A Photoactivatable AIE Polymer for Light‐Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking
Identifieur interne : 001D46 ( Istex/Corpus ); précédent : 001D45; suivant : 001D47A Photoactivatable AIE Polymer for Light‐Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking
Auteurs : Youyong Yuan ; Chong-Jing Zhang ; Bin LiuSource :
- Angewandte Chemie [ 0044-8249 ] ; 2015-09-21.
Abstract
Endo/lysosomal escape of gene vectors and the subsequent unpacking of nucleic acids in cytosol are two major challenges for efficient gene delivery. Herein, we report a polymeric gene delivery vector, which consists of a photosensitizer (PS) with aggregation‐induced emission (AIE) characteristics and oligoethylenimine (OEI) conjugated via an aminoacrylate (AA) linker that can be cleaved by reactive oxygen species (ROS). In aqueous media, the polymer could self‐assemble into bright red fluorescent nanoparticles (NPs), which can efficiently bind to DNA through electrostatic interaction for gene delivery. Upon visible light irradiation, the generated ROS can break the endo/lysosomal membrane and the polymer, resulting in light‐controlled endo/lysosomal escape and unpacking of DNA for efficient gene delivery. The smart polymer represents the first successful gene vector to simultaneously address both challenges with a single light excitation process.
Durch eine einzige Bestrahlung mit Licht kann ein photoaktiver polymerer Genvektor aus dem Endo/Lysosom entweichen und Nukleinsäuren ins Zytosol abgeben. Das Polymer besteht aus einem Fluorogen mit aggregationsverstärkter Emission und einem Linker, der durch reaktive Sauerstoffspezies gespalten wird. Es bildet Nanopartikel, die endozytotisch aufgenommen werden und an DNA binden.
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DOI: 10.1002/ange.201503640
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<titleGroup><title type="main" xml:lang="en">A Photoactivatable AIE Polymer for Light‐Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking<link href="#nss"></link>
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<creators><creator xml:id="au1" creatorRole="author" affiliationRef="#aa" noteRef="#np"><personName><honorifics>Dr.</honorifics>
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<keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Aggregationsinduzierte Emission</keyword>
<keyword xml:id="kwd2">Endo/Lysosom</keyword>
<keyword xml:id="kwd3">Gentransport</keyword>
<keyword xml:id="kwd4">Polymere</keyword>
<keyword xml:id="kwd5">Reaktive Sauerstoffspezies</keyword>
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<fundingInfo><fundingAgency>SMART</fundingAgency>
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<fundingInfo><fundingAgency>Ministry of Education</fundingAgency>
<fundingNumber>R279‐000‐391‐112</fundingNumber>
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<fundingInfo><fundingAgency>Singapore NRF Investigatorship</fundingAgency>
<fundingNumber>R279‐000‐444‐281</fundingNumber>
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<supportingInformation><p>As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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<abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title>
<p>Endo/lysosomal escape of gene vectors and the subsequent unpacking of nucleic acids in cytosol are two major challenges for efficient gene delivery. Herein, we report a polymeric gene delivery vector, which consists of a photosensitizer (PS) with aggregation‐induced emission (AIE) characteristics and oligoethylenimine (OEI) conjugated via an aminoacrylate (AA) linker that can be cleaved by reactive oxygen species (ROS). In aqueous media, the polymer could self‐assemble into bright red fluorescent nanoparticles (NPs), which can efficiently bind to DNA through electrostatic interaction for gene delivery. Upon visible light irradiation, the generated ROS can break the endo/lysosomal membrane and the polymer, resulting in light‐controlled endo/lysosomal escape and unpacking of DNA for efficient gene delivery. The smart polymer represents the first successful gene vector to simultaneously address both challenges with a single light excitation process.</p>
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<abstract type="graphical" xml:lang="de"><p><b>Durch eine einzige Bestrahlung</b>
mit Licht kann ein photoaktiver polymerer Genvektor aus dem Endo/Lysosom entweichen und Nukleinsäuren ins Zytosol abgeben. Das Polymer besteht aus einem Fluorogen mit aggregationsverstärkter Emission und einem Linker, der durch reaktive Sauerstoffspezies gespalten wird. Es bildet Nanopartikel, die endozytotisch aufgenommen werden und an DNA binden.<blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" href="urn:x-wiley:00448249:media:ANGE201503640:content" eRights="yes" copyright="WILEY-VCH"></mediaResource>
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<noteGroup><note xml:id="nss"><p>We thank the SMART (R279‐000‐378‐592), the Ministry of Education (R279‐000‐391‐112), Singapore NRF Investigatorship (R279‐000‐444‐281) and the Institute of Materials Research and Engineering of Singapore (IMRE/14‐8P1110) for financial support. AIE=aggregation‐induced emission.</p>
</note>
<note xml:id="np"><p>These authors contributed equally to this work.</p>
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<mods version="3.6"><titleInfo lang="en"><title>A Photoactivatable AIE Polymer for Light‐Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking</title>
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<namePart type="given">Youyong</namePart>
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<abstract lang="en">Endo/lysosomal escape of gene vectors and the subsequent unpacking of nucleic acids in cytosol are two major challenges for efficient gene delivery. Herein, we report a polymeric gene delivery vector, which consists of a photosensitizer (PS) with aggregation‐induced emission (AIE) characteristics and oligoethylenimine (OEI) conjugated via an aminoacrylate (AA) linker that can be cleaved by reactive oxygen species (ROS). In aqueous media, the polymer could self‐assemble into bright red fluorescent nanoparticles (NPs), which can efficiently bind to DNA through electrostatic interaction for gene delivery. Upon visible light irradiation, the generated ROS can break the endo/lysosomal membrane and the polymer, resulting in light‐controlled endo/lysosomal escape and unpacking of DNA for efficient gene delivery. The smart polymer represents the first successful gene vector to simultaneously address both challenges with a single light excitation process.</abstract>
<abstract type="graphical" lang="de">Durch eine einzige Bestrahlung mit Licht kann ein photoaktiver polymerer Genvektor aus dem Endo/Lysosom entweichen und Nukleinsäuren ins Zytosol abgeben. Das Polymer besteht aus einem Fluorogen mit aggregationsverstärkter Emission und einem Linker, der durch reaktive Sauerstoffspezies gespalten wird. Es bildet Nanopartikel, die endozytotisch aufgenommen werden und an DNA binden.</abstract>
<note type="content">*We thank the SMART (R279‐000‐378‐592), the Ministry of Education (R279‐000‐391‐112), Singapore NRF Investigatorship (R279‐000‐444‐281) and the Institute of Materials Research and Engineering of Singapore (IMRE/14‐8P1110) for financial support. AIE=aggregation‐induced emission.</note>
<note type="funding">SMART - No. R279‐000‐378‐592; </note>
<note type="funding">Ministry of Education - No. R279‐000‐391‐112; </note>
<note type="funding">Singapore NRF Investigatorship - No. R279‐000‐444‐281; </note>
<note type="funding">Institute of Materials Research and Engineering of Singapore - No. IMRE/14‐8P1110; </note>
<subject lang="en"><genre>keywords</genre>
<topic>Aggregationsinduzierte Emission</topic>
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<topic>Gentransport</topic>
<topic>Polymere</topic>
<topic>Reaktive Sauerstoffspezies</topic>
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<relatedItem type="host"><titleInfo><title>Angewandte Chemie</title>
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<titleInfo type="abbreviated"><title>Angew. Chem.</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<note type="content"> As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.Supporting Info Item: miscellaneous_information - </note>
<subject><genre>article-category</genre>
<topic>Zuschrift</topic>
<topic>Zuschriften</topic>
<topic>Genvektoren</topic>
</subject>
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<part><date>2015</date>
<detail type="title"><title>Internationales Jahr des Lichts</title>
</detail>
<detail type="volume"><caption>vol.</caption>
<number>127</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>39</number>
</detail>
<extent unit="pages"><start>11581</start>
<end>11585</end>
<total>5</total>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit1"><titleInfo><title>Nat. Rev. Genet.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">M. A. Kay, Nat. Rev. Genet. 2011, 12, 316.</note>
<name type="personal"><namePart type="given">M. A.</namePart>
<namePart type="family">Kay</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2011</date>
<detail type="volume"><caption>vol.</caption>
<number>12</number>
</detail>
<extent unit="pages"><start>316</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit2"><titleInfo><title>Acc. Chem. Res.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">X. Guo, L. Huang, Acc. Chem. Res. 2012, 45, 971.</note>
<name type="personal"><namePart type="given">X.</namePart>
<namePart type="family">Guo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L.</namePart>
<namePart type="family">Huang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>45</number>
</detail>
<extent unit="pages"><start>971</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit3"><titleInfo><title> </title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="cit4"><titleInfo><title>Chem. Rev.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">M. A. Mintzer, E. E. Simanek, Chem. Rev. 2009, 109, 259;</note>
<name type="personal"><namePart type="given">M. A.</namePart>
<namePart type="family">Mintzer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E. E.</namePart>
<namePart type="family">Simanek</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>109</number>
</detail>
<extent unit="pages"><start>259</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit5"><titleInfo><title>Acc. Chem. Res.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">J. Nguyen, F. C. Szoka, Acc. Chem. Res. 2012, 45, 1153.</note>
<name type="personal"><namePart type="given">J.</namePart>
<namePart type="family">Nguyen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F. C.</namePart>
<namePart type="family">Szoka</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>45</number>
</detail>
<extent unit="pages"><start>1153</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit6"><titleInfo><title> </title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="cit7"><titleInfo><title>Biotechnol. Bioeng.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">D. V. Schaffer, N. A. Fidelman, N. Dan, D. A. Lauffenburger, Biotechnol. Bioeng. 2000, 67, 598;</note>
<name type="personal"><namePart type="given">D. V.</namePart>
<namePart type="family">Schaffer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N. A.</namePart>
<namePart type="family">Fidelman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N.</namePart>
<namePart type="family">Dan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D. A.</namePart>
<namePart type="family">Lauffenburger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>67</number>
</detail>
<extent unit="pages"><start>598</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit8"><titleInfo><title>Chem. Sci.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">H. Y. Kuchelmeister, A. Gutschmidt, S. Tillmann, S. Knauerb, C. Schmuck, Chem. Sci. 2012, 3, 996;</note>
<name type="personal"><namePart type="given">H. Y.</namePart>
<namePart type="family">Kuchelmeister</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A.</namePart>
<namePart type="family">Gutschmidt</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S.</namePart>
<namePart type="family">Tillmann</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S.</namePart>
<namePart type="family">Knauerb</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C.</namePart>
<namePart type="family">Schmuck</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>996</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit9"><titleInfo><title>Biotechnol. Adv.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">K. Luo, B. He, Y. Wu, Y. Q. Shen, Z. W. Gu, Biotechnol. Adv. 2014, 32, 818.</note>
<name type="personal"><namePart type="given">K.</namePart>
<namePart type="family">Luo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B.</namePart>
<namePart type="family">He</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y.</namePart>
<namePart type="family">Wu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y. Q.</namePart>
<namePart type="family">Shen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Z. W.</namePart>
<namePart type="family">Gu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>32</number>
</detail>
<extent unit="pages"><start>818</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit10"><titleInfo><title>Proc. Natl. Acad. Sci. USA</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">O. Boussif, F. Lezoualch, M. A. Zanta, M. D. Mergny, D. Scherman, B. Demeneix, J. P. Behr, Proc. Natl. Acad. Sci. USA 1995, 92, 7297.</note>
<name type="personal"><namePart type="given">O.</namePart>
<namePart type="family">Boussif</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F.</namePart>
<namePart type="family">Lezoualch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M. A.</namePart>
<namePart type="family">Zanta</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M. D.</namePart>
<namePart type="family">Mergny</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D.</namePart>
<namePart type="family">Scherman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B.</namePart>
<namePart type="family">Demeneix</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J. P.</namePart>
<namePart type="family">Behr</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>92</number>
</detail>
<extent unit="pages"><start>7297</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit11"><titleInfo><title>Nat. Commun.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, A. Arnida, Y. Matsumoto, M. Oba, K. Miyata, K. Osada, N. Nishiyama, K. Kataoka, Nat. Commun. 2014, 5, 3545.</note>
<name type="personal"><namePart type="given">T.</namePart>
<namePart type="family">Nomoto</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S.</namePart>
<namePart type="family">Fukushima</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M.</namePart>
<namePart type="family">Kumagai</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K.</namePart>
<namePart type="family">Machitani</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A.</namePart>
<namePart type="family">Arnida</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y.</namePart>
<namePart type="family">Matsumoto</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M.</namePart>
<namePart type="family">Oba</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K.</namePart>
<namePart type="family">Miyata</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K.</namePart>
<namePart type="family">Osada</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N.</namePart>
<namePart type="family">Nishiyama</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K.</namePart>
<namePart type="family">Kataoka</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>3545</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit12"><titleInfo><title> </title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="cit13"><titleInfo><title>Cancer Gene Ther.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">A. Høgset, B. O. Engesæter, L. Prasmickaite, K. Berg, O. Fodstad, G. M. Mælandsmo, Cancer Gene Ther. 2002, 9, 365;</note>
<name type="personal"><namePart type="given">A.</namePart>
<namePart type="family">Høgset</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B. O.</namePart>
<namePart type="family">Engesæter</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L.</namePart>
<namePart type="family">Prasmickaite</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K.</namePart>
<namePart type="family">Berg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">O.</namePart>
<namePart type="family">Fodstad</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G. M.</namePart>
<namePart type="family">Mælandsmo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>9</number>
</detail>
<extent unit="pages"><start>365</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit14"><titleInfo><title>Nanoscale</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">X. Wang, K. Liu, G. B. Yang, L. Cheng, L. He, Y. M. Liu, Y. G. Li, L. Guo, Z. Liu, Nanoscale 2014, 6, 9198;</note>
<name type="personal"><namePart type="given">X.</namePart>
<namePart type="family">Wang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K.</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G. B.</namePart>
<namePart type="family">Yang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L.</namePart>
<namePart type="family">Cheng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L.</namePart>
<namePart type="family">He</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y. M.</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y. G.</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L.</namePart>
<namePart type="family">Guo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Z.</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>9198</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit15"><titleInfo><title>Adv. Funct. Mater.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">K. Han, L. Qi, H. Jia, S. Wang, W. Yin, W. Chen, S. Cheng, X. Zhang, Adv. Funct. Mater. 2015, 25, 1248.</note>
<name type="personal"><namePart type="given">K.</namePart>
<namePart type="family">Han</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L.</namePart>
<namePart type="family">Qi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H.</namePart>
<namePart type="family">Jia</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S.</namePart>
<namePart type="family">Wang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W.</namePart>
<namePart type="family">Yin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W.</namePart>
<namePart type="family">Chen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S.</namePart>
<namePart type="family">Cheng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">X.</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2015</date>
<detail type="volume"><caption>vol.</caption>
<number>25</number>
</detail>
<extent unit="pages"><start>1248</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit16"><titleInfo><title>Adv. Drug Delivery Rev.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">M. S. Shim, Y. J. Kwon, Adv. Drug Delivery Rev. 2012, 64, 1046.</note>
<name type="personal"><namePart type="given">M. S.</namePart>
<namePart type="family">Shim</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y. J.</namePart>
<namePart type="family">Kwon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>64</number>
</detail>
<extent unit="pages"><start>1046</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit17"><titleInfo><title> </title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="cit18"><titleInfo><title>Biomaterials</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">M. Ou, R. Z. Xu, S. H. Kim, D. A. Bull, S. W. Kim, Biomaterials 2009, 30, 5804;</note>
<name type="personal"><namePart type="given">M.</namePart>
<namePart type="family">Ou</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R. Z.</namePart>
<namePart type="family">Xu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S. H.</namePart>
<namePart type="family">Kim</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D. A.</namePart>
<namePart type="family">Bull</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S. W.</namePart>
<namePart type="family">Kim</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>30</number>
</detail>
<extent unit="pages"><start>5804</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit19"><titleInfo><title>Biomaterials</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">F. H. Meng, W. E. Hennink, Z. Zhong, Biomaterials 2009, 30, 2180;</note>
<name type="personal"><namePart type="given">F. H.</namePart>
<namePart type="family">Meng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W. E.</namePart>
<namePart type="family">Hennink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Z.</namePart>
<namePart type="family">Zhong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>30</number>
</detail>
<extent unit="pages"><start>2180</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit20"><titleInfo><title>J. Am. Chem. Soc.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">J. Li, C. Zheng, S. Cansiz, C. C. Wu, J. H. Xu, C. Cui, Y. Liu, W. J. Hou, Y. Y. Wang, L. Q. Zhang, T. Teng, H. H. Yang, W. H. Tan, J. Am. Chem. Soc. 2015, 137, 1412.</note>
<name type="personal"><namePart type="given">J.</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C.</namePart>
<namePart type="family">Zheng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S.</namePart>
<namePart type="family">Cansiz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C. C.</namePart>
<namePart type="family">Wu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J. H.</namePart>
<namePart type="family">Xu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C.</namePart>
<namePart type="family">Cui</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y.</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W. J.</namePart>
<namePart type="family">Hou</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y. Y.</namePart>
<namePart type="family">Wang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L. Q.</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T.</namePart>
<namePart type="family">Teng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H. H.</namePart>
<namePart type="family">Yang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W. H.</namePart>
<namePart type="family">Tan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2015</date>
<detail type="volume"><caption>vol.</caption>
<number>137</number>
</detail>
<extent unit="pages"><start>1412</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit21"><titleInfo><title> </title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="cit22"><titleInfo><title>Angew. Chem. Int. Ed.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">M. A. Kostiainen, D. K. Smith, O. Ikkala, Angew. Chem. Int. Ed. 2007, 46, 7600;</note>
<name type="personal"><namePart type="given">M. A.</namePart>
<namePart type="family">Kostiainen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D. K.</namePart>
<namePart type="family">Smith</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">O.</namePart>
<namePart type="family">Ikkala</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>46</number>
</detail>
<extent unit="pages"><start>7600</start>
</extent>
</part>
<titleInfo><title>Angew. Chem.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">Angew. Chem. 2007, 119, 7744;</note>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>119</number>
</detail>
<extent unit="pages"><start>7744</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit24"><titleInfo><title>Angew. Chem. Int. Ed.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">L. C. Yin, H. Y. Tang, K. H. Kim, N. Zheng, Z. Y. Song, N. P. Gabrielson, H. Lu, J. J. Cheng, Angew. Chem. Int. Ed. 2013, 52, 9182;</note>
<name type="personal"><namePart type="given">L. C.</namePart>
<namePart type="family">Yin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H. Y.</namePart>
<namePart type="family">Tang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K. H.</namePart>
<namePart type="family">Kim</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N.</namePart>
<namePart type="family">Zheng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Z. Y.</namePart>
<namePart type="family">Song</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N. P.</namePart>
<namePart type="family">Gabrielson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H.</namePart>
<namePart type="family">Lu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J. J.</namePart>
<namePart type="family">Cheng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>52</number>
</detail>
<extent unit="pages"><start>9182</start>
</extent>
</part>
<titleInfo><title>Angew. Chem.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">Angew. Chem. 2013, 125, 9352.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>125</number>
</detail>
<extent unit="pages"><start>9352</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit26"><titleInfo><title> </title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="cit27"><titleInfo><title>R. T. Kwok, C. W. Leung, J. W. Lam, B. Z. Tang, Chem. Soc. Rev. 2015, DOI: ;</title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="cit28"><titleInfo><title>Acc. Chem. Res.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">D. Ding, K. Li, B. Liu, B. Z. Tang, Acc. Chem. Res. 2013, 46, 2441;</note>
<name type="personal"><namePart type="given">D.</namePart>
<namePart type="family">Ding</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K.</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B.</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B. Z.</namePart>
<namePart type="family">Tang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>46</number>
</detail>
<extent unit="pages"><start>2441</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit29"><titleInfo><title>J. Mater. Chem. B</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">X. Zhang, X. Zhang, L. Tao, Z. Chi, J. Xu, Y. Wei, J. Mater. Chem. B 2014, 2, 4398;</note>
<name type="personal"><namePart type="given">X.</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">X.</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L.</namePart>
<namePart type="family">Tao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Z.</namePart>
<namePart type="family">Chi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J.</namePart>
<namePart type="family">Xu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y.</namePart>
<namePart type="family">Wei</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>4398</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit30"><titleInfo><title>Angew. Chem. Int. Ed.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">Q. L. Hu, M. Gao, G. X. Feng, B. Liu, Angew. Chem. Int. Ed. 2014, 53, 14225–14229;</note>
<name type="personal"><namePart type="given">Q. L.</namePart>
<namePart type="family">Hu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M.</namePart>
<namePart type="family">Gao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G. X.</namePart>
<namePart type="family">Feng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B.</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>53</number>
</detail>
<extent unit="pages"><start>14225</start>
<end>14229</end>
</extent>
</part>
<titleInfo><title>Angew. Chem.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">Angew. Chem. 2014, 126, 14449–14453;</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>126</number>
</detail>
<extent unit="pages"><start>14449</start>
<end>14453</end>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit32"><titleInfo><title>J. Am. Chem. Soc.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">X. R. Wang, J. M. Hu, G. Y. Zhang, S. Y. Liu, J. Am. Chem. Soc. 2014, 136, 9890.</note>
<name type="personal"><namePart type="given">X. R.</namePart>
<namePart type="family">Wang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J. M.</namePart>
<namePart type="family">Hu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G. Y.</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S. Y.</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>136</number>
</detail>
<extent unit="pages"><start>9890</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit33"><titleInfo><title> </title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="cit34"><titleInfo><title>Angew. Chem. Int. Ed.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">Y. Yuan, C. J. Zhang, M. Gao, R. Zhang, B. Z. Tang, B. Liu, Angew. Chem. Int. Ed. 2015, 54, 1780;</note>
<name type="personal"><namePart type="given">Y.</namePart>
<namePart type="family">Yuan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C. J.</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M.</namePart>
<namePart type="family">Gao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R.</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B. Z.</namePart>
<namePart type="family">Tang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B.</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2015</date>
<detail type="volume"><caption>vol.</caption>
<number>54</number>
</detail>
<extent unit="pages"><start>1780</start>
</extent>
</part>
<titleInfo><title>Angew. Chem.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">Angew. Chem. 2015, 127, 1800;</note>
<part><date>2015</date>
<detail type="volume"><caption>vol.</caption>
<number>127</number>
</detail>
<extent unit="pages"><start>1800</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit36"><titleInfo><title>Anal. Chem.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">F. Hu, Y. Y. Huang, G. X. Zhang, R. Zhao, H. Yang, D. Q. Zhang, Anal. Chem. 2014, 86, 7987;</note>
<name type="personal"><namePart type="given">F.</namePart>
<namePart type="family">Hu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y. Y.</namePart>
<namePart type="family">Huang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G. X.</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R.</namePart>
<namePart type="family">Zhao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H.</namePart>
<namePart type="family">Yang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D. Q.</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>86</number>
</detail>
<extent unit="pages"><start>7987</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit37"><titleInfo><title>Chem. Commun.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">Y. Y. Yuan, G. X. Feng, W. Qin, B. Z. Tang, B. Liu, Chem. Commun. 2014, 50, 8757–8760.</note>
<name type="personal"><namePart type="given">Y. Y.</namePart>
<namePart type="family">Yuan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G. X.</namePart>
<namePart type="family">Feng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W.</namePart>
<namePart type="family">Qin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B. Z.</namePart>
<namePart type="family">Tang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B.</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>50</number>
</detail>
<extent unit="pages"><start>8757</start>
<end>8760</end>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit38"><titleInfo><title> </title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="cit39"><titleInfo><title>Adv. Healthcare Mater.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">S. H. Lee, M. K. Gupta, J. B. Bang, H. Bae, H. J. Sung, Adv. Healthcare Mater. 2013, 2, 908;</note>
<name type="personal"><namePart type="given">S. H.</namePart>
<namePart type="family">Lee</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M. K.</namePart>
<namePart type="family">Gupta</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J. B.</namePart>
<namePart type="family">Bang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H.</namePart>
<namePart type="family">Bae</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H. J.</namePart>
<namePart type="family">Sung</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>908</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit40"><titleInfo><title>Med. Chem.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">B. Moses, Y. You, Med. Chem. 2013, 3, 192.</note>
<name type="personal"><namePart type="given">B.</namePart>
<namePart type="family">Moses</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y.</namePart>
<namePart type="family">You</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>192</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit41"><titleInfo><title>Pharm. Res.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">D. Fischer, T. Bieber, Y. X. Li, H. P. Elsasser, T. Kissel, Pharm. Res. 1999, 16, 1273.</note>
<name type="personal"><namePart type="given">D.</namePart>
<namePart type="family">Fischer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T.</namePart>
<namePart type="family">Bieber</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y. X.</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H. P.</namePart>
<namePart type="family">Elsasser</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T.</namePart>
<namePart type="family">Kissel</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>16</number>
</detail>
<extent unit="pages"><start>1273</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit42"><titleInfo><title>Biochemistry</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">G. Krishnamoorthy, G. Duportail, Y. Mely, Biochemistry 2002, 41, 15277.</note>
<name type="personal"><namePart type="given">G.</namePart>
<namePart type="family">Krishnamoorthy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G.</namePart>
<namePart type="family">Duportail</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y.</namePart>
<namePart type="family">Mely</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>41</number>
</detail>
<extent unit="pages"><start>15277</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit43"><titleInfo><title>Nat. Med.</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">J. S. Wadia, R. V. Stan, S. F. Dowdy, Nat. Med. 2004, 10, 310.</note>
<name type="personal"><namePart type="given">J. S.</namePart>
<namePart type="family">Wadia</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R. V.</namePart>
<namePart type="family">Stan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S. F.</namePart>
<namePart type="family">Dowdy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>310</start>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit44"><titleInfo><title>J. Controlled Release</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">M. Bertschinger, G. Backliwal, A. Schertenleib, M. Jordan, D. L. Hacker, F. M. Wurm, J. Controlled Release 2006, 116, 96.</note>
<name type="personal"><namePart type="given">M.</namePart>
<namePart type="family">Bertschinger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G.</namePart>
<namePart type="family">Backliwal</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A.</namePart>
<namePart type="family">Schertenleib</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M.</namePart>
<namePart type="family">Jordan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D. L.</namePart>
<namePart type="family">Hacker</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F. M.</namePart>
<namePart type="family">Wurm</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>116</number>
</detail>
<extent unit="pages"><start>96</start>
</extent>
</part>
</relatedItem>
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