Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs
Identifieur interne : 002397 ( Istex/Corpus ); précédent : 002396; suivant : 002398Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs
Auteurs : Melissa N. Carr ; Sheila M. F. Torres ; Sandra N. Koch ; Lisa V. ReiterSource :
- Veterinary Dermatology [ 0959-4493 ] ; 2009-04.
Abstract
There are numerous studies of the pruritus‐producing effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in humans and mice, but very little reported in dogs even though a common reason dogs are presented to veterinarians is pruritus. The aim of this study was to determine whether substances known to cause pruritus in humans also cause pruritus in dogs. Twenty‐five clinically healthy research beagle dogs were included in the study. All dogs first received an intradermal injection of 0.05 mL saline as a control substance and were video‐recorded for 20 min before and after the injection. Twenty‐four hours later the dogs were randomly divided into five groups of five dogs each and randomly assigned to receive histamine, serotonin, tryptase, substance P or interleukin‐2 injected intradermally each at the volume of 0.05 mL. On subsequent days, increasing concentrations of each substance were used. Before (baseline) and after the injection of each concentration of the substances, the dogs were video‐recorded for 20 min. The frequency and character of pruritus episodes (scratching, licking, chewing, rubbing or rolling) were noted and these data were used for statistical analysis. The number of pruritus episodes was compared among baseline, saline and the different concentrations of each substance. The results showed that dogs did not have a significant increase in pruritic behaviour above baseline or saline after injection of any of the investigated substances (generalized linear model; P = 0.23).
Url:
DOI: 10.1111/j.1365-3164.2008.00716.x
Links to Exploration step
ISTEX:0C3FE0DCC27843D6D1E5C8DBAE524266C73D8322Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs</title><author><name sortKey="Carr, Melissa N" sort="Carr, Melissa N" uniqKey="Carr M" first="Melissa N." last="Carr">Melissa N. Carr</name><affiliation><mods:affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</mods:affiliation></affiliation></author><author><name sortKey="Torres, Sheila M F" sort="Torres, Sheila M F" uniqKey="Torres S" first="Sheila M. F." last="Torres">Sheila M. F. Torres</name><affiliation><mods:affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</mods:affiliation></affiliation></author><author><name sortKey="Koch, Sandra N" sort="Koch, Sandra N" uniqKey="Koch S" first="Sandra N." last="Koch">Sandra N. Koch</name><affiliation><mods:affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</mods:affiliation></affiliation></author><author><name sortKey="Reiter, Lisa V" sort="Reiter, Lisa V" uniqKey="Reiter L" first="Lisa V." last="Reiter">Lisa V. Reiter</name><affiliation><mods:affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0C3FE0DCC27843D6D1E5C8DBAE524266C73D8322</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1365-3164.2008.00716.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-K3R7VPWG-W/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002397</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002397</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs</title><author><name sortKey="Carr, Melissa N" sort="Carr, Melissa N" uniqKey="Carr M" first="Melissa N." last="Carr">Melissa N. Carr</name><affiliation><mods:affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</mods:affiliation></affiliation></author><author><name sortKey="Torres, Sheila M F" sort="Torres, Sheila M F" uniqKey="Torres S" first="Sheila M. F." last="Torres">Sheila M. F. Torres</name><affiliation><mods:affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</mods:affiliation></affiliation></author><author><name sortKey="Koch, Sandra N" sort="Koch, Sandra N" uniqKey="Koch S" first="Sandra N." last="Koch">Sandra N. Koch</name><affiliation><mods:affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</mods:affiliation></affiliation></author><author><name sortKey="Reiter, Lisa V" sort="Reiter, Lisa V" uniqKey="Reiter L" first="Lisa V." last="Reiter">Lisa V. Reiter</name><affiliation><mods:affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Veterinary Dermatology</title><title level="j" type="alt">VETERINARY DERMATOLOGY</title><idno type="ISSN">0959-4493</idno><idno type="eISSN">1365-3164</idno><imprint><biblScope unit="vol">20</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="105">105</biblScope><biblScope unit="page" to="110">110</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-04">2009-04</date></imprint><idno type="ISSN">0959-4493</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-4493</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are numerous studies of the pruritus‐producing effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in humans and mice, but very little reported in dogs even though a common reason dogs are presented to veterinarians is pruritus. The aim of this study was to determine whether substances known to cause pruritus in humans also cause pruritus in dogs. Twenty‐five clinically healthy research beagle dogs were included in the study. All dogs first received an intradermal injection of 0.05 mL saline as a control substance and were video‐recorded for 20 min before and after the injection. Twenty‐four hours later the dogs were randomly divided into five groups of five dogs each and randomly assigned to receive histamine, serotonin, tryptase, substance P or interleukin‐2 injected intradermally each at the volume of 0.05 mL. On subsequent days, increasing concentrations of each substance were used. Before (baseline) and after the injection of each concentration of the substances, the dogs were video‐recorded for 20 min. The frequency and character of pruritus episodes (scratching, licking, chewing, rubbing or rolling) were noted and these data were used for statistical analysis. The number of pruritus episodes was compared among baseline, saline and the different concentrations of each substance. The results showed that dogs did not have a significant increase in pruritic behaviour above baseline or saline after injection of any of the investigated substances (generalized linear model; P = 0.23).</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>pruritus</json:string><json:string>wheal</json:string><json:string>erythema</json:string><json:string>histamine</json:string><json:string>pruritic</json:string><json:string>serotonin</json:string><json:string>tryptase</json:string><json:string>dermatology</json:string><json:string>pruritic episode</json:string><json:string>intradermal</json:string><json:string>intradermally</json:string><json:string>perros</json:string><json:string>pruritic behaviour</json:string><json:string>cutaneous</json:string><json:string>baseline</json:string><json:string>pruritogenic</json:string><json:string>cause pruritus</json:string><json:string>prurito</json:string><json:string>dermatitis</json:string><json:string>atopic</json:string><json:string>wurden</json:string><json:string>intradermal injection</json:string><json:string>journal compilation</json:string><json:string>atopic dermatitis</json:string><json:string>saline injection</json:string><json:string>lowest concentration</json:string><json:string>generalized linear model</json:string><json:string>pruritogenic substance</json:string><json:string>mild erythema</json:string><json:string>investigative dermatology</json:string><json:string>british journal</json:string><json:string>different concentration</json:string><json:string>datum</json:string><json:string>injection</json:string><json:string>time higher</json:string><json:string>mast cell</json:string><json:string>pruritic response</json:string><json:string>erythema reaction</json:string><json:string>healthy dog</json:string><json:string>skin reaction</json:string><json:string>human lung</json:string><json:string>veterinary dermatology</json:string><json:string>same substance</json:string><json:string>pruritus episode</json:string><json:string>erythema formation</json:string></teeft></keywords><author><json:item><name>Melissa N. Carr</name><affiliations><json:string>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</json:string></affiliations></json:item><json:item><name>Sheila M. F. Torres</name><affiliations><json:string>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</json:string></affiliations></json:item><json:item><name>Sandra N. Koch</name><affiliations><json:string>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</json:string></affiliations></json:item><json:item><name>Lisa V. Reiter</name><affiliations><json:string>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</json:string></affiliations></json:item></author><articleId><json:string>VDE716</json:string></articleId><arkIstex>ark:/67375/WNG-K3R7VPWG-W</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>There are numerous studies of the pruritus‐producing effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in humans and mice, but very little reported in dogs even though a common reason dogs are presented to veterinarians is pruritus. The aim of this study was to determine whether substances known to cause pruritus in humans also cause pruritus in dogs. Twenty‐five clinically healthy research beagle dogs were included in the study. All dogs first received an intradermal injection of 0.05 mL saline as a control substance and were video‐recorded for 20 min before and after the injection. Twenty‐four hours later the dogs were randomly divided into five groups of five dogs each and randomly assigned to receive histamine, serotonin, tryptase, substance P or interleukin‐2 injected intradermally each at the volume of 0.05 mL. On subsequent days, increasing concentrations of each substance were used. Before (baseline) and after the injection of each concentration of the substances, the dogs were video‐recorded for 20 min. The frequency and character of pruritus episodes (scratching, licking, chewing, rubbing or rolling) were noted and these data were used for statistical analysis. The number of pruritus episodes was compared among baseline, saline and the different concentrations of each substance. The results showed that dogs did not have a significant increase in pruritic behaviour above baseline or saline after injection of any of the investigated substances (generalized linear model; P = 0.23).</abstract><qualityIndicators><score>9.374</score><pdfWordCount>4650</pdfWordCount><pdfCharCount>28614</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><pdfWordsPerPage>775</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>227</abstractWordCount><abstractCharCount>1536</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs</title><pmid><json:string>19159412</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Veterinary Dermatology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1365-3164</json:string></doi><issn><json:string>0959-4493</json:string></issn><eissn><json:string>1365-3164</json:string></eissn><publisherId><json:string>VDE</json:string></publisherId><volume>20</volume><issue>2</issue><pages><first>105</first><last>110</last><total>6</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2009</json:string><json:string>1965</json:string></date><geogName></geogName><orgName><json:string>Use Committee of the University of Minnesota</json:string><json:string>University of Minnesota</json:string><json:string>Veterinary Clinical Sciences Department, University of Minnesota, St</json:string><json:string>Genscript Corporation</json:string><json:string>North American Veterinary Dermatology Forum, Veterinary Dermatology</json:string><json:string>Greer Laboratories</json:string><json:string>Tany TechnoGene Ltd, Rehovot, Israel</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Consulting Service</json:string><json:string>Melissa N. Carr</json:string><json:string>Birgit Grund</json:string><json:string>M. F. Torres</json:string><json:string>Sandra N. Koch</json:string><json:string>Lisa</json:string><json:string>Tryptase</json:string><json:string>Lisa Lendway</json:string></persName><placeName><json:string>Piscataway</json:string><json:string>NC</json:string><json:string>USA</json:string><json:string>NJ</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Carr et al.</json:string><json:string>Vienna, Austria, 2006</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-K3R7VPWG-W</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - veterinary sciences</json:string><json:string>2 - dermatology</json:string></wos><scienceMetrix><json:string>1 - applied sciences</json:string><json:string>2 - agriculture, fisheries & forestry</json:string><json:string>3 - veterinary sciences</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Veterinary</json:string><json:string>3 - General Veterinary</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1111/j.1365-3164.2008.00716.x</json:string></doi><id>0C3FE0DCC27843D6D1E5C8DBAE524266C73D8322</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-K3R7VPWG-W/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-K3R7VPWG-W/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-K3R7VPWG-W/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs</title><title level="a" type="short">Pruritogenic substances in healthy dogs</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2009 The Authors. Journal compilation © 2009 ESVD and ACVD</licence></availability><date type="published" when="2009-04"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs</title><title level="a" type="short">Pruritogenic substances in healthy dogs</title><author xml:id="author-0000"><persName><forename type="first">Melissa N.</forename><surname>Carr</surname></persName><affiliation><orgName type="division">Veterinary Clinical Sciences Department</orgName><orgName type="institution">University of Minnesota</orgName><address><addrLine>St. Paul</addrLine><addrLine>MN, USA</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Sheila M. F.</forename><surname>Torres</surname></persName><affiliation><orgName type="division">Veterinary Clinical Sciences Department</orgName><orgName type="institution">University of Minnesota</orgName><address><addrLine>St. Paul</addrLine><addrLine>MN, USA</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Sandra N.</forename><surname>Koch</surname></persName><affiliation><orgName type="division">Veterinary Clinical Sciences Department</orgName><orgName type="institution">University of Minnesota</orgName><address><addrLine>St. Paul</addrLine><addrLine>MN, USA</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Lisa V.</forename><surname>Reiter</surname></persName><affiliation><orgName type="division">Veterinary Clinical Sciences Department</orgName><orgName type="institution">University of Minnesota</orgName><address><addrLine>St. Paul</addrLine><addrLine>MN, USA</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><idno type="istex">0C3FE0DCC27843D6D1E5C8DBAE524266C73D8322</idno><idno type="ark">ark:/67375/WNG-K3R7VPWG-W</idno><idno type="DOI">10.1111/j.1365-3164.2008.00716.x</idno><idno type="unit">VDE716</idno><idno type="toTypesetVersion">file:VDE.VDE716.pdf</idno></analytic><monogr><title level="j" type="main">Veterinary Dermatology</title><title level="j" type="alt">VETERINARY DERMATOLOGY</title><idno type="pISSN">0959-4493</idno><idno type="eISSN">1365-3164</idno><idno type="book-DOI">10.1111/(ISSN)1365-3164</idno><idno type="book-part-DOI">10.1111/vde.2009.20.issue-2</idno><idno type="product">VDE</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">20</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="105">105</biblScope><biblScope unit="page" to="110">110</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-04"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>There are numerous studies of the pruritus‐producing effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in humans and mice, but very little reported in dogs even though a common reason dogs are presented to veterinarians is pruritus. The aim of this study was to determine whether substances known to cause pruritus in humans also cause pruritus in dogs. Twenty‐five clinically healthy research beagle dogs were included in the study. All dogs first received an intradermal injection of 0.05 mL saline as a control substance and were video‐recorded for 20 min before and after the injection. Twenty‐four hours later the dogs were randomly divided into five groups of five dogs each and randomly assigned to receive histamine, serotonin, tryptase, substance P or interleukin‐2 injected intradermally each at the volume of 0.05 mL. On subsequent days, increasing concentrations of each substance were used. Before (baseline) and after the injection of each concentration of the substances, the dogs were video‐recorded for 20 min. The frequency and character of pruritus episodes (scratching, licking, chewing, rubbing or rolling) were noted and these data were used for statistical analysis. The number of pruritus episodes was compared among baseline, saline and the different concentrations of each substance. The results showed that dogs did not have a significant increase in pruritic behaviour above baseline or saline after injection of any of the investigated substances (generalized linear model; <hi rend="italic">P</hi> = 0.23).</p></abstract><textClass><keywords rend="tocHeading1"><term>Scientific Papers</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-K3R7VPWG-W/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-3164</doi><issn type="print">0959-4493</issn><issn type="electronic">1365-3164</issn><idGroup><id type="product" value="VDE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="VETERINARY DERMATOLOGY">Veterinary Dermatology</title></titleGroup></publicationMeta><publicationMeta level="part" position="04002"><doi origin="wiley">10.1111/vde.2009.20.issue-2</doi><numberingGroup><numbering type="journalVolume" number="20">20</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="2009-04">April 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley">10.1111/j.1365-3164.2008.00716.x</doi><idGroup><id type="unit" value="VDE716"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Scientific Papers</title></titleGroup><copyright>© 2009 The Authors. Journal compilation © 2009 ESVD and ACVD</copyright><eventGroup><event type="firstOnline" date="2009-01-21"></event><event type="publishedOnlineFinalForm" date="2009-03-13"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-02"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="105">105</numbering><numbering type="pageLast" number="110">110</numbering></numberingGroup><correspondenceTo> Melissa N. Carr, Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA. E‐mail: <email>carr0293@umn.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:VDE.VDE716.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted 29 August 2008</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="28"></count><count type="wordTotal" number="3096"></count></countGroup><titleGroup><title type="main">Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs</title><title type="shortAuthors">Carr et al.</title><title type="short">Pruritogenic substances in healthy dogs</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>Melissa N.</givenNames><familyName>Carr</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>Sheila M. F.</givenNames><familyName>Torres</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#aff-1-1"><personName><givenNames>Sandra N.</givenNames><familyName>Koch</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#aff-1-1"><personName><givenNames>Lisa V.</givenNames><familyName>Reiter</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="US"><unparsedAffiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>There are numerous studies of the pruritus‐producing effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in humans and mice, but very little reported in dogs even though a common reason dogs are presented to veterinarians is pruritus. The aim of this study was to determine whether substances known to cause pruritus in humans also cause pruritus in dogs. Twenty‐five clinically healthy research beagle dogs were included in the study. All dogs first received an intradermal injection of 0.05 mL saline as a control substance and were video‐recorded for 20 min before and after the injection. Twenty‐four hours later the dogs were randomly divided into five groups of five dogs each and randomly assigned to receive histamine, serotonin, tryptase, substance P or interleukin‐2 injected intradermally each at the volume of 0.05 mL. On subsequent days, increasing concentrations of each substance were used. Before (baseline) and after the injection of each concentration of the substances, the dogs were video‐recorded for 20 min. The frequency and character of pruritus episodes (scratching, licking, chewing, rubbing or rolling) were noted and these data were used for statistical analysis. The number of pruritus episodes was compared among baseline, saline and the different concentrations of each substance. The results showed that dogs did not have a significant increase in pruritic behaviour above baseline or saline after injection of any of the investigated substances (generalized linear model; <i>P</i> = 0.23).</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="n-fnt-1" numbered="no"><p>This study was published as an abstract of the North American Veterinary Dermatology Forum, <i>Veterinary Dermatology</i> 2008; 19: 107.</p></note><note xml:id="n-fnt-2" numbered="no"><p> <b>Sources of funding</b>
Self‐funded.
<b>Conflict of interest</b>
None.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pruritogenic substances in healthy dogs</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs</title></titleInfo><name type="personal"><namePart type="given">Melissa N.</namePart><namePart type="family">Carr</namePart><affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sheila M. F.</namePart><namePart type="family">Torres</namePart><affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sandra N.</namePart><namePart type="family">Koch</namePart><affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lisa V.</namePart><namePart type="family">Reiter</namePart><affiliation>Veterinary Clinical Sciences Department, University of Minnesota, St. Paul, MN, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2009-04</dateIssued><edition>Accepted 29 August 2008</edition><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">2</extent><extent unit="formulas">0</extent><extent unit="references">28</extent><extent unit="words">3096</extent></physicalDescription><abstract lang="en">There are numerous studies of the pruritus‐producing effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in humans and mice, but very little reported in dogs even though a common reason dogs are presented to veterinarians is pruritus. The aim of this study was to determine whether substances known to cause pruritus in humans also cause pruritus in dogs. Twenty‐five clinically healthy research beagle dogs were included in the study. All dogs first received an intradermal injection of 0.05 mL saline as a control substance and were video‐recorded for 20 min before and after the injection. Twenty‐four hours later the dogs were randomly divided into five groups of five dogs each and randomly assigned to receive histamine, serotonin, tryptase, substance P or interleukin‐2 injected intradermally each at the volume of 0.05 mL. On subsequent days, increasing concentrations of each substance were used. Before (baseline) and after the injection of each concentration of the substances, the dogs were video‐recorded for 20 min. The frequency and character of pruritus episodes (scratching, licking, chewing, rubbing or rolling) were noted and these data were used for statistical analysis. The number of pruritus episodes was compared among baseline, saline and the different concentrations of each substance. The results showed that dogs did not have a significant increase in pruritic behaviour above baseline or saline after injection of any of the investigated substances (generalized linear model; P = 0.23).</abstract><relatedItem type="host"><titleInfo><title>Veterinary Dermatology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0959-4493</identifier><identifier type="eISSN">1365-3164</identifier><identifier type="DOI">10.1111/(ISSN)1365-3164</identifier><identifier type="PublisherID">VDE</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>105</start><end>110</end><total>6</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Itch</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Yosipovitch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MW</namePart><namePart type="family">Greaves</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Schmelz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yosipovitch G, Greaves MW, Schmelz M. Itch. The Lancet 2003; 361: 690–4.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>690</start><end>4</end></extent></part><relatedItem type="host"><titleInfo><title>The Lancet</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>690</start><end>4</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Itch: scratching more than the surface</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Twycross</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MW</namePart><namePart type="family">Greaves</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Handwerker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Twycross R, Greaves MW, Handwerker H et al. Itch: scratching more than the surface. Quarterly Journal of Medicine 2003; 96: 7–26.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>96</number></detail><extent unit="pages"><start>7</start><end>26</end></extent></part><relatedItem type="host"><titleInfo><title>Quarterly Journal of Medicine</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>96</number></detail><extent unit="pages"><start>7</start><end>26</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Recent advances in pathophysiology and current management of itch</title></titleInfo><name type="personal"><namePart type="given">MW</namePart><namePart type="family">Greaves</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Greaves MW. Recent advances in pathophysiology and current management of itch. Annals of the Academy of Medicine, Singapore 2007; 36: 788–92.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>788</start><end>92</end></extent></part><relatedItem type="host"><titleInfo><title>Annals of the Academy of Medicine, Singapore</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>788</start><end>92</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>The itch‐producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Davidson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CH</namePart><namePart type="family">Yoon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SG</namePart><namePart type="family">Khasabov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Simone</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">Giesler</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Davidson S, Zhang X, Yoon CH, Khasabov SG, Simone DA, Giesler GJ. The itch‐producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. Journal of Neuroscience 2007; 27: 10007–14.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>10007</start><end>14</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Neuroscience</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>10007</start><end>14</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Cutaneous manifestations of neurological diseases: review of neuro‐pathophysiology and diseases causing pruritus</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Gnirs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Prélaud</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gnirs K, Prélaud P. Cutaneous manifestations of neurological diseases: review of neuro‐pathophysiology and diseases causing pruritus. Veterinary Dermatology 2005; 16: 137–46.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>137</start><end>46</end></extent></part><relatedItem type="host"><titleInfo><title>Veterinary Dermatology</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>137</start><end>46</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Intradermal skin test reactivity to histamine and substance P is blunted in dogs with atopic dermatitis</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Marsella</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CF</namePart><namePart type="family">Nicklin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Marsella R, Nicklin CF. Intradermal skin test reactivity to histamine and substance P is blunted in dogs with atopic dermatitis. Veterinary Dermatology 2001; 12: 149–54.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>149</start><end>54</end></extent></part><relatedItem type="host"><titleInfo><title>Veterinary Dermatology</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>149</start><end>54</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>The reaction of canine skin to histamine and 48/80</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Schwartzman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Schwartzman RM. The reaction of canine skin to histamine and 48/80. Journal of Investigative Dermatology 1965; 44: 39–42.</note><part><date>1965</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>39</start><end>42</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Investigative Dermatology</title></titleInfo><part><date>1965</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>39</start><end>42</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Experimental itch in sodium lauryl sulphate‐inflamed and normal skin in humans. A randomized, double‐blind, placebo‐controlled study of histamine and other inducers of itch</title></titleInfo><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Thomsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Sonne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Benfeldt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SB</namePart><namePart type="family">Jensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Serup</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ÉT.</namePart><namePart type="family">Menn</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Thomsen JS, Sonne M, Benfeldt E, Jensen SB, Serup J, Menn ÉT. Experimental itch in sodium lauryl sulphate‐inflamed and normal skin in humans. A randomized, double‐blind, placebo‐controlled study of histamine and other inducers of itch. British Journal of Dermatology 2002; 146: 792–800.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>146</number></detail><extent unit="pages"><start>792</start><end>800</end></extent></part><relatedItem type="host"><titleInfo><title>British Journal of Dermatology</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>146</number></detail><extent unit="pages"><start>792</start><end>800</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Skin reactions and itch sensation induced by epicutaneous histamine application in atopic dermatitis and controls</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Heyer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">OP</namePart><namePart type="family">Hornstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HO</namePart><namePart type="family">Handwerker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Heyer G, Hornstein OP, Handwerker HO. Skin reactions and itch sensation induced by epicutaneous histamine application in atopic dermatitis and controls. Journal of Investigative Dermatology 1989; 93: 492–6.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>492</start><end>6</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Investigative Dermatology</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>492</start><end>6</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>The magnitude and duration of itch produced by intracutaneous injections of histamine</title></titleInfo><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Simone</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JY</namePart><namePart type="family">Ngeow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Whitehouse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Becerra‐Cabal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">Putterman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RH</namePart><namePart type="family">LaMotte</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Simone DA, Ngeow JY, Whitehouse J, Becerra‐Cabal L, Putterman GJ, LaMotte RH. The magnitude and duration of itch produced by intracutaneous injections of histamine. Somatosensory Research 1987; 5: 81–92.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>81</start><end>92</end></extent></part><relatedItem type="host"><titleInfo><title>Somatosensory Research</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>81</start><end>92</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Neurophysiology of pruritus. Cutaneous elicitation of itch</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Ständer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Steinhoff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schmelz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Weisshaar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Metze</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Luger</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ständer S, Steinhoff M, Schmelz M, Weisshaar E, Metze D, Luger T. Neurophysiology of pruritus. Cutaneous elicitation of itch. Archives of Dermatology 2003; 139: 1463–70.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>139</number></detail><extent unit="pages"><start>1463</start><end>70</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Dermatology</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>139</number></detail><extent unit="pages"><start>1463</start><end>70</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Sertraline as a first‐line treatment for cholestatic pruritus</title></titleInfo><name type="personal"><namePart type="given">MJ</namePart><namePart type="family">Mayo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Handem</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Saldana</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jacobe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Getachew</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AJ</namePart><namePart type="family">Rush</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mayo MJ, Handem I, Saldana S, Jacobe H, Getachew Y, Rush AJ. Sertraline as a first‐line treatment for cholestatic pruritus. Hepatology 2007; 45: 666–74.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>666</start><end>74</end></extent></part><relatedItem type="host"><titleInfo><title>Hepatology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>666</start><end>74</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>A randomized, placebo‐controlled, double‐blind trial of ondansetron in renal itch</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Murphy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Reaich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Pai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Finn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AJ</namePart><namePart type="family">Carmichael</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Murphy M, Reaich D, Pai P, Finn P, Carmichael AJ. A randomized, placebo‐controlled, double‐blind trial of ondansetron in renal itch. British Journal of Dermatology 2003; 148: 314–7.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>148</number></detail><extent unit="pages"><start>314</start><end>7</end></extent></part><relatedItem type="host"><titleInfo><title>British Journal of Dermatology</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>148</number></detail><extent unit="pages"><start>314</start><end>7</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Mirtazapine for pruritus</title></titleInfo><name type="personal"><namePart type="given">MP</namePart><namePart type="family">Davis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Frandsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Walsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Andresen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Davis MP, Frandsen JL, Walsh D, Andresen S, Taylor S. Mirtazapine for pruritus. Journal of Pain and Symptom Management 2003; 25: 288–91.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>288</start><end>91</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Pain and Symptom Management</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>288</start><end>91</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Potent pruritogenic action of tryptase mediated by PAR‐2 receptor and its involvement in anti‐pruritic effect of nafamostat mesilate in mice</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Ui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Andoh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Nojima</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Kuraishi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ui H, Andoh T, Lee J, Nojima H, Kuraishi Y. Potent pruritogenic action of tryptase mediated by PAR‐2 receptor and its involvement in anti‐pruritic effect of nafamostat mesilate in mice. European Journal of Pharmacology 2006; 530: 172–8.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>530</number></detail><extent unit="pages"><start>172</start><end>8</end></extent></part><relatedItem type="host"><titleInfo><title>European Journal of Pharmacology</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>530</number></detail><extent unit="pages"><start>172</start><end>8</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Interactions of mast cell tryptase with thrombin receptors and PAR‐2</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Molino</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ES</namePart><namePart type="family">Barnathan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Numerof</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Molino M, Barnathan ES, Numerof R et al. Interactions of mast cell tryptase with thrombin receptors and PAR‐2. Journal of Biological Chemistry 1997; 272: 4043–9.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>272</number></detail><extent unit="pages"><start>4043</start><end>9</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Biological Chemistry</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>272</number></detail><extent unit="pages"><start>4043</start><end>9</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Proteinase‐activated receptor‐2 mediates itch: a novel pathway for pruritus in human skin</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Steinhoff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Neisius</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ikoma</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Steinhoff M, Neisius U, Ikoma A et al. Proteinase‐activated receptor‐2 mediates itch: a novel pathway for pruritus in human skin. Journal of Neuroscience 2003; 23: 6176–80.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>6176</start><end>80</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Neuroscience</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>6176</start><end>80</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Agonists of proteinase‐activated receptor 2 induce inflammation by a neurogenic mechanism</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Steinhoff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Vergnolle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SH</namePart><namePart type="family">Young</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Steinhoff M, Vergnolle N, Young SH et al. Agonists of proteinase‐activated receptor 2 induce inflammation by a neurogenic mechanism. Nature Medicine 2000; 6: 151–8.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>151</start><end>8</end></extent></part><relatedItem type="host"><titleInfo><title>Nature Medicine</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>151</start><end>8</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Substance P‐induced histamine release in human cutaneous mast cells</title></titleInfo><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Ebertz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Hirshman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NS</namePart><namePart type="family">Kettelkamp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Uno</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Hanifin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ebertz JM, Hirshman CA, Kettelkamp NS, Uno H, Hanifin JM. Substance P‐induced histamine release in human cutaneous mast cells. Journal of Investigative Dermatology 1987; 88: 682–5.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>682</start><end>5</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Investigative Dermatology</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>682</start><end>5</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Flare and itch induced by substance P in human skin</title></titleInfo><name type="personal"><namePart type="given">O</namePart><namePart type="family">Hägermark</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Hökfelt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Pernow</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hägermark O, Hökfelt T, Pernow B. Flare and itch induced by substance P in human skin. Journal of Investigative Dermatology 1978; 71: 233–5.</note><part><date>1978</date><detail type="volume"><caption>vol.</caption><number>71</number></detail><extent unit="pages"><start>233</start><end>5</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Investigative Dermatology</title></titleInfo><part><date>1978</date><detail type="volume"><caption>vol.</caption><number>71</number></detail><extent unit="pages"><start>233</start><end>5</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Dermatologic changes associated with interleukin 2 administration</title></titleInfo><name type="personal"><namePart type="given">AA</namePart><namePart type="family">Gaspari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MT</namePart><namePart type="family">Lotze</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Rosenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JB</namePart><namePart type="family">Stern</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SI</namePart><namePart type="family">Katz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gaspari AA, Lotze MT, Rosenberg SA, Stern JB, Katz SI. Dermatologic changes associated with interleukin 2 administration. Journal of the American Medical Association 1987; 258: 1624–9.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>258</number></detail><extent unit="pages"><start>1624</start><end>9</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of the American Medical Association</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>258</number></detail><extent unit="pages"><start>1624</start><end>9</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>Itch and inflammation induced by intradermally injected interleukin‐2 in atopic dermatitis patients and healthy subjects</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Wahlgren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Hägermark</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MT</namePart><namePart type="family">Linder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Scheynius</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wahlgren C, Hägermark O, Linder MT, Scheynius A. Itch and inflammation induced by intradermally injected interleukin‐2 in atopic dermatitis patients and healthy subjects. Archives of Dermatological Research 1995; 287: 572–80.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>287</number></detail><extent unit="pages"><start>572</start><end>80</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Dermatological Research</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>287</number></detail><extent unit="pages"><start>572</start><end>80</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Skin testing of the pruritogenic activity of histamine and cytokines (interleukin‐2 and tumour necrosis factor‐alpha) at the dermal‐epidermal junction</title></titleInfo><name type="personal"><namePart type="given">U</namePart><namePart type="family">Darsow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Scharein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Bromm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Ring</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Darsow U, Scharein E, Bromm B, Ring J. Skin testing of the pruritogenic activity of histamine and cytokines (interleukin‐2 and tumour necrosis factor‐alpha) at the dermal‐epidermal junction. British Journal of Dermatology 1997; 137: 415–7.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>137</number></detail><extent unit="pages"><start>415</start><end>7</end></extent></part><relatedItem type="host"><titleInfo><title>British Journal of Dermatology</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>137</number></detail><extent unit="pages"><start>415</start><end>7</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>The peripheral mechanism of itch in man</title></titleInfo><name type="personal"><namePart type="given">RP</namePart><namePart type="family">Arthur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WB</namePart><namePart type="family">Shelley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>Pain and Itch: Nervous Mechanisms</title></titleInfo><originInfo><publisher>Little, Brown and Company</publisher></originInfo><part><date>1959</date><extent unit="pages"><start>84</start><end>97</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>An experimental method for screening antipruritic agents</title></titleInfo><name type="personal"><namePart type="given">GV</namePart><namePart type="family">Joglekar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MB</namePart><namePart type="family">Bhide</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Balwani</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Joglekar GV, Bhide MB, Balwani JH. An experimental method for screening antipruritic agents. British Journal of Dermatology 1963; 75: 117–9.</note><part><date>1963</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>117</start><end>9</end></extent></part><relatedItem type="host"><titleInfo><title>British Journal of Dermatology</title></titleInfo><part><date>1963</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>117</start><end>9</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Experimental study of itch stimuli in animals</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Koenigstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Koenigstein H. Experimental study of itch stimuli in animals. Archives of Dermatology and Syphilology 1948; 57: 828–49.</note><part><date>1948</date><detail type="volume"><caption>vol.</caption><number>57</number></detail><extent unit="pages"><start>828</start><end>49</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Dermatology and Syphilology</title></titleInfo><part><date>1948</date><detail type="volume"><caption>vol.</caption><number>57</number></detail><extent unit="pages"><start>828</start><end>49</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Structure activity relationships in the pruritogenicity of chloroquine and amodiaquine metabolites in a dog model</title></titleInfo><name type="personal"><namePart type="given">GN</namePart><namePart type="family">Osifo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Osifo GN. Structure activity relationships in the pruritogenicity of chloroquine and amodiaquine metabolites in a dog model. Journal of Dermatological Science 1991; 2: 92–6.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>92</start><end>6</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Dermatological Science</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>92</start><end>6</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>An animal model of chloroquine‐induced pruritus</title></titleInfo><name type="personal"><namePart type="given">GN</namePart><namePart type="family">Osifo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Osifo GN. An animal model of chloroquine‐induced pruritus. Nigerian Journal of Physiological Sciences 1987; 3: 31–5.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>31</start><end>5</end></extent></part><relatedItem type="host"><titleInfo><title>Nigerian Journal of Physiological Sciences</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>31</start><end>5</end></extent></part></relatedItem></relatedItem><identifier type="istex">0C3FE0DCC27843D6D1E5C8DBAE524266C73D8322</identifier><identifier type="ark">ark:/67375/WNG-K3R7VPWG-W</identifier><identifier type="DOI">10.1111/j.1365-3164.2008.00716.x</identifier><identifier type="ArticleID">VDE716</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2009 The Authors. Journal compilation © 2009 ESVD and ACVD</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-16</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-K3R7VPWG-W/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002397 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002397 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:0C3FE0DCC27843D6D1E5C8DBAE524266C73D8322
|texte= Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin‐2 in healthy dogs
}}
| This area was generated with Dilib version V0.6.33. |  |