Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants
Identifieur interne : 001623 ( Istex/Corpus ); précédent : 001622; suivant : 001624Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants
Auteurs : Renate Lüllmann-RauchSource :
- Virchows Archiv B [ 0340-6075 ] ; 1975-12-01.
English descriptors
- KwdEn :
- Teeft :
- Abnormal inclusions, Academic press, Acid hematein, Antidepressant, Approx, Araldite section, Autophagic activity, Cell types, Chlorphentermine, Considerable numbers, Cytological alterations, Cytoplasmic inclusions, Dense bodies, Dense inclusions, Distal tubules, Duct, Duct cells, Duct system, Electron microscope, Electron microscopy, Epithelial cells, Generalized lipidosis, Generalized phospholipidosis, Glomerular podocytes, Hematein, Higher magnification, Histochemical demonstration, Histochemical properties, Holland publishing, Inclusion, Inner medulla, Interstitial cells, Iprindole, Lamellar, Lamellar bodies, Lamellar inclusions, Lamellated, Light cells, Lipidosis, Lysosomelike bodies, Medulla, Multilamellated cytoplasmic inclusions, Other tissues, Outer medulla, Outer region, Outer stripe, Phospholipid, Proximal, Renal, Renal cortex, Renal tissues, Same animal, Staining material, Straight portions, Thin limb, Tricyclic, Tricyclic antidepressants, Tubule, Ultrastructural appearance, Untreated control, Uriniferous tubules, Virchows arch.
Abstract
Summary: Histological, histochemical and ultrastructural examinations were performed on renal tissues of rats after prolonged oral administration of the anorectic drug chlorphentermine or of the tricyclic antidepressants iprindole, imipramine and clomipramine. All drugs caused the formation of multilamellated cytoplasmic inclusions throughout the nephron and the collecting duct system, and in interstitial cells. The cytological alterations were most prominent in the glomerular podocytes, in the proximal convoluted tubules, and in the collecting duct system. In view of the histochemical properties (staining with Baker’s acid hematein) and the ultrastructural appearance of the cytoplasmic inclusions the cellular alterations are interpreted as a renal manifestation of a generalized lipidosis induced by drugs of amphiphilic character.
Url:
DOI: 10.1007/BF02889233
Links to Exploration step
ISTEX:F68B01D99E1C0D77303CD9479D7DAC8E73F1C1B4Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants</title><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><affiliation><mods:affiliation>Department of Anatomy, University of Kiel, Kiel, West Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F68B01D99E1C0D77303CD9479D7DAC8E73F1C1B4</idno><date when="1975" year="1975">1975</date><idno type="doi">10.1007/BF02889233</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-4DZ7L5F2-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001623</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001623</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants</title><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><affiliation><mods:affiliation>Department of Anatomy, University of Kiel, Kiel, West Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Virchows Archiv B</title><title level="j" type="sub">Cell Pathology</title><title level="j" type="abbrev">Virchows Arch. B Cell Path.</title><idno type="ISSN">0340-6075</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1975-12-01">1975-12-01</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="51">51</biblScope><biblScope unit="page" to="60">60</biblScope></imprint><idno type="ISSN">0340-6075</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-6075</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-depressants, Tricyclic</term><term>Chlorphentermine</term><term>Kidney</term><term>Lipidosis, Drug-Induced</term><term>Rat</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abnormal inclusions</term><term>Academic press</term><term>Acid hematein</term><term>Antidepressant</term><term>Approx</term><term>Araldite section</term><term>Autophagic activity</term><term>Cell types</term><term>Chlorphentermine</term><term>Considerable numbers</term><term>Cytological alterations</term><term>Cytoplasmic inclusions</term><term>Dense bodies</term><term>Dense inclusions</term><term>Distal tubules</term><term>Duct</term><term>Duct cells</term><term>Duct system</term><term>Electron microscope</term><term>Electron microscopy</term><term>Epithelial cells</term><term>Generalized lipidosis</term><term>Generalized phospholipidosis</term><term>Glomerular podocytes</term><term>Hematein</term><term>Higher magnification</term><term>Histochemical demonstration</term><term>Histochemical properties</term><term>Holland publishing</term><term>Inclusion</term><term>Inner medulla</term><term>Interstitial cells</term><term>Iprindole</term><term>Lamellar</term><term>Lamellar bodies</term><term>Lamellar inclusions</term><term>Lamellated</term><term>Light cells</term><term>Lipidosis</term><term>Lysosomelike bodies</term><term>Medulla</term><term>Multilamellated cytoplasmic inclusions</term><term>Other tissues</term><term>Outer medulla</term><term>Outer region</term><term>Outer stripe</term><term>Phospholipid</term><term>Proximal</term><term>Renal</term><term>Renal cortex</term><term>Renal tissues</term><term>Same animal</term><term>Staining material</term><term>Straight portions</term><term>Thin limb</term><term>Tricyclic</term><term>Tricyclic antidepressants</term><term>Tubule</term><term>Ultrastructural appearance</term><term>Untreated control</term><term>Uriniferous tubules</term><term>Virchows arch</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Histological, histochemical and ultrastructural examinations were performed on renal tissues of rats after prolonged oral administration of the anorectic drug chlorphentermine or of the tricyclic antidepressants iprindole, imipramine and clomipramine. All drugs caused the formation of multilamellated cytoplasmic inclusions throughout the nephron and the collecting duct system, and in interstitial cells. The cytological alterations were most prominent in the glomerular podocytes, in the proximal convoluted tubules, and in the collecting duct system. In view of the histochemical properties (staining with Baker’s acid hematein) and the ultrastructural appearance of the cytoplasmic inclusions the cellular alterations are interpreted as a renal manifestation of a generalized lipidosis induced by drugs of amphiphilic character.</div></front></TEI><istex><corpusName>springer-journals</corpusName><keywords><teeft><json:string>tubule</json:string><json:string>medulla</json:string><json:string>chlorphentermine</json:string><json:string>iprindole</json:string><json:string>inner medulla</json:string><json:string>duct</json:string><json:string>approx</json:string><json:string>phospholipid</json:string><json:string>lamellar</json:string><json:string>lamellated</json:string><json:string>tricyclic</json:string><json:string>lipidosis</json:string><json:string>hematein</json:string><json:string>antidepressant</json:string><json:string>renal</json:string><json:string>inclusion</json:string><json:string>outer region</json:string><json:string>acid hematein</json:string><json:string>staining material</json:string><json:string>araldite section</json:string><json:string>interstitial cells</json:string><json:string>duct cells</json:string><json:string>epithelial cells</json:string><json:string>higher magnification</json:string><json:string>same animal</json:string><json:string>outer medulla</json:string><json:string>proximal</json:string><json:string>virchows arch</json:string><json:string>uriniferous tubules</json:string><json:string>duct system</json:string><json:string>distal tubules</json:string><json:string>academic press</json:string><json:string>renal cortex</json:string><json:string>lamellar bodies</json:string><json:string>outer stripe</json:string><json:string>lysosomelike bodies</json:string><json:string>ultrastructural appearance</json:string><json:string>histochemical demonstration</json:string><json:string>dense inclusions</json:string><json:string>generalized phospholipidosis</json:string><json:string>considerable numbers</json:string><json:string>abnormal inclusions</json:string><json:string>straight portions</json:string><json:string>generalized lipidosis</json:string><json:string>thin limb</json:string><json:string>untreated control</json:string><json:string>cytoplasmic inclusions</json:string><json:string>electron microscopy</json:string><json:string>cell types</json:string><json:string>electron microscope</json:string><json:string>histochemical properties</json:string><json:string>glomerular podocytes</json:string><json:string>cytological alterations</json:string><json:string>light cells</json:string><json:string>dense bodies</json:string><json:string>multilamellated cytoplasmic inclusions</json:string><json:string>lamellar inclusions</json:string><json:string>other tissues</json:string><json:string>autophagic activity</json:string><json:string>holland publishing</json:string><json:string>renal tissues</json:string><json:string>tricyclic antidepressants</json:string></teeft></keywords><author><json:item><name>Renate Lüllmann-Rauch</name><affiliations><json:string>Department of Anatomy, University of Kiel, Kiel, West Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Rat</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Kidney</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lipidosis, Drug-Induced</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Chlorphentermine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Anti-depressants, Tricyclic</value></json:item></subject><articleId><json:string>BF02889233</json:string><json:string>Art4</json:string></articleId><arkIstex>ark:/67375/1BB-4DZ7L5F2-8</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Summary: Histological, histochemical and ultrastructural examinations were performed on renal tissues of rats after prolonged oral administration of the anorectic drug chlorphentermine or of the tricyclic antidepressants iprindole, imipramine and clomipramine. All drugs caused the formation of multilamellated cytoplasmic inclusions throughout the nephron and the collecting duct system, and in interstitial cells. The cytological alterations were most prominent in the glomerular podocytes, in the proximal convoluted tubules, and in the collecting duct system. In view of the histochemical properties (staining with Baker’s acid hematein) and the ultrastructural appearance of the cytoplasmic inclusions the cellular alterations are interpreted as a renal manifestation of a generalized lipidosis induced by drugs of amphiphilic character.</abstract><qualityIndicators><score>6.724</score><pdfWordCount>3392</pdfWordCount><pdfCharCount>17157</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>440.64 x 684 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>111</abstractWordCount><abstractCharCount>842</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants</title><genre><json:string>research-article</json:string></genre><host><title>Virchows Archiv B</title><language><json:string>unknown</json:string></language><publicationDate>1975</publicationDate><copyrightDate>1975</copyrightDate><issn><json:string>0340-6075</json:string></issn><journalId><json:string>443</json:string></journalId><volume>18</volume><issue>1</issue><pages><first>51</first><last>60</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Medicine & Public Health</value></json:item><json:item><value>Pathology</value></json:item><json:item><value>Cell Biology</value></json:item></subject></host><namedEntities><unitex><date></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/1BB-4DZ7L5F2-8</json:string></ark><categories><wos></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pathology and Forensic Medicine</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - maladies metaboliques</json:string></inist></categories><publicationDate>1975</publicationDate><copyrightDate>1975</copyrightDate><doi><json:string>10.1007/BF02889233</json:string></doi><id>F68B01D99E1C0D77303CD9479D7DAC8E73F1C1B4</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-4DZ7L5F2-8/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-4DZ7L5F2-8/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/1BB-4DZ7L5F2-8/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><licence><p>Springer-Verlag, 1975</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>1974-12-23</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">Renate</forename><surname>Lüllmann-Rauch</surname></persName><affiliation>Department of Anatomy, University of Kiel, Kiel, West Germany</affiliation></author><idno type="istex">F68B01D99E1C0D77303CD9479D7DAC8E73F1C1B4</idno><idno type="ark">ark:/67375/1BB-4DZ7L5F2-8</idno><idno type="DOI">10.1007/BF02889233</idno><idno type="article-id">BF02889233</idno><idno type="article-id">Art4</idno></analytic><monogr><title level="j">Virchows Archiv B</title><title level="j" type="sub">Cell Pathology</title><title level="j" type="abbrev">Virchows Arch. B Cell Path.</title><idno type="pISSN">0340-6075</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">32</idno><idno type="volume-issue-count">0</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1975-12-01"></date><biblScope unit="volume">18</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="51">51</biblScope><biblScope unit="page" to="60">60</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1974-12-23</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: Histological, histochemical and ultrastructural examinations were performed on renal tissues of rats after prolonged oral administration of the anorectic drug chlorphentermine or of the tricyclic antidepressants iprindole, imipramine and clomipramine. All drugs caused the formation of multilamellated cytoplasmic inclusions throughout the nephron and the collecting duct system, and in interstitial cells. The cytological alterations were most prominent in the glomerular podocytes, in the proximal convoluted tubules, and in the collecting duct system. In view of the histochemical properties (staining with Baker’s acid hematein) and the ultrastructural appearance of the cytoplasmic inclusions the cellular alterations are interpreted as a renal manifestation of a generalized lipidosis induced by drugs of amphiphilic character.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Rat</term></item><item><term>Kidney</term></item><item><term>Lipidosis, Drug-Induced</term></item><item><term>Chlorphentermine</term></item><item><term>Anti-depressants, Tricyclic</term></item></list></keywords></textClass><textClass><keywords scheme="Journal-Subject-Group"><list><label>HX</label><item><term>Medicine & Public Health</term></item><label>H4800X</label><item><term>Pathology</term></item><label>L16008</label><item><term>Cell Biology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1974-12-23">Created</change><change when="1975-12-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-4DZ7L5F2-8/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>443</JournalID><JournalPrintISSN>0340-6075</JournalPrintISSN><JournalTitle>Virchows Archiv B</JournalTitle><JournalSubTitle>Cell Pathology</JournalSubTitle><JournalAbbreviatedTitle>Virchows Arch. B Cell Path.</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Code="HX" Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Code="H4800X" Priority="1" Type="Secondary">Pathology</JournalSubject><JournalSubject Code="L16008" Priority="2" Type="Secondary">Cell Biology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo TocLevels="0" VolumeType="Regular"><VolumeIDStart>18</VolumeIDStart><VolumeIDEnd>18</VolumeIDEnd><VolumeIssueCount>0</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd><IssueArticleCount>32</IssueArticleCount><IssueHistory><CoverDate><Year>1975</Year><Month>12</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1975</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art4"><ArticleInfo ArticleType="OriginalPaper" ContainsESM="No" Language="En" NumberingStyle="Unnumbered" TocLevels="0"><ArticleID>BF02889233</ArticleID><ArticleDOI>10.1007/BF02889233</ArticleDOI><ArticleSequenceNumber>4</ArticleSequenceNumber><ArticleTitle Language="En">Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants</ArticleTitle><ArticleFirstPage>51</ArticleFirstPage><ArticleLastPage>60</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2008</Year><Month>4</Month><Day>7</Day></RegistrationDate><Received><Year>1974</Year><Month>12</Month><Day>23</Day></Received></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1975</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>443</JournalID><VolumeIDStart>18</VolumeIDStart><VolumeIDEnd>18</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Renate</GivenName><FamilyName>Lüllmann-Rauch</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Anatomy</OrgDivision><OrgName>University of Kiel</OrgName><OrgAddress><City>Kiel</City><Country>West Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>Histological, histochemical and ultrastructural examinations were performed on renal tissues of rats after prolonged oral administration of the anorectic drug chlorphentermine or of the tricyclic antidepressants iprindole, imipramine and clomipramine. All drugs caused the formation of multilamellated cytoplasmic inclusions throughout the nephron and the collecting duct system, and in interstitial cells. The cytological alterations were most prominent in the glomerular podocytes, in the proximal convoluted tubules, and in the collecting duct system. In view of the histochemical properties (staining with Baker’s acid hematein) and the ultrastructural appearance of the cytoplasmic inclusions the cellular alterations are interpreted as a renal manifestation of a generalized lipidosis induced by drugs of amphiphilic character.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Rat</Keyword><Keyword>Kidney</Keyword><Keyword>Lipidosis, Drug-Induced</Keyword><Keyword>Chlorphentermine</Keyword><Keyword>Anti-depressants, Tricyclic</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Renate</namePart><namePart type="family">Lüllmann-Rauch</namePart><affiliation>Department of Anatomy, University of Kiel, Kiel, West Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1974-12-23</dateCreated><dateIssued encoding="w3cdtf">1975-12-01</dateIssued><copyrightDate encoding="w3cdtf">1975</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: Histological, histochemical and ultrastructural examinations were performed on renal tissues of rats after prolonged oral administration of the anorectic drug chlorphentermine or of the tricyclic antidepressants iprindole, imipramine and clomipramine. All drugs caused the formation of multilamellated cytoplasmic inclusions throughout the nephron and the collecting duct system, and in interstitial cells. The cytological alterations were most prominent in the glomerular podocytes, in the proximal convoluted tubules, and in the collecting duct system. In view of the histochemical properties (staining with Baker’s acid hematein) and the ultrastructural appearance of the cytoplasmic inclusions the cellular alterations are interpreted as a renal manifestation of a generalized lipidosis induced by drugs of amphiphilic character.</abstract><subject lang="en"><genre>Key words</genre><topic>Rat</topic><topic>Kidney</topic><topic>Lipidosis, Drug-Induced</topic><topic>Chlorphentermine</topic><topic>Anti-depressants, Tricyclic</topic></subject><relatedItem type="host"><titleInfo><title>Virchows Archiv B</title><subTitle>Cell Pathology</subTitle></titleInfo><titleInfo type="abbreviated"><title>Virchows Arch. B Cell Path.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1975-12-01</dateIssued><copyrightDate encoding="w3cdtf">1975</copyrightDate></originInfo><subject><genre>Journal-Subject-Group</genre><topic authority="SpringerSubjectCodes" authorityURI="HX">Medicine & Public Health</topic><topic authority="SpringerSubjectCodes" authorityURI="H4800X">Pathology</topic><topic authority="SpringerSubjectCodes" authorityURI="L16008">Cell Biology</topic></subject><identifier type="ISSN">0340-6075</identifier><identifier type="JournalID">443</identifier><identifier type="IssueArticleCount">32</identifier><identifier type="VolumeIssueCount">0</identifier><part><date>1975</date><detail type="volume"><number>18</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>51</start><end>60</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1975</recordOrigin></recordInfo></relatedItem><identifier type="istex">F68B01D99E1C0D77303CD9479D7DAC8E73F1C1B4</identifier><identifier type="ark">ark:/67375/1BB-4DZ7L5F2-8</identifier><identifier type="DOI">10.1007/BF02889233</identifier><identifier type="ArticleID">BF02889233</identifier><identifier type="ArticleID">Art4</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1975</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1975</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-4DZ7L5F2-8/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001623 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001623 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:F68B01D99E1C0D77303CD9479D7DAC8E73F1C1B4
|texte= Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants
}}
| This area was generated with Dilib version V0.6.33. |  |