Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use
Identifieur interne : 002391 ( Istex/Corpus ); précédent : 002390; suivant : 002392Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use
Auteurs : Tore SkotlandSource :
- Contrast Media & Molecular Imaging [ 1555-4309 ] ; 2012-01.
English descriptors
- Teeft :
- Amine groups, Animal studies, Background level, Background signal, Bioconjug chem, Biol, Biol chem, Body imaging, Cancer biomedicine, Cancer cells, Cancer research, Cell membrane, Cell membranes, Cell surface, Cellular processes, Cellular uptake, Chem, Clinical imaging, Contrast agents, Contrast media, Copyright, Curr opin chem biol, Cytosol, Different types, Diseased, Diseased area, Drug deliv, Drug delivery, Endocytic mechanisms, Endocytic vesicle, Endocytosis, Endoplasmic reticulum, Endosomes, Excretion, Extracellular, Extracellular structure, Extracellular targets, Future studies, Golgi apparatus, Good images, Great challenge, High sensitivity, Imaging, Imaging agent, Imaging agents, Imaging modalities, Imaging molecules, Imaging techniques, Intracellular, Intracellular targets, Intracellular transport, Intravenous injection, John wiley sons, Large number, Lipophilic, Long time, Lysosome, Magn reson, Magnetic resonance imaging, Magnetic resonance spectroscopy, Medical imaging, Modality, Molecular imaging, Molecular target, Molecule, Monoclonal antibodies, Norwegian radium hospital, Optical imaging, Passive diffusion, Peptide, Plasma membrane, Positive charge, Positron emission tomography, Present article, Proton sponge, Radiolabeled antibodies, Rapid clearance, Recent years, Receptor, Sensitive imaging techniques, Single photon emission computer tomography, Skotland, Slow excretion, Spect, Spect imaging, Successful imaging, Such compounds, Superparamagnetic iron oxide particles, Tissue volume, Toxin, Transporter, Tumor cells, Ultrasound, Ultrasound imaging, Uorescent probe, Viable cancer cells, Vivo imaging.
Abstract
Molecular imaging (MI) takes advantage of several new techniques to detect biomarkers or biochemical and cellular processes, with the goal of obtaining high sensitivity, specificity and signal‐to‐noise ratio imaging of disease. The imaging modalities bearing the most promise for MI are positron emission tomography (PET), single photon emission computer tomography (SPECT) and different optical imaging techniques with high sensitivity. Also magnetic resonance imaging (MRI) with contrast agents like ultra‐small superparamagnetic iron oxide particles (USPIO), magnetic resonance spectroscopy and ultrasound imaging with contrast agents may be useful approaches. MI techniques have been used in the clinic for many years, i.e. PET imaging using 18 F‐labeled fluorodeoxyglucose. Animal studies have during the last years revealed great potential for MI also with several other agents. The focus of the present article is the challenges of clinical imaging of intracellular targets following intravenous injection of the agents. Thus, the great challenge of getting enough contrast agent into the cytosol and at the same time obtaining a low signal from tissue just outside the diseased area is discussed. Copyright © 2012 John Wiley & Sons, Ltd.
Animal studies have during the last years revealed a great potential for molecular imaging with different types of targeting molecules. Challenges of bringing such agents into common clinical use are discussed, with a special focus on the challenges to image intracellular targets following intravenous injection of the agents.
Url:
DOI: 10.1002/cmmi.458
Links to Exploration step
ISTEX:663C4DAA027BF59AC8F27510ACA4F252F073F20CLe document en format XML
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Copyright © 2012 John Wiley & Sons, Ltd.</div><div type="abstract">Animal studies have during the last years revealed a great potential for molecular imaging with different types of targeting molecules. 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Skotland</json:string><json:string>John Wiley</json:string></persName><placeName><json:string>Norway</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Ogawa et al.</json:string><json:string>Iversen et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-0QB3PDB4-K</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - radiology, nuclear medicine & medical imaging</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - nuclear medicine & medical imaging</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Radiology Nuclear Medicine and imaging</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2012</publicationDate><copyrightDate>2012</copyrightDate><doi><json:string>10.1002/cmmi.458</json:string></doi><id>663C4DAA027BF59AC8F27510ACA4F252F073F20C</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-0QB3PDB4-K/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-0QB3PDB4-K/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-0QB3PDB4-K/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use</title><title level="a" type="short">MOLECULAR IMAGING AND INTRACELLULAR TARGETS</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><availability><licence>Copyright © 2012 John Wiley & Sons, Ltd.</licence></availability><date type="published" when="2012-01"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use</title><title level="a" type="short">MOLECULAR IMAGING AND INTRACELLULAR TARGETS</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Tore</forename><surname>Skotland</surname></persName><state type="biography"><desc>
Tore Skotland is a guest researcher at The Centre for Cancer Biomedicine, The Norwegian Radium Hospital in Oslo, Norway. He received his PhD in biochemistry from the University of Bergen, Norway, in 1980. After 11 years in basic research (protein chemistry and enzymology), he moved to pharmaceutical R&D in 1983 where he stayed for 26 years within the same company, Nycomed/Amersham/GE Healthcare, one of the leading companies in developing contrast agents for medical imaging. In the last 20 years he has headed work to characterize the metabolism and excretion of all types of contrast agents (CT, MRI, ultrasound, SPECT, PET and optical imaging). He is co‐author of approximately 75 publications.
</desc></state><email>tore.skotland@rr‐research.no</email><affiliation><orgName type="division">Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital</orgName><orgName type="institution">University of Oslo</orgName><address><country key="NO" xml:lang="en">NORWAY</country></address></affiliation><affiliation><orgName type="division">Department of Biochemistry, Institute of Cancer Research</orgName><orgName type="institution">Norwegian Radium Hospital</orgName><address><street>Montebello</street><postCode>0310</postCode><settlement>Oslo</settlement><country key="NO" xml:lang="en">NORWAY</country></address></affiliation></author><idno type="istex">663C4DAA027BF59AC8F27510ACA4F252F073F20C</idno><idno type="ark">ark:/67375/WNG-0QB3PDB4-K</idno><idno type="DOI">10.1002/cmmi.458</idno><idno type="unit">CMMI458</idno><idno type="toTypesetVersion">file:CMMI.CMMI458.pdf</idno></analytic><monogr><title level="j" type="main">Contrast Media & Molecular Imaging</title><title level="j" type="alt">CONTRAST MEDIA AND MOLECULAR IMAGING</title><idno type="pISSN">1555-4309</idno><idno type="eISSN">1555-4317</idno><idno type="book-DOI">10.1002/(ISSN)1555-4317</idno><idno type="book-part-DOI">10.1002/cmmi.v7.1</idno><idno type="product">CMMI</idno><imprint><biblScope unit="vol">7</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="6">6</biblScope><biblScope unit="page-count">6</biblScope><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2012-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main"><p>Molecular imaging (MI) takes advantage of several new techniques to detect biomarkers or biochemical and cellular processes, with the goal of obtaining high sensitivity, specificity and signal‐to‐noise ratio imaging of disease. The imaging modalities bearing the most promise for MI are positron emission tomography (PET), single photon emission computer tomography (SPECT) and different optical imaging techniques with high sensitivity. Also magnetic resonance imaging (MRI) with contrast agents like ultra‐small superparamagnetic iron oxide particles (USPIO), magnetic resonance spectroscopy and ultrasound imaging with contrast agents may be useful approaches. MI techniques have been used in the clinic for many years, i.e. PET imaging using <hi rend="superscript">18</hi> F‐labeled fluorodeoxyglucose. Animal studies have during the last years revealed great potential for MI also with several other agents. The focus of the present article is the challenges of clinical imaging of intracellular targets following intravenous injection of the agents. Thus, the great challenge of getting enough contrast agent into the cytosol and at the same time obtaining a low signal from tissue just outside the diseased area is discussed. Copyright © 2012 John Wiley & Sons, Ltd.</p></abstract><abstract style="graphical" xml:id="cmmi458-abs-0002"><p>Animal studies have during the last years revealed a great potential for molecular imaging with different types of targeting molecules. Challenges of bringing such agents into common clinical use are discussed, with a special focus on the challenges to image intracellular targets following intravenous injection of the agents.
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Imaging</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi>10.1002/cmmi.v7.1</doi><copyright ownership="publisher">Copyright © 2012 John Wiley & Sons, Ltd.</copyright><numberingGroup><numbering type="journalVolume" number="7">7</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2012-01">January/February 2012</coverDate></publicationMeta><publicationMeta level="unit" position="2" type="article" status="forIssue"><doi>10.1002/cmmi.458</doi><idGroup><id type="unit" value="CMMI458"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Review</title><title type="tocHeading1">Reviews</title></titleGroup><copyright ownership="publisher">Copyright © 2012 John Wiley & Sons, Ltd.</copyright><eventGroup><event type="manuscriptReceived" date="2010-11-10"></event><event type="manuscriptRevised" date="2011-04-11"></event><event type="manuscriptAccepted" date="2011-05-16"></event><event type="xmlCreated" agent="SPi Global" date="2011-06-18"></event><event type="publishedOnlineFinalForm" date="2012-01-30"></event><event type="firstOnline" date="2012-01-30"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-24"></event></eventGroup><numberingGroup><numbering type="pageFirst">1</numbering><numbering type="pageLast">6</numbering></numberingGroup><correspondenceTo>T. Skotland, Centre for Cancer Biomedicine, Faculty Division, Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CMMI.CMMI458.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use</title><title type="short">MOLECULAR IMAGING AND INTRACELLULAR TARGETS</title><title type="shortAuthors">T. SKOTLAND</title></titleGroup><creators><creator creatorRole="author" xml:id="cmmi458-cr-0001" affiliationRef="#cmmi458-aff-0001 #cmmi458-aff-0002" corresponding="yes"><personName><givenNames>Tore</givenNames><familyName>Skotland</familyName></personName><biographyInfo xml:id="cmmi458-biog-0001"><p>Tore Skotland is a guest researcher at The Centre for Cancer Biomedicine, The Norwegian Radium Hospital in Oslo, Norway. He received his PhD in biochemistry from the University of Bergen, Norway, in 1980. After 11 years in basic research (protein chemistry and enzymology), he moved to pharmaceutical R&D in 1983 where he stayed for 26 years within the same company, Nycomed/Amersham/GE Healthcare, one of the leading companies in developing contrast agents for medical imaging. In the last 20 years he has headed work to characterize the metabolism and excretion of all types of contrast agents (CT, MRI, ultrasound, SPECT, PET and optical imaging). He is co‐author of approximately 75 publications.</p></biographyInfo><contactDetails><email normalForm="tore.skotland@rr-research.no">tore.skotland@rr‐research.no</email><phone>+47 2278 1932</phone><fax>+47 2250 1845</fax></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="cmmi458-aff-0001" countryCode="NO" type="organization"><orgDiv>Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital</orgDiv><orgName>University of Oslo</orgName><address><country>Norway</country></address></affiliation><affiliation xml:id="cmmi458-aff-0002" countryCode="NO" type="organization"><orgDiv>Department of Biochemistry, Institute of Cancer Research</orgDiv><orgName>Norwegian Radium Hospital</orgName><address><street>Montebello</street><postCode>0310</postCode><city>Oslo</city><country>Norway</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="cmmi444-kwd-0001">molecular imaging</keyword><keyword xml:id="cmmi444-kwd-0002">intracellular targets</keyword><keyword xml:id="cmmi444-kwd-0003">endocytosis</keyword><keyword xml:id="cmmi444-kwd-0004">metabolism</keyword><keyword xml:id="cmmi444-kwd-0005">distribution</keyword></keywordGroup><abstractGroup><abstract type="main"><p>Molecular imaging (MI) takes advantage of several new techniques to detect biomarkers or biochemical and cellular processes, with the goal of obtaining high sensitivity, specificity and signal‐to‐noise ratio imaging of disease. The imaging modalities bearing the most promise for MI are positron emission tomography (PET), single photon emission computer tomography (SPECT) and different optical imaging techniques with high sensitivity. Also magnetic resonance imaging (MRI) with contrast agents like ultra‐small superparamagnetic iron oxide particles (USPIO), magnetic resonance spectroscopy and ultrasound imaging with contrast agents may be useful approaches. MI techniques have been used in the clinic for many years, i.e. PET imaging using <sup>18</sup> F‐labeled fluorodeoxyglucose. Animal studies have during the last years revealed great potential for MI also with several other agents. The focus of the present article is the challenges of clinical imaging of intracellular targets following intravenous injection of the agents. Thus, the great challenge of getting enough contrast agent into the cytosol and at the same time obtaining a low signal from tissue just outside the diseased area is discussed. Copyright © 2012 John Wiley & Sons, Ltd.</p></abstract><abstract type="graphical" xml:id="cmmi458-abs-0002"><p>Animal studies have during the last years revealed a great potential for molecular imaging with different types of targeting molecules. Challenges of bringing such agents into common clinical use are discussed, with a special focus on the challenges to image intracellular targets following intravenous injection of the agents.
<blockFixed type="graphic" xml:id="cmmi458-blkfxd-0001"><mediaResourceGroup><mediaResource alt="image" href="urn:x-wiley:15554309:media:cmmi458:cmmi458-toc-0001"></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>MOLECULAR IMAGING AND INTRACELLULAR TARGETS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use</title></titleInfo><name type="personal"><namePart type="given">Tore</namePart><namePart type="family">Skotland</namePart><affiliation>Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Norway</affiliation><affiliation>Department of Biochemistry, Institute of Cancer Research, Norwegian Radium Hospital, Montebello, 0310, Oslo, Norway</affiliation><affiliation>E-mail: tore.skotland@rr‐research.no</affiliation><affiliation>Correspondence address: T. Skotland, Centre for Cancer Biomedicine, Faculty Division, Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>John Wiley & Sons, Ltd</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2012-01</dateIssued><dateCreated encoding="w3cdtf">2011-06-18</dateCreated><dateCaptured encoding="w3cdtf">2010-11-10</dateCaptured><dateValid encoding="w3cdtf">2011-05-16</dateValid><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Molecular imaging (MI) takes advantage of several new techniques to detect biomarkers or biochemical and cellular processes, with the goal of obtaining high sensitivity, specificity and signal‐to‐noise ratio imaging of disease. The imaging modalities bearing the most promise for MI are positron emission tomography (PET), single photon emission computer tomography (SPECT) and different optical imaging techniques with high sensitivity. Also magnetic resonance imaging (MRI) with contrast agents like ultra‐small superparamagnetic iron oxide particles (USPIO), magnetic resonance spectroscopy and ultrasound imaging with contrast agents may be useful approaches. MI techniques have been used in the clinic for many years, i.e. PET imaging using 18 F‐labeled fluorodeoxyglucose. Animal studies have during the last years revealed great potential for MI also with several other agents. The focus of the present article is the challenges of clinical imaging of intracellular targets following intravenous injection of the agents. Thus, the great challenge of getting enough contrast agent into the cytosol and at the same time obtaining a low signal from tissue just outside the diseased area is discussed. Copyright © 2012 John Wiley & Sons, Ltd.</abstract><abstract type="graphical">Animal studies have during the last years revealed a great potential for molecular imaging with different types of targeting molecules. Challenges of bringing such agents into common clinical use are discussed, with a special focus on the challenges to image intracellular targets following intravenous injection of the agents.</abstract><subject><genre>keywords</genre><topic>molecular imaging</topic><topic>intracellular targets</topic><topic>endocytosis</topic><topic>metabolism</topic><topic>distribution</topic></subject><relatedItem type="host"><titleInfo><title>Contrast Media & Molecular Imaging</title></titleInfo><titleInfo type="abbreviated"><title>Contrast Media Mol. Imaging</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Review</topic><topic>Reviews</topic></subject><identifier type="ISSN">1555-4309</identifier><identifier type="eISSN">1555-4317</identifier><identifier type="DOI">10.1002/(ISSN)1555-4317</identifier><identifier type="PublisherID">CMMI</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>1</start><end>6</end><total>6</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0001"><titleInfo><title>Molecular imaging: current status and emerging strategies</title></titleInfo><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Pysz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SS</namePart><namePart type="family">Gambhir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Willmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pysz MA, Gambhir SS, Willmann JK. Molecular imaging: current status and emerging strategies. Clin Radiol 2010; 65: 500–516.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>500</start><end>516</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Radiol</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>500</start><end>516</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0002"><titleInfo><title>In vivo imaging in cancer</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Condeelis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Weissleder</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Condeelis J, Weissleder R. In vivo imaging in cancer. Cold Spring Harb Perspect Biol 2010; 2: a003848.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>a003848</start></extent></part><relatedItem type="host"><titleInfo><title>Cold Spring Harb Perspect Biol</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>a003848</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0003"><titleInfo><title>Challenges for molecular magnetic resonance imaging</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Terreno</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DD</namePart><namePart type="family">Castelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Viale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Aime</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Terreno E, Castelli DD, Viale A, Aime S. Challenges for molecular magnetic resonance imaging. Chem Rev 2010; 110: 3019–3042.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>110</number></detail><extent unit="pages"><start>3019</start><end>3042</end></extent></part><relatedItem type="host"><titleInfo><title>Chem Rev</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>110</number></detail><extent unit="pages"><start>3019</start><end>3042</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0004"><titleInfo><title>Imaging in the era of molecular oncology</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Weissleder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MJ</namePart><namePart type="family">Pittet</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Weissleder R, Pittet MJ. Imaging in the era of molecular oncology. Nature 2008; 452: 580–589.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>452</number></detail><extent unit="pages"><start>580</start><end>589</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>452</number></detail><extent unit="pages"><start>580</start><end>589</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0005"><titleInfo><title>Near‐infrared fluorescence: application to in vivo molecular imaging</title></titleInfo><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Hilderbrand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Weissleder</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hilderbrand SA, Weissleder R. Near‐infrared fluorescence: application to in vivo molecular imaging. Curr Opin Chem Biol 2010; 14: 71–79.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>71</start><end>79</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Opin Chem Biol</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>71</start><end>79</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0006"><titleInfo><title>Target‐specific delivery of peptide‐based probes for PET imaging</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PS</namePart><namePart type="family">Conti</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen K, Conti PS. Target‐specific delivery of peptide‐based probes for PET imaging. Adv Drug Deliv Rev 2010; 62: 1005–1022.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>62</number></detail><extent unit="pages"><start>1005</start><end>1022</end></extent></part><relatedItem type="host"><titleInfo><title>Adv Drug Deliv Rev</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>62</number></detail><extent unit="pages"><start>1005</start><end>1022</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0007"><titleInfo><title>Targeted delivery of multifunctional magnetic nanoparticles</title></titleInfo><name type="personal"><namePart type="given">JR</namePart><namePart type="family">McCarthy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Kelly</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EY</namePart><namePart type="family">Sun</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Weissleder</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">McCarthy JR, Kelly KA, Sun EY, Weissleder R. Targeted delivery of multifunctional magnetic nanoparticles. Nanomedicine 2007; 2: 153–167.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>153</start><end>167</end></extent></part><relatedItem type="host"><titleInfo><title>Nanomedicine</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>153</start><end>167</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0008"><titleInfo><title>Pushing the sensitivity envelope of lanthanide‐based magnetic resonance imaging (MRI) contrast agents for molecular imaging applications</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Aime</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DD</namePart><namePart type="family">Castelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SG</namePart><namePart type="family">Crich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Gianolio</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Terreno</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Aime S, Castelli DD, Crich SG, Gianolio E, Terreno E. Pushing the sensitivity envelope of lanthanide‐based magnetic resonance imaging (MRI) contrast agents for molecular imaging applications. Acc Chem Res 2009; 42: 822–831.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>822</start><end>831</end></extent></part><relatedItem type="host"><titleInfo><title>Acc Chem Res</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>822</start><end>831</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0009"><titleInfo><title>PET/CT in cancer research: from preclinical to clinical applications</title></titleInfo><name type="personal"><namePart type="given">VS</namePart><namePart type="family">Del</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Zannetti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Fonti</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Del VS, Zannetti A, Fonti R, et al. PET/CT in cancer research: from preclinical to clinical applications. Contrast Media Mol Imag 2010; 5: 190–200.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>190</start><end>200</end></extent></part><relatedItem type="host"><titleInfo><title>Contrast Media Mol Imag</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>190</start><end>200</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0010"><titleInfo><title>Cardiovascular molecular imaging</title></titleInfo><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FM</namePart><namePart type="family">Bengel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SS</namePart><namePart type="family">Gambhir</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wu JC, Bengel FM, Gambhir SS. Cardiovascular molecular imaging. Radiology 2007; 244: 337–355.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>244</number></detail><extent unit="pages"><start>337</start><end>355</end></extent></part><relatedItem type="host"><titleInfo><title>Radiology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>244</number></detail><extent unit="pages"><start>337</start><end>355</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0011"><titleInfo><title>Molecular imaging: integration of molecular imaging into the musculoskeletal imaging practice</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Biswal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DL</namePart><namePart type="family">Resnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Hoffman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SS</namePart><namePart type="family">Gambhir</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Biswal S, Resnick DL, Hoffman JM, Gambhir SS. Molecular imaging: integration of molecular imaging into the musculoskeletal imaging practice. Radiology 2007; 244: 651–671.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>244</number></detail><extent unit="pages"><start>651</start><end>671</end></extent></part><relatedItem type="host"><titleInfo><title>Radiology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>244</number></detail><extent unit="pages"><start>651</start><end>671</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0012"><titleInfo><title>Molecular neuroimaging: from conventional to emerging techniques</title></titleInfo><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Hammoud</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Hoffman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MG</namePart><namePart type="family">Pomper</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hammoud DA, Hoffman JM, Pomper MG. Molecular neuroimaging: from conventional to emerging techniques. Radiology 2007; 245: 21–42.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>245</number></detail><extent unit="pages"><start>21</start><end>42</end></extent></part><relatedItem type="host"><titleInfo><title>Radiology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>245</number></detail><extent unit="pages"><start>21</start><end>42</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0013"><titleInfo><title>Molecular imaging techniques in body imaging</title></titleInfo><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Margolis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Hoffman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RJ</namePart><namePart type="family">Herfkens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RB</namePart><namePart type="family">Jeffrey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Quon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SS</namePart><namePart type="family">Gambhir</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Margolis DJ, Hoffman JM, Herfkens RJ, Jeffrey RB, Quon A, Gambhir SS. Molecular imaging techniques in body imaging. Radiology 2007; 245: 333–356.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>245</number></detail><extent unit="pages"><start>333</start><end>356</end></extent></part><relatedItem type="host"><titleInfo><title>Radiology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>245</number></detail><extent unit="pages"><start>333</start><end>356</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0014"><titleInfo><title>Molecular imaging using hyperpolarized 13C</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Golman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LE</namePart><namePart type="family">Olsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Axelsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Mansson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Karlsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Petersson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Golman K, Olsson LE, Axelsson O, Mansson S, Karlsson M, Petersson JS. Molecular imaging using hyperpolarized 13C. Br J Radiol 2003; 76: S118–S127.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>76</number></detail><extent unit="pages"><start>S118</start><end>S127</end></extent></part><relatedItem type="host"><titleInfo><title>Br J Radiol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>76</number></detail><extent unit="pages"><start>S118</start><end>S127</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0015"><titleInfo><title>Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy</title></titleInfo><name type="personal"><namePart type="given">SE</namePart><namePart type="family">Day</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MI</namePart><namePart type="family">Kettunen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FA</namePart><namePart type="family">Gallagher</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Day SE, Kettunen MI, Gallagher FA, et al. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat Med 2007; 13: 1382–1387.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>1382</start><end>1387</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Med</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>1382</start><end>1387</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0016"><titleInfo><title>Current concepts on hyperpolarized molecules in MRI</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Viale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Aime</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Viale A, Aime S. Current concepts on hyperpolarized molecules in MRI. Curr Opin Chem Biol 2010; 14: 90–96.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>90</start><end>96</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Opin Chem Biol</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>90</start><end>96</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0017"><titleInfo><title>Molecular imaging with targeted contrast ultrasound</title></titleInfo><name type="personal"><namePart type="given">BA</namePart><namePart type="family">Kaufmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Lindner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kaufmann BA, Lindner JR. Molecular imaging with targeted contrast ultrasound. Curr Opin Biotechnol 2007; 18: 11–16.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>11</start><end>16</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Opin Biotechnol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>11</start><end>16</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0018"><titleInfo><title>Ultrasound molecular imaging with targeted microbubble contrast agents</title></titleInfo><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Klibanov</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Klibanov AL. Ultrasound molecular imaging with targeted microbubble contrast agents. J Nucl Cardiol 2007; 14: 876–884.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>876</start><end>884</end></extent></part><relatedItem type="host"><titleInfo><title>J Nucl Cardiol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>876</start><end>884</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0019"><titleInfo><title>A review of molecular imaging studies reaching the clinical stage</title></titleInfo><name type="personal"><namePart type="given">FC</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EE</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wong FC, Kim EE. A review of molecular imaging studies reaching the clinical stage. Eur J Radiol 2009; 70: 205–211.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><extent unit="pages"><start>205</start><end>211</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Radiol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><extent unit="pages"><start>205</start><end>211</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0020"><titleInfo><title>PET: the merging of biology and imaging into molecular imaging</title></titleInfo><name type="personal"><namePart type="given">ME</namePart><namePart type="family">Phelps</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Phelps ME. PET: the merging of biology and imaging into molecular imaging. J Nucl Med 2000; 41: 661–681.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>661</start><end>681</end></extent></part><relatedItem type="host"><titleInfo><title>J Nucl Med</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>661</start><end>681</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0021"><titleInfo><title>Detection threshold of single SPIO‐labeled cells with FIESTA</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Heyn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CV</namePart><namePart type="family">Bowen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BK</namePart><namePart type="family">Rutt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Foster</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Heyn C, Bowen CV, Rutt BK, Foster PJ. Detection threshold of single SPIO‐labeled cells with FIESTA. Magn Reson Med 2005; 53: 312–320.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>312</start><end>320</end></extent></part><relatedItem type="host"><titleInfo><title>Magn Reson Med</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>312</start><end>320</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0022"><titleInfo><title>Advancing role of radiolabeled antibodies in the therapy of cancer</title></titleInfo><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Goldenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Goldenberg DM. Advancing role of radiolabeled antibodies in the therapy of cancer. Cancer Immunol Immunother 2003; 52: 281–296.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>281</start><end>296</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Immunol Immunother</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>281</start><end>296</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0023"><titleInfo><title>Improved cancer therapy and molecular imaging with multivalent, multispecific antibodies</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Sharkey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EA</namePart><namePart type="family">Rossi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CH</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Goldenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sharkey RM, Rossi EA, Chang CH, Goldenberg DM. Improved cancer therapy and molecular imaging with multivalent, multispecific antibodies. Cancer Biother Radiopharm 2010; 25: 1–12.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>1</start><end>12</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Biother Radiopharm</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>1</start><end>12</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0024"><titleInfo><title>The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Fang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Nakamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Maeda</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Fang J, Nakamura H, Maeda H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev 2011; 63: 136–151.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>136</start><end>151</end></extent></part><relatedItem type="host"><titleInfo><title>Adv Drug Deliv Rev</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>136</start><end>151</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0025"><titleInfo><title>New metal‐based nanoparticles for intravenous use: requirements for clinical success with focus on medical imaging</title></titleInfo><name type="personal"><namePart type="given">T</namePart><namePart type="family">Skotland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TG</namePart><namePart type="family">Iversen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Sandvig</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Skotland T, Iversen TG, Sandvig K. New metal‐based nanoparticles for intravenous use: requirements for clinical success with focus on medical imaging. Nanomedicine 2010; 6: 730–737.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>730</start><end>737</end></extent></part><relatedItem type="host"><titleInfo><title>Nanomedicine</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>730</start><end>737</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0026"><titleInfo><title>On the selection of a tracer for PET imaging of HER2‐expressing tumors: direct comparison of a 124I‐labeled affibody molecule and trastuzumab in a murine xenograft model</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Orlova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Wallberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Stone‐Elander</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Tolmachev</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Orlova A, Wallberg H, Stone‐Elander S, Tolmachev V. On the selection of a tracer for PET imaging of HER2‐expressing tumors: direct comparison of a 124I‐labeled affibody molecule and trastuzumab in a murine xenograft model. J Nucl Med 2009; 50: 417–425.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>417</start><end>425</end></extent></part><relatedItem type="host"><titleInfo><title>J Nucl Med</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>417</start><end>425</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0027"><titleInfo><title>Peptide‐based probes for targeted molecular imaging</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Xie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lee S, Xie J, Chen X. Peptide‐based probes for targeted molecular imaging. Biochemistry 2010; 49: 1364–1376.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>1364</start><end>1376</end></extent></part><relatedItem type="host"><titleInfo><title>Biochemistry</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>1364</start><end>1376</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0028"><titleInfo><title>Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Eiklid</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Olsnes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Pihl</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Eiklid K, Olsnes S, Pihl A. Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells. Exp Cell Res 1980; 126: 321–326.</note><part><date>1980</date><detail type="volume"><caption>vol.</caption><number>126</number></detail><extent unit="pages"><start>321</start><end>326</end></extent></part><relatedItem type="host"><titleInfo><title>Exp Cell Res</title></titleInfo><part><date>1980</date><detail type="volume"><caption>vol.</caption><number>126</number></detail><extent unit="pages"><start>321</start><end>326</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0029"><titleInfo><title>On the origin of cancer cells</title></titleInfo><name type="personal"><namePart type="given">O</namePart><namePart type="family">Warburg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Warburg O. On the origin of cancer cells. Science 1956; 123: 309–314.</note><part><date>1956</date><detail type="volume"><caption>vol.</caption><number>123</number></detail><extent unit="pages"><start>309</start><end>314</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1956</date><detail type="volume"><caption>vol.</caption><number>123</number></detail><extent unit="pages"><start>309</start><end>314</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0030"><titleInfo><title>Positron emission tomography/computed tomography potential pitfalls and artifacts</title></titleInfo><name type="personal"><namePart type="given">X</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Koch</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wang X, Koch S. Positron emission tomography/computed tomography potential pitfalls and artifacts. Curr Probl Diagn Radiol 2009; 38: 156–169.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>156</start><end>169</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Probl Diagn Radiol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>156</start><end>169</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0031"><titleInfo><title>Selective molecular imaging of viable cancer cells with pH‐activatable fluorescence probes</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Urano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Asanuma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Hama</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Urano Y, Asanuma D, Hama Y, et al. Selective molecular imaging of viable cancer cells with pH‐activatable fluorescence probes. Nat Med 2009; 15: 104–109.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>104</start><end>109</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Med</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>104</start><end>109</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0032"><titleInfo><title>In vivo molecular imaging of cancer with a quenching near‐infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ogawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Kosaka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PL</namePart><namePart type="family">Choyke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kobayashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ogawa M, Kosaka N, Choyke PL, Kobayashi H. In vivo molecular imaging of cancer with a quenching near‐infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green. Cancer Res 2009; 69: 1268–1272.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><extent unit="pages"><start>1268</start><end>1272</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Res</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><extent unit="pages"><start>1268</start><end>1272</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0033"><titleInfo><title>Clathrin‐independent endocytosis: from nonexisting to an extreme degree of complexity</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Sandvig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Torgersen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HA</namePart><namePart type="family">Raa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">van Deurs</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sandvig K, Torgersen ML, Raa HA, van Deurs B. Clathrin‐independent endocytosis: from nonexisting to an extreme degree of complexity. Histochem Cell Biol 2008; 129: 267–276.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>129</number></detail><extent unit="pages"><start>267</start><end>276</end></extent></part><relatedItem type="host"><titleInfo><title>Histochem Cell Biol</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>129</number></detail><extent unit="pages"><start>267</start><end>276</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0034"><titleInfo><title>SnapShot: endocytic trafficking</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Wieffer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Maritzen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Haucke</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wieffer M, Maritzen T, Haucke V. SnapShot: endocytic trafficking. Cell 2009; 137: 382–383.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>137</number></detail><extent unit="pages"><start>382</start><end>383</end></extent></part><relatedItem type="host"><titleInfo><title>Cell</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>137</number></detail><extent unit="pages"><start>382</start><end>383</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0035"><titleInfo><title>Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies</title></titleInfo><name type="personal"><namePart type="given">TG</namePart><namePart type="family">Iversen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Skotland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Sandvig</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Iversen TG, Skotland T, Sandvig K. Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies. Nano Today 2011; 6: 176–185.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>176</start><end>185</end></extent></part><relatedItem type="host"><titleInfo><title>Nano Today</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>176</start><end>185</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0036"><titleInfo><title>Delivery into cells: lessons learned from plant and bacterial toxins</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Sandvig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">van Deurs</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sandvig K, van Deurs B. Delivery into cells: lessons learned from plant and bacterial toxins. Gene Ther 2005; 12: 865–872.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>865</start><end>872</end></extent></part><relatedItem type="host"><titleInfo><title>Gene Ther</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>865</start><end>872</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0037"><titleInfo><title>Virus entry by endocytosis</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Mercer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schelhaas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Helenius</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mercer J, Schelhaas M, Helenius A. Virus entry by endocytosis. Annu Rev Biochem 2010; 79: 803–833.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>803</start><end>833</end></extent></part><relatedItem type="host"><titleInfo><title>Annu Rev Biochem</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>803</start><end>833</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0038"><titleInfo><title>Cell biology and immunology of Listeria monocytogenes infections: novel insights</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Stavru</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Archambaud</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Cossart</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Stavru F, Archambaud C, Cossart P. Cell biology and immunology of Listeria monocytogenes infections: novel insights. Immunol Rev 2011; 240: 160–184.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>240</number></detail><extent unit="pages"><start>160</start><end>184</end></extent></part><relatedItem type="host"><titleInfo><title>Immunol Rev</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>240</number></detail><extent unit="pages"><start>160</start><end>184</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0039"><titleInfo><title>Photochemical internalization: a new tool for drug delivery</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Berg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Folini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Prasmickaite</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Berg K, Folini M, Prasmickaite L, et al. Photochemical internalization: a new tool for drug delivery. Curr Pharm Biotechnol 2007; 8: 362–372.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>362</start><end>372</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Pharm Biotechnol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>362</start><end>372</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0040"><titleInfo><title>Photochemical activation of endosomal escape of MRI‐Gd‐agents in tumor cells</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Gianolio</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Arena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">Strijkers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Nicolay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hogset</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Aime</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gianolio E, Arena F, Strijkers GJ, Nicolay K, Hogset A, Aime S. Photochemical activation of endosomal escape of MRI‐Gd‐agents in tumor cells. Magn Reson Med 2011; 65: 212–219.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>212</start><end>219</end></extent></part><relatedItem type="host"><titleInfo><title>Magn Reson Med</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>212</start><end>219</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0041"><titleInfo><title>Polyethylenimine‐based non‐viral gene delivery systems</title></titleInfo><name type="personal"><namePart type="given">U</namePart><namePart type="family">Lungwitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Breunig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Blunk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Gopferich</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lungwitz U, Breunig M, Blunk T, Gopferich A. Polyethylenimine‐based non‐viral gene delivery systems. Eur J Pharm Biopharm 2005; 60: 247–266.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>60</number></detail><extent unit="pages"><start>247</start><end>266</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Pharm Biopharm</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>60</number></detail><extent unit="pages"><start>247</start><end>266</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0042"><titleInfo><title>Monitoring caspase‐3 activation with a multimodality imaging sensor in living subjects</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Ray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">De</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Patel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SS</namePart><namePart type="family">Gambhir</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ray P, De A, Patel M, Gambhir SS. Monitoring caspase‐3 activation with a multimodality imaging sensor in living subjects. Clin Cancer Res 2008; 14: 5801–5809.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>5801</start><end>5809</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Cancer Res</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>5801</start><end>5809</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0043"><titleInfo><title>Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies</title></titleInfo><name type="personal"><namePart type="given">VR</namePart><namePart type="family">Solomon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Solomon VR, Lee H. Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies. Eur J Pharmacol 2009; 625: 220–233.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>625</number></detail><extent unit="pages"><start>220</start><end>233</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Pharmacol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>625</number></detail><extent unit="pages"><start>220</start><end>233</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0044"><titleInfo><title>Effects of charge on antibody tissue distribution and pharmacokinetics</title></titleInfo><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Boswell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DB</namePart><namePart type="family">Tesar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Mukhyala</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FP</namePart><namePart type="family">Theil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Fielder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Khawli</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Boswell CA, Tesar DB, Mukhyala K, Theil FP, Fielder PJ, Khawli LA. Effects of charge on antibody tissue distribution and pharmacokinetics. Bioconjug Chem 2010; 21: 2153–2163.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>2153</start><end>2163</end></extent></part><relatedItem type="host"><titleInfo><title>Bioconjug Chem</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>2153</start><end>2163</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0045"><titleInfo><title>Cell‐penetrating peptides. A reevaluation of the mechanism of cellular uptake</title></titleInfo><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Richard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Melikov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Vives</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Richard JP, Melikov K, Vives E, et al. Cell‐penetrating peptides. A reevaluation of the mechanism of cellular uptake. J Biol Chem 2003; 278: 585–590.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>278</number></detail><extent unit="pages"><start>585</start><end>590</end></extent></part><relatedItem type="host"><titleInfo><title>J Biol Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>278</number></detail><extent unit="pages"><start>585</start><end>590</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0046"><titleInfo><title>Cellular uptake of unconjugated TAT peptide involves clathrin‐dependent endocytosis and heparan sulfate receptors</title></titleInfo><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Richard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Melikov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Brooks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Prevot</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Lebleu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LV</namePart><namePart type="family">Chernomordik</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Richard JP, Melikov K, Brooks H, Prevot P, Lebleu B, Chernomordik LV. Cellular uptake of unconjugated TAT peptide involves clathrin‐dependent endocytosis and heparan sulfate receptors. J Biol Chem 2005; 280: 15300–15306.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>280</number></detail><extent unit="pages"><start>15300</start><end>15306</end></extent></part><relatedItem type="host"><titleInfo><title>J Biol Chem</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>280</number></detail><extent unit="pages"><start>15300</start><end>15306</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0047"><titleInfo><title>A comprehensive model for the cellular uptake of cationic cell‐penetrating peptides</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Duchardt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Fotin‐Mleczek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Schwarz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Fischer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Brock</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Duchardt F, Fotin‐Mleczek M, Schwarz H, Fischer R, Brock R. A comprehensive model for the cellular uptake of cationic cell‐penetrating peptides. Traffic 2007; 8: 848–866.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>848</start><end>866</end></extent></part><relatedItem type="host"><titleInfo><title>Traffic</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>848</start><end>866</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0048"><titleInfo><title>Distinct uptake routes of cell‐penetrating peptide conjugates</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Lundin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Johansson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Guterstam</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lundin P, Johansson H, Guterstam P, et al. Distinct uptake routes of cell‐penetrating peptide conjugates. Bioconjug Chem 2008; 19: 2535–2542.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>2535</start><end>2542</end></extent></part><relatedItem type="host"><titleInfo><title>Bioconjug Chem</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>2535</start><end>2542</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0049"><titleInfo><title>Modeling the endosomal escape of cell‐penetrating peptides: transmembrane pH gradient driven translocation across phospholipid bilayers</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Magzoub</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Pramanik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Graslund</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Magzoub M, Pramanik A, Graslund A. Modeling the endosomal escape of cell‐penetrating peptides: transmembrane pH gradient driven translocation across phospholipid bilayers. Biochemistry 2005; 44: 14890–14897.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>14890</start><end>14897</end></extent></part><relatedItem type="host"><titleInfo><title>Biochemistry</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>14890</start><end>14897</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0050"><titleInfo><title>Cell entry of arginine‐rich peptides is independent of endocytosis</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Ter‐Avetisyan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Tunnemann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Nowak</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ter‐Avetisyan G, Tunnemann G, Nowak D, et al. Cell entry of arginine‐rich peptides is independent of endocytosis. J Biol Chem 2009; 284: 3370–3378.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>284</number></detail><extent unit="pages"><start>3370</start><end>3378</end></extent></part><relatedItem type="host"><titleInfo><title>J Biol Chem</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>284</number></detail><extent unit="pages"><start>3370</start><end>3378</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0051"><titleInfo><title>NC100668, a new tracer tested for imaging of venous thromboembolism: pharmacokinetics and metabolism in humans</title></titleInfo><name type="personal"><namePart type="given">KG</namePart><namePart type="family">Toft</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Johnson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Oulie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Skotland</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Toft KG, Johnson JA, Oulie I, Skotland T. NC100668, a new tracer tested for imaging of venous thromboembolism: pharmacokinetics and metabolism in humans. Drug Metab Dispos 2007; 35: 1979–1984.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>1979</start><end>1984</end></extent></part><relatedItem type="host"><titleInfo><title>Drug Metab Dispos</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>1979</start><end>1984</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cmmi458-cit-0052"><titleInfo><title>Human urinary excretion of NC100692, an RGD‐peptide for imaging angiogenesis</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Roed</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Oulie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BJ</namePart><namePart type="family">McParland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Skotland</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Roed L, Oulie I, McParland BJ, Skotland T. Human urinary excretion of NC100692, an RGD‐peptide for imaging angiogenesis. Eur J Pharm Sci 2009; 37: 279–283.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>279</start><end>283</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Pharm Sci</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>279</start><end>283</end></extent></part></relatedItem></relatedItem><identifier type="istex">663C4DAA027BF59AC8F27510ACA4F252F073F20C</identifier><identifier type="ark">ark:/67375/WNG-0QB3PDB4-K</identifier><identifier type="DOI">10.1002/cmmi.458</identifier><identifier type="ArticleID">CMMI458</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 John Wiley & Sons, Ltd.Copyright © 2012 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-14</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-0QB3PDB4-K/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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