Comparative toxicity of chloroguanide and nitroguanil
Identifieur interne : 001C71 ( Istex/Corpus ); précédent : 001C70; suivant : 001C72Comparative toxicity of chloroguanide and nitroguanil
Auteurs : Domingo M. Aviado ; Tsutomu Inoh ; Young W. ChoSource :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1968.
English descriptors
- Teeft :
- Acute toxicity, Aminami aromatyczymi, Antimalarial, Antimalarial activity, Aortic, Aortic blood pressure, Aromatic amines, Atria1, Atria1 contraction, Atria1 muscle, Aviado, Berghei, Blood pressure, Body weight, Cardiac, Cardiac effects, Cardiac output, Chloroguanide, Control chloroguanide, Control nitroguanil, Derivative, Dmso, Dos, Drug administration, Drug injection, Femoral artery, First group, Gastric, Gastric acidity, Gastric juice, Gastric secretion, Histamine, Intestinal motility, Intravenous injections, Malarial parasite, Mouse, Mouse mouse, Nictitating membrane, Nitroguanil, Normal malaria nitroguanil, Normal nitroguanil, Optical density, Parasitemia, Pathologic physiology, Petechial hemorrhages, Plasmodium, Plasmodium berghei, Present address, Pulmonary artery, Pulmonary resistance, Respiratory enzymes, Same dose, Statham transducer, Systemic blood pressure, Tidal volume, Toxicity, Tsutomu inoh, Untreated controls, Urbanski.
Abstract
Abstract: The pharmacologic actions of these two antimalarial drugs were compared in mice, rats, cats, and dogs. The cardiac effects of both chloroguanide and nitroguanil include depression of excitability of rat atrial muscle, depression of respiratory enzymes of mouse heart homogenate, and depression of myocardial contractility of cat heart. The dog showed an elevation in cardiac output following nitroguanil, but no change following chloroguanide. The decrease in fertility and reduction of body weight induced by chronic administration of nitroguanil in the mouse were less severe than those of chloroguanide. In the cat, chloroguanide but not nitroguanil, reduced gastric secretion. Both drugs suppressed the parasitemia and prolonged the survival of the rat and mouse infected with Plasmodium berghei.
Url:
DOI: 10.1016/0041-008X(68)90097-5
Links to Exploration step
ISTEX:D62F064F06189F5231462EAC42DB59AA04D53439Le document en format XML
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The cardiac effects of both chloroguanide and nitroguanil include depression of excitability of rat atrial muscle, depression of respiratory enzymes of mouse heart homogenate, and depression of myocardial contractility of cat heart. The dog showed an elevation in cardiac output following nitroguanil, but no change following chloroguanide. The decrease in fertility and reduction of body weight induced by chronic administration of nitroguanil in the mouse were less severe than those of chloroguanide. In the cat, chloroguanide but not nitroguanil, reduced gastric secretion. 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(1960a,b)</json:string><json:string>Skowronska-Serafin and Urbanski 1960</json:string><json:string>Aviado, 1967</json:string><json:string>Chin et al., 1960b</json:string><json:string>Cho et al., 1965</json:string><json:string>Jakimowska et al., 1964</json:string><json:string>Burn and Vane (1948)</json:string><json:string>Urbanski et al. 1953a,b</json:string><json:string>Clyde, 1961</json:string><json:string>Palecek et al., 1967</json:string><json:string>Vane (1948)</json:string><json:string>Urbanski et al., 1965</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-4RZPHBLV-Z</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - toxicology</json:string><json:string>2 - pharmacology & pharmacy</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - toxicology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Pharmacology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Toxicology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1968</publicationDate><copyrightDate>1968</copyrightDate><doi><json:string>10.1016/0041-008X(68)90097-5</json:string></doi><id>D62F064F06189F5231462EAC42DB59AA04D53439</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-4RZPHBLV-Z/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-4RZPHBLV-Z/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-4RZPHBLV-Z/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Comparative toxicity of chloroguanide and nitroguanil</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1968</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>This study is contribution No. 363 from the Army Research Program on Malaria, and is based on work supported under Contract No. DA-49-193-MD-2755 by U.S. Army Medical Research and Development Command.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Comparative toxicity of chloroguanide and nitroguanil</title><author xml:id="author-0000"><persName><forename type="first">Domingo M.</forename><surname>Aviado</surname></persName><affiliation>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104 USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Tsutomu</forename><surname>Inoh</surname></persName><note type="biography">Present address: Department of Medicine, Kobe Medical College, Kobe, Japan.</note><affiliation>Present address: Department of Medicine, Kobe Medical College, Kobe, Japan.</affiliation><affiliation>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104 USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Young W.</forename><surname>Cho</surname></persName><note type="biography">Present address: The WM. S. Merrell Company, Department of Medical Research, Cincinnati, Ohio 45215.</note><affiliation>Present address: The WM. S. Merrell Company, Department of Medical Research, Cincinnati, Ohio 45215.</affiliation><affiliation>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104 USA</affiliation></author><idno type="istex">D62F064F06189F5231462EAC42DB59AA04D53439</idno><idno type="ark">ark:/67375/6H6-4RZPHBLV-Z</idno><idno type="DOI">10.1016/0041-008X(68)90097-5</idno><idno type="PII">0041-008X(68)90097-5</idno></analytic><monogr><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="pISSN">0041-008X</idno><idno type="PII">S0041-008X(00)X0513-3</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1968"></date><biblScope unit="volume">13</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="228">228</biblScope><biblScope unit="page" to="241">241</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1968</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The pharmacologic actions of these two antimalarial drugs were compared in mice, rats, cats, and dogs. The cardiac effects of both chloroguanide and nitroguanil include depression of excitability of rat atrial muscle, depression of respiratory enzymes of mouse heart homogenate, and depression of myocardial contractility of cat heart. The dog showed an elevation in cardiac output following nitroguanil, but no change following chloroguanide. The decrease in fertility and reduction of body weight induced by chronic administration of nitroguanil in the mouse were less severe than those of chloroguanide. In the cat, chloroguanide but not nitroguanil, reduced gastric secretion. Both drugs suppressed the parasitemia and prolonged the survival of the rat and mouse infected with Plasmodium berghei.</p></abstract></profileDesc><revisionDesc><change when="1968">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-4RZPHBLV-Z/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YTAAP</jid><aid>68900975</aid><ce:pii>0041-008X(68)90097-5</ce:pii><ce:doi>10.1016/0041-008X(68)90097-5</ce:doi><ce:copyright type="unknown" year="1968"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This study is contribution No. 363 from the Army Research Program on Malaria, and is based on work supported under Contract No. DA-49-193-MD-2755 by U.S. Army Medical Research and Development Command.</ce:note-para></ce:article-footnote><ce:title>Comparative toxicity of chloroguanide and nitroguanil</ce:title><ce:author-group><ce:author><ce:given-name>Domingo M.</ce:given-name><ce:surname>Aviado</ce:surname></ce:author><ce:author><ce:given-name>Tsutomu</ce:given-name><ce:surname>Inoh</ce:surname><ce:cross-ref refid="FN1"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Young W.</ce:given-name><ce:surname>Cho</ce:surname><ce:cross-ref refid="FN2"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104 USA</ce:textfn></ce:affiliation><ce:footnote id="FN1"><ce:label>2</ce:label><ce:note-para>Present address: Department of Medicine, Kobe Medical College, Kobe, Japan.</ce:note-para></ce:footnote><ce:footnote id="FN2"><ce:label>3</ce:label><ce:note-para>Present address: The WM. S. Merrell Company, Department of Medical Research, Cincinnati, Ohio 45215.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="8" month="3" year="1968"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The pharmacologic actions of these two antimalarial drugs were compared in mice, rats, cats, and dogs. The cardiac effects of both chloroguanide and nitroguanil include depression of excitability of rat atrial muscle, depression of respiratory enzymes of mouse heart homogenate, and depression of myocardial contractility of cat heart. The dog showed an elevation in cardiac output following nitroguanil, but no change following chloroguanide. The decrease in fertility and reduction of body weight induced by chronic administration of nitroguanil in the mouse were less severe than those of chloroguanide. In the cat, chloroguanide but not nitroguanil, reduced gastric secretion. Both drugs suppressed the parasitemia and prolonged the survival of the rat and mouse infected with <ce:italic>Plasmodium berghei</ce:italic>.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Comparative toxicity of chloroguanide and nitroguanil</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Comparative toxicity of chloroguanide and nitroguanil</title></titleInfo><name type="personal"><namePart type="given">Domingo M.</namePart><namePart type="family">Aviado</namePart><affiliation>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tsutomu</namePart><namePart type="family">Inoh</namePart><affiliation>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104 USA</affiliation><description>Present address: Department of Medicine, Kobe Medical College, Kobe, Japan.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Young W.</namePart><namePart type="family">Cho</namePart><affiliation>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104 USA</affiliation><description>Present address: The WM. S. Merrell Company, Department of Medical Research, Cincinnati, Ohio 45215.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1968</dateIssued><copyrightDate encoding="w3cdtf">1968</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The pharmacologic actions of these two antimalarial drugs were compared in mice, rats, cats, and dogs. The cardiac effects of both chloroguanide and nitroguanil include depression of excitability of rat atrial muscle, depression of respiratory enzymes of mouse heart homogenate, and depression of myocardial contractility of cat heart. The dog showed an elevation in cardiac output following nitroguanil, but no change following chloroguanide. The decrease in fertility and reduction of body weight induced by chronic administration of nitroguanil in the mouse were less severe than those of chloroguanide. In the cat, chloroguanide but not nitroguanil, reduced gastric secretion. Both drugs suppressed the parasitemia and prolonged the survival of the rat and mouse infected with Plasmodium berghei.</abstract><note>This study is contribution No. 363 from the Army Research Program on Malaria, and is based on work supported under Contract No. DA-49-193-MD-2755 by U.S. Army Medical Research and Development Command.</note><relatedItem type="host"><titleInfo><title>Toxicology and Applied Pharmacology</title></titleInfo><titleInfo type="abbreviated"><title>YTAAP</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1968</dateIssued></originInfo><identifier type="ISSN">0041-008X</identifier><identifier type="PII">S0041-008X(00)X0513-3</identifier><part><date>1968</date><detail type="volume"><number>13</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue-pages"><start>133</start><end>270</end></extent><extent unit="pages"><start>228</start><end>241</end></extent></part></relatedItem><identifier type="istex">D62F064F06189F5231462EAC42DB59AA04D53439</identifier><identifier type="ark">ark:/67375/6H6-4RZPHBLV-Z</identifier><identifier type="DOI">10.1016/0041-008X(68)90097-5</identifier><identifier type="PII">0041-008X(68)90097-5</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-4RZPHBLV-Z/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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