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Generalized granuloma annulare: Clinical and laboratory findings in 100 patients

Identifieur interne : 002305 ( Istex/Corpus ); précédent : 002304; suivant : 002306

Generalized granuloma annulare: Clinical and laboratory findings in 100 patients

Auteurs : Krzysztof Dabski ; R. K. Winkelmann

Source :

RBID : ISTEX:B576307CA9650A278EAFBDEADA152B4756D9D1A5

English descriptors

Abstract

Abstract: Clinical and laboratory records of 100 biopsy-proved cases of generalized granuloma annulare seen at the Mayo Clinic between 1966 and 1986 were reviewed. The skin eruption involved predominantly annular lesions in 67 patients and predominantly nonannular papules in 33. The ratio of female-to-male patients was 2.9∶1 in the annular group and 1.4∶1 in the nonannular group, The mean age at onset was 51.7 years. The eruption was symptomatic in 34 patients, and specific precipitating factors could be implicated in 16 patients. No consistently associated systemic disorders were identified. Diabetes mellitus was diagnosed in 21% of our referral group of generalized granuloma annulare cases, compared with 9.7% in 1350 cases of localized granuloma annulare and 10.3% in 1383 cases of all forms of granuloma annulare seen at the Mayo Clinic in the same period. Serum lipid abnormalities were more common in the generalized annular group. Follow-up data indicated a chronic, relapsing course in most patients.

Url:
DOI: 10.1016/S0190-9622(89)70005-0

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ISTEX:B576307CA9650A278EAFBDEADA152B4756D9D1A5

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<ce:surname>Haim</ce:surname>
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<sb:author>
<ce:given-name>R</ce:given-name>
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</sb:author>
<sb:author>
<ce:given-name>A</ce:given-name>
<ce:surname>Shafrir</ce:surname>
</sb:author>
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<sb:title>
<sb:maintitle>Generalized granuloma annulare: relationship to diabetes mellitus as revealed in 8 cases</sb:maintitle>
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<sb:maintitle>Br J Dermatol</sb:maintitle>
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<sb:volume-nr>83</sb:volume-nr>
</sb:series>
<sb:date>1970</sb:date>
</sb:issue>
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<sb:first-page>302</sb:first-page>
<sb:last-page>305</sb:last-page>
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<ce:surname>Haim</ce:surname>
</sb:author>
<sb:author>
<ce:given-name>R</ce:given-name>
<ce:surname>Friedman-Birnbaum</ce:surname>
</sb:author>
<sb:author>
<ce:given-name>N</ce:given-name>
<ce:surname>Haim</ce:surname>
</sb:author>
<sb:author>
<ce:given-name>A</ce:given-name>
<ce:surname>Shafrir</ce:surname>
</sb:author>
<sb:author>
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<ce:surname>Ravina</ce:surname>
</sb:author>
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<sb:title>
<sb:maintitle>Carbohydrate tolerance in patients with granuloma annulare: study of fifty-two cases</sb:maintitle>
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<title>Generalized granuloma annulare: Clinical and laboratory findings in 100 patients</title>
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<title>Generalized granuloma annulare: Clinical and laboratory findings in 100 patients</title>
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<namePart type="given">Krzysztof</namePart>
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<namePart type="termsOfAddress">M.D</namePart>
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<description>From the Department of Dermatology, Mayo Clinic and Mayo Foundation.</description>
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<namePart type="given">R.K.</namePart>
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<affiliation>Rochester, Minnesota, USA</affiliation>
<description>Reprint requests: R. K. Winkelmann, MD, Department of Dermatology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905.</description>
<description>From the Department of Dermatology, Mayo Clinic and Mayo Foundation.</description>
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<abstract lang="en">Abstract: Clinical and laboratory records of 100 biopsy-proved cases of generalized granuloma annulare seen at the Mayo Clinic between 1966 and 1986 were reviewed. The skin eruption involved predominantly annular lesions in 67 patients and predominantly nonannular papules in 33. The ratio of female-to-male patients was 2.9∶1 in the annular group and 1.4∶1 in the nonannular group, The mean age at onset was 51.7 years. The eruption was symptomatic in 34 patients, and specific precipitating factors could be implicated in 16 patients. No consistently associated systemic disorders were identified. Diabetes mellitus was diagnosed in 21% of our referral group of generalized granuloma annulare cases, compared with 9.7% in 1350 cases of localized granuloma annulare and 10.3% in 1383 cases of all forms of granuloma annulare seen at the Mayo Clinic in the same period. Serum lipid abnormalities were more common in the generalized annular group. Follow-up data indicated a chronic, relapsing course in most patients.</abstract>
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