Ion channels in toxicology
Identifieur interne : 001A56 ( Istex/Corpus ); précédent : 001A55; suivant : 001A57Ion channels in toxicology
Auteurs : Iván Restrepo-Angulo ; Andrea De Vizcaya-Ruiz ; Javier CamachoSource :
- Journal of Applied Toxicology [ 0260-437X ] ; 2010-08.
Abstract
Ion channels play essential roles in human physiology and toxicology. Cardiac contraction, neural transmission, temperature sensing, insulin release, regulation of apoptosis, cellular pH and oxidative stress, as well as detection of active compounds from chilli, are some of the processes in which ion channels have an important role. Regulation of ion channels by several chemicals including those found in air, water and soil represents an interesting potential link between environmental pollution and human diseases; for instance, de novo expression of ion channels in response to exposure to carcinogens is being considered as a potential tool for cancer diagnosis and therapy. Non‐specific binding of several drugs to ion channels is responsible for a huge number of undesirable side‐effects, and testing guidelines for several drugs now require ion channel screening for pharmaceutical safety. Animal toxins targeting human ion channels have serious effects on the population and have also provided a remarkable tool to study the molecular structure and function of ion channels. In this review, we will summarize the participation of ion channels in biological processes extensively used in toxicological studies, including cardiac function, apoptosis and cell proliferation. Major findings on the adverse effects of drugs on ion channels as well as the regulation of these proteins by different chemicals, including some pesticides, are also reviewed. Association of ion channels and toxicology in several biological processes strongly suggests these proteins to be excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of life‐threatening situations including chronic degenerative diseases. Copyright © 2010 John Wiley & Sons, Ltd.
Ion channels play key roles in physiology. Disruption of either expression or activity of these proteins accounts for many diseases. Accordingly, a huge number of drugs target ion channels. Pesticides, carcinogens, toxins and chemicals found in the environment (air, water or soil) regulate ion channels. In addition, several adverse effects of drugs are mediated via ion channels. These observations suggest ion channels as excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of chronic degenerative diseases.
Url:
DOI: 10.1002/jat.1556
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ISTEX:90280FE3AC9C418D273F64E2B258DD0CBBE19059Le document en format XML
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Cardiac contraction, neural transmission, temperature sensing, insulin release, regulation of apoptosis, cellular pH and oxidative stress, as well as detection of active compounds from chilli, are some of the processes in which ion channels have an important role. Regulation of ion channels by several chemicals including those found in air, water and soil represents an interesting potential link between environmental pollution and human diseases; for instance, de novo expression of ion channels in response to exposure to carcinogens is being considered as a potential tool for cancer diagnosis and therapy. Non‐specific binding of several drugs to ion channels is responsible for a huge number of undesirable side‐effects, and testing guidelines for several drugs now require ion channel screening for pharmaceutical safety. Animal toxins targeting human ion channels have serious effects on the population and have also provided a remarkable tool to study the molecular structure and function of ion channels. In this review, we will summarize the participation of ion channels in biological processes extensively used in toxicological studies, including cardiac function, apoptosis and cell proliferation. Major findings on the adverse effects of drugs on ion channels as well as the regulation of these proteins by different chemicals, including some pesticides, are also reviewed. Association of ion channels and toxicology in several biological processes strongly suggests these proteins to be excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of life‐threatening situations including chronic degenerative diseases. Copyright © 2010 John Wiley & Sons, Ltd.</div><div type="abstract" xml:lang="en">Ion channels play key roles in physiology. Disruption of either expression or activity of these proteins accounts for many diseases. Accordingly, a huge number of drugs target ion channels. Pesticides, carcinogens, toxins and chemicals found in the environment (air, water or soil) regulate ion channels. In addition, several adverse effects of drugs are mediated via ion channels. 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F. 07360, México</json:string></affiliations></json:item><json:item><name>Andrea De Vizcaya‐Ruiz</name><affiliations><json:string>Department of Toxicology, Centro de Investigación y de Estudios Avanzados, Avenida Instituto Politécnico Nacional 2508, México D. F. 07360, México</json:string></affiliations></json:item><json:item><name>Javier Camacho</name><affiliations><json:string>Department of Pharmacology, Centro de Investigación y de Estudios Avanzados, Avenida Instituto Politécnico Nacional 2508, México D. F. 07360, México</json:string><json:string>E-mail: fcamacho@cinvestav.mx</json:string><json:string>Correspondence address: Department of Pharmacology, Centro de Investigación y de Estudios Avanzados. Avenida Instituto Politécnico Nacional 2508, México D. F. 07360, México</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>ion channels</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>drug side effects</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cardiac arrhythmia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>apoptosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>oxidative stress</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>toxins</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>human toxicology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pesticides</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pollutants</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cancer</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ether à‐go‐go</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HERG</value></json:item></subject><articleId><json:string>JAT1556</json:string></articleId><arkIstex>ark:/67375/WNG-365L3QNH-1</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>reviewArticle</json:string></originalGenre><abstract>Ion channels play essential roles in human physiology and toxicology. Cardiac contraction, neural transmission, temperature sensing, insulin release, regulation of apoptosis, cellular pH and oxidative stress, as well as detection of active compounds from chilli, are some of the processes in which ion channels have an important role. Regulation of ion channels by several chemicals including those found in air, water and soil represents an interesting potential link between environmental pollution and human diseases; for instance, de novo expression of ion channels in response to exposure to carcinogens is being considered as a potential tool for cancer diagnosis and therapy. Non‐specific binding of several drugs to ion channels is responsible for a huge number of undesirable side‐effects, and testing guidelines for several drugs now require ion channel screening for pharmaceutical safety. Animal toxins targeting human ion channels have serious effects on the population and have also provided a remarkable tool to study the molecular structure and function of ion channels. In this review, we will summarize the participation of ion channels in biological processes extensively used in toxicological studies, including cardiac function, apoptosis and cell proliferation. Major findings on the adverse effects of drugs on ion channels as well as the regulation of these proteins by different chemicals, including some pesticides, are also reviewed. Association of ion channels and toxicology in several biological processes strongly suggests these proteins to be excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of life‐threatening situations including chronic degenerative diseases. 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Appl</json:string><json:string>John Wiley</json:string><json:string>In</json:string><json:string>J. Camacho</json:string><json:string>Javier Camachoa</json:string><json:string>J. App</json:string></persName><placeName></placeName><ref_url><json:string>http://www.atsdr.cdc</json:string><json:string>http://www.atsdr.cdc.gov/tfacts</json:string><json:string>http://www.paho.org/English/AD/DPC/VP/ poisonous-animals</json:string><json:string>http://www.who.int/ countries/mex/es</json:string></ref_url><ref_bibl><json:string>Black et al., 1986</json:string><json:string>Moreno, 1999</json:string><json:string>Ousingsawat et al., 2007</json:string><json:string>Catterall et al. 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Non‐specific binding of several drugs to ion channels is responsible for a huge number of undesirable side‐effects, and testing guidelines for several drugs now require ion channel screening for pharmaceutical safety. Animal toxins targeting human ion channels have serious effects on the population and have also provided a remarkable tool to study the molecular structure and function of ion channels. In this review, we will summarize the participation of ion channels in biological processes extensively used in toxicological studies, including cardiac function, apoptosis and cell proliferation. Major findings on the adverse effects of drugs on ion channels as well as the regulation of these proteins by different chemicals, including some pesticides, are also reviewed. Association of ion channels and toxicology in several biological processes strongly suggests these proteins to be excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of life‐threatening situations including chronic degenerative diseases. Copyright © 2010 John Wiley & Sons, Ltd.</p></abstract><abstract xml:lang="en" style="short"><p>Ion channels play key roles in physiology. Disruption of either expression or activity of these proteins accounts for many diseases. Accordingly, a huge number of drugs target ion channels. Pesticides, carcinogens, toxins and chemicals found in the environment (air, water or soil) regulate ion channels. In addition, several adverse effects of drugs are mediated via ion channels. These observations suggest ion channels as excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of chronic degenerative diseases.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">ion channels</term><term xml:id="kwd2">drug side effects</term><term xml:id="kwd3">cardiac arrhythmia</term><term xml:id="kwd4">apoptosis</term><term xml:id="kwd5">oxidative stress</term><term xml:id="kwd6">toxins</term><term xml:id="kwd7">human toxicology</term><term xml:id="kwd8">pesticides</term><term xml:id="kwd9">pollutants</term><term xml:id="kwd10">cancer</term><term xml:id="kwd11">ether à‐go‐go</term><term xml:id="kwd12">HERG</term></keywords><keywords rend="articleCategory"><term>Review</term></keywords><keywords rend="tocHeading1"><term>Reviews</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-365L3QNH-1/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd.</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1099-1263</doi><issn type="print">0260-437X</issn><issn type="electronic">1099-1263</issn><idGroup><id type="product" value="JAT"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF APPLIED TOXICOLOGY">Journal of Applied Toxicology</title><title type="short">J. 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Cardiac contraction, neural transmission, temperature sensing, insulin release, regulation of apoptosis, cellular pH and oxidative stress, as well as detection of active compounds from chilli, are some of the processes in which ion channels have an important role. Regulation of ion channels by several chemicals including those found in air, water and soil represents an interesting potential link between environmental pollution and human diseases; for instance, <i>de novo</i> expression of ion channels in response to exposure to carcinogens is being considered as a potential tool for cancer diagnosis and therapy. Non‐specific binding of several drugs to ion channels is responsible for a huge number of undesirable side‐effects, and testing guidelines for several drugs now require ion channel screening for pharmaceutical safety. Animal toxins targeting human ion channels have serious effects on the population and have also provided a remarkable tool to study the molecular structure and function of ion channels. In this review, we will summarize the participation of ion channels in biological processes extensively used in toxicological studies, including cardiac function, apoptosis and cell proliferation. Major findings on the adverse effects of drugs on ion channels as well as the regulation of these proteins by different chemicals, including some pesticides, are also reviewed. Association of ion channels and toxicology in several biological processes strongly suggests these proteins to be excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of life‐threatening situations including chronic degenerative diseases. Copyright © 2010 John Wiley & Sons, Ltd.</p></abstract><abstract type="short" xml:lang="en"><p>Ion channels play key roles in physiology. Disruption of either expression or activity of these proteins accounts for many diseases. Accordingly, a huge number of drugs target ion channels. Pesticides, carcinogens, toxins and chemicals found in the environment (air, water or soil) regulate ion channels. In addition, several adverse effects of drugs are mediated via ion channels. These observations suggest ion channels as excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of chronic degenerative diseases.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Ion channels in toxicology</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Ion channels in toxicology</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Ion channels in toxicology</title></titleInfo><name type="personal"><namePart type="given">Iván</namePart><namePart type="family">Restrepo‐Angulo</namePart><affiliation>Department of Pharmacology, Centro de Investigación y de Estudios Avanzados, Avenida Instituto Politécnico Nacional 2508, México D. F. 07360, México</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrea</namePart><namePart type="family">De Vizcaya‐Ruiz</namePart><affiliation>Department of Toxicology, Centro de Investigación y de Estudios Avanzados, Avenida Instituto Politécnico Nacional 2508, México D. F. 07360, México</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Javier</namePart><namePart type="family">Camacho</namePart><affiliation>Department of Pharmacology, Centro de Investigación y de Estudios Avanzados, Avenida Instituto Politécnico Nacional 2508, México D. F. 07360, México</affiliation><affiliation>E-mail: fcamacho@cinvestav.mx</affiliation><affiliation>Correspondence address: Department of Pharmacology, Centro de Investigación y de Estudios Avanzados. Avenida Instituto Politécnico Nacional 2508, México D. F. 07360, México</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-08</dateIssued><dateCaptured encoding="w3cdtf">2010-03-12</dateCaptured><dateValid encoding="w3cdtf">2010-05-05</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">3</extent><extent unit="tables">1</extent><extent unit="references">144</extent></physicalDescription><abstract lang="en">Ion channels play essential roles in human physiology and toxicology. Cardiac contraction, neural transmission, temperature sensing, insulin release, regulation of apoptosis, cellular pH and oxidative stress, as well as detection of active compounds from chilli, are some of the processes in which ion channels have an important role. Regulation of ion channels by several chemicals including those found in air, water and soil represents an interesting potential link between environmental pollution and human diseases; for instance, de novo expression of ion channels in response to exposure to carcinogens is being considered as a potential tool for cancer diagnosis and therapy. Non‐specific binding of several drugs to ion channels is responsible for a huge number of undesirable side‐effects, and testing guidelines for several drugs now require ion channel screening for pharmaceutical safety. Animal toxins targeting human ion channels have serious effects on the population and have also provided a remarkable tool to study the molecular structure and function of ion channels. In this review, we will summarize the participation of ion channels in biological processes extensively used in toxicological studies, including cardiac function, apoptosis and cell proliferation. Major findings on the adverse effects of drugs on ion channels as well as the regulation of these proteins by different chemicals, including some pesticides, are also reviewed. Association of ion channels and toxicology in several biological processes strongly suggests these proteins to be excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of life‐threatening situations including chronic degenerative diseases. Copyright © 2010 John Wiley & Sons, Ltd.</abstract><abstract type="short" lang="en">Ion channels play key roles in physiology. Disruption of either expression or activity of these proteins accounts for many diseases. Accordingly, a huge number of drugs target ion channels. Pesticides, carcinogens, toxins and chemicals found in the environment (air, water or soil) regulate ion channels. In addition, several adverse effects of drugs are mediated via ion channels. These observations suggest ion channels as excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of chronic degenerative diseases.</abstract><subject lang="en"><genre>keywords</genre><topic>ion channels</topic><topic>drug side effects</topic><topic>cardiac arrhythmia</topic><topic>apoptosis</topic><topic>oxidative stress</topic><topic>toxins</topic><topic>human toxicology</topic><topic>pesticides</topic><topic>pollutants</topic><topic>cancer</topic><topic>ether à‐go‐go</topic><topic>HERG</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Applied Toxicology</title></titleInfo><titleInfo type="abbreviated"><title>J. Appl. 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