ChloroquineV1, Istex, Corpus, bibRecord, 001C92

Pharmacological/Biological Effects of Berberine

Identifieur interne : 001C92 ( Istex/Corpus ); précédent : 001C91; suivant : 001C93

Pharmacological/Biological Effects of Berberine

Auteurs : Eva M. Galvez ; M. Perez ; P. Domingo ; D. Nu Ez ; V. L. Cebolla ; M. Matt ; J. Pardo

Source :

RBID : ISTEX:3417A3CE75F0F49DFB4152350ABBAE42EF18DA62

Abstract

Abstract: Berberine is a yellow alkaloid naturally produced by a diversity of plants. It is extracted from the roots, rhizome, and stem bark of several plants. This natural product has been used for centuries in the Chinese medicinal herb. Berberine presents a wide range of pharmacological applications such as antidiabetic, hypolipidemic, antihypertensive, anti-inflammatory, antioxidant, antidepressant, anticancer, antidiarrheal, hepatoprotective, and, above all, antimicrobial. It has been tested clinically in the treatment of oriental sore, diarrhea, trachoma, diabetes mellitus type 2, hypercholesterolemia, and congestive cardiac failure. This alkaloid is also used in the treatment of gastric and inflammatory diseases and more recently is being investigated for its application in neurology, cardiology, and oncology.

Url:

https://api.istex.fr/ark:/67375/HCB-W571QTRR-N/fulltext.pdf

DOI: 10.1007/978-3-642-22144-6_182

Links to Exploration step

ISTEX:3417A3CE75F0F49DFB4152350ABBAE42EF18DA62

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Berberine is a yellow alkaloid naturally produced by a diversity of plants. It is extracted from the roots, rhizome, and stem bark of several plants. This natural product has been used for centuries in the Chinese medicinal herb. Berberine presents a wide range of pharmacological applications such as antidiabetic, hypolipidemic, antihypertensive, anti-inflammatory, antioxidant, antidepressant, anticancer, antidiarrheal, hepatoprotective, and, above all, antimicrobial. It has been tested clinically in the treatment of oriental sore, diarrhea, trachoma, diabetes mellitus type 2, hypercholesterolemia, and congestive cardiac failure. This alkaloid is also used in the treatment of gastric and inflammatory diseases and more recently is being investigated for its application in neurology, cardiology, and oncology.</div>
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<p>Berberine is a yellow alkaloid naturally produced by a diversity of plants. It is extracted from the roots, rhizome, and stem bark of several plants. This natural product has been used for centuries in the Chinese medicinal herb. Berberine presents a wide range of pharmacological applications such as antidiabetic, hypolipidemic, antihypertensive, anti-inflammatory, antioxidant, antidepressant, anticancer, antidiarrheal, hepatoprotective, and, above all, antimicrobial. It has been tested clinically in the treatment of oriental sore, diarrhea, trachoma, diabetes mellitus type 2, hypercholesterolemia, and congestive cardiac failure. This alkaloid is also used in the treatment of gastric and inflammatory diseases and more recently is being investigated for its application in neurology, cardiology, and oncology.</p>
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<textClass ana="abbreviation"><keywords scheme="abbreviations"><list><head>Abbreviations</head>
<item><term>AChE</term>
<desc>
                  Acetylcholinesterase enzyme
                </desc>
</item>
<item><term>AML</term>
<desc>
                  Acute myeloid leukemia
                </desc>
</item>
<item><term>AMPK</term>
<desc>
                  Adenosine monophosphate-activated protein kinase
                </desc>
</item>
<item><term>ATP</term>
<desc>
                  Adenosine triphosphate
                </desc>
</item>
<item><term>AD</term>
<desc>
                  Alzheimer’s disease
                </desc>
</item>
<item><term>Aβ peptide</term>
<desc>
                  Amyloid β-peptide
                </desc>
</item>
<item><term>AR</term>
<desc>
                  Androgen receptor
                </desc>
</item>
<item><term>ACE</term>
<desc>
                  Angiotensin-converting enzyme
                </desc>
</item>
<item><term>ATM</term>
<desc>
                  Ataxia-telangiectasia mutated
                </desc>
</item>
<item><term>Bcl-2</term>
<desc>
                  B cell lymphoma 2
                </desc>
</item>
<item><term>COX2</term>
<desc>
                  Cyclooxygenase-2
                </desc>
</item>
<item><term>ER</term>
<desc>
                  Endoplasmic reticulum
                </desc>
</item>
<item><term>ERK1/2</term>
<desc>
                  Extracellular signal-regulated kinase1/2
                </desc>
</item>
<item><term>HDL</term>
<desc>
                  High-density lipoprotein
                </desc>
</item>
<item><term>HIV</term>
<desc>
                  Human immunodeficiency virus
                </desc>
</item>
<item><term>iNOS</term>
<desc>
                  Inducible nitric oxide synthase
                </desc>
</item>
<item><term>IC50</term>
<desc>
                  Inhibition concentration 50%
                </desc>
</item>
<item><term>LD50</term>
<desc>
                  Lethal dose 50
                </desc>
</item>
<item><term>LXR</term>
<desc>
                  Liver X receptor α
                </desc>
</item>
<item><term>LDLR</term>
<desc>
                  Low-density lipoprotein receptor
                </desc>
</item>
<item><term>MMP</term>
<desc>
                  Matrix metalloproteinase
                </desc>
</item>
<item><term>MDR</term>
<desc>
                  Multidrug resistance
                </desc>
</item>
<item><term>NF-κB</term>
<desc>
                  Nuclear factor-κB
                </desc>
</item>
<item><term>PPAR</term>
<desc>
                  Peroxisome proliferator-activated receptor α
                </desc>
</item>
<item><term>PI</term>
<desc>
                  Protease inhibitor
                </desc>
</item>
<item><term>SREBPs</term>
<desc>
                  Sterol regulatory element-binding protein ()
                </desc>
</item>
</list>
</keywords>
</textClass>
<textClass ana="keyword"><keywords xml:lang="en"><term>Alkaloid</term>
<term>berberine</term>
<term>bioavailability</term>
<term>medicine</term>
</keywords>
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<ChapterHeader><AuthorGroup><Author AffiliationIDS="Aff01821" CorrespondingAffiliationID="Aff01821"><AuthorName DisplayOrder="Western"><Prefix>Dr.</Prefix>
<GivenName>Eva</GivenName>
<GivenName>M.</GivenName>
<FamilyName>Galvez</FamilyName>
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<FamilyName>Domingo</FamilyName>
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<Author AffiliationIDS="Aff01821"><AuthorName DisplayOrder="Western"><GivenName>D.</GivenName>
<FamilyName>Nuñez</FamilyName>
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<Author AffiliationIDS="Aff01821"><AuthorName DisplayOrder="Western"><GivenName>V.</GivenName>
<GivenName>L.</GivenName>
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<Author AffiliationIDS="Aff01822"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName>
<FamilyName>Matt</FamilyName>
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<Author AffiliationIDS="Aff01823 Aff01824 Aff01825 Aff01826"><AuthorName DisplayOrder="Western"><GivenName>J.</GivenName>
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<Postcode>50018</Postcode>
<City>Zaragoza</City>
<Country>Spain</Country>
</OrgAddress>
</Affiliation>
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<OrgName>Université de Metz</OrgName>
<OrgAddress><Street>1, bd Arago</Street>
<Postcode>57078</Postcode>
<City>Metz</City>
<Country>France</Country>
</OrgAddress>
</Affiliation>
<Affiliation ID="Aff01823"><OrgDivision>Departamento Bioquímica y Biología Molecular y Celular, Facultad de Ciencias</OrgDivision>
<OrgName>Universidad de Zaragoza</OrgName>
<OrgAddress><City>Zaragoza</City>
<Country>Spain</Country>
</OrgAddress>
</Affiliation>
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<OrgAddress><City>Zaragoza</City>
<Country>Spain</Country>
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<Country>Spain</Country>
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<Country>Spain</Country>
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<Abstract ID="Abs01821" Language="En" OutputMedium="All"><Heading>Abstract</Heading>
<Para TextBreak="No">Berberine is a yellow alkaloid naturally produced by a diversity of plants. It is extracted from the roots, rhizome, and stem bark of several plants. This natural product has been used for centuries in the Chinese medicinal herb. Berberine presents a wide range of pharmacological applications such as antidiabetic, hypolipidemic, antihypertensive, anti-inflammatory, antioxidant, antidepressant, anticancer, antidiarrheal, hepatoprotective, and, above all, antimicrobial. It has been tested clinically in the treatment of oriental sore, diarrhea, trachoma, diabetes mellitus type 2, hypercholesterolemia, and congestive cardiac failure. This alkaloid is also used in the treatment of gastric and inflammatory diseases and more recently is being investigated for its application in neurology, cardiology, and oncology.</Para>
</Abstract>
<KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading>
<Keyword>Alkaloid</Keyword>
<Keyword>berberine</Keyword>
<Keyword>bioavailability</Keyword>
<Keyword>medicine</Keyword>
</KeywordGroup>
<AbbreviationGroup><Heading>Abbreviations</Heading>
<DefinitionList><DefinitionListEntry><Term>AChE</Term>
<Description><Para TextBreak="No">Acetylcholinesterase enzyme</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>AML</Term>
<Description><Para TextBreak="No">Acute myeloid leukemia</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>AMPK</Term>
<Description><Para TextBreak="No">Adenosine monophosphate-activated protein kinase</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>ATP</Term>
<Description><Para TextBreak="No">Adenosine triphosphate</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>AD</Term>
<Description><Para TextBreak="No">Alzheimer’s disease</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>Aβ peptide</Term>
<Description><Para TextBreak="No">Amyloid β-peptide</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>AR</Term>
<Description><Para TextBreak="No">Androgen receptor</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>ACE</Term>
<Description><Para TextBreak="No">Angiotensin-converting enzyme</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>ATM</Term>
<Description><Para TextBreak="No">Ataxia-telangiectasia mutated</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>Bcl-2</Term>
<Description><Para TextBreak="No">B cell lymphoma 2</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>COX2</Term>
<Description><Para TextBreak="No">Cyclooxygenase-2</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>ER</Term>
<Description><Para TextBreak="No">Endoplasmic reticulum</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>ERK1/2</Term>
<Description><Para TextBreak="No">Extracellular signal-regulated kinase1/2</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>HDL</Term>
<Description><Para TextBreak="No">High-density lipoprotein</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>HIV</Term>
<Description><Para TextBreak="No">Human immunodeficiency virus</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>iNOS</Term>
<Description><Para TextBreak="No">Inducible nitric oxide synthase</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>IC50</Term>
<Description><Para TextBreak="No">Inhibition concentration 50%</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>LD50</Term>
<Description><Para TextBreak="No">Lethal dose 50</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>LXR</Term>
<Description><Para TextBreak="No">Liver X receptor α</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>LDLR</Term>
<Description><Para TextBreak="No">Low-density lipoprotein receptor</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>MMP</Term>
<Description><Para TextBreak="No">Matrix metalloproteinase</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>MDR</Term>
<Description><Para TextBreak="No">Multidrug resistance</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>NF-κB</Term>
<Description><Para TextBreak="No">Nuclear factor-κB</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PPAR</Term>
<Description><Para TextBreak="No">Peroxisome proliferator-activated receptor α</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PI</Term>
<Description><Para TextBreak="No">Protease inhibitor</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>SREBPs</Term>
<Description><Para TextBreak="No">Sterol regulatory element-binding protein ()</Para>
</Description>
</DefinitionListEntry>
</DefinitionList>
</AbbreviationGroup>
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<namePart type="given">L.</namePart>
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<affiliation>Fundación Aragón I + D (ARAID), Zaragoza, Spain</affiliation>
<affiliation>Grupo Inmunidad Celular Efectora (ICE), Instituto de Investigaciones Sanitarias de Aragón, Zaragoza, Spain</affiliation>
<affiliation>Instituto de Nanociencia de Aragón (INA), Universidad de Zaragoza, Zaragoza, Spain</affiliation>
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<name type="personal"><namePart type="given">Kishan Gopal</namePart>
<namePart type="family">Ramawat</namePart>
<affiliation>Botany Department, M.L. Sukhadia University, Durga Nursery Road, 313001, Udaipur, Rajasthan, India</affiliation>
<affiliation>E-mail: kg_ramawat@yahoo.com</affiliation>
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</name>
<name type="personal"><namePart type="given">Jean-Michel</namePart>
<namePart type="family">Mérillon</namePart>
<affiliation>Institute of Vine and Wine Sciences, Biological-Active Plant Substances Study, University of Bordeaux, 210 Chemin de Leysotte CS 50008, 33882, Villenave d'Ornon, France</affiliation>
<affiliation>E-mail: jean-michel.merillon@u-bordeaux2.fr</affiliation>
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<abstract lang="en">Abstract: Berberine is a yellow alkaloid naturally produced by a diversity of plants. It is extracted from the roots, rhizome, and stem bark of several plants. This natural product has been used for centuries in the Chinese medicinal herb. Berberine presents a wide range of pharmacological applications such as antidiabetic, hypolipidemic, antihypertensive, anti-inflammatory, antioxidant, antidepressant, anticancer, antidiarrheal, hepatoprotective, and, above all, antimicrobial. It has been tested clinically in the treatment of oriental sore, diarrhea, trachoma, diabetes mellitus type 2, hypercholesterolemia, and congestive cardiac failure. This alkaloid is also used in the treatment of gastric and inflammatory diseases and more recently is being investigated for its application in neurology, cardiology, and oncology.</abstract>
<subject lang="en"><genre>Keywords</genre>
<topic>Alkaloid</topic>
<topic>berberine</topic>
<topic>bioavailability</topic>
<topic>medicine</topic>
</subject>
<subject><genre>Abbreviations</genre>
<topic>AChE : Acetylcholinesterase enzyme</topic>
<topic>AML : Acute myeloid leukemia</topic>
<topic>AMPK : Adenosine monophosphate-activated protein kinase</topic>
<topic>ATP : Adenosine triphosphate</topic>
<topic>AD : Alzheimer’s disease</topic>
<topic>Aβ peptide : Amyloid β-peptide</topic>
<topic>AR : Androgen receptor</topic>
<topic>ACE : Angiotensin-converting enzyme</topic>
<topic>ATM : Ataxia-telangiectasia mutated</topic>
<topic>Bcl-2 : B cell lymphoma 2</topic>
<topic>COX2 : Cyclooxygenase-2</topic>
<topic>ER : Endoplasmic reticulum</topic>
<topic>ERK1/2 : Extracellular signal-regulated kinase1/2</topic>
<topic>HDL : High-density lipoprotein</topic>
<topic>HIV : Human immunodeficiency virus</topic>
<topic>iNOS : Inducible nitric oxide synthase</topic>
<topic>IC50 : Inhibition concentration 50%</topic>
<topic>LD50 : Lethal dose 50</topic>
<topic>LXR : Liver X receptor α</topic>
<topic>LDLR : Low-density lipoprotein receptor</topic>
<topic>MMP : Matrix metalloproteinase</topic>
<topic>MDR : Multidrug resistance</topic>
<topic>NF-κB : Nuclear factor-κB</topic>
<topic>PPAR : Peroxisome proliferator-activated receptor α</topic>
<topic>PI : Protease inhibitor</topic>
<topic>SREBPs : Sterol regulatory element-binding protein ()</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Natural Products</title>
<subTitle>Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes</subTitle>
</titleInfo>
<name type="personal"><namePart type="given">Kishan Gopal</namePart>
<namePart type="family">Ramawat</namePart>
<affiliation>Botany Department, M.L. Sukhadia University, Durga Nursery Road, 313001, Udaipur, Rajasthan, India</affiliation>
<affiliation>E-mail: kg_ramawat@yahoo.com</affiliation>
<role><roleTerm type="text">editor</roleTerm>
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<name type="personal"><namePart type="given">Jean-Michel</namePart>
<namePart type="family">Mérillon</namePart>
<affiliation>Institute of Vine and Wine Sciences, Biological-Active Plant Substances Study, University of Bordeaux, 210 Chemin de Leysotte CS 50008, 33882, Villenave d'Ornon, France</affiliation>
<affiliation>E-mail: jean-michel.merillon@u-bordeaux2.fr</affiliation>
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<issuance>monographic</issuance>
<edition>2013</edition>
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<topic authority="SpringerSubjectCodes" authorityURI="SUCO11644">Chemistry and Materials Science</topic>
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<topic authority="SpringerSubjectCodes" authorityURI="SCC">Chemistry</topic>
<topic authority="SpringerSubjectCodes" authorityURI="SCC28000">Medicinal Chemistry</topic>
<topic authority="SpringerSubjectCodes" authorityURI="SCB21007">Pharmacology/Toxicology</topic>
<topic authority="SpringerSubjectCodes" authorityURI="SCL14021">Plant Biochemistry</topic>
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<topic authority="SpringerSubjectCodes" authorityURI="SCC12002">Biotechnology</topic>
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<identifier type="DOI">10.1007/978-3-642-22144-6</identifier>
<identifier type="ISBN">978-3-642-22143-9</identifier>
<identifier type="eISBN">978-3-642-22144-6</identifier>
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<part><date>2013</date>
<detail type="part"><title>Part IV: Alkaloids: Pharmacology</title>
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<detail type="part"><number>Part IV</number>
</detail>
<detail type="chapter"><number>41</number>
<caption>chapter</caption>
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<extent unit="pages"><start>1301</start>
<end>1329</end>
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Pharmacological/Biological Effects of Berberine

Pharmacological/Biological Effects of Berberine

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