High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension
Identifieur interne : 001E04 ( Istex/Corpus ); précédent : 001E03; suivant : 001E05High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension
Auteurs : Ki-Jo Kim ; In-Woon Baek ; Yune-Jung Park ; Chong-Hyeon Yoon ; Wan-Uk Kim ; Chul-Soo ChoSource :
- International Journal of Rheumatic Diseases [ 1756-1841 ] ; 2015-06.
Abstract
Aim: To estimate the point prevalence of pulmonary hypertension (PH) and determine the associated factors for PH in patients with systemic lupus erythematosus (SLE). Methods: A prospective cross‐sectional study of 114 patients with SLE was conducted in a single tertiary center. Transthoracic echocardiography was performed to estimate the pulmonary arterial pressures. PH was defined as resting systolic pulmonary artery pressure (sPAP) ≥ 40 mmHg, in the absence of left heart disease. Results: PH was identified in nine patients (7.9%) who had few cardiopulmonary symptoms. SLE patients with PH had higher SLE disease activity index score. In particular, serum uric acid (UA) was significantly higher in patients with PH than in those without PH. In multivariate analysis, UA remained significant for the presence of PH. Moreover, serum UA level correlated significantly with plasma NT‐pro‐B‐type natriuretic peptide level as well as sPAP. At the cutoff level of 6.5 mg/dL, serum UA had reasonable accuracy for predicting the presence of PH in SLE patients (sensitivity 66.7% and specificity 96.2%). Conclusion: A significant number of SLE patients in rheumatology practice have undiagnosed PH with few discernible symptoms. Serum UA level may be useful as a surrogate marker for screening of PH in patients with SLE.
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DOI: 10.1111/1756-185X.12262
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension</title><author><name sortKey="Kim, Ki O" sort="Kim, Ki O" uniqKey="Kim K" first="Ki-Jo" last="Kim">Ki-Jo Kim</name><affiliation><mods:affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Baek, In Oon" sort="Baek, In Oon" uniqKey="Baek I" first="In-Woon" last="Baek">In-Woon Baek</name><affiliation><mods:affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Park, Yune Ung" sort="Park, Yune Ung" uniqKey="Park Y" first="Yune-Jung" last="Park">Yune-Jung Park</name><affiliation><mods:affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Yoon, Chong Yeon" sort="Yoon, Chong Yeon" uniqKey="Yoon C" first="Chong-Hyeon" last="Yoon">Chong-Hyeon Yoon</name><affiliation><mods:affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Wan K" sort="Kim, Wan K" uniqKey="Kim W" first="Wan-Uk" last="Kim">Wan-Uk Kim</name><affiliation><mods:affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Cho, Chul Oo" sort="Cho, Chul Oo" uniqKey="Cho C" first="Chul-Soo" last="Cho">Chul-Soo Cho</name><affiliation><mods:affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>: Professor Chul‐Soo Cho, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, 10, 63‐ro, Yeongdeungpo‐gu, Seoul, 150–713, Korea.Email:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: chocs@catholic.ac.kr</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:55577B7FC030B9597446B8A0BBAE48943CD86764</idno><date when="2015" year="2015">2015</date><idno type="doi">10.1111/1756-185X.12262</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-KDV0SVP3-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001E04</idno><idno type="wicri:explorRef" wicri:stream="Istex" 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Park</name><affiliation><mods:affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Yoon, Chong Yeon" sort="Yoon, Chong Yeon" uniqKey="Yoon C" first="Chong-Hyeon" last="Yoon">Chong-Hyeon Yoon</name><affiliation><mods:affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Wan K" sort="Kim, Wan K" uniqKey="Kim W" first="Wan-Uk" last="Kim">Wan-Uk Kim</name><affiliation><mods:affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Cho, Chul Oo" sort="Cho, Chul Oo" uniqKey="Cho C" first="Chul-Soo" last="Cho">Chul-Soo Cho</name><affiliation><mods:affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>: Professor Chul‐Soo Cho, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, 10, 63‐ro, Yeongdeungpo‐gu, Seoul, 150–713, Korea.Email:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: chocs@catholic.ac.kr</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Rheumatic Diseases</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES</title><idno type="ISSN">1756-1841</idno><idno type="eISSN">1756-185X</idno><imprint><biblScope unit="vol">18</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="524">524</biblScope><biblScope unit="page" to="532">532</biblScope><biblScope unit="page-count">9</biblScope><date type="published" when="2015-06">2015-06</date></imprint><idno type="ISSN">1756-1841</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1756-1841</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Aim: To estimate the point prevalence of pulmonary hypertension (PH) and determine the associated factors for PH in patients with systemic lupus erythematosus (SLE). Methods: A prospective cross‐sectional study of 114 patients with SLE was conducted in a single tertiary center. Transthoracic echocardiography was performed to estimate the pulmonary arterial pressures. PH was defined as resting systolic pulmonary artery pressure (sPAP) ≥ 40 mmHg, in the absence of left heart disease. Results: PH was identified in nine patients (7.9%) who had few cardiopulmonary symptoms. SLE patients with PH had higher SLE disease activity index score. In particular, serum uric acid (UA) was significantly higher in patients with PH than in those without PH. In multivariate analysis, UA remained significant for the presence of PH. Moreover, serum UA level correlated significantly with plasma NT‐pro‐B‐type natriuretic peptide level as well as sPAP. At the cutoff level of 6.5 mg/dL, serum UA had reasonable accuracy for predicting the presence of PH in SLE patients (sensitivity 66.7% and specificity 96.2%). Conclusion: A significant number of SLE patients in rheumatology practice have undiagnosed PH with few discernible symptoms. Serum UA level may be useful as a surrogate marker for screening of PH in patients with SLE.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Ki‐Jo Kim</name><affiliations><json:string>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</json:string></affiliations></json:item><json:item><name>In‐Woon Baek</name><affiliations><json:string>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Yune‐Jung Park</name><affiliations><json:string>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Chong‐Hyeon Yoon</name><affiliations><json:string>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Wan‐Uk Kim</name><affiliations><json:string>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Chul‐Soo Cho</name><affiliations><json:string>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</json:string><json:string>: Professor Chul‐Soo Cho, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, 10, 63‐ro, Yeongdeungpo‐gu, Seoul, 150–713, Korea.Email:</json:string><json:string>E-mail: chocs@catholic.ac.kr</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>lupus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pulmonary hypertension</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>uric acid</value></json:item></subject><articleId><json:string>APL12262</json:string></articleId><arkIstex>ark:/67375/WNG-KDV0SVP3-S</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Aim: To estimate the point prevalence of pulmonary hypertension (PH) and determine the associated factors for PH in patients with systemic lupus erythematosus (SLE). Methods: A prospective cross‐sectional study of 114 patients with SLE was conducted in a single tertiary center. Transthoracic echocardiography was performed to estimate the pulmonary arterial pressures. PH was defined as resting systolic pulmonary artery pressure (sPAP) ≥ 40 mmHg, in the absence of left heart disease. Results: PH was identified in nine patients (7.9%) who had few cardiopulmonary symptoms. SLE patients with PH had higher SLE disease activity index score. In particular, serum uric acid (UA) was significantly higher in patients with PH than in those without PH. In multivariate analysis, UA remained significant for the presence of PH. Moreover, serum UA level correlated significantly with plasma NT‐pro‐B‐type natriuretic peptide level as well as sPAP. At the cutoff level of 6.5 mg/dL, serum UA had reasonable accuracy for predicting the presence of PH in SLE patients (sensitivity 66.7% and specificity 96.2%). Conclusion: A significant number of SLE patients in rheumatology practice have undiagnosed PH with few discernible symptoms. 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main" xml:id="apl12262-abs-0001"><head>Abstract</head><head>Aim</head><p>To estimate the point prevalence of pulmonary hypertension (<hi rend="fc">PH</hi>) and determine the associated factors for <hi rend="fc">PH</hi> in patients with systemic lupus erythematosus (<hi rend="fc">SLE</hi>).</p><head>Methods</head><p>A prospective cross‐sectional study of 114 patients with SLE was conducted in a single tertiary center. Transthoracic echocardiography was performed to estimate the pulmonary arterial pressures. PH was defined as resting systolic pulmonary artery pressure (<hi rend="fc">sPAP</hi>) ≥ 40 mmHg, in the absence of left heart disease.</p><head>Results</head><p>PH was identified in nine patients (7.9%) who had few cardiopulmonary symptoms. SLE patients with PH had higher SLE disease activity index score. In particular, serum uric acid (UA) was significantly higher in patients with PH than in those without PH. In multivariate analysis, UA remained significant for the presence of PH. Moreover, serum UA level correlated significantly with plasma NT‐pro‐B‐type natriuretic peptide level as well as <hi rend="fc">sPAP</hi>. At the cutoff level of 6.5 mg/dL, serum UA had reasonable accuracy for predicting the presence of PH in SLE patients (sensitivity 66.7% and specificity 96.2%).</p><head>Conclusion</head><p>A significant number of <hi rend="fc">SLE</hi> patients in rheumatology practice have undiagnosed <hi rend="fc">PH</hi> with few discernible symptoms. Serum <hi rend="fc">UA</hi> level may be useful as a surrogate marker for screening of <hi rend="fc">PH</hi> in patients with <hi rend="fc">SLE</hi>.</p></abstract><textClass><keywords><term xml:id="apl12262-kwd-0001">lupus</term><term xml:id="apl12262-kwd-0002">pulmonary hypertension</term><term xml:id="apl12262-kwd-0003">uric acid</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-KDV0SVP3-S/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="apl12262" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1756-185X</doi><issn type="print">1756-1841</issn><issn type="electronic">1756-185X</issn><idGroup><id type="product" value="APL"></id></idGroup><titleGroup><title sort="INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES" type="main">International Journal of Rheumatic Diseases</title><title type="short">Int J Rheum Dis</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley">10.1111/apl.2015.18.issue-5</doi><copyright ownership="joint">International Journal of Rheumatic Diseases © 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd</copyright><numberingGroup><numbering type="journalVolume" number="18">18</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2015-06">June 2015</coverDate></publicationMeta><publicationMeta level="unit" position="80" status="forIssue" type="article"><doi>10.1111/1756-185X.12262</doi><idGroup><id type="unit" value="APL12262"></id></idGroup><countGroup><count number="9" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">© 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd</copyright><eventGroup><event agent="SPS" date="2013-11-29" type="xmlCreated"></event><event type="publishedOnlineEarlyUnpaginated" date="2014-01-16"></event><event type="firstOnline" date="2014-01-16"></event><event type="publishedOnlineFinalForm" date="2015-06-17"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.7.2 mode:FullText" date="2016-01-05"></event></eventGroup><numberingGroup><numbering type="pageFirst">524</numbering><numbering type="pageLast">532</numbering></numberingGroup><correspondenceTo><lineatedText><line><i>Correspondence</i>: Professor Chul‐Soo Cho, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, 10, 63‐ro, Yeongdeungpo‐gu, Seoul, 150–713, Korea.</line><line>Email: <email>chocs@catholic.ac.kr</email></line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:APL.APL12262.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension</title><title type="shortAuthors">K.‐J. Kim <i>et al</i>.</title></titleGroup><creators><creator affiliationRef="#apl12262-aff-0001" creatorRole="author" xml:id="apl12262-cr-0001"><personName><givenNames>Ki‐Jo</givenNames> <familyName>Kim</familyName></personName></creator><creator affiliationRef="#apl12262-aff-0001" creatorRole="author" xml:id="apl12262-cr-0002"><personName><givenNames>In‐Woon</givenNames> <familyName>Baek</familyName></personName></creator><creator affiliationRef="#apl12262-aff-0001" creatorRole="author" xml:id="apl12262-cr-0003"><personName><givenNames>Yune‐Jung</givenNames> <familyName>Park</familyName></personName></creator><creator affiliationRef="#apl12262-aff-0001" creatorRole="author" xml:id="apl12262-cr-0004"><personName><givenNames>Chong‐Hyeon</givenNames> <familyName>Yoon</familyName></personName></creator><creator affiliationRef="#apl12262-aff-0001" creatorRole="author" xml:id="apl12262-cr-0005"><personName><givenNames>Wan‐Uk</givenNames> <familyName>Kim</familyName></personName></creator><creator affiliationRef="#apl12262-aff-0001" corresponding="yes" creatorRole="author" xml:id="apl12262-cr-0006"><personName><givenNames>Chul‐Soo</givenNames> <familyName>Cho</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="KP" type="organization" xml:id="apl12262-aff-0001"><orgDiv>Division of Rheumatology</orgDiv> <orgDiv>Department of Internal Medicine</orgDiv> <orgName>College of Medicine</orgName> <orgName>The Catholic University of Korea</orgName> <address><city>Seoul</city> <country>Korea</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="apl12262-kwd-0001">lupus</keyword><keyword xml:id="apl12262-kwd-0002">pulmonary hypertension</keyword><keyword xml:id="apl12262-kwd-0003">uric acid</keyword></keywordGroup><abstractGroup><abstract type="main" xml:id="apl12262-abs-0001"><title type="main">Abstract</title><section xml:id="apl12262-sec-0001"><title type="main">Aim</title><p>To estimate the point prevalence of pulmonary hypertension (<fc>PH</fc>) and determine the associated factors for <fc>PH</fc> in patients with systemic lupus erythematosus (<fc>SLE</fc>).</p></section><section xml:id="apl12262-sec-0002"><title type="main">Methods</title><p>A prospective cross‐sectional study of 114 patients with SLE was conducted in a single tertiary center. Transthoracic echocardiography was performed to estimate the pulmonary arterial pressures. PH was defined as resting systolic pulmonary artery pressure (<fc>sPAP</fc>) ≥ 40 mmHg, in the absence of left heart disease.</p></section><section xml:id="apl12262-sec-0003"><title type="main">Results</title><p>PH was identified in nine patients (7.9%) who had few cardiopulmonary symptoms. SLE patients with PH had higher SLE disease activity index score. In particular, serum uric acid (UA) was significantly higher in patients with PH than in those without PH. In multivariate analysis, UA remained significant for the presence of PH. Moreover, serum UA level correlated significantly with plasma NT‐pro‐B‐type natriuretic peptide level as well as <fc>sPAP</fc>. At the cutoff level of 6.5 mg/dL, serum UA had reasonable accuracy for predicting the presence of PH in SLE patients (sensitivity 66.7% and specificity 96.2%).</p></section><section xml:id="apl12262-sec-0004"><title type="main">Conclusion</title><p>A significant number of <fc>SLE</fc> patients in rheumatology practice have undiagnosed <fc>PH</fc> with few discernible symptoms. Serum <fc>UA</fc> level may be useful as a surrogate marker for screening of <fc>PH</fc> in patients with <fc>SLE</fc>.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension</title></titleInfo><name type="personal"><namePart type="given">Ki‐Jo</namePart><namePart type="family">Kim</namePart><affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">In‐Woon</namePart><namePart type="family">Baek</namePart><affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yune‐Jung</namePart><namePart type="family">Park</namePart><affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chong‐Hyeon</namePart><namePart type="family">Yoon</namePart><affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wan‐Uk</namePart><namePart type="family">Kim</namePart><affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chul‐Soo</namePart><namePart type="family">Cho</namePart><affiliation>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea</affiliation><affiliation>: Professor Chul‐Soo Cho, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, 10, 63‐ro, Yeongdeungpo‐gu, Seoul, 150–713, Korea.Email:</affiliation><affiliation>E-mail: chocs@catholic.ac.kr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2015-06</dateIssued><dateCreated encoding="w3cdtf">2013-11-29</dateCreated><copyrightDate encoding="w3cdtf">2015</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Aim: To estimate the point prevalence of pulmonary hypertension (PH) and determine the associated factors for PH in patients with systemic lupus erythematosus (SLE). Methods: A prospective cross‐sectional study of 114 patients with SLE was conducted in a single tertiary center. Transthoracic echocardiography was performed to estimate the pulmonary arterial pressures. PH was defined as resting systolic pulmonary artery pressure (sPAP) ≥ 40 mmHg, in the absence of left heart disease. Results: PH was identified in nine patients (7.9%) who had few cardiopulmonary symptoms. SLE patients with PH had higher SLE disease activity index score. In particular, serum uric acid (UA) was significantly higher in patients with PH than in those without PH. In multivariate analysis, UA remained significant for the presence of PH. Moreover, serum UA level correlated significantly with plasma NT‐pro‐B‐type natriuretic peptide level as well as sPAP. At the cutoff level of 6.5 mg/dL, serum UA had reasonable accuracy for predicting the presence of PH in SLE patients (sensitivity 66.7% and specificity 96.2%). Conclusion: A significant number of SLE patients in rheumatology practice have undiagnosed PH with few discernible symptoms. Serum UA level may be useful as a surrogate marker for screening of PH in patients with SLE.</abstract><subject><genre>keywords</genre><topic>lupus</topic><topic>pulmonary hypertension</topic><topic>uric acid</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Rheumatic Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Int J Rheum Dis</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic><topic>Original Articles</topic></subject><identifier type="ISSN">1756-1841</identifier><identifier type="eISSN">1756-185X</identifier><identifier type="DOI">10.1111/(ISSN)1756-185X</identifier><identifier type="PublisherID">APL</identifier><part><date>2015</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>524</start><end>532</end><total>9</total></extent></part></relatedItem><relatedItem type="references" displayLabel="apl12262-cit-0001"><titleInfo><title>ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Associati</title></titleInfo><name type="personal"><namePart type="given">VV</namePart><namePart type="family">McLaughlin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Archer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DB</namePart><namePart type="family">Badesch</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">McLaughlin VV, Archer SL, Badesch DB et al. 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Heart 97, 612–22.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>97</number></detail><extent unit="pages"><start>612</start><end>22</end></extent></part><relatedItem type="host"><titleInfo><title>Heart</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>97</number></detail><extent unit="pages"><start>612</start><end>22</end></extent></part></relatedItem></relatedItem><identifier type="istex">55577B7FC030B9597446B8A0BBAE48943CD86764</identifier><identifier type="ark">ark:/67375/WNG-KDV0SVP3-S</identifier><identifier type="DOI">10.1111/1756-185X.12262</identifier><identifier type="ArticleID">APL12262</identifier><accessCondition type="use and reproduction" contentType="copyright">International Journal of Rheumatic Diseases © 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd© 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-13</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-KDV0SVP3-S/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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