Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report
Identifieur interne : 002517 ( Istex/Corpus ); précédent : 002516; suivant : 002518Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report
Auteurs : Ann Woolfrey ; Jan Storek ; Suzanne Bowyer ; Robert Nelson ; Michael Robertson ; Carol WallaceSource :
- Pediatric Transplantation [ 1397-3142 ] ; 2010-09.
Abstract
Woolfrey A, Storek J, Bowyer S, Nelson R, Robertson M, Wallace C. Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report.
Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S. Abstract: Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.
Url:
DOI: 10.1111/j.1399-3046.2009.01129.x
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Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report.
Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S. Abstract: Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>autologous</json:string><json:string>hdit</json:string><json:string>transplantation</json:string><json:string>immune</json:string><json:string>pbsc</json:string><json:string>lymphocyte</json:string><json:string>refractory</json:string><json:string>disease response</json:string><json:string>regimen</json:string><json:string>cell transplantation</json:string><json:string>autologous peripheral blood</json:string><json:string>juvenile idiopathic arthritis</json:string><json:string>active joint</json:string><json:string>critical joint</json:string><json:string>autologous cell</json:string><json:string>conditioning regimen</json:string><json:string>total dose</json:string><json:string>total body irradiation</json:string><json:string>immunosuppressive therapy</json:string><json:string>total lymphoid irradiation</json:string><json:string>systemic onset</json:string><json:string>adult patient</json:string><json:string>transplant</json:string><json:string>arthritis</json:string><json:string>rheumatoid arthritis</json:string><json:string>consecutive day</json:string><json:string>cell dose</json:string><json:string>central venous line</json:string><json:string>hematopoietic cell transplantation</json:string><json:string>autoimmune disorder</json:string><json:string>chaq score</json:string><json:string>pain score</json:string><json:string>inclusion criterion</json:string><json:string>dendritic cell</json:string><json:string>autologous pbsc transplant</json:string><json:string>autoreactive state</json:string><json:string>medical therapy</json:string><json:string>autoimmune disease</json:string><json:string>pilot study</json:string><json:string>arthritis rheum</json:string><json:string>refractory juvenile idiopathic arthritis</json:string><json:string>fred hutchinson cancer research center</json:string></teeft></keywords><author><json:item><name>Ann Woolfrey</name><affiliations><json:string>Fred Hutchinson Cancer Research Center, Seattle, WA, USA</json:string><json:string>University of Washington, Seattle, WA, USA</json:string></affiliations></json:item><json:item><name>Jan Storek</name><affiliations><json:string>University of Washington, Seattle, WA, USA</json:string><json:string>University of Calgary, Calgary, AB, Canada</json:string></affiliations></json:item><json:item><name>Suzanne Bowyer</name><affiliations><json:string>Indiana University, Indianapolis, IN, USA</json:string></affiliations></json:item><json:item><name>Robert Nelson</name><affiliations><json:string>Indiana University, Indianapolis, IN, USA</json:string></affiliations></json:item><json:item><name>Michael Robertson</name><affiliations><json:string>Indiana University, Indianapolis, IN, USA</json:string></affiliations></json:item><json:item><name>Carol Wallace</name><affiliations><json:string>University of Washington, Seattle, WA, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>irradiation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autologous peripheral blood stem cells</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>juvenile idiopathic arthritis</value></json:item></subject><articleId><json:string>PETR1129</json:string></articleId><arkIstex>ark:/67375/WNG-6GL89T9W-8</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>caseStudy</json:string></originalGenre><abstract>Woolfrey A, Storek J, Bowyer S, Nelson R, Robertson M, Wallace C. 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Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S.</p><p><hi rend="bold">Abstract: </hi> Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">irradiation</term><term xml:id="k2">autologous peripheral blood stem cells</term><term xml:id="k3">juvenile idiopathic arthritis</term></keywords><keywords rend="tocHeading1"><term>Case Reports</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-6GL89T9W-8/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1399-3046</doi><issn type="print">1397-3142</issn><issn type="electronic">1399-3046</issn><idGroup><id type="product" value="PETR"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="PEDIATRIC TRANSPLANTATION">Pediatric Transplantation</title></titleGroup></publicationMeta><publicationMeta level="part" position="09106"><doi origin="wiley">10.1111/ptr.2010.14.issue-6</doi><numberingGroup><numbering type="journalVolume" number="14">14</numbering><numbering type="journalIssue" number="6">6</numbering></numberingGroup><coverDate startDate="2010-09">September 2010</coverDate></publicationMeta><publicationMeta level="unit" type="caseStudy" position="17" status="forIssue"><doi origin="wiley">10.1111/j.1399-3046.2009.01129.x</doi><idGroup><id type="unit" value="PETR1129"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1"><sc>Case Reports</sc></title></titleGroup><copyright>© 2009 John Wiley & Sons A/S</copyright><eventGroup><event type="firstOnline" date="2009-02-19"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2009-02-19"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.25 mode:FullText source:FullText result:FullText" date="2010-11-05"></event><event type="publishedOnlineFinalForm" date="2010-08-16"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-03"></event></eventGroup><numberingGroup><numbering type="pageFirst">E65</numbering><numbering type="pageLast">E69</numbering></numberingGroup><correspondenceTo>Carol Wallace, MD, Division of Immunology & Rheumatology, Children’s Hospital & Regional Medical Center, 4800 Sandpoint Way NE, Seattle, WA 98105, USA
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E‐mail: <email>carol.wallace@seattlechildrens.org</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:PETR.PETR1129.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 5 December 2008</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="1"></count></countGroup><titleGroup><title type="main">Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report</title><title type="shortAuthors"><b>Woolfrey et al.</b></title><title type="short"><b>Autologous PBSC transplant for JIA</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>Ann</givenNames><familyName>Woolfrey</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2 #a3"><personName><givenNames>Jan</givenNames><familyName>Storek</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a4"><personName><givenNames>Suzanne</givenNames><familyName>Bowyer</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>Robert</givenNames><familyName>Nelson</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>Michael</givenNames><familyName>Robertson</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>Carol</givenNames><familyName>Wallace</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>University of Washington, Seattle, WA, USA</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="CA"><unparsedAffiliation>University of Calgary, Calgary, AB, Canada</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="US"><unparsedAffiliation>Indiana University, Indianapolis, IN, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">irradiation</keyword><keyword xml:id="k2">autologous peripheral blood stem cells</keyword><keyword xml:id="k3">juvenile idiopathic arthritis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Woolfrey A, Storek J, Bowyer S, Nelson R, Robertson M, Wallace C. Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report.
Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S.</p><p><b>Abstract: </b> Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Autologous PBSC transplant for JIA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report</title></titleInfo><name type="personal"><namePart type="given">Ann</namePart><namePart type="family">Woolfrey</namePart><affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA</affiliation><affiliation>University of Washington, Seattle, WA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Storek</namePart><affiliation>University of Washington, Seattle, WA, USA</affiliation><affiliation>University of Calgary, Calgary, AB, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Suzanne</namePart><namePart type="family">Bowyer</namePart><affiliation>Indiana University, Indianapolis, IN, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Nelson</namePart><affiliation>Indiana University, Indianapolis, IN, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Robertson</namePart><affiliation>Indiana University, Indianapolis, IN, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carol</namePart><namePart type="family">Wallace</namePart><affiliation>University of Washington, Seattle, WA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="case-report" displayLabel="caseStudy" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-09</dateIssued><edition>Accepted for publication 5 December 2008</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">2</extent><extent unit="tables">1</extent></physicalDescription><abstract lang="en">Woolfrey A, Storek J, Bowyer S, Nelson R, Robertson M, Wallace C. Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report.
Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S. Abstract: Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.</abstract><subject lang="en"><genre>keywords</genre><topic>irradiation</topic><topic>autologous peripheral blood stem cells</topic><topic>juvenile idiopathic arthritis</topic></subject><relatedItem type="host"><titleInfo><title>Pediatric Transplantation</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1397-3142</identifier><identifier type="eISSN">1399-3046</identifier><identifier type="DOI">10.1111/(ISSN)1399-3046</identifier><identifier type="PublisherID">PETR</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>E65</start><end>E69</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Autologous haemopoietic stem‐cell transplantation in four patients with refractory juvenile chronic arthritis</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Wulffraat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Van Royen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Bierings</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Vossen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Kuis</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wulffraat N, Van Royen A, Bierings M, Vossen J, Kuis W. 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