Localized scleroderma in childhood: A report of 30 cases
Identifieur interne : 002782 ( Istex/Corpus ); précédent : 002781; suivant : 002783Localized scleroderma in childhood: A report of 30 cases
Auteurs : Yosef Uziel ; Bernice R. Krafchik ; Earl D. Silverman ; Paul S. Thorner ; Ronald M. LaxerSource :
- Seminars in Arthritis and Rheumatism [ 0049-0172 ] ; 1994.
English descriptors
- Teeft :
- Achilles tendon, Acta derm venereol, Active phase, Anticentromere antibodies, Antihistone antibodies, Antinuclear antibodies, Arch dermatol, Arthritis rheum, Cerebral calcification, Clinical evaluation, Clinical study, Collagen, Collagen fibers, Convulsive disorders, Coup, Crest syndrome, Degranulated mast cells, Dermatol, Disease activity, Erythrocyte sedimentation rate, Family history, Fibroblast, Fibroblast proliferation, Fibrotic, Frontal lobe, Generalized morphea, Growth factor, Growth failure, Intravenous immunoglobulin, Intravenous methylprednisolone, Laboratory results, Lesion, Limited range, Linear sclcroderma, Linear scleroderma, Localized, Localized cutaneous scleroderma, Localized scleroderma, Many patients, Mast cell activation, Mast cell tryptase, Mast cells, Maxillary antrum, Medical history, Morphea, Mouse model, Muscle atrophy, Neurological symptoms, Nsaid, Pediatric, Pediatric series, Penicillamine, Pigmentary changes, Plastic surgery, Rare disease, Rheum, Rheumatoid factor, Rheumatol, Romberg syndrome, Sabre, Scleroderma, Sclerosis, Skin adnexa, Skin fibrosis, Skin lesion, Skin lesions, Subcutaneous, Subcutaneous tissue, Syndrome, Systemic, Systemic sclerosis, Tiny calcifications.
Abstract
Abstract: Localized scleroderma (LS), a rare disease that occurs primarily in the pediatric age group, differs from systemic sclerosis (SSc) in that it is usually limited to the skin and subcutaneous tissue and is only rarely associated with systemic manifestations. The authors' experience with pediatric LS seen in 30 patients at a tertiary care center was reviewed: 26 had linear scleroderma, 19 on an extremity and 7 on the face; 3 had morphea; and 1 had generalized morphea. Antinuclear antibodies were present in 76% and rheumatoid factor in 39%. Five of 19 patients with linear scleroderma that involved an extremity had growth failure in that limb, and 1 required surgery. Sclerodermatous involvement over a joint resulted in limited range of movement in 6 patients, and 1 required surgery. One of the 30 patients developed SSc and polymyositis. There was difficulty in evaluating disease activity and hence in evaluating treatment. This experience with a large patient population suggests that LS, although usually a self-limiting disease, can result in significant morbidity.
Url:
DOI: 10.1016/0049-0172(94)90028-0
Links to Exploration step
ISTEX:516E15ABCB12A88E1B4DB6AE376A73629B74E6CFLe document en format XML
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Krafchik</name><affiliation><mods:affiliation>Division of Dermatology, The Hospital for Sick Children, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</mods:affiliation></affiliation></author><author><name sortKey="Silverman, Earl D" sort="Silverman, Earl D" uniqKey="Silverman E" first="Earl D." last="Silverman">Earl D. Silverman</name><affiliation><mods:affiliation>Division of Rheumatology, The Hospital for Sick Children, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>3Drs Silverman and Laxer are Associates of the Arthritis Society.</mods:affiliation></affiliation></author><author><name sortKey="Thorner, Paul S" sort="Thorner, Paul S" uniqKey="Thorner P" first="Paul S." last="Thorner">Paul S. Thorner</name><affiliation><mods:affiliation>The Hospital for Sick Children, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</mods:affiliation></affiliation></author><author><name sortKey="Laxer, Ronald M" sort="Laxer, Ronald M" uniqKey="Laxer R" first="Ronald M." last="Laxer">Ronald M. Laxer</name><affiliation><mods:affiliation>Address correspondence to Ronald M. Laxer, MD, Division of Rheumatology, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8.</mods:affiliation></affiliation><affiliation><mods:affiliation>Head, Division of Rheumatology, The Hospital for Sick Children, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Seminars in Arthritis and Rheumatism</title><title level="j" type="abbrev">YSARH</title><idno type="ISSN">0049-0172</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="328">328</biblScope><biblScope unit="page" to="340">340</biblScope></imprint><idno type="ISSN">0049-0172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0049-0172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Achilles tendon</term><term>Acta derm venereol</term><term>Active phase</term><term>Anticentromere antibodies</term><term>Antihistone antibodies</term><term>Antinuclear antibodies</term><term>Arch dermatol</term><term>Arthritis rheum</term><term>Cerebral calcification</term><term>Clinical evaluation</term><term>Clinical study</term><term>Collagen</term><term>Collagen fibers</term><term>Convulsive disorders</term><term>Coup</term><term>Crest syndrome</term><term>Degranulated mast cells</term><term>Dermatol</term><term>Disease activity</term><term>Erythrocyte sedimentation rate</term><term>Family history</term><term>Fibroblast</term><term>Fibroblast proliferation</term><term>Fibrotic</term><term>Frontal lobe</term><term>Generalized morphea</term><term>Growth factor</term><term>Growth failure</term><term>Intravenous immunoglobulin</term><term>Intravenous methylprednisolone</term><term>Laboratory results</term><term>Lesion</term><term>Limited range</term><term>Linear sclcroderma</term><term>Linear scleroderma</term><term>Localized</term><term>Localized cutaneous scleroderma</term><term>Localized scleroderma</term><term>Many patients</term><term>Mast cell activation</term><term>Mast cell tryptase</term><term>Mast cells</term><term>Maxillary antrum</term><term>Medical history</term><term>Morphea</term><term>Mouse model</term><term>Muscle atrophy</term><term>Neurological symptoms</term><term>Nsaid</term><term>Pediatric</term><term>Pediatric series</term><term>Penicillamine</term><term>Pigmentary changes</term><term>Plastic surgery</term><term>Rare disease</term><term>Rheum</term><term>Rheumatoid factor</term><term>Rheumatol</term><term>Romberg syndrome</term><term>Sabre</term><term>Scleroderma</term><term>Sclerosis</term><term>Skin adnexa</term><term>Skin fibrosis</term><term>Skin lesion</term><term>Skin lesions</term><term>Subcutaneous</term><term>Subcutaneous tissue</term><term>Syndrome</term><term>Systemic</term><term>Systemic sclerosis</term><term>Tiny calcifications</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Localized scleroderma (LS), a rare disease that occurs primarily in the pediatric age group, differs from systemic sclerosis (SSc) in that it is usually limited to the skin and subcutaneous tissue and is only rarely associated with systemic manifestations. The authors' experience with pediatric LS seen in 30 patients at a tertiary care center was reviewed: 26 had linear scleroderma, 19 on an extremity and 7 on the face; 3 had morphea; and 1 had generalized morphea. Antinuclear antibodies were present in 76% and rheumatoid factor in 39%. Five of 19 patients with linear scleroderma that involved an extremity had growth failure in that limb, and 1 required surgery. Sclerodermatous involvement over a joint resulted in limited range of movement in 6 patients, and 1 required surgery. One of the 30 patients developed SSc and polymyositis. There was difficulty in evaluating disease activity and hence in evaluating treatment. This experience with a large patient population suggests that LS, although usually a self-limiting disease, can result in significant morbidity.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>scleroderma</json:string><json:string>linear scleroderma</json:string><json:string>morphea</json:string><json:string>localized</json:string><json:string>dermatol</json:string><json:string>localized scleroderma</json:string><json:string>fibroblast</json:string><json:string>generalized morphea</json:string><json:string>fibrotic</json:string><json:string>arthritis rheum</json:string><json:string>subcutaneous</json:string><json:string>mast cells</json:string><json:string>rheumatol</json:string><json:string>nsaid</json:string><json:string>pediatric</json:string><json:string>lesion</json:string><json:string>penicillamine</json:string><json:string>systemic sclerosis</json:string><json:string>rheum</json:string><json:string>sclerosis</json:string><json:string>disease activity</json:string><json:string>subcutaneous tissue</json:string><json:string>antihistone antibodies</json:string><json:string>sabre</json:string><json:string>arch dermatol</json:string><json:string>skin fibrosis</json:string><json:string>tiny calcifications</json:string><json:string>laboratory results</json:string><json:string>anticentromere antibodies</json:string><json:string>muscle atrophy</json:string><json:string>growth failure</json:string><json:string>romberg syndrome</json:string><json:string>antinuclear antibodies</json:string><json:string>skin lesions</json:string><json:string>systemic</json:string><json:string>syndrome</json:string><json:string>collagen</json:string><json:string>achilles tendon</json:string><json:string>many patients</json:string><json:string>pigmentary changes</json:string><json:string>active phase</json:string><json:string>pediatric series</json:string><json:string>cerebral calcification</json:string><json:string>rheumatoid factor</json:string><json:string>collagen fibers</json:string><json:string>skin adnexa</json:string><json:string>frontal lobe</json:string><json:string>mast cell activation</json:string><json:string>fibroblast proliferation</json:string><json:string>growth factor</json:string><json:string>skin lesion</json:string><json:string>degranulated mast cells</json:string><json:string>mouse model</json:string><json:string>mast cell tryptase</json:string><json:string>family history</json:string><json:string>medical history</json:string><json:string>limited range</json:string><json:string>crest syndrome</json:string><json:string>linear sclcroderma</json:string><json:string>erythrocyte sedimentation rate</json:string><json:string>convulsive disorders</json:string><json:string>maxillary antrum</json:string><json:string>plastic surgery</json:string><json:string>clinical evaluation</json:string><json:string>acta derm venereol</json:string><json:string>localized cutaneous scleroderma</json:string><json:string>rare disease</json:string><json:string>intravenous immunoglobulin</json:string><json:string>clinical study</json:string><json:string>neurological symptoms</json:string><json:string>intravenous methylprednisolone</json:string><json:string>coup</json:string></teeft></keywords><author><json:item><name>Yosef Uziel MSc</name><affiliations><json:string>Division of Rheumatology, The Hospital for Sick Children, Canada</json:string><json:string>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</json:string></affiliations></json:item><json:item><name>Bernice R. Krafchik MB, ChB, FRCP(C)</name><affiliations><json:string>Division of Dermatology, The Hospital for Sick Children, Canada</json:string><json:string>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</json:string></affiliations></json:item><json:item><name>Earl D. Silverman MD, FRCPC</name><affiliations><json:string>Division of Rheumatology, The Hospital for Sick Children, Canada</json:string><json:string>3Drs Silverman and Laxer are Associates of the Arthritis Society.</json:string></affiliations></json:item><json:item><name>Paul S. Thorner MD, PhD, FRCPC, FCAP</name><affiliations><json:string>The Hospital for Sick Children, Canada</json:string><json:string>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</json:string></affiliations></json:item><json:item><name>Ronald M. Laxer MD, FRCPC</name><affiliations><json:string>Address correspondence to Ronald M. Laxer, MD, Division of Rheumatology, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8.</json:string><json:string>Head, Division of Rheumatology, The Hospital for Sick Children, Canada</json:string><json:string>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Localized scleroderma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>children</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>morphea</value></json:item></subject><arkIstex>ark:/67375/6H6-S7Z8STZ9-R</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Localized scleroderma (LS), a rare disease that occurs primarily in the pediatric age group, differs from systemic sclerosis (SSc) in that it is usually limited to the skin and subcutaneous tissue and is only rarely associated with systemic manifestations. The authors' experience with pediatric LS seen in 30 patients at a tertiary care center was reviewed: 26 had linear scleroderma, 19 on an extremity and 7 on the face; 3 had morphea; and 1 had generalized morphea. Antinuclear antibodies were present in 76% and rheumatoid factor in 39%. Five of 19 patients with linear scleroderma that involved an extremity had growth failure in that limb, and 1 required surgery. Sclerodermatous involvement over a joint resulted in limited range of movement in 6 patients, and 1 required surgery. One of the 30 patients developed SSc and polymyositis. There was difficulty in evaluating disease activity and hence in evaluating treatment. This experience with a large patient population suggests that LS, although usually a self-limiting disease, can result in significant morbidity.</abstract><qualityIndicators><score>9.028</score><pdfWordCount>5211</pdfWordCount><pdfCharCount>37646</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>13</pdfPageCount><pdfPageSize>540 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>169</abstractWordCount><abstractCharCount>1085</abstractCharCount><keywordCount>3</keywordCount></qualityIndicators><title>Localized scleroderma in childhood: A report of 30 cases</title><pmid><json:string>8036522</json:string></pmid><pii><json:string>0049-0172(94)90028-0</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Proc Soc Exp Biol Med</title><language><json:string>unknown</json:string></language><volume>180</volume><pages><first>323</first><last>328</last></pages></serie><host><title>Seminars in Arthritis and Rheumatism</title><language><json:string>unknown</json:string></language><publicationDate>1994</publicationDate><issn><json:string>0049-0172</json:string></issn><pii><json:string>S0049-0172(00)X0035-2</json:string></pii><volume>23</volume><issue>5</issue><pages><first>328</first><last>340</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1994</json:string></date><geogName></geogName><orgName><json:string>Laboratory Findings Autoantibodies</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Paul S. Thorner</json:string><json:string>AL Genetic</json:string><json:string>Ann Rheum</json:string><json:string>S. Fi</json:string><json:string>Schachterls</json:string><json:string>R. Jacotot</json:string><json:string>LittmarQH</json:string><json:string>S. Verasertniyon</json:string><json:string>Ann Intern</json:string><json:string>D. Silverman</json:string><json:string>X. Kimhall</json:string><json:string>Ann DermatolVenerol</json:string><json:string>Case</json:string><json:string>X. Irani</json:string><json:string>K. Koh</json:string></persName><placeName><json:string>American</json:string><json:string>Segovia</json:string><json:string>Chicago</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Christianson et al</json:string><json:string>Blackwell Scientific, 1986</json:string><json:string>Kornreich et al</json:string><json:string>Borrelia et al</json:string><json:string>Chazen et al</json:string><json:string>Christianson et al.</json:string><json:string>David et al</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-S7Z8STZ9-R</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - rheumatology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - arthritis & rheumatology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Anesthesiology and Pain Medicine</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Rheumatology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1994</publicationDate><copyrightDate>1994</copyrightDate><doi><json:string>10.1016/0049-0172(94)90028-0</json:string></doi><id>516E15ABCB12A88E1B4DB6AE376A73629B74E6CF</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-S7Z8STZ9-R/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-S7Z8STZ9-R/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-S7Z8STZ9-R/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Localized scleroderma in childhood: A report of 30 cases</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1994</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Localized scleroderma in childhood: A report of 30 cases</title><author xml:id="author-0000"><persName><forename type="first">Yosef</forename><surname>Uziel</surname></persName><roleName type="degree">MSc</roleName><note type="biography">Fellow</note><affiliation>Fellow</affiliation><affiliation>Division of Rheumatology, The Hospital for Sick Children, Canada</affiliation><affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Bernice R.</forename><surname>Krafchik</surname></persName><roleName type="degree">MB, ChB, FRCP(C)</roleName><note type="biography">Associate Professor of Paediatrics</note><affiliation>Associate Professor of Paediatrics</affiliation><affiliation>Division of Dermatology, The Hospital for Sick Children, Canada</affiliation><affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Earl D.</forename><surname>Silverman</surname></persName><roleName type="degree">MD, FRCPC</roleName><note type="biography">Associate Professor of Paediatrics and Immunology</note><affiliation>Associate Professor of Paediatrics and Immunology</affiliation><affiliation>Division of Rheumatology, The Hospital for Sick Children, Canada</affiliation><affiliation>3Drs Silverman and Laxer are Associates of the Arthritis Society.</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Paul S.</forename><surname>Thorner</surname></persName><roleName type="degree">MD, PhD, FRCPC, FCAP</roleName><note type="biography">Director of Surgical Pathology</note><affiliation>Director of Surgical Pathology</affiliation><affiliation>The Hospital for Sick Children, Canada</affiliation><affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Ronald M.</forename><surname>Laxer</surname></persName><roleName type="degree">MD, FRCPC</roleName><note type="biography">Associate Professor of Paediatrics and Medicine</note><affiliation>Associate Professor of Paediatrics and Medicine</affiliation><affiliation>Address correspondence to Ronald M. Laxer, MD, Division of Rheumatology, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8.</affiliation><affiliation>Head, Division of Rheumatology, The Hospital for Sick Children, Canada</affiliation><affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</affiliation></author><idno type="istex">516E15ABCB12A88E1B4DB6AE376A73629B74E6CF</idno><idno type="ark">ark:/67375/6H6-S7Z8STZ9-R</idno><idno type="DOI">10.1016/0049-0172(94)90028-0</idno><idno type="PII">0049-0172(94)90028-0</idno></analytic><monogr><title level="j">Seminars in Arthritis and Rheumatism</title><title level="j" type="abbrev">YSARH</title><idno type="pISSN">0049-0172</idno><idno type="PII">S0049-0172(00)X0035-2</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994"></date><biblScope unit="volume">23</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="328">328</biblScope><biblScope unit="page" to="340">340</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Localized scleroderma (LS), a rare disease that occurs primarily in the pediatric age group, differs from systemic sclerosis (SSc) in that it is usually limited to the skin and subcutaneous tissue and is only rarely associated with systemic manifestations. The authors' experience with pediatric LS seen in 30 patients at a tertiary care center was reviewed: 26 had linear scleroderma, 19 on an extremity and 7 on the face; 3 had morphea; and 1 had generalized morphea. Antinuclear antibodies were present in 76% and rheumatoid factor in 39%. Five of 19 patients with linear scleroderma that involved an extremity had growth failure in that limb, and 1 required surgery. Sclerodermatous involvement over a joint resulted in limited range of movement in 6 patients, and 1 required surgery. One of the 30 patients developed SSc and polymyositis. There was difficulty in evaluating disease activity and hence in evaluating treatment. This experience with a large patient population suggests that LS, although usually a self-limiting disease, can result in significant morbidity.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Localized scleroderma</term></item><item><term>children</term></item><item><term>morphea</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-S7Z8STZ9-R/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YSARH</jid><aid>94900280</aid><ce:pii>0049-0172(94)90028-0</ce:pii><ce:doi>10.1016/0049-0172(94)90028-0</ce:doi><ce:copyright type="unknown" year="1994"></ce:copyright></item-info><head><ce:title>Localized scleroderma in childhood: A report of 30 cases</ce:title><ce:author-group><ce:author><ce:given-name>Yosef</ce:given-name><ce:surname>Uziel</ce:surname><ce:degrees>MSc</ce:degrees><ce:roles>Fellow</ce:roles><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="FN2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Bernice R.</ce:given-name><ce:surname>Krafchik</ce:surname><ce:degrees>MB, ChB, FRCP(C)</ce:degrees><ce:roles>Associate Professor of Paediatrics</ce:roles><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Earl D.</ce:given-name><ce:surname>Silverman</ce:surname><ce:degrees>MD, FRCPC</ce:degrees><ce:roles>Associate Professor of Paediatrics and Immunology</ce:roles><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="FN3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Paul S.</ce:given-name><ce:surname>Thorner</ce:surname><ce:degrees>MD, PhD, FRCPC, FCAP</ce:degrees><ce:ranking>Associate Professor of Pathology</ce:ranking><ce:roles>Director of Surgical Pathology</ce:roles><ce:cross-ref refid="AFF4"><ce:sup>d</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Ronald M.</ce:given-name><ce:surname>Laxer</ce:surname><ce:degrees>MD, FRCPC</ce:degrees><ce:roles>Associate Professor of Paediatrics and Medicine</ce:roles><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF5"><ce:sup>e</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Division of Rheumatology, The Hospital for Sick Children, Canada</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Division of Dermatology, The Hospital for Sick Children, Canada</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Division of Rheumatology, The Hospital for Sick Children, Canada</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>d</ce:label><ce:textfn>The Hospital for Sick Children, Canada</ce:textfn></ce:affiliation><ce:affiliation id="AFF5"><ce:label>e</ce:label><ce:textfn>Head, Division of Rheumatology, The Hospital for Sick Children, Canada</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address correspondence to Ronald M. Laxer, MD, Division of Rheumatology, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8.</ce:text></ce:correspondence><ce:footnote id="FN3"><ce:label>3</ce:label><ce:note-para>Drs Silverman and Laxer are Associates of the Arthritis Society.</ce:note-para></ce:footnote><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</ce:note-para></ce:footnote><ce:footnote id="FN2"><ce:label>2</ce:label><ce:note-para>Dr. Uziel is a Recipient of the Abraham Shore Memorial Medical Fellowship and the American Physicians Fellowship.</ce:note-para></ce:footnote></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Localized scleroderma (LS), a rare disease that occurs primarily in the pediatric age group, differs from systemic sclerosis (SSc) in that it is usually limited to the skin and subcutaneous tissue and is only rarely associated with systemic manifestations. The authors' experience with pediatric LS seen in 30 patients at a tertiary care center was reviewed: 26 had linear scleroderma, 19 on an extremity and 7 on the face; 3 had morphea; and 1 had generalized morphea. Antinuclear antibodies were present in 76% and rheumatoid factor in 39%. Five of 19 patients with linear scleroderma that involved an extremity had growth failure in that limb, and 1 required surgery. Sclerodermatous involvement over a joint resulted in limited range of movement in 6 patients, and 1 required surgery. One of the 30 patients developed SSc and polymyositis. There was difficulty in evaluating disease activity and hence in evaluating treatment. This experience with a large patient population suggests that LS, although usually a self-limiting disease, can result in significant morbidity.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="idt"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Localized scleroderma</ce:text></ce:keyword><ce:keyword><ce:text>children</ce:text></ce:keyword><ce:keyword><ce:text>morphea</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Localized scleroderma in childhood: A report of 30 cases</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Localized scleroderma in childhood: A report of 30 cases</title></titleInfo><name type="personal"><namePart type="given">Yosef</namePart><namePart type="family">Uziel</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Division of Rheumatology, The Hospital for Sick Children, Canada</affiliation><affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</affiliation><description>Fellow</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernice R.</namePart><namePart type="family">Krafchik</namePart><namePart type="termsOfAddress">MB, ChB, FRCP(C)</namePart><affiliation>Division of Dermatology, The Hospital for Sick Children, Canada</affiliation><affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</affiliation><description>Associate Professor of Paediatrics</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Earl D.</namePart><namePart type="family">Silverman</namePart><namePart type="termsOfAddress">MD, FRCPC</namePart><affiliation>Division of Rheumatology, The Hospital for Sick Children, Canada</affiliation><affiliation>3Drs Silverman and Laxer are Associates of the Arthritis Society.</affiliation><description>Associate Professor of Paediatrics and Immunology</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul S.</namePart><namePart type="family">Thorner</namePart><namePart type="termsOfAddress">MD, PhD, FRCPC, FCAP</namePart><affiliation>The Hospital for Sick Children, Canada</affiliation><affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</affiliation><description>Director of Surgical Pathology</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ronald M.</namePart><namePart type="family">Laxer</namePart><namePart type="termsOfAddress">MD, FRCPC</namePart><affiliation>Address correspondence to Ronald M. Laxer, MD, Division of Rheumatology, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8.</affiliation><affiliation>Head, Division of Rheumatology, The Hospital for Sick Children, Canada</affiliation><affiliation>1From the Divisions of Rheumatology and Dermatology, Department of Paediatrics, and the Department of Pathologe, The Hospital for Sick Children: und the Departments of Paediatrics, Immunology, Medicine, and Pathology, the University of Toronto, Toronto, Canada.</affiliation><description>Associate Professor of Paediatrics and Medicine</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Localized scleroderma (LS), a rare disease that occurs primarily in the pediatric age group, differs from systemic sclerosis (SSc) in that it is usually limited to the skin and subcutaneous tissue and is only rarely associated with systemic manifestations. The authors' experience with pediatric LS seen in 30 patients at a tertiary care center was reviewed: 26 had linear scleroderma, 19 on an extremity and 7 on the face; 3 had morphea; and 1 had generalized morphea. Antinuclear antibodies were present in 76% and rheumatoid factor in 39%. Five of 19 patients with linear scleroderma that involved an extremity had growth failure in that limb, and 1 required surgery. Sclerodermatous involvement over a joint resulted in limited range of movement in 6 patients, and 1 required surgery. One of the 30 patients developed SSc and polymyositis. There was difficulty in evaluating disease activity and hence in evaluating treatment. This experience with a large patient population suggests that LS, although usually a self-limiting disease, can result in significant morbidity.</abstract><subject><genre>Keywords</genre><topic>Localized scleroderma</topic><topic>children</topic><topic>morphea</topic></subject><relatedItem type="host"><titleInfo><title>Seminars in Arthritis and Rheumatism</title></titleInfo><titleInfo type="abbreviated"><title>YSARH</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued></originInfo><identifier type="ISSN">0049-0172</identifier><identifier type="PII">S0049-0172(00)X0035-2</identifier><part><date>1994</date><detail type="volume"><number>23</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="issue-pages"><start>289</start><end>356</end></extent><extent unit="pages"><start>328</start><end>340</end></extent></part></relatedItem><identifier type="istex">516E15ABCB12A88E1B4DB6AE376A73629B74E6CF</identifier><identifier type="ark">ark:/67375/6H6-S7Z8STZ9-R</identifier><identifier type="DOI">10.1016/0049-0172(94)90028-0</identifier><identifier type="PII">0049-0172(94)90028-0</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-S7Z8STZ9-R/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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