Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells
Identifieur interne : 002434 ( Istex/Corpus ); précédent : 002433; suivant : 002435Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells
Auteurs : John O. Suberu ; Isolda Romero-Canel N ; Neil Sullivan ; Alexei A. Lapkin ; Guy C. BarkerSource :
- ChemMedChem [ 1860-7179 ] ; 2014-12.
Abstract
In parts of Africa and Asia, self‐medication with a hot water infusion of Artemisia annua (Artemisia tea) is a common practice for a number of ailments including malaria and cancer. In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine‐sensitive and ‐resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC50 values (>200 μM). The combination of artemisinin and 3‐caffeoylquinic acid (3CA), two major components in the extract, was strongly antagonistic and gave a near total loss of cytotoxicity for artemisinin. We observed that the interaction of 3CAs with another cytotoxic compound, cisplatin, showed potentiation of activity by 2.5‐fold. The chelation of cellular iron by 3CA is hypothesized as a possible explanation for the loss of artemisinin activity.
Ironing out the infusion: Strong antagonistic interactions between artemisinin and chlorogenic acids in MCF7 cells has negative implications for the use of Artemisia tea in chemotherapy. It is possible that the chlorogenic acids present sap artemisinin of its potency by chelating cellular iron.
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DOI: 10.1002/cmdc.201402285
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In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine‐sensitive and ‐resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC50 values (>200 μM). The combination of artemisinin and 3‐caffeoylquinic acid (3CA), two major components in the extract, was strongly antagonistic and gave a near total loss of cytotoxicity for artemisinin. We observed that the interaction of 3CAs with another cytotoxic compound, cisplatin, showed potentiation of activity by 2.5‐fold. The chelation of cellular iron by 3CA is hypothesized as a possible explanation for the loss of artemisinin activity.</div><div type="abstract" xml:lang="en">Ironing out the infusion: Strong antagonistic interactions between artemisinin and chlorogenic acids in MCF7 cells has negative implications for the use of Artemisia tea in chemotherapy. It is possible that the chlorogenic acids present sap artemisinin of its potency by chelating cellular iron.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Dr. John O. Suberu</name><affiliations><json:string>Chemical Engineering and Biotechnology, University of Cambridge, CB2 3RA (UK)</json:string></affiliations></json:item><json:item><name>Dr. Isolda Romero‐Canelón</name><affiliations><json:string>Department of Chemistry, University of Warwick, CV4 7AL (UK)</json:string></affiliations></json:item><json:item><name>Dr. Neil Sullivan</name><affiliations><json:string>SensaPharm Ltd., 123i Bioscience Centre, Sunderland, SR5 2TA (UK)</json:string></affiliations></json:item><json:item><name>Prof. Alexei A. Lapkin</name><affiliations><json:string>Chemical Engineering and Biotechnology, University of Cambridge, CB2 3RA (UK)</json:string></affiliations></json:item><json:item><name>Dr. Guy C. 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Published by Wiley‐VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.</copyright><eventGroup><event type="manuscriptReceived" date="2014-07-10"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.3.5 mode:FullText" date="2014-11-22"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.5 mode:FullText" date="2014-11-22"></event><event type="publishedOnlineEarlyUnpaginated" date="2014-09-10"></event><event type="firstOnline" date="2014-09-10"></event><event type="publishedOnlineFinalForm" date="2014-11-22"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-06"></event></eventGroup><numberingGroup><numbering type="pageFirst">2791</numbering><numbering type="pageLast">2797</numbering></numberingGroup><correspondenceTo>School of Life Sciences, University of Warwick, CV4 7AL (UK)</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CMDC.CMDC201402285.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="8"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="69"></count></countGroup><titleGroup><title type="main" xml:lang="en">Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#ab"><personName><honorifics>Dr.</honorifics><givenNames>John O.</givenNames><familyName>Suberu</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#ac"><personName><honorifics>Dr.</honorifics><givenNames>Isolda</givenNames><familyName>Romero‐Canelón</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#ad"><personName><honorifics>Dr.</honorifics><givenNames>Neil</givenNames><familyName>Sullivan</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#ab"><personName><honorifics>Prof.</honorifics><givenNames>Alexei A.</givenNames><familyName>Lapkin</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#aa" corresponding="yes"><personName><honorifics>Dr.</honorifics><givenNames>Guy C.</givenNames><familyName>Barker</familyName></personName><contactDetails><email>Guy.Barker@warwick.ac.uk</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="aa" countryCode="GB" type="organization"><unparsedAffiliation>School of Life Sciences, University of Warwick, CV4 7AL (UK)</unparsedAffiliation></affiliation><affiliation xml:id="ab" countryCode="GB" type="organization"><unparsedAffiliation>Chemical Engineering and Biotechnology, University of Cambridge, CB2 3RA (UK)</unparsedAffiliation></affiliation><affiliation xml:id="ac" countryCode="GB" type="organization"><unparsedAffiliation>Department of Chemistry, University of Warwick, CV4 7AL (UK)</unparsedAffiliation></affiliation><affiliation xml:id="ad" countryCode="GB" type="organization"><unparsedAffiliation>SensaPharm Ltd., 123i Bioscience Centre, Sunderland, SR5 2TA (UK)</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">antagonism</keyword><keyword xml:id="kwd2"><i>Artemisia</i> tea</keyword><keyword xml:id="kwd3">artemisinin</keyword><keyword xml:id="kwd4">chlorogenic acid</keyword><keyword xml:id="kwd5">cisplatin</keyword><keyword xml:id="kwd6">synergy</keyword></keywordGroup><fundingInfo><fundingAgency>Funded Access</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Engineering and Physical Sciences Research Council (EPSRC, UK)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>SensaPharm Ltd.</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>In parts of Africa and Asia, self‐medication with a hot water infusion of <i>Artemisia annua</i> (<i>Artemisia</i> tea) is a common practice for a number of ailments including malaria and cancer. In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine‐sensitive and ‐resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC<sub>50</sub> values (>200 μ<sc>M</sc>). The combination of artemisinin and 3‐caffeoylquinic acid (3CA), two major components in the extract, was strongly antagonistic and gave a near total loss of cytotoxicity for artemisinin. We observed that the interaction of 3CAs with another cytotoxic compound, cisplatin, showed potentiation of activity by 2.5‐fold. The chelation of cellular iron by 3CA is hypothesized as a possible explanation for the loss of artemisinin activity.</p></abstract><abstract type="graphical" xml:lang="en"><p><b>Ironing out the infusion:</b> Strong antagonistic interactions between artemisinin and chlorogenic acids in MCF7 cells has negative implications for the use of <i>Artemisia</i> tea in chemotherapy. It is possible that the chlorogenic acids present sap artemisinin of its potency by chelating cellular iron.<blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" eRights="yes" copyright="WILEY-VCH" href="urn:x-wiley:18607179:media:CMDC201402285:content"></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">John O.</namePart><namePart type="family">Suberu</namePart><affiliation>Chemical Engineering and Biotechnology, University of Cambridge, CB2 3RA (UK)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Isolda</namePart><namePart type="family">Romero‐Canelón</namePart><affiliation>Department of Chemistry, University of Warwick, CV4 7AL (UK)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Neil</namePart><namePart type="family">Sullivan</namePart><affiliation>SensaPharm Ltd., 123i Bioscience Centre, Sunderland, SR5 2TA (UK)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Prof.</namePart><namePart type="given">Alexei A.</namePart><namePart type="family">Lapkin</namePart><affiliation>Chemical Engineering and Biotechnology, University of Cambridge, CB2 3RA (UK)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Guy C.</namePart><namePart type="family">Barker</namePart><affiliation>School of Life Sciences, University of Warwick, CV4 7AL (UK)</affiliation><affiliation>E-mail: Guy.Barker@warwick.ac.uk</affiliation><affiliation>Correspondence address: School of Life Sciences, University of Warwick, CV4 7AL (UK)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2014-12</dateIssued><dateCaptured encoding="w3cdtf">2014-07-10</dateCaptured><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">8</extent><extent unit="tables">3</extent><extent unit="references">69</extent></physicalDescription><abstract lang="en">In parts of Africa and Asia, self‐medication with a hot water infusion of Artemisia annua (Artemisia tea) is a common practice for a number of ailments including malaria and cancer. In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine‐sensitive and ‐resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC50 values (>200 μM). The combination of artemisinin and 3‐caffeoylquinic acid (3CA), two major components in the extract, was strongly antagonistic and gave a near total loss of cytotoxicity for artemisinin. We observed that the interaction of 3CAs with another cytotoxic compound, cisplatin, showed potentiation of activity by 2.5‐fold. The chelation of cellular iron by 3CA is hypothesized as a possible explanation for the loss of artemisinin activity.</abstract><abstract type="graphical" lang="en">Ironing out the infusion: Strong antagonistic interactions between artemisinin and chlorogenic acids in MCF7 cells has negative implications for the use of Artemisia tea in chemotherapy. It is possible that the chlorogenic acids present sap artemisinin of its potency by chelating cellular iron.</abstract><note type="funding">Funded Access</note><note type="funding">Engineering and Physical Sciences Research Council (EPSRC, UK)</note><note type="funding">SensaPharm Ltd.</note><subject lang="en"><genre>keywords</genre><topic>antagonism</topic><topic>Artemisia tea</topic><topic>artemisinin</topic><topic>chlorogenic acid</topic><topic>cisplatin</topic><topic>synergy</topic></subject><relatedItem type="host"><titleInfo><title>ChemMedChem</title></titleInfo><titleInfo type="abbreviated"><title>ChemMedChem</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Full Paper</topic><topic>Full Papers</topic></subject><identifier type="ISSN">1860-7179</identifier><identifier type="eISSN">1860-7187</identifier><identifier type="DOI">10.1002/(ISSN)1860-7187</identifier><identifier type="PublisherID">CMDC</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>2791</start><end>2797</end><total>7</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Int. 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