Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline
Identifieur interne : 001800 ( Istex/Corpus ); précédent : 001799; suivant : 001801Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline
Auteurs : M. Hristova ; R. IstatkovaSource :
- Phytomedicine [ 0944-7113 ] ; 1999.
English descriptors
- KwdEn :
- Teeft :
- Albicans, Alkaloid, Antiinflammatory, Antiinflammatory effect, Bisbenzylisoquinoline, Bisbenzylisoquinoline alkaloid fangchinoline, Bisbenzylisoquinoline alkaloids, Bulgarian academy, Candida, Candida albicans, Chang, Complement activation, Complement activity, Control group, Different concentrations, Fangchinoline, Fangchinoline action, Functional activity, Hemolysis, Hemolytic phase, Inflammation, Isopyrum thalictroides, Mouse serum, Pathway, Peritoneal, Tetrandrine, Yeast cells.
Abstract
Summary: Complement-mediated mode of action of bisbenzylisoquinoline alkaloid fangchinoline was investigated in vivo and in vitro. The application of fangchinoline intraperitoneally (i.p.) to complement normal mice, strain ICR, inhibited the complement activity in serum and peritoneal exudate. The substance activated serum complement of C5-deficient DBA/2 mice. Fangchinoline was able to provoke local inflammatory reaction in both strains after subcutaneous (s.c.) injection. The alkaloid suppressed paw swelling induced by live Candida albicans in ICR and DBA/2 mice. Its effect depended on the dose and time of injection prior to inflammatory reaction. The in vitro experiments proved the interference of fangchinoline action with post-C5 reactions. The substance augmented C5-convertase formation and functional activity. These results are in correspondence with our previous investigations, proving the complement-mediated action of fangchinoline. The antiinflammatory effect could be a consequence of the caused complement exhaustion.
Url:
DOI: 10.1016/S0944-7113(99)80059-2
Links to Exploration step
ISTEX:CE03CA7EE43EB01C57799245A19E3486A35CD441Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline</title><author><name sortKey="Hristova, M" sort="Hristova, M" uniqKey="Hristova M" first="M." last="Hristova">M. Hristova</name><affiliation><mods:affiliation>Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria</mods:affiliation></affiliation><affiliation><mods:affiliation>aAddress Maria Hristova, Institute of Microbiology, Bulgarian Academy of Sciences, 26 G. Bonchev Str., 1113 Sofia, Bulgaria</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: maria@microbio.bas.bg</mods:affiliation></affiliation></author><author><name sortKey="Istatkova, R" sort="Istatkova, R" uniqKey="Istatkova R" first="R." last="Istatkova">R. Istatkova</name><affiliation><mods:affiliation>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CE03CA7EE43EB01C57799245A19E3486A35CD441</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0944-7113(99)80059-2</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-8L98SMP9-H/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001800</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001800</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline</title><author><name sortKey="Hristova, M" sort="Hristova, M" uniqKey="Hristova M" first="M." last="Hristova">M. Hristova</name><affiliation><mods:affiliation>Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria</mods:affiliation></affiliation><affiliation><mods:affiliation>aAddress Maria Hristova, Institute of Microbiology, Bulgarian Academy of Sciences, 26 G. Bonchev Str., 1113 Sofia, Bulgaria</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: maria@microbio.bas.bg</mods:affiliation></affiliation></author><author><name sortKey="Istatkova, R" sort="Istatkova, R" uniqKey="Istatkova R" first="R." last="Istatkova">R. Istatkova</name><affiliation><mods:affiliation>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Phytomedicine</title><title level="j" type="abbrev">PHYMED</title><idno type="ISSN">0944-7113</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="357">357</biblScope><biblScope unit="page" to="362">362</biblScope></imprint><idno type="ISSN">0944-7113</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0944-7113</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>C5-convertase</term><term>Candida albicans paw inflammation</term><term>Fangchinoline</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Albicans</term><term>Alkaloid</term><term>Antiinflammatory</term><term>Antiinflammatory effect</term><term>Bisbenzylisoquinoline</term><term>Bisbenzylisoquinoline alkaloid fangchinoline</term><term>Bisbenzylisoquinoline alkaloids</term><term>Bulgarian academy</term><term>Candida</term><term>Candida albicans</term><term>Chang</term><term>Complement activation</term><term>Complement activity</term><term>Control group</term><term>Different concentrations</term><term>Fangchinoline</term><term>Fangchinoline action</term><term>Functional activity</term><term>Hemolysis</term><term>Hemolytic phase</term><term>Inflammation</term><term>Isopyrum thalictroides</term><term>Mouse serum</term><term>Pathway</term><term>Peritoneal</term><term>Tetrandrine</term><term>Yeast cells</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Summary: Complement-mediated mode of action of bisbenzylisoquinoline alkaloid fangchinoline was investigated in vivo and in vitro. The application of fangchinoline intraperitoneally (i.p.) to complement normal mice, strain ICR, inhibited the complement activity in serum and peritoneal exudate. The substance activated serum complement of C5-deficient DBA/2 mice. Fangchinoline was able to provoke local inflammatory reaction in both strains after subcutaneous (s.c.) injection. The alkaloid suppressed paw swelling induced by live Candida albicans in ICR and DBA/2 mice. Its effect depended on the dose and time of injection prior to inflammatory reaction. The in vitro experiments proved the interference of fangchinoline action with post-C5 reactions. The substance augmented C5-convertase formation and functional activity. These results are in correspondence with our previous investigations, proving the complement-mediated action of fangchinoline. The antiinflammatory effect could be a consequence of the caused complement exhaustion.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>fangchinoline</json:string><json:string>alkaloid</json:string><json:string>bisbenzylisoquinoline</json:string><json:string>candida</json:string><json:string>hemolysis</json:string><json:string>peritoneal</json:string><json:string>bisbenzylisoquinoline alkaloids</json:string><json:string>antiinflammatory</json:string><json:string>tetrandrine</json:string><json:string>chang</json:string><json:string>pathway</json:string><json:string>complement activity</json:string><json:string>yeast cells</json:string><json:string>functional activity</json:string><json:string>antiinflammatory effect</json:string><json:string>mouse serum</json:string><json:string>inflammation</json:string><json:string>albicans</json:string><json:string>complement activation</json:string><json:string>isopyrum thalictroides</json:string><json:string>different concentrations</json:string><json:string>bulgarian academy</json:string><json:string>bisbenzylisoquinoline alkaloid fangchinoline</json:string><json:string>candida albicans</json:string><json:string>fangchinoline action</json:string><json:string>hemolytic phase</json:string><json:string>control group</json:string></teeft></keywords><author><json:item><name>M. Hristova</name><affiliations><json:string>Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria</json:string><json:string>aAddress Maria Hristova, Institute of Microbiology, Bulgarian Academy of Sciences, 26 G. Bonchev Str., 1113 Sofia, Bulgaria</json:string><json:string>E-mail: maria@microbio.bas.bg</json:string></affiliations></json:item><json:item><name>R. Istatkova</name><affiliations><json:string>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Fangchinoline</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>C5-convertase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Candida albicans paw inflammation</value></json:item></subject><articleId><json:string>80059</json:string></articleId><arkIstex>ark:/67375/6H6-8L98SMP9-H</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Summary: Complement-mediated mode of action of bisbenzylisoquinoline alkaloid fangchinoline was investigated in vivo and in vitro. The application of fangchinoline intraperitoneally (i.p.) to complement normal mice, strain ICR, inhibited the complement activity in serum and peritoneal exudate. The substance activated serum complement of C5-deficient DBA/2 mice. Fangchinoline was able to provoke local inflammatory reaction in both strains after subcutaneous (s.c.) injection. The alkaloid suppressed paw swelling induced by live Candida albicans in ICR and DBA/2 mice. Its effect depended on the dose and time of injection prior to inflammatory reaction. The in vitro experiments proved the interference of fangchinoline action with post-C5 reactions. The substance augmented C5-convertase formation and functional activity. These results are in correspondence with our previous investigations, proving the complement-mediated action of fangchinoline. The antiinflammatory effect could be a consequence of the caused complement exhaustion.</abstract><qualityIndicators><score>6.74</score><pdfWordCount>3084</pdfWordCount><pdfCharCount>19691</pdfCharCount><pdfVersion>1.7</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>576 x 806.4 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>138</abstractWordCount><abstractCharCount>1042</abstractCharCount><keywordCount>3</keywordCount></qualityIndicators><title>Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline</title><pii><json:string>S0944-7113(99)80059-2</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Phytomedicine</title><language><json:string>unknown</json:string></language><publicationDate>1999</publicationDate><issn><json:string>0944-7113</json:string></issn><pii><json:string>S0944-7113(99)X8050-0</json:string></pii><volume>6</volume><issue>5</issue><pages><first>357</first><last>362</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>40S</json:string><json:string>1000</json:string><json:string>1999</json:string></date><geogName></geogName><orgName><json:string>Institute of Botany, Bulgarian Academy of Sciences</json:string><json:string>Dynatech</json:string><json:string>National Fund for Scientific Research, Republic</json:string><json:string>Grant L-639</json:string></orgName><orgName_funder><json:string>National Fund for Scientific Research, Republic</json:string><json:string>Grant L-639</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>R. 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Hristova et al.</json:string><json:string>Kozel et al., 1996</json:string><json:string>Likhitwitayawuid et al., 1993</json:string><json:string>Marshall et al., 1994</json:string><json:string>Seow et al., 1992</json:string><json:string>Fulurija et al., 1995</json:string><json:string>Nakamura et al., 1992</json:string><json:string>Philipov et al., 1997</json:string><json:string>Akiba et al., 1992</json:string><json:string>Kozel, 1998</json:string><json:string>Ye et al., 1993</json:string><json:string>Ivanovska et al., 1999a, b</json:string><json:string>Ho et al., 1999b</json:string><json:string>May 1995</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-8L98SMP9-H</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - plant sciences</json:string><json:string>2 - pharmacology & pharmacy</json:string><json:string>2 - integrative & complementary medicine</json:string><json:string>2 - chemistry, medicinal</json:string></wos><scienceMetrix><json:string>1 - natural sciences</json:string><json:string>2 - chemistry</json:string><json:string>3 - medicinal & biomolecular chemistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Complementary and alternative medicine</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Drug Discovery</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Pharmaceutical Science</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Pharmacology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Molecular Medicine</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - pharmacologie. traitements medicamenteux</json:string></inist></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1016/S0944-7113(99)80059-2</json:string></doi><id>CE03CA7EE43EB01C57799245A19E3486A35CD441</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-8L98SMP9-H/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-8L98SMP9-H/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-8L98SMP9-H/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©1999 Urban & Fischer Verlag</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1999</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline</title><author xml:id="author-0000"><persName><forename type="first">M.</forename><surname>Hristova</surname></persName><email>maria@microbio.bas.bg</email><affiliation>Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria</affiliation><affiliation>aAddress Maria Hristova, Institute of Microbiology, Bulgarian Academy of Sciences, 26 G. Bonchev Str., 1113 Sofia, Bulgaria</affiliation></author><author xml:id="author-0001"><persName><forename type="first">R.</forename><surname>Istatkova</surname></persName><affiliation>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences</affiliation></author><idno type="istex">CE03CA7EE43EB01C57799245A19E3486A35CD441</idno><idno type="ark">ark:/67375/6H6-8L98SMP9-H</idno><idno type="DOI">10.1016/S0944-7113(99)80059-2</idno><idno type="PII">S0944-7113(99)80059-2</idno><idno type="article-id">80059</idno></analytic><monogr><title level="j">Phytomedicine</title><title level="j" type="abbrev">PHYMED</title><idno type="pISSN">0944-7113</idno><idno type="PII">S0944-7113(99)X8050-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">6</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="357">357</biblScope><biblScope unit="page" to="362">362</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Summary: Complement-mediated mode of action of bisbenzylisoquinoline alkaloid fangchinoline was investigated in vivo and in vitro. The application of fangchinoline intraperitoneally (i.p.) to complement normal mice, strain ICR, inhibited the complement activity in serum and peritoneal exudate. The substance activated serum complement of C5-deficient DBA/2 mice. Fangchinoline was able to provoke local inflammatory reaction in both strains after subcutaneous (s.c.) injection. The alkaloid suppressed paw swelling induced by live Candida albicans in ICR and DBA/2 mice. Its effect depended on the dose and time of injection prior to inflammatory reaction. The in vitro experiments proved the interference of fangchinoline action with post-C5 reactions. The substance augmented C5-convertase formation and functional activity. These results are in correspondence with our previous investigations, proving the complement-mediated action of fangchinoline. The antiinflammatory effect could be a consequence of the caused complement exhaustion.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Fangchinoline</term></item><item><term>C5-convertase</term></item><item><term>Candida albicans paw inflammation</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-8L98SMP9-H/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" </istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.1.0//EN//XML" URI="art510.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.1" xml:lang="en" docsubtype="fla"><item-info><jid>PHYMED</jid><aid>80059</aid><ce:pii>S0944-7113(99)80059-2</ce:pii><ce:doi>10.1016/S0944-7113(99)80059-2</ce:doi><ce:copyright type="other" year="1999">Urban & Fischer Verlag</ce:copyright></item-info><head><ce:title>Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline</ce:title><ce:author-group><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Hristova</ce:surname><ce:cross-ref refid="aff1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="fn1"><ce:sup>a</ce:sup></ce:cross-ref><ce:e-address type="email">maria@microbio.bas.bg</ce:e-address></ce:author><ce:author><ce:given-name>R.</ce:given-name><ce:surname>Istatkova</ce:surname><ce:cross-ref refid="aff2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>1</ce:label><ce:textfn>Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>2</ce:label><ce:textfn>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences</ce:textfn></ce:affiliation><ce:footnote id="fn1"><ce:label>a</ce:label><ce:note-para><ce:bold>Address</ce:bold> Maria Hristova, Institute of Microbiology, Bulgarian Academy of Sciences, 26 G. Bonchev Str., 1113 Sofia, Bulgaria</ce:note-para></ce:footnote></ce:author-group><ce:abstract id="ab1"><ce:section-title>Summary</ce:section-title><ce:abstract-sec><ce:simple-para id="SP0005">Complement-mediated mode of action of bisbenzylisoquinoline alkaloid fangchinoline was investigated <ce:italic>in vivo</ce:italic> and <ce:italic>in vitro</ce:italic>. The application of fangchinoline intraperitoneally (i.p.) to complement normal mice, strain ICR, inhibited the complement activity in serum and peritoneal exudate. The substance activated serum complement of C5-deficient DBA/2 mice. Fangchinoline was able to provoke local inflammatory reaction in both strains after subcutaneous (s.c.) injection. The alkaloid suppressed paw swelling induced by live <ce:italic>Candida albicans</ce:italic> in ICR and DBA/2 mice. Its effect depended on the dose and time of injection prior to inflammatory reaction. The <ce:italic>in vitro</ce:italic> experiments proved the interference of fangchinoline action with post-C5 reactions. The substance augmented C5-convertase formation and functional activity. These results are in correspondence with our previous investigations, proving the complement-mediated action of fangchinoline. The antiinflammatory effect could be a consequence of the caused complement exhaustion.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Key words</ce:section-title><ce:keyword><ce:text>Fangchinoline</ce:text></ce:keyword><ce:keyword><ce:text>C5-convertase</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>Candida albicans</ce:italic> paw inflammation</ce:text></ce:keyword></ce:keywords></head><tail><ce:bibliography id="R0005"><ce:section-title>References</ce:section-title><ce:bibliography-sec id="RS0005"><ce:bib-reference id="bib1"><ce:label>Akiba et al., 1992</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:given-name>S.</ce:given-name><ce:surname>Akiba</ce:surname></sb:author><sb:author><ce:given-name>E.</ce:given-name><ce:surname>Kato</ce:surname></sb:author><sb:author><ce:given-name>T.</ce:given-name><ce:surname>Sato</ce:surname></sb:author><sb:author><ce:given-name>T.</ce:given-name><ce:surname>Fujii</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Biochem. 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Commun.</sb:maintitle></sb:title><sb:volume-nr>156</sb:volume-nr></sb:series><sb:date>1989</sb:date></sb:issue><sb:pages><sb:first-page>75S</sb:first-page><sb:last-page>65</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hristova</namePart><affiliation>Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria</affiliation><affiliation>aAddress Maria Hristova, Institute of Microbiology, Bulgarian Academy of Sciences, 26 G. Bonchev Str., 1113 Sofia, Bulgaria</affiliation><affiliation>E-mail: maria@microbio.bas.bg</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Istatkova</namePart><affiliation>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract>Summary: Complement-mediated mode of action of bisbenzylisoquinoline alkaloid fangchinoline was investigated in vivo and in vitro. The application of fangchinoline intraperitoneally (i.p.) to complement normal mice, strain ICR, inhibited the complement activity in serum and peritoneal exudate. The substance activated serum complement of C5-deficient DBA/2 mice. Fangchinoline was able to provoke local inflammatory reaction in both strains after subcutaneous (s.c.) injection. The alkaloid suppressed paw swelling induced by live Candida albicans in ICR and DBA/2 mice. Its effect depended on the dose and time of injection prior to inflammatory reaction. The in vitro experiments proved the interference of fangchinoline action with post-C5 reactions. The substance augmented C5-convertase formation and functional activity. These results are in correspondence with our previous investigations, proving the complement-mediated action of fangchinoline. The antiinflammatory effect could be a consequence of the caused complement exhaustion.</abstract><subject lang="en"><genre>Key words</genre><topic>Fangchinoline</topic><topic>C5-convertase</topic><topic>Candida albicans paw inflammation</topic></subject><relatedItem type="host"><titleInfo><title>Phytomedicine</title></titleInfo><titleInfo type="abbreviated"><title>PHYMED</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued></originInfo><identifier type="ISSN">0944-7113</identifier><identifier type="PII">S0944-7113(99)X8050-0</identifier><part><date>1999</date><detail type="volume"><number>6</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="issue-pages"><start>305</start><end>391</end></extent><extent unit="pages"><start>357</start><end>362</end></extent></part></relatedItem><identifier type="istex">CE03CA7EE43EB01C57799245A19E3486A35CD441</identifier><identifier type="ark">ark:/67375/6H6-8L98SMP9-H</identifier><identifier type="DOI">10.1016/S0944-7113(99)80059-2</identifier><identifier type="PII">S0944-7113(99)80059-2</identifier><identifier type="ArticleID">80059</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 Urban & Fischer Verlag</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Urban & Fischer Verlag, ©1999</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-8L98SMP9-H/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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