Anaplastic large cell lymphoma in a patient with systemic onset juvenile arthritis: case report and review of literature
Identifieur interne : 002540 ( Istex/Corpus ); précédent : 002539; suivant : 002541Anaplastic large cell lymphoma in a patient with systemic onset juvenile arthritis: case report and review of literature
Auteurs : Bharat K. Singh ; Paul T. Antony ; Surendra K. Verma ; Debdutta Basu ; Vir S. NegiSource :
- International Journal of Rheumatic Diseases [ 1756-1841 ] ; 2014-06.
Abstract
The association of malignancy with autoimmune rheumatic diseases has been a subject of investigation. It has been shown that there is increased risk of malignancies, mainly non‐Hodgkin lymphoma, in patients with autoimmune disorders. There is scarcity of data about malignancy in juvenile idiopathic arthritis (JIA). We report the occurrence of anaplastic large cell lymphoma in a patient with systemic onset juvenile idiopathic arthritis treated with low dose methotrexate (MTX). A relationship between MTX treatment and the occurrence of lymphoma in autoimmune diseases has been suggested. The hypothesis that MTX has a role in the aetiology of lymphoproliferative disorders is supported by the observation of spontaneous remission of lymphoma in few cases on cessation of MTX therapy. However, systemic onset juvenile idiopathic arthritis patients receiving MTX must be periodically examined for the development of lymphoproliferative disorder especially if the disease is difficult to control or patient develop new symptoms on therapy.
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DOI: 10.1111/1756-185X.12361
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Negi, Professor and Head, Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India. Email: <email>vsnegi22@yahoo.co.in</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:APL.APL12361.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Anaplastic large cell lymphoma in a patient with systemic onset juvenile arthritis: case report and review of literature</title><title type="shortAuthors">B. K. Singh <i>et al</i>.</title></titleGroup><creators><creator affiliationRef="#apl12361-aff-0001" creatorRole="author" xml:id="apl12361-cr-0001"><personName><givenNames>Bharat K.</givenNames> <familyName>Singh</familyName></personName></creator><creator affiliationRef="#apl12361-aff-0001" creatorRole="author" xml:id="apl12361-cr-0002"><personName><givenNames>Paul T.</givenNames> <familyName>Antony</familyName></personName></creator><creator affiliationRef="#apl12361-aff-0002" creatorRole="author" xml:id="apl12361-cr-0003"><personName><givenNames>Surendra K.</givenNames> <familyName>Verma</familyName></personName></creator><creator affiliationRef="#apl12361-aff-0002" creatorRole="author" xml:id="apl12361-cr-0004"><personName><givenNames>Debdutta</givenNames> <familyName>Basu</familyName></personName></creator><creator affiliationRef="#apl12361-aff-0001" corresponding="yes" creatorRole="author" xml:id="apl12361-cr-0005"><personName><givenNames>Vir S.</givenNames> <familyName>Negi</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="IN" type="organization" xml:id="apl12361-aff-0001"><orgDiv>Department of Clinical Immunology</orgDiv> <orgName>Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)</orgName> <address><city>Puducherry</city> <country>India</country></address></affiliation><affiliation countryCode="IN" type="organization" xml:id="apl12361-aff-0002"><orgDiv>Department of Pathology</orgDiv> <orgName>Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)</orgName> <address><city>Puducherry</city> <country>India</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="apl12361-kwd-0001">anaplastic large cell lymphoma <fc>ALK</fc> negative</keyword><keyword xml:id="apl12361-kwd-0002">methotrexate</keyword><keyword xml:id="apl12361-kwd-0003">systemic onset juvenile idiopathic arthritis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:id="apl12361-abs-0001"><title type="main">Abstract</title><section xml:id="apl12361-sec-0001"><p>The association of malignancy with autoimmune rheumatic diseases has been a subject of investigation. It has been shown that there is increased risk of malignancies, mainly non‐Hodgkin lymphoma, in patients with autoimmune disorders. There is scarcity of data about malignancy in juvenile idiopathic arthritis (<fc>JIA</fc>). We report the occurrence of anaplastic large cell lymphoma in a patient with systemic onset juvenile idiopathic arthritis treated with low dose methotrexate (<fc>MTX</fc>). A relationship between <fc>MTX</fc> treatment and the occurrence of lymphoma in autoimmune diseases has been suggested. The hypothesis that <fc>MTX</fc> has a role in the aetiology of lymphoproliferative disorders is supported by the observation of spontaneous remission of lymphoma in few cases on cessation of <fc>MTX</fc> therapy. However, systemic onset juvenile idiopathic arthritis patients receiving <fc>MTX</fc> must be periodically examined for the development of lymphoproliferative disorder especially if the disease is difficult to control or patient develop new symptoms on therapy.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Anaplastic large cell lymphoma in a patient with systemic onset juvenile arthritis: case report and review of literature</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Anaplastic large cell lymphoma in a patient with systemic onset juvenile arthritis: case report and review of literature</title></titleInfo><name type="personal"><namePart type="given">Bharat K.</namePart><namePart type="family">Singh</namePart><affiliation>Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul T.</namePart><namePart type="family">Antony</namePart><affiliation>Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Surendra K.</namePart><namePart type="family">Verma</namePart><affiliation>Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Debdutta</namePart><namePart type="family">Basu</namePart><affiliation>Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vir S.</namePart><namePart type="family">Negi</namePart><affiliation>Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India</affiliation><affiliation>E-mail: vsnegi22@yahoo.co.in</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-06</dateIssued><dateCreated encoding="w3cdtf">2014-03-24</dateCreated><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>The association of malignancy with autoimmune rheumatic diseases has been a subject of investigation. It has been shown that there is increased risk of malignancies, mainly non‐Hodgkin lymphoma, in patients with autoimmune disorders. There is scarcity of data about malignancy in juvenile idiopathic arthritis (JIA). We report the occurrence of anaplastic large cell lymphoma in a patient with systemic onset juvenile idiopathic arthritis treated with low dose methotrexate (MTX). A relationship between MTX treatment and the occurrence of lymphoma in autoimmune diseases has been suggested. The hypothesis that MTX has a role in the aetiology of lymphoproliferative disorders is supported by the observation of spontaneous remission of lymphoma in few cases on cessation of MTX therapy. However, systemic onset juvenile idiopathic arthritis patients receiving MTX must be periodically examined for the development of lymphoproliferative disorder especially if the disease is difficult to control or patient develop new symptoms on therapy.</abstract><subject><genre>keywords</genre><topic>anaplastic large cell lymphoma ALK negative</topic><topic>methotrexate</topic><topic>systemic onset juvenile idiopathic arthritis</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Rheumatic Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Int J Rheum Dis</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>APLAR grand round case</topic><topic>APLAR grand round case</topic></subject><identifier type="ISSN">1756-1841</identifier><identifier type="eISSN">1756-185X</identifier><identifier type="DOI">10.1111/(ISSN)1756-185X</identifier><identifier type="PublisherID">APL</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>573</start><end>577</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="apl12361-cit-0001"><titleInfo><title>Malignancies in Juvenile Idiopathic Arthritis: a Preliminary Report</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Bernatsky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Rosenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KG</namePart><namePart type="family">Oen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bernatsky S, Rosenberg AM, Oen KG et al. 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