Idiopathic pulmonary hemosiderosis complicated by Down syndrome
Identifieur interne : 001913 ( Istex/Corpus ); précédent : 001912; suivant : 001914Idiopathic pulmonary hemosiderosis complicated by Down syndrome
Auteurs : Hirofumi Watanabe ; Mamoru Ayusawa ; Masataka Kato ; Ami Chou ; Akiko Komori ; Yuriko Abe ; Masaharu Matsumura ; Hiroshi Kamiyama ; Hiroyuki Izumi ; Shori TakahashiSource :
- Pediatrics International [ 1328-8067 ] ; 2015-10.
Abstract
We report the case of a 9‐year‐old girl with Down syndrome (DS) diagnosed with idiopathic pulmonary hemosiderosis (IPH). Although acute pneumonia complicated by hemolytic anemia was suspected, IPH was finally diagnosed on bronchoscopy. Treatment with prednisolone achieved good clinical response. An association between IPH and DS was not able to be identified, but immunological issues in DS may contribute to the onset of IPH. Recurrent and intractable respiratory symptoms with marked infiltrative shadows in the bilateral lungs and complicated by severe anemia in patients with DS should suggest IPH.
Url:
DOI: 10.1111/ped.12690
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syndrome</title><author><name sortKey="Watanabe, Hirofumi" sort="Watanabe, Hirofumi" uniqKey="Watanabe H" first="Hirofumi" last="Watanabe">Hirofumi Watanabe</name><affiliation><mods:affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: mehi11016@g.nihon‐u.ac.jp</mods:affiliation></affiliation></author><author><name sortKey="Ayusawa, Mamoru" sort="Ayusawa, Mamoru" uniqKey="Ayusawa M" first="Mamoru" last="Ayusawa">Mamoru Ayusawa</name><affiliation><mods:affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kato, Masataka" sort="Kato, Masataka" uniqKey="Kato M" first="Masataka" last="Kato">Masataka Kato</name><affiliation><mods:affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Chou, Ami" sort="Chou, Ami" uniqKey="Chou A" first="Ami" last="Chou">Ami Chou</name><affiliation><mods:affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Komori, Akiko" sort="Komori, Akiko" uniqKey="Komori A" first="Akiko" last="Komori">Akiko Komori</name><affiliation><mods:affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Abe, Yuriko" sort="Abe, Yuriko" uniqKey="Abe Y" first="Yuriko" last="Abe">Yuriko Abe</name><affiliation><mods:affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Matsumura, Masaharu" sort="Matsumura, Masaharu" uniqKey="Matsumura M" first="Masaharu" last="Matsumura">Masaharu Matsumura</name><affiliation><mods:affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kamiyama, Hiroshi" sort="Kamiyama, Hiroshi" uniqKey="Kamiyama H" first="Hiroshi" last="Kamiyama">Hiroshi Kamiyama</name><affiliation><mods:affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Izumi, Hiroyuki" sort="Izumi, Hiroyuki" uniqKey="Izumi H" first="Hiroyuki" last="Izumi">Hiroyuki Izumi</name><affiliation><mods:affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Itabashi Medical Association Hospital, Tokyo, Itabashi, Japan</mods:affiliation></affiliation></author><author><name sortKey="Takahashi, Shori" sort="Takahashi, Shori" uniqKey="Takahashi S" first="Shori" last="Takahashi">Shori Takahashi</name><affiliation><mods:affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pediatrics International</title><title level="j" type="alt">PEDIATRICS INTERNATIONAL</title><idno type="ISSN">1328-8067</idno><idno type="eISSN">1442-200X</idno><imprint><biblScope unit="vol">57</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1009">1009</biblScope><biblScope unit="page" to="1012">1012</biblScope><biblScope unit="page-count">4</biblScope><date type="published" when="2015-10">2015-10</date></imprint><idno type="ISSN">1328-8067</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1328-8067</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">We report the case of a 9‐year‐old girl with Down syndrome (DS) diagnosed with idiopathic pulmonary hemosiderosis (IPH). Although acute pneumonia complicated by hemolytic anemia was suspected, IPH was finally diagnosed on bronchoscopy. Treatment with prednisolone achieved good clinical response. An association between IPH and DS was not able to be identified, but immunological issues in DS may contribute to the onset of IPH. Recurrent and intractable respiratory symptoms with marked infiltrative shadows in the bilateral lungs and complicated by severe anemia in patients with DS should suggest IPH.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Hirofumi Watanabe</name><affiliations><json:string>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</json:string><json:string>E-mail: mehi11016@g.nihon‐u.ac.jp</json:string></affiliations></json:item><json:item><name>Mamoru Ayusawa</name><affiliations><json:string>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Masataka Kato</name><affiliations><json:string>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Ami Chou</name><affiliations><json:string>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Akiko Komori</name><affiliations><json:string>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Yuriko Abe</name><affiliations><json:string>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Masaharu Matsumura</name><affiliations><json:string>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Hiroshi Kamiyama</name><affiliations><json:string>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Hiroyuki Izumi</name><affiliations><json:string>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</json:string><json:string>Itabashi Medical Association Hospital, Tokyo, Itabashi, Japan</json:string></affiliations></json:item><json:item><name>Shori Takahashi</name><affiliations><json:string>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Down syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hemolytic anemia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hemoptysis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>idiopathic pulmonary hemosiderosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>prednisolone</value></json:item></subject><articleId><json:string>PED12690</json:string></articleId><arkIstex>ark:/67375/WNG-1DWVTX0Q-R</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>caseStudy</json:string></originalGenre><abstract>We report the case of a 9‐year‐old girl with Down syndrome (DS) diagnosed with idiopathic pulmonary hemosiderosis (IPH). 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Recurrent and intractable respiratory symptoms with marked infiltrative shadows in the bilateral lungs and complicated by severe anemia in patients with DS should suggest IPH.</p></abstract><textClass><keywords><term xml:id="ped12690-kwd-0001">Down syndrome</term><term xml:id="ped12690-kwd-0002">hemolytic anemia</term><term xml:id="ped12690-kwd-0003">hemoptysis</term><term xml:id="ped12690-kwd-0004">idiopathic pulmonary hemosiderosis</term><term xml:id="ped12690-kwd-0005">prednisolone</term></keywords><keywords rend="articleCategory"><term>Patient Report</term></keywords><keywords rend="tocHeading1"><term>PATIENT REPORTS</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-1DWVTX0Q-R/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="ped12690"><header><publicationMeta level="product"><doi>10.1111/(ISSN)1442-200X</doi><issn type="print">1328-8067</issn><issn type="electronic">1442-200X</issn><idGroup><id type="product" value="PED"></id></idGroup><titleGroup><title type="main" sort="PEDIATRICS INTERNATIONAL">Pediatrics International</title><title type="short">Pediatrics International</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi>10.1111/ped.2015.57.issue-5</doi><copyright>© 2015 Japan Pediatric Society</copyright><numberingGroup><numbering type="journalVolume" number="57">57</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2015-10">October 2015</coverDate></publicationMeta><publicationMeta level="unit" position="420" type="caseStudy" status="forIssue"><doi>10.1111/ped.12690</doi><idGroup><id type="unit" value="PED12690"></id><id type="society" value="PED-00488-2014.R1"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Patient Report</title><title type="tocHeading1">PATIENT REPORTS</title></titleGroup><copyright ownership="publisher">© 2015 Japan Pediatric Society</copyright><eventGroup><event type="manuscriptReceived" date="2014-10-02"></event><event type="manuscriptRevised" date="2015-02-08"></event><event type="manuscriptAccepted" date="2015-03-18"></event><event type="xmlCreated" agent="SPi Global" date="2015-06-06"></event><event type="firstOnline" date="2015-10-28"></event><event type="publishedOnlineFinalForm" date="2015-10-28"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.8 mode:FullText" date="2015-10-28"></event></eventGroup><numberingGroup><numbering type="pageFirst">1009</numbering><numbering type="pageLast">1012</numbering></numberingGroup><correspondenceTo>Correspondence: Hirofumi Watanabe, MD, Department of Pediatrics and Child Health, Nihon University School of Medicine, 30‐1 Ooyaguchikamichou, Itabashi‐ku, Tokyo 173‐8610, Japan. Email: <email normalForm="mehi11016@g.nihon-u.ac.jp">mehi11016@g.nihon‐u.ac.jp</email></correspondenceTo><selfCitationGroup><citation type="self" xml:id="ped12690-cit-0000"><author><familyName>Watanabe</familyName>, <givenNames>H.</givenNames></author>, <author><familyName>Ayusawa</familyName>, <givenNames>M.</givenNames></author>, <author><familyName>Kato</familyName>, <givenNames>M.</givenNames></author>, <author><familyName>Chou</familyName>, <givenNames>A.</givenNames></author>, <author><familyName>Komori</familyName>, <givenNames>A.</givenNames></author>, <author><familyName>Abe</familyName>, <givenNames>Y.</givenNames></author>, <author><familyName>Matsumura</familyName>, <givenNames>M.</givenNames></author>, <author><familyName>Kamiyama</familyName>, <givenNames>H.</givenNames></author>, <author><familyName>Izumi</familyName>, <givenNames>H.</givenNames></author>, and <author><familyName>Takahashi</familyName>, <givenNames>S.</givenNames></author> (<pubYear year="2015">2015</pubYear>) <articleTitle>Idiopathic pulmonary hemosiderosis complicated by Down syndrome</articleTitle>. <journalTitle>Pediatrics International</journalTitle>, <vol>57</vol>: <pageFirst>1009</pageFirst>–<pageLast>1012</pageLast>. doi: <accessionId ref="info:doi/10.1111/ped.12690">10.1111/ped.12690</accessionId>.</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:PED.PED12690.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Idiopathic pulmonary hemosiderosis complicated by Down syndrome</title><title type="short">Pulmonary hemosiderosis with DS</title><title type="shortAuthors">H Watanabe <i>et al.</i></title></titleGroup><creators><creator creatorRole="author" xml:id="ped12690-cr-0001" affiliationRef="#ped12690-aff-0001" corresponding="yes"><personName><givenNames>Hirofumi</givenNames><familyName>Watanabe</familyName></personName></creator><creator creatorRole="author" xml:id="ped12690-cr-0002" affiliationRef="#ped12690-aff-0001"><personName><givenNames>Mamoru</givenNames><familyName>Ayusawa</familyName></personName></creator><creator creatorRole="author" xml:id="ped12690-cr-0003" affiliationRef="#ped12690-aff-0001"><personName><givenNames>Masataka</givenNames><familyName>Kato</familyName></personName></creator><creator creatorRole="author" xml:id="ped12690-cr-0004" affiliationRef="#ped12690-aff-0001"><personName><givenNames>Ami</givenNames><familyName>Chou</familyName></personName></creator><creator creatorRole="author" xml:id="ped12690-cr-0005" affiliationRef="#ped12690-aff-0001"><personName><givenNames>Akiko</givenNames><familyName>Komori</familyName></personName></creator><creator creatorRole="author" xml:id="ped12690-cr-0006" affiliationRef="#ped12690-aff-0001"><personName><givenNames>Yuriko</givenNames><familyName>Abe</familyName></personName></creator><creator creatorRole="author" xml:id="ped12690-cr-0007" affiliationRef="#ped12690-aff-0001"><personName><givenNames>Masaharu</givenNames><familyName>Matsumura</familyName></personName></creator><creator creatorRole="author" xml:id="ped12690-cr-0008" affiliationRef="#ped12690-aff-0001"><personName><givenNames>Hiroshi</givenNames><familyName>Kamiyama</familyName></personName></creator><creator creatorRole="author" xml:id="ped12690-cr-0009" affiliationRef="#ped12690-aff-0001 #ped12690-aff-0002"><personName><givenNames>Hiroyuki</givenNames><familyName>Izumi</familyName></personName></creator><creator creatorRole="author" xml:id="ped12690-cr-0010" affiliationRef="#ped12690-aff-0001"><personName><givenNames>Shori</givenNames><familyName>Takahashi</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="JP" type="organization" xml:id="ped12690-aff-0001"><orgDiv>Department of Pediatrics and Child Health</orgDiv><orgName>Nihon University School of Medicine</orgName><address><city>Tokyo</city><country>Japan</country></address></affiliation><affiliation countryCode="JP" type="organization" xml:id="ped12690-aff-0002"><orgName>Itabashi Medical Association Hospital</orgName><address><city>Itabashi</city><countryPart>Tokyo</countryPart><country>Japan</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="ped12690-kwd-0001">Down syndrome</keyword><keyword xml:id="ped12690-kwd-0002">hemolytic anemia</keyword><keyword xml:id="ped12690-kwd-0003">hemoptysis</keyword><keyword xml:id="ped12690-kwd-0004">idiopathic pulmonary hemosiderosis</keyword><keyword xml:id="ped12690-kwd-0005">prednisolone</keyword></keywordGroup><abstractGroup><abstract type="main"><title type="main">Abstract</title><p>We report the case of a 9‐year‐old girl with Down syndrome (DS) diagnosed with idiopathic pulmonary hemosiderosis (IPH). Although acute pneumonia complicated by hemolytic anemia was suspected, IPH was finally diagnosed on bronchoscopy. Treatment with prednisolone achieved good clinical response. An association between IPH and DS was not able to be identified, but immunological issues in DS may contribute to the onset of IPH. Recurrent and intractable respiratory symptoms with marked infiltrative shadows in the bilateral lungs and complicated by severe anemia in patients with DS should suggest IPH.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Idiopathic pulmonary hemosiderosis complicated by Down syndrome</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pulmonary hemosiderosis with DS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Idiopathic pulmonary hemosiderosis complicated by Down syndrome</title></titleInfo><name type="personal"><namePart type="given">Hirofumi</namePart><namePart type="family">Watanabe</namePart><affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</affiliation><affiliation>E-mail: mehi11016@g.nihon‐u.ac.jp</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mamoru</namePart><namePart type="family">Ayusawa</namePart><affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Masataka</namePart><namePart type="family">Kato</namePart><affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ami</namePart><namePart type="family">Chou</namePart><affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Akiko</namePart><namePart type="family">Komori</namePart><affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yuriko</namePart><namePart type="family">Abe</namePart><affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Masaharu</namePart><namePart type="family">Matsumura</namePart><affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroshi</namePart><namePart type="family">Kamiyama</namePart><affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroyuki</namePart><namePart type="family">Izumi</namePart><affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</affiliation><affiliation>Itabashi Medical Association Hospital, Tokyo, Itabashi, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shori</namePart><namePart type="family">Takahashi</namePart><affiliation>Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="case-report" displayLabel="caseStudy" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2015-10</dateIssued><dateCreated encoding="w3cdtf">2015-06-06</dateCreated><dateCaptured encoding="w3cdtf">2014-10-02</dateCaptured><dateValid encoding="w3cdtf">2015-03-18</dateValid><edition>Watanabe, H., Ayusawa, M., Kato, M., Chou, A., Komori, A., Abe, Y., Matsumura, M., Kamiyama, H., Izumi, H., and Takahashi, S. (2015) Idiopathic pulmonary hemosiderosis complicated by Down syndrome. Pediatrics International, 57: 1009–1012. doi: 10.1111/ped.12690.</edition><copyrightDate encoding="w3cdtf">2015</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>We report the case of a 9‐year‐old girl with Down syndrome (DS) diagnosed with idiopathic pulmonary hemosiderosis (IPH). Although acute pneumonia complicated by hemolytic anemia was suspected, IPH was finally diagnosed on bronchoscopy. Treatment with prednisolone achieved good clinical response. An association between IPH and DS was not able to be identified, but immunological issues in DS may contribute to the onset of IPH. Recurrent and intractable respiratory symptoms with marked infiltrative shadows in the bilateral lungs and complicated by severe anemia in patients with DS should suggest IPH.</abstract><subject><genre>keywords</genre><topic>Down syndrome</topic><topic>hemolytic anemia</topic><topic>hemoptysis</topic><topic>idiopathic pulmonary hemosiderosis</topic><topic>prednisolone</topic></subject><relatedItem type="host"><titleInfo><title>Pediatrics International</title></titleInfo><titleInfo type="abbreviated"><title>Pediatrics International</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Patient Report</topic><topic>PATIENT REPORTS</topic></subject><identifier type="ISSN">1328-8067</identifier><identifier type="eISSN">1442-200X</identifier><identifier type="DOI">10.1111/(ISSN)1442-200X</identifier><identifier type="PublisherID">PED</identifier><part><date>2015</date><detail type="volume"><caption>vol.</caption><number>57</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>1009</start><end>1012</end><total>4</total></extent></part></relatedItem><relatedItem type="references" displayLabel="ped12690-cit-0001"><titleInfo><title>Idiopathic pulmonary haemosiderosis in Japan: 39 possible cases from a survey questionnaire</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Ohga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Takahashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Miyazaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ohga S, Takahashi K, Miyazaki S et al. 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