
<p><bold>Objective:</bold>
To investigate the effects of corticosteroids and immunosuppressors on myocarditis in patients with inflammatory myopathies.</p>
<p><bold>Methods:</bold>
Patients with inflammatory myositis of recent onset who had not received treatment were evaluated for associated myocarditis by magnetic resonance imaging (MRI) and reinvestigated after treatment with high dose corticosteroids and immunosuppressors.</p>
<p><bold>Results:</bold>
Four patients with histologically proven myositis were included. Two patients with polymyositis had cardiac clinical symptoms. Two other patients with dermatomyositis and diffuse cutaneous systemic sclerosis-polymyositis overlap syndrome were asymptomatic. In three cases the usual conventional screening tests were normal. For all patients an area of contrast enhancement and hypokinesia detected by cardiac MRI was markedly reduced after treatment with corticosteroids and immunosuppressors for 6 months.</p>
<p><bold>Conclusion:</bold>
Treatment with intravenous methylprednisolone followed by prednisone and immunosuppressive therapy seems to be effective for treating myocardial involvement in patients with idiopathic inflammatory myopathies, either alone or presenting as overlap syndromes. Cardiovascular MRI is a non-invasive technique that may be a powerful tool for diagnosis and monitoring of myocardial inflammation in this setting.</p>
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<abstract lang="en">Background: Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical. Objective: To investigate the effects of corticosteroids and immunosuppressors on myocarditis in patients with inflammatory myopathies. Methods: Patients with inflammatory myositis of recent onset who had not received treatment were evaluated for associated myocarditis by magnetic resonance imaging (MRI) and reinvestigated after treatment with high dose corticosteroids and immunosuppressors. Results: Four patients with histologically proven myositis were included. Two patients with polymyositis had cardiac clinical symptoms. Two other patients with dermatomyositis and diffuse cutaneous systemic sclerosis-polymyositis overlap syndrome were asymptomatic. In three cases the usual conventional screening tests were normal. For all patients an area of contrast enhancement and hypokinesia detected by cardiac MRI was markedly reduced after treatment with corticosteroids and immunosuppressors for 6 months. Conclusion: Treatment with intravenous methylprednisolone followed by prednisone and immunosuppressive therapy seems to be effective for treating myocardial involvement in patients with idiopathic inflammatory myopathies, either alone or presenting as overlap syndromes. Cardiovascular MRI is a non-invasive technique that may be a powerful tool for diagnosis and monitoring of myocardial inflammation in this setting.</abstract>
<note type="author-notes">Correspondence to:
Dr Y Allanore
Service de Rhumatologie A, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; yannick.allanore@cch.ap-hop-paris.fr</note>
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