ChloroquineV1, Istex, Corpus, bibRecord, 001D42

A Photoactivatable AIE Polymer for Light‐Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking

Identifieur interne : 001D42 ( Istex/Corpus ); précédent : 001D41; suivant : 001D43

A Photoactivatable AIE Polymer for Light‐Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking

Auteurs : Youyong Yuan ; Chong-Jing Zhang ; Bin Liu

Source :

Angewandte Chemie International Edition [ 1433-7851 ] ; 2015-09-21.

RBID : ISTEX:7C11EBDB582E51A0299BEC4015AF04545C31DDEB

Abstract

Endo/lysosomal escape of gene vectors and the subsequent unpacking of nucleic acids in cytosol are two major challenges for efficient gene delivery. Herein, we report a polymeric gene delivery vector, which consists of a photosensitizer (PS) with aggregation‐induced emission (AIE) characteristics and oligoethylenimine (OEI) conjugated via an aminoacrylate (AA) linker that can be cleaved by reactive oxygen species (ROS). In aqueous media, the polymer could self‐assemble into bright red fluorescent nanoparticles (NPs), which can efficiently bind to DNA through electrostatic interaction for gene delivery. Upon visible light irradiation, the generated ROS can break the endo/lysosomal membrane and the polymer, resulting in light‐controlled endo/lysosomal escape and unpacking of DNA for efficient gene delivery. The smart polymer represents the first successful gene vector to simultaneously address both challenges with a single light excitation process.

Special delivery! A photoactive polymeric gene delivery vector can concurrently escape from the endo/lysosome and unpack nucleic acids in cytosol in a single light irradiation process. The polymer, which comprises a fluorogen with aggregation‐enhanced‐emission characteristics and a linker that can be cleaved by reactive oxygen species, forms nanoparticles that bind DNA and are endocytosed by cells.

Url:

https://api.istex.fr/ark:/67375/WNG-503C4XX3-X/fulltext.pdf

DOI: 10.1002/anie.201503640

Links to Exploration step

ISTEX:7C11EBDB582E51A0299BEC4015AF04545C31DDEB

Le document en format XML

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<familyName>Zhang</familyName>
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<givenNames>Bin</givenNames>
<familyName>Liu</familyName>
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<contactDetails><email>cheliub@nus.edu.sg</email>
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<keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">aggregation‐induced emission</keyword>
<keyword xml:id="kwd2">endo/lysosomes</keyword>
<keyword xml:id="kwd3">gene delivery</keyword>
<keyword xml:id="kwd4">polymers</keyword>
<keyword xml:id="kwd5">reactive oxygen species</keyword>
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<fundingInfo><fundingAgency>SMART</fundingAgency>
<fundingNumber>R279‐000‐378‐592</fundingNumber>
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<fundingInfo><fundingAgency>Ministry of Education</fundingAgency>
<fundingNumber>R279‐000‐391‐112</fundingNumber>
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<fundingInfo><fundingAgency>Singapore NRF Investigatorship</fundingAgency>
<fundingNumber>R279‐000‐444‐281</fundingNumber>
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<fundingInfo><fundingAgency>Institute of Materials Research and Engineering of Singapore</fundingAgency>
<fundingNumber>IMRE/14‐8P1110</fundingNumber>
</fundingInfo>
<supportingInformation><p>As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. 
</p>
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<abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title>
<p>Endo/lysosomal escape of gene vectors and the subsequent unpacking of nucleic acids in cytosol are two major challenges for efficient gene delivery. Herein, we report a polymeric gene delivery vector, which consists of a photosensitizer (PS) with aggregation‐induced emission (AIE) characteristics and oligoethylenimine (OEI) conjugated via an aminoacrylate (AA) linker that can be cleaved by reactive oxygen species (ROS). In aqueous media, the polymer could self‐assemble into bright red fluorescent nanoparticles (NPs), which can efficiently bind to DNA through electrostatic interaction for gene delivery. Upon visible light irradiation, the generated ROS can break the endo/lysosomal membrane and the polymer, resulting in light‐controlled endo/lysosomal escape and unpacking of DNA for efficient gene delivery. The smart polymer represents the first successful gene vector to simultaneously address both challenges with a single light excitation process.</p>
</abstract>
<abstract type="graphical" xml:lang="en"><p><b>Special delivery!</b>
 A photoactive polymeric gene delivery vector can concurrently escape from the endo/lysosome and unpack nucleic acids in cytosol in a single light irradiation process. The polymer, which comprises a fluorogen with aggregation‐enhanced‐emission characteristics and a linker that can be cleaved by reactive oxygen species, forms nanoparticles that bind DNA and are endocytosed by cells.<blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" href="urn:x-wiley:14337851:media:ANIE201503640:content" eRights="yes" copyright="WILEY-VCH"></mediaResource>
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<noteGroup><note xml:id="nss"><p>We thank the SMART (R279‐000‐378‐592), the Ministry of Education (R279‐000‐391‐112), Singapore NRF Investigatorship (R279‐000‐444‐281) and the Institute of Materials Research and Engineering of Singapore (IMRE/14‐8P1110) for financial support. AIE=aggregation‐induced emission.</p>
</note>
<note xml:id="np"><p>These authors contributed equally to this work.</p>
</note>
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<mods version="3.6"><titleInfo lang="en"><title>A Photoactivatable AIE Polymer for Light‐Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>A Photoactivatable AIE Polymer for Light‐Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking</title>
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<name type="personal"><namePart type="termsOfAddress">Dr.</namePart>
<namePart type="given">Youyong</namePart>
<namePart type="family">Yuan</namePart>
<affiliation>Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive, Singapore 117585 (Singapore)</affiliation>
<description>These authors contributed equally to this work.</description>
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<name type="personal"><namePart type="termsOfAddress">Dr.</namePart>
<namePart type="given">Chong‐Jing</namePart>
<namePart type="family">Zhang</namePart>
<affiliation>Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive, Singapore 117585 (Singapore)</affiliation>
<description>These authors contributed equally to this work.</description>
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<namePart type="given">Bin</namePart>
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<affiliation>Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive, Singapore 117585 (Singapore)</affiliation>
<affiliation>Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 3 Research Link, Singapore, 117602 (Singapore)</affiliation>
<affiliation>E-mail: cheliub@nus.edu.sg</affiliation>
<affiliation>Correspondence address: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive, Singapore 117585 (Singapore)</affiliation>
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<abstract lang="en">Endo/lysosomal escape of gene vectors and the subsequent unpacking of nucleic acids in cytosol are two major challenges for efficient gene delivery. Herein, we report a polymeric gene delivery vector, which consists of a photosensitizer (PS) with aggregation‐induced emission (AIE) characteristics and oligoethylenimine (OEI) conjugated via an aminoacrylate (AA) linker that can be cleaved by reactive oxygen species (ROS). In aqueous media, the polymer could self‐assemble into bright red fluorescent nanoparticles (NPs), which can efficiently bind to DNA through electrostatic interaction for gene delivery. Upon visible light irradiation, the generated ROS can break the endo/lysosomal membrane and the polymer, resulting in light‐controlled endo/lysosomal escape and unpacking of DNA for efficient gene delivery. The smart polymer represents the first successful gene vector to simultaneously address both challenges with a single light excitation process.</abstract>
<abstract type="graphical" lang="en">Special delivery! A photoactive polymeric gene delivery vector can concurrently escape from the endo/lysosome and unpack nucleic acids in cytosol in a single light irradiation process. The polymer, which comprises a fluorogen with aggregation‐enhanced‐emission characteristics and a linker that can be cleaved by reactive oxygen species, forms nanoparticles that bind DNA and are endocytosed by cells.</abstract>
<note type="content">*We thank the SMART (R279‐000‐378‐592), the Ministry of Education (R279‐000‐391‐112), Singapore NRF Investigatorship (R279‐000‐444‐281) and the Institute of Materials Research and Engineering of Singapore (IMRE/14‐8P1110) for financial support. AIE=aggregation‐induced emission.</note>
<note type="funding">SMART - No. R279‐000‐378‐592; </note>
<note type="funding">Ministry of Education - No. R279‐000‐391‐112; </note>
<note type="funding">Singapore NRF Investigatorship - No. R279‐000‐444‐281; </note>
<note type="funding">Institute of Materials Research and Engineering of Singapore - No. IMRE/14‐8P1110; </note>
<subject lang="en"><genre>keywords</genre>
<topic>aggregation‐induced emission</topic>
<topic>endo/lysosomes</topic>
<topic>gene delivery</topic>
<topic>polymers</topic>
<topic>reactive oxygen species</topic>
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<relatedItem type="host"><titleInfo><title>Angewandte Chemie International Edition</title>
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<titleInfo type="abbreviated"><title>Angew. Chem. Int. Ed.</title>
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<note type="content"> As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.Supporting Info Item: miscellaneous_information - </note>
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<topic>Communication</topic>
<topic>Communications</topic>
<topic>Gene Vectors</topic>
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<identifier type="ISSN">1433-7851</identifier>
<identifier type="eISSN">1521-3773</identifier>
<identifier type="DOI">10.1002/(ISSN)1521-3773</identifier>
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A Photoactivatable AIE Polymer for Light‐Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking

A Photoactivatable AIE Polymer for Light‐Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking

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