ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes
Identifieur interne : 001D80 ( Istex/Corpus ); précédent : 001D79; suivant : 001D81ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes
Auteurs : Ranjna C. Dutta ; Erwin GoldbergSource :
- American Journal of Reproductive Immunology [ 1046-7408 ] ; 2008-07.
English descriptors
- Teeft :
- American journal, Antibody titer, Authors journal compilation, Binding association, Blackwell munksgaard, Blackwell munksgaard immunoliposome, Capacitated, Capacitated spermatozoa, Control liposome, Control liposomes, Dutta, Elisa, Human cancer, Immunoliposome, Immunoliposome binding, Immunoliposome preparation, Immunoliposomes, Immunology, Journal compilation, Liposome, Liposome concentration, Lmol, Munksgaard, Photon, Photon count, Photon counts, Relative binding, Reproductive, Reproductive immunology, Sephadex column, Single isomer, Sperm, Spermatozoon, Splice variants, Testis, Tissue distribution, Total counts.
Abstract
Problem Is it possible to deliver therapeutic agents to testis through specific targeting? Method of study Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase‐C4 (LDH‐C4), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo. Results It is observed that LDHC4‐immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo. Conclusion Specific targeting through LDH‐C4 appears to be a feasible strategy for delivering therapeutic as well as anti‐spermatogenic agents to testis.
Url:
DOI: 10.1111/j.1600-0897.2008.00587.x
Links to Exploration step
ISTEX:6F7D053C598CCADF455BC9350494394C984CFD42Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes</title><author><name sortKey="Dutta, Ranjna C" sort="Dutta, Ranjna C" uniqKey="Dutta R" first="Ranjna C." last="Dutta">Ranjna C. Dutta</name></author><author><name sortKey="Goldberg, Erwin" sort="Goldberg, Erwin" uniqKey="Goldberg E" first="Erwin" last="Goldberg">Erwin Goldberg</name><affiliation><mods:affiliation>Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6F7D053C598CCADF455BC9350494394C984CFD42</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1600-0897.2008.00587.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-PT280T76-G/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001D80</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001D80</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes</title><author><name sortKey="Dutta, Ranjna C" sort="Dutta, Ranjna C" uniqKey="Dutta R" first="Ranjna C." last="Dutta">Ranjna C. Dutta</name></author><author><name sortKey="Goldberg, Erwin" sort="Goldberg, Erwin" uniqKey="Goldberg E" first="Erwin" last="Goldberg">Erwin Goldberg</name><affiliation><mods:affiliation>Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">American Journal of Reproductive Immunology</title><title level="j" type="alt">AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY</title><idno type="ISSN">1046-7408</idno><idno type="eISSN">1600-0897</idno><imprint><biblScope unit="vol">60</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="26">26</biblScope><biblScope unit="page" to="32">32</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-07">2008-07</date></imprint><idno type="ISSN">1046-7408</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1046-7408</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>American journal</term><term>Antibody titer</term><term>Authors journal compilation</term><term>Binding association</term><term>Blackwell munksgaard</term><term>Blackwell munksgaard immunoliposome</term><term>Capacitated</term><term>Capacitated spermatozoa</term><term>Control liposome</term><term>Control liposomes</term><term>Dutta</term><term>Elisa</term><term>Human cancer</term><term>Immunoliposome</term><term>Immunoliposome binding</term><term>Immunoliposome preparation</term><term>Immunoliposomes</term><term>Immunology</term><term>Journal compilation</term><term>Liposome</term><term>Liposome concentration</term><term>Lmol</term><term>Munksgaard</term><term>Photon</term><term>Photon count</term><term>Photon counts</term><term>Relative binding</term><term>Reproductive</term><term>Reproductive immunology</term><term>Sephadex column</term><term>Single isomer</term><term>Sperm</term><term>Spermatozoon</term><term>Splice variants</term><term>Testis</term><term>Tissue distribution</term><term>Total counts</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Problem Is it possible to deliver therapeutic agents to testis through specific targeting? Method of study Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase‐C4 (LDH‐C4), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo. Results It is observed that LDHC4‐immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo. Conclusion Specific targeting through LDH‐C4 appears to be a feasible strategy for delivering therapeutic as well as anti‐spermatogenic agents to testis.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>liposome</json:string><json:string>immunoliposomes</json:string><json:string>spermatozoon</json:string><json:string>immunoliposome</json:string><json:string>sperm</json:string><json:string>capacitated</json:string><json:string>testis</json:string><json:string>photon</json:string><json:string>capacitated spermatozoa</json:string><json:string>control liposome</json:string><json:string>lmol</json:string><json:string>dutta</json:string><json:string>reproductive immunology</json:string><json:string>munksgaard</json:string><json:string>elisa</json:string><json:string>immunology</json:string><json:string>american journal</json:string><json:string>tissue distribution</json:string><json:string>immunoliposome binding</json:string><json:string>control liposomes</json:string><json:string>relative binding</json:string><json:string>journal compilation</json:string><json:string>photon count</json:string><json:string>liposome concentration</json:string><json:string>splice variants</json:string><json:string>immunoliposome preparation</json:string><json:string>reproductive</json:string><json:string>total counts</json:string><json:string>authors journal compilation</json:string><json:string>antibody titer</json:string><json:string>photon counts</json:string><json:string>blackwell munksgaard</json:string><json:string>single isomer</json:string><json:string>blackwell munksgaard immunoliposome</json:string><json:string>binding association</json:string><json:string>human cancer</json:string><json:string>sephadex column</json:string></teeft></keywords><author><json:item><name>Ranjna C. Dutta</name></json:item><json:item><name>Erwin Goldberg</name><affiliations><json:string>Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Antispermatozoa</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>contraception</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>immunoliposomes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LDH‐C4</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sperms</value></json:item></subject><articleId><json:string>AJI587</json:string></articleId><arkIstex>ark:/67375/WNG-PT280T76-G</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Problem Is it possible to deliver therapeutic agents to testis through specific targeting? Method of study Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase‐C4 (LDH‐C4), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo. Results It is observed that LDHC4‐immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo. Conclusion Specific targeting through LDH‐C4 appears to be a feasible strategy for delivering therapeutic as well as anti‐spermatogenic agents to testis.</abstract><qualityIndicators><score>6.722</score><pdfWordCount>3630</pdfWordCount><pdfCharCount>24048</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><pdfWordsPerPage>519</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>91</abstractWordCount><abstractCharCount>635</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes</title><pmid><json:string>18593435</json:string></pmid><genre><json:string>article</json:string></genre><host><title>American Journal of Reproductive Immunology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0897</json:string></doi><issn><json:string>1046-7408</json:string></issn><eissn><json:string>1600-0897</json:string></eissn><publisherId><json:string>AJI</json:string></publisherId><volume>60</volume><issue>1</issue><pages><first>26</first><last>32</last><total>7</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>12-5-149</json:string><json:string>2008</json:string></date><geogName></geogName><orgName><json:string>Northwestern University</json:string><json:string>Dutta Department of Biochemistry, Molecular Biology and Cell Biology</json:string><json:string>India Method</json:string><json:string>American Journal of Reproductive Immunology</json:string><json:string>Zymed Laboratories, Inc</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>P. Ltd</json:string><json:string>Facility</json:string><json:string>R.C. Dutta</json:string><json:string>E. Testis</json:string><json:string>R. C. Dutta</json:string></persName><placeName><json:string>IL</json:string><json:string>Bradford</json:string><json:string>LA</json:string><json:string>New Orleans</json:string><json:string>Evanston</json:string><json:string>USA</json:string><json:string>San Francisco</json:string><json:string>Hyderabad</json:string><json:string>CA</json:string><json:string>MA</json:string><json:string>Cambridge</json:string><json:string>GOLDBERG</json:string><json:string>Goldberg</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Koslowski et al</json:string><json:string>Owais et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-PT280T76-G</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - reproductive biology</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - obstetrics & reproductive medicine</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Obstetrics and Gynaecology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Reproductive Medicine</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1111/j.1600-0897.2008.00587.x</json:string></doi><id>6F7D053C598CCADF455BC9350494394C984CFD42</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-PT280T76-G/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-PT280T76-G/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-PT280T76-G/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes</title><title level="a" type="short">IMMUNOLIPOSOME TARGETING TO TESTIS</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard</licence></availability><date type="published" when="2008-07"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes</title><title level="a" type="short">IMMUNOLIPOSOME TARGETING TO TESTIS</title><author xml:id="author-0000"><persName><forename type="first">Ranjna C.</forename><surname>Dutta</surname></persName></author><author xml:id="author-0001"><persName><forename type="first">Erwin</forename><surname>Goldberg</surname></persName><affiliation><orgName type="division">Department of Biochemistry</orgName><orgName type="institution">Molecular Biology and Cell Biology Northwestern University</orgName><address><addrLine>Evanston</addrLine><addrLine>IL, USA</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><idno type="istex">6F7D053C598CCADF455BC9350494394C984CFD42</idno><idno type="ark">ark:/67375/WNG-PT280T76-G</idno><idno type="DOI">10.1111/j.1600-0897.2008.00587.x</idno><idno type="unit">AJI587</idno><idno type="toTypesetVersion">file:AJI.AJI587.pdf</idno></analytic><monogr><title level="j" type="main">American Journal of Reproductive Immunology</title><title level="j" type="alt">AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY</title><idno type="pISSN">1046-7408</idno><idno type="eISSN">1600-0897</idno><idno type="book-DOI">10.1111/(ISSN)1600-0897</idno><idno type="book-part-DOI">10.1111/aji.2008.60.issue-1</idno><idno type="product">AJI</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">60</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="26">26</biblScope><biblScope unit="page" to="32">32</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-07"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Problem </hi> Is it possible to deliver therapeutic agents to testis through specific targeting?</p><p><hi rend="bold">Method of study </hi> Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase‐C4 (LDH‐C<hi rend="subscript">4</hi>), which is the product of a testis specific gene. Their targeting and delivering ability is investigated <hi rend="italic">in vitro</hi> and <hi rend="italic">in vivo</hi>.</p><p><hi rend="bold">Results </hi> It is observed that LDHC<hi rend="subscript">4</hi>‐immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both <hi rend="italic">in vitro</hi> and <hi rend="italic">in vivo</hi>.</p><p><hi rend="bold">Conclusion </hi> Specific targeting through LDH‐C<hi rend="subscript">4</hi> appears to be a feasible strategy for delivering therapeutic as well as anti‐spermatogenic agents to testis.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Antispermatozoa</term><term xml:id="k2">contraception</term><term xml:id="k3">immunoliposomes</term><term xml:id="k4">LDH‐C<hi rend="subscript">4</hi></term><term xml:id="k5">sperms</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-PT280T76-G/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0897</doi><issn type="print">1046-7408</issn><issn type="electronic">1600-0897</issn><idGroup><id type="product" value="AJI"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY">American Journal of Reproductive Immunology</title></titleGroup></publicationMeta><publicationMeta level="part" position="07001"><doi origin="wiley">10.1111/aji.2008.60.issue-1</doi><numberingGroup><numbering type="journalVolume" number="60">60</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2008-07">July 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1600-0897.2008.00587.x</doi><idGroup><id type="unit" value="AJI587"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard</copyright><eventGroup><event type="firstOnline" date="2008-06-28"></event><event type="publishedOnlineFinalForm" date="2008-06-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.16 mode:FullText" date="2010-08-17"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="26">26</numbering><numbering type="pageLast" number="32">32</numbering></numberingGroup><correspondenceTo>R.C. Dutta Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL 60208, USA.
E‐mail: <email>ranjna_dutta@rediffmail.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:AJI.AJI587.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Submitted November 30, 2007; accepted January 28, 2008.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="4"></count><count type="tableTotal" number="0"></count></countGroup><titleGroup><title type="main">ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes</title><title type="shortAuthors">DUTTA AND GOLDBERG</title><title type="short">IMMUNOLIPOSOME TARGETING TO TESTIS</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" noteRef="#fn1"><personName><givenNames>Ranjna C.</givenNames><familyName>Dutta</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>Erwin</givenNames><familyName>Goldberg</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="US"><unparsedAffiliation>Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Antispermatozoa</keyword><keyword xml:id="k2">contraception</keyword><keyword xml:id="k3">immunoliposomes</keyword><keyword xml:id="k4">LDH‐C<sub>4</sub></keyword><keyword xml:id="k5">sperms</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Problem </b> Is it possible to deliver therapeutic agents to testis through specific targeting?</p><p><b>Method of study </b> Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase‐C4 (LDH‐C<sub>4</sub>), which is the product of a testis specific gene. Their targeting and delivering ability is investigated <i>in vitro</i> and <i>in vivo</i>.</p><p><b>Results </b> It is observed that LDHC<sub>4</sub>‐immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both <i>in vitro</i> and <i>in vivo</i>.</p><p><b>Conclusion </b> Specific targeting through LDH‐C<sub>4</sub> appears to be a feasible strategy for delivering therapeutic as well as anti‐spermatogenic agents to testis.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>*</label><p>
Present affiliation: ExCel Matrix Biological Devices P. Ltd., 12‐5‐149/16‐2, Vijayapuri, South Lalaguda, Opp. NIN, Hyderabad–500 017, India</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>IMMUNOLIPOSOME TARGETING TO TESTIS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes</title></titleInfo><name type="personal"><namePart type="given">Ranjna C.</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Erwin</namePart><namePart type="family">Goldberg</namePart><affiliation>Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2008-07</dateIssued><edition>Submitted November 30, 2007; accepted January 28, 2008.</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">4</extent><extent unit="tables">0</extent></physicalDescription><abstract lang="en">Problem Is it possible to deliver therapeutic agents to testis through specific targeting? Method of study Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase‐C4 (LDH‐C4), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo. Results It is observed that LDHC4‐immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo. Conclusion Specific targeting through LDH‐C4 appears to be a feasible strategy for delivering therapeutic as well as anti‐spermatogenic agents to testis.</abstract><subject lang="en"><genre>keywords</genre><topic>Antispermatozoa</topic><topic>contraception</topic><topic>immunoliposomes</topic><topic>LDH‐C4</topic><topic>sperms</topic></subject><relatedItem type="host"><titleInfo><title>American Journal of Reproductive Immunology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1046-7408</identifier><identifier type="eISSN">1600-0897</identifier><identifier type="DOI">10.1111/(ISSN)1600-0897</identifier><identifier type="PublisherID">AJI</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>60</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>26</start><end>32</end><total>7</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Abundance of repetitive sequence elements in the mouse testis‐specific lactate dehydrogenase‐C gene</title></titleInfo><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Markert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JB</namePart><namePart type="family">Shaklee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GS</namePart><namePart type="family">Whitt</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Markert CL, Shaklee JB, Whitt GS: Abundance of repetitive sequence elements in the mouse testis‐specific lactate dehydrogenase‐C gene. Science 1975; 189:102–114.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>189</number></detail><extent unit="pages"><start>102</start><end>114</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>189</number></detail><extent unit="pages"><start>102</start><end>114</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from xenopus, pig, and rat</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Tsuji</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Qureshi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EW</namePart><namePart type="family">Hou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WM</namePart><namePart type="family">Fitch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Steven</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tsuji S, Qureshi MA, Hou EW, Fitch WM, Steven S, Li L: Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from xenopus, pig, and rat. Proc Natl Acad Sci U S A 1994; 91:9392–9396.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>91</number></detail><extent unit="pages"><start>9392</start><end>9396</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci U S A</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>91</number></detail><extent unit="pages"><start>9392</start><end>9396</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Immunochemical specificity of lactate dehydrogenase‐X</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Goldberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Goldberg E: Immunochemical specificity of lactate dehydrogenase‐X. Proc Natl Acad Sci USA 1971; 68:349–352.</note><part><date>1971</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>349</start><end>352</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1971</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>349</start><end>352</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Antibody coating of liposomes with 1‐ethyl‐3‐(3‐dimethyl‐aminopropyl)carbodiimide and the effect on target specificity</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Endoh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Hashimoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Endoh H, Suzuki Y, Hashimoto Y: Antibody coating of liposomes with 1‐ethyl‐3‐(3‐dimethyl‐aminopropyl)carbodiimide and the effect on target specificity. J Immunol Methods 1981; 44:79–85.</note><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>79</start><end>85</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol Methods</title></titleInfo><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>79</start><end>85</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Preparation of antibody‐coupled liposomes containing horseradish peroxidase as a marker molecule</title></titleInfo><name type="personal"><namePart type="given">T</namePart><namePart type="family">Suita</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Kamidate</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Suita T, Kamidate T: Preparation of antibody‐coupled liposomes containing horseradish peroxidase as a marker molecule. Anal Sci 1999; 15:349–352.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>349</start><end>352</end></extent></part><relatedItem type="host"><titleInfo><title>Anal Sci</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>349</start><end>352</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid</title></titleInfo><name type="personal"><namePart type="given">BN</namePart><namePart type="family">Ames</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DT</namePart><namePart type="family">Dubin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ames BN, Dubin DT: The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. J Biol Chem 1960; 235:769–775.</note><part><date>1960</date><detail type="volume"><caption>vol.</caption><number>235</number></detail><extent unit="pages"><start>769</start><end>775</end></extent></part><relatedItem type="host"><titleInfo><title>J Biol Chem</title></titleInfo><part><date>1960</date><detail type="volume"><caption>vol.</caption><number>235</number></detail><extent unit="pages"><start>769</start><end>775</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Chloroquine encapsulated in malaria‐infected erythrocyte‐specific antibody‐bearing liposomes effectively controls chloroquine‐resistant plasmodium berghei infections in mice</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Owais</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GC</namePart><namePart type="family">Varshney</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Choudhury</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Chandra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Gupta</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Owais M, Varshney GC, Choudhury A, Chandra S, Gupta CM: Chloroquine encapsulated in malaria‐infected erythrocyte‐specific antibody‐bearing liposomes effectively controls chloroquine‐resistant plasmodium berghei infections in mice. Antimicrob Agents Chemother 1995; 39:180–184.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>180</start><end>184</end></extent></part><relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>180</start><end>184</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Effect of seminal phospholipid‐binding proteins and follicular fluid on bovine sperm capacitation</title></titleInfo><name type="personal"><namePart type="given">I</namePart><namePart type="family">The′rien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Bousquet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Manjunath</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">The′rien I, Bousquet D, Manjunath P: Effect of seminal phospholipid‐binding proteins and follicular fluid on bovine sperm capacitation. Biol Reprod 2001; 65:41–51.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>41</start><end>51</end></extent></part><relatedItem type="host"><titleInfo><title>Biol Reprod</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>41</start><end>51</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Neutral sterols of rat epididymis: high concentrations of dehydrocholesterols in rat caput epididymidis</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Lindenthal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TA</namePart><namePart type="family">Aldaghlas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Kelleher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Henkel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Tolba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Haidl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KV</namePart><namePart type="family">Bergmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lindenthal B, Aldaghlas TA, Kelleher JK, Henkel SM, Tolba R, Haidl G, Bergmann KV: Neutral sterols of rat epididymis: high concentrations of dehydrocholesterols in rat caput epididymidis. J Lipid Res 2001; 42:1089–1095.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>1089</start><end>1095</end></extent></part><relatedItem type="host"><titleInfo><title>J Lipid Res</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>1089</start><end>1095</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Clearance properties of liposomes involving conjugated proteins for targeting</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Tardi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MB</namePart><namePart type="family">Bally</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TO</namePart><namePart type="family">Harasym</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tardi P, Bally MB, Harasym TO: Clearance properties of liposomes involving conjugated proteins for targeting. Adv Drug Deliv Rev 1998; 32:99–118.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>99</start><end>118</end></extent></part><relatedItem type="host"><titleInfo><title>Adv Drug Deliv Rev</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>99</start><end>118</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Uptake and processing of immunoglobulin‐coated liposomes by subpopulations of rat liver macrophages</title></titleInfo><name type="personal"><namePart type="given">JT</namePart><namePart type="family">Derksen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HW</namePart><namePart type="family">Morselt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GL</namePart><namePart type="family">Scherphof</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Derksen JT, Morselt HW, Scherphof GL: Uptake and processing of immunoglobulin‐coated liposomes by subpopulations of rat liver macrophages. Biochim Biophys Acta 1988; 971:127–136.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>971</number></detail><extent unit="pages"><start>127</start><end>136</end></extent></part><relatedItem type="host"><titleInfo><title>Biochim Biophys Acta</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>971</number></detail><extent unit="pages"><start>127</start><end>136</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Immune clearance of liposomes inhibited by an anti‐Fc receptor antibody in vivo</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Aragnol</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LD</namePart><namePart type="family">Leserman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Aragnol D, Leserman LD: Immune clearance of liposomes inhibited by an anti‐Fc receptor antibody in vivo. Proc Natl Acad Sci USA 1986; 83:2699–2703.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>2699</start><end>2703</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>2699</start><end>2703</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Designing of “intelligent” liposomes for efficient delivery of drugs</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Voinea</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Simionescu</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Voinea M, Simionescu M: Designing of “intelligent” liposomes for efficient delivery of drugs. J Cell Mol Med 2002; 6:465–474.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>465</start><end>474</end></extent></part><relatedItem type="host"><titleInfo><title>J Cell Mol Med</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>465</start><end>474</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Immunoliposomes for the targeted delivery of antitumor drugs</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Mastrobattista</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GA</namePart><namePart type="family">Koning</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Storm</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mastrobattista E, Koning GA, Storm G: Immunoliposomes for the targeted delivery of antitumor drugs. Adv Drug Deliv Rev 1999; 40:103–127.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>103</start><end>127</end></extent></part><relatedItem type="host"><titleInfo><title>Adv Drug Deliv Rev</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>103</start><end>127</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Sperm specific proteins‐potential candidate molecules for fertility control</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Suri</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Suri A: Sperm specific proteins‐potential candidate molecules for fertility control. Reprod Biol Endocrinol 2004; 2:10–15.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>10</start><end>15</end></extent></part><relatedItem type="host"><titleInfo><title>Reprod Biol Endocrinol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>10</start><end>15</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Immunologic properties of LDH‐C4 for contraceptive vaccine development</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Goldberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>Male Contraception Advances and Future Prospects</title></titleInfo><originInfo><publisher>Harper and Row</publisher></originInfo><part><date>1986</date><extent unit="pages"><start>435</start><end>436</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>The role of multivalency in antibody mediated liposome targeting</title></titleInfo><name type="personal"><namePart type="given">KS</namePart><namePart type="family">Houck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Houck KS, Huang L: The role of multivalency in antibody mediated liposome targeting. Biochem Biophys Res Commun 1987; 145:1205–1210.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>145</number></detail><extent unit="pages"><start>1205</start><end>1210</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem Biophys Res Commun</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>145</number></detail><extent unit="pages"><start>1205</start><end>1210</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>The effect of β‐tubulin‐specific antisense oligonucleotide encapsulated in different cationic liposomes on the supression of intracellular L. donovani parasites in vitro</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Dasgupta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Adhya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MK</namePart><namePart type="family">Basu</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dasgupta D, Adhya S, Basu MK: The effect of β‐tubulin‐specific antisense oligonucleotide encapsulated in different cationic liposomes on the supression of intracellular L. donovani parasites in vitro. J Biochem 2002; 132:23–27.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>132</number></detail><extent unit="pages"><start>23</start><end>27</end></extent></part><relatedItem type="host"><titleInfo><title>J Biochem</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>132</number></detail><extent unit="pages"><start>23</start><end>27</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Koslowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Türeci</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Bell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Krause</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HA</namePart><namePart type="family">Lehr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Brunner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Seitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FO</namePart><namePart type="family">Nestle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Huber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Sahin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Koslowski M, Türeci O, Bell C, Krause P, Lehr HA, Brunner J, Seitz G, Nestle FO, Huber C, Sahin U: Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer. Cancer Res 2002; 62:6750–6755.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>62</number></detail><extent unit="pages"><start>6750</start><end>6755</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Res</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>62</number></detail><extent unit="pages"><start>6750</start><end>6755</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer</title></titleInfo><name type="personal"><namePart type="given">SB</namePart><namePart type="family">Baylin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Esteller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MR</namePart><namePart type="family">Rountree</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KE</namePart><namePart type="family">Bachman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Schuebel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JG</namePart><namePart type="family">Herman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG: Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genet 2001; 10:687–692.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><end>692</end></extent></part><relatedItem type="host"><titleInfo><title>Hum Mol Genet</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><end>692</end></extent></part></relatedItem></relatedItem><identifier type="istex">6F7D053C598CCADF455BC9350494394C984CFD42</identifier><identifier type="ark">ark:/67375/WNG-PT280T76-G</identifier><identifier type="DOI">10.1111/j.1600-0897.2008.00587.x</identifier><identifier type="ArticleID">AJI587</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-13</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-PT280T76-G/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D80 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001D80 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:6F7D053C598CCADF455BC9350494394C984CFD42
|texte= ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes
}}
| This area was generated with Dilib version V0.6.33. |  |