ChloroquineV1, Istex, Corpus, bibRecord, 001615

Drug and Gene Delivery Based on Supramolecular Assembly of PEG-Polypeptide Hybrid Block Copolymers

Identifieur interne : 001615 ( Istex/Corpus ); précédent : 001614; suivant : 001616

Drug and Gene Delivery Based on Supramolecular Assembly of PEG-Polypeptide Hybrid Block Copolymers

Auteurs : Kensuke Osada ; Kazunori Kataoka

Source :

Advances in Polymer Science [ 0065-3195 ]

RBID : ISTEX:A9FAFE14946D3AA310D96BE32498B6F377E92DD8

Abstract

Abstract: Recently, polypeptide hybrid polymers, particularly poly(ethylene glycol) (PEG)-polypeptide block copolymers, have been attracting significant interest for polymeric therapeutics, such as drug and gene delivery systems, utilizing their most relevant feature, that is the formation of micelles with a distinguished core-shell architecture. Of particular interest in the polypeptides is that a variety of functional groups, such as carboxyl groups and amino groups, are available as a side chain, and that they have propensities of low toxicity and biodegradability. The segregated polypeptide core of the micelle embedded in the hydrophilic palisade serves as a reservoir for a variety of drugs as well as of genes with diverse characteristics. The micelles have been developed with various functions, such as biocompatibility, stimuli- and environment-sensitivity, and targetability, aimed at their clinical use. Smart micelles have emerged as promising carriers that enhance the effect of drugs and genes with minimal side effects. In this review, recent advances in drug and gene delivery by polypeptide hybrid micelles, mostly accomplished in our group, are comprehensively described. Focus is placed on the design of PEG-polypeptide hybrid block copolymers, starting from the development of the drug-loading micelle systems to current efforts to establish a gene delivery system with a polyion complex (PIC) micelle, one of the most attractive topics in nanomedicine.

Url:

https://api.istex.fr/ark:/67375/HCB-N2XQCLD4-0/fulltext.pdf

DOI: 10.1007/12_084

Links to Exploration step

ISTEX:A9FAFE14946D3AA310D96BE32498B6F377E92DD8

Le document en format XML

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<author><name sortKey="Osada, Kensuke" sort="Osada, Kensuke" uniqKey="Osada K" first="Kensuke" last="Osada">Kensuke Osada</name>
<affiliation><mods:affiliation>Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Tokyo, Japan</mods:affiliation>
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<affiliation><mods:affiliation>E-mail: osada@bmw.t.u-tokyo.ac.jp</mods:affiliation>
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<author><name sortKey="Kataoka, Kazunori" sort="Kataoka, Kazunori" uniqKey="Kataoka K" first="Kazunori" last="Kataoka">Kazunori Kataoka</name>
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<affiliation><mods:affiliation>Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan</mods:affiliation>
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<front><div type="abstract" xml:lang="en">Abstract: Recently, polypeptide hybrid polymers, particularly poly(ethylene glycol) (PEG)-polypeptide block copolymers, have been attracting significant interest for polymeric therapeutics, such as drug and gene delivery systems, utilizing their most relevant feature, that is the formation of micelles with a distinguished core-shell architecture. Of particular interest in the polypeptides is that a variety of functional groups, such as carboxyl groups and amino groups, are available as a side chain, and that they have propensities of low toxicity and biodegradability. The segregated polypeptide core of the micelle embedded in the hydrophilic palisade serves as a reservoir for a variety of drugs as well as of genes with diverse characteristics. The micelles have been developed with various functions, such as biocompatibility, stimuli- and environment-sensitivity, and targetability, aimed at their clinical use. Smart micelles have emerged as promising carriers that enhance the effect of drugs and genes with minimal side effects. In this review, recent advances in drug and gene delivery by polypeptide hybrid micelles, mostly accomplished in our group, are comprehensively described. Focus is placed on the design of PEG-polypeptide hybrid block copolymers, starting from the development of the drug-loading micelle systems to current efforts to establish a gene delivery system with a polyion complex (PIC) micelle, one of the most attractive topics in nanomedicine.</div>
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<value>Block copolymer</value>
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<json:item><lang><json:string>eng</json:string>
</lang>
<value>Poly(ethylene glycol)</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
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<value>Polyion complex</value>
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<json:item><lang><json:string>eng</json:string>
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<value>Non-viral gene vector</value>
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<value>EPR effect : enhanced permeability and retention effect</value>
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<value>RES : reticuloendothelial system</value>
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<value>PEG : poly(ethylene glycol)</value>
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<value>NCA : amino acid N-carboxyanhydride</value>
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<value>PLL : poly(l-lysine)</value>
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<value>PAsp : poly(α,β-aspartic acid)</value>
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<value>PBLA : poly(β-benzyl-l-aspartate)</value>
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<value>PGlu : poly(l-glutamic acid)</value>
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<value>PEG-PAsp(DPT) : poly(ethylene glycol)-b-poly(3-[(3-aminopropyl)amino]propylaspartamide)</value>
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<value>PEG-PAsp(DMAPA) : PEG-poly(3-dimethylamino)propyl aspartamide</value>
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<value>PAsp(MPA) : poly[(3-morpholinopropyl) aspartamide]</value>
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<value>PEG-PAsp(MPA)-PLL : PEG-b-poly[(3-morpholinopropyl) aspartamide]-b-PLL</value>
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<value>PEG-PAMA : PEG-b-poly(2-(dimethylamino)ethyl methacrylate))</value>
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<value>PEI : poly(ethyleneimine)</value>
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<json:item><lang><json:string>eng</json:string>
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<value>Dox : doxorubicin</value>
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<value>PIC micelle : polyion complex micelle</value>
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<profileDesc><abstract xml:lang="en"><head>Abstract</head>
<p>Recently, polypeptide hybrid polymers, particularly poly(ethylene glycol) (PEG)-polypeptide
  block copolymers, have been attracting significant interest for polymeric therapeutics, such as drug
  and gene delivery systems, utilizing their most relevant feature, that is the formation of micelles
  with a distinguished core-shell architecture. Of particular interest in the polypeptides is
  that a variety of functional groups, such as carboxyl groups and amino groups, are available
  as a side chain, and that they have propensities of low toxicity and biodegradability. The segregated
  polypeptide core of the micelle embedded in the hydrophilic palisade serves as a reservoir for
  a variety of drugs as well as of genes with diverse characteristics. The micelles have been
  developed with various functions, such as biocompatibility, stimuli- and environment-sensitivity,
  and targetability, aimed at their clinical use. Smart micelles have emerged as promising carriers
  that enhance the effect of drugs and genes with minimal side effects. In this review, recent advances
  in drug and gene delivery by polypeptide hybrid micelles, mostly accomplished in our group, are comprehensively
  described. Focus is placed on the design of PEG-polypeptide hybrid block copolymers, starting from
  the development of the drug-loading micelle systems to current efforts to establish a gene delivery
  system with a polyion complex (PIC) micelle, one of the most attractive topics in nanomedicine.
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<textClass ana="abbreviation"><keywords scheme="abbreviations"><list><head>Abbreviations</head>
<item><term>EPR effect</term>
<desc>
                  enhanced permeability and retention effect
                </desc>
</item>
<item><term>RES</term>
<desc>
                  reticuloendothelial system
                </desc>
</item>
<item><term>PEG</term>
<desc>
                  poly(ethylene glycol)
                </desc>
</item>
<item><term>NCA</term>
<desc>
                  amino acid <hi rend="italic">N</hi>-carboxyanhydride
                </desc>
</item>
<item><term>PLL</term>
<desc>
                  poly(<hi rend="smallCaps">l</hi>-lysine)
                </desc>
</item>
<item><term>PAsp</term>
<desc>
                  poly(α,β-aspartic acid)
                </desc>
</item>
<item><term>PBLA</term>
<desc>
                  poly(β-benzyl-<hi rend="smallCaps">l</hi>-aspartate)
                </desc>
</item>
<item><term>PGlu</term>
<desc>
                  poly(<hi rend="smallCaps">l</hi>-glutamic acid)
                </desc>
</item>
<item><term>PEG-PAsp(DPT)</term>
<desc>
                  poly(ethylene glycol)-<hi rend="italic">b</hi>-poly(3-[(3-aminopropyl)amino]propylaspartamide)
                </desc>
</item>
<item><term>PEG-PAsp(DMAPA)</term>
<desc>
                  PEG-poly(3-dimethylamino)propyl aspartamide
                </desc>
</item>
<item><term>PAsp(MPA)</term>
<desc>
                  poly[(3-morpholinopropyl) aspartamide]
                </desc>
</item>
<item><term>PEG-PAsp(MPA)-PLL</term>
<desc>
                  PEG-<hi rend="italic">b</hi>
-poly[(3-morpholinopropyl) aspartamide]-<hi rend="italic">b</hi>-PLL
                </desc>
</item>
<item><term>PEG-PAMA</term>
<desc>
                  PEG-<hi rend="italic">b</hi>-poly(2-(dimethylamino)ethyl methacrylate))
                </desc>
</item>
<item><term>PEI</term>
<desc>
                  poly(ethyleneimine)
                </desc>
</item>
<item><term>Dox</term>
<desc>
                  doxorubicin
                </desc>
</item>
<item><term>PIC micelle</term>
<desc>
                  polyion complex micelle
                </desc>
</item>
<item><term>N/P ratio</term>
<desc>
                  ratio of [amino group in polycation]/[phosphate group in polynucleic acid]
                </desc>
</item>
</list>
</keywords>
</textClass>
<textClass ana="keyword"><keywords xml:lang="en"><term>Block copolymer</term>
<term>Poly(ethylene glycol)</term>
<term>Polyion complex</term>
<term>Polymeric micelle</term>
<term>Non-viral gene vector</term>
</keywords>
</textClass>
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</item>
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      Hybrid Block Copolymers</ChapterTitle>
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<Postcode>113-8656</Postcode>
<City>Tokyo</City>
<Country>Japan</Country>
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   Graduate School of Medicine</OrgDivision>
<OrgName>The University of Tokyo</OrgName>
<OrgAddress><Street>7-3-1 Hongo, Bunkyo-ku</Street>
<Postcode>113-0033</Postcode>
<City>Tokyo</City>
<Country>Japan</Country>
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<Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading>
<Para>Recently, polypeptide hybrid polymers, particularly poly(ethylene glycol) (PEG)-polypeptide
  block copolymers, have been attracting significant interest for polymeric therapeutics, such as drug
  and gene delivery systems, utilizing their most relevant feature, that is the formation of micelles
  with a distinguished core-shell architecture. Of particular interest in the polypeptides is
  that a variety of functional groups, such as carboxyl groups and amino groups, are available
  as a side chain, and that they have propensities of low toxicity and biodegradability. The segregated
  polypeptide core of the micelle embedded in the hydrophilic palisade serves as a reservoir for
  a variety of drugs as well as of genes with diverse characteristics. The micelles have been
  developed with various functions, such as biocompatibility, stimuli- and environment-sensitivity,
  and targetability, aimed at their clinical use. Smart micelles have emerged as promising carriers
  that enhance the effect of drugs and genes with minimal side effects. In this review, recent advances
  in drug and gene delivery by polypeptide hybrid micelles, mostly accomplished in our group, are comprehensively
  described. Focus is placed on the design of PEG-polypeptide hybrid block copolymers, starting from
  the development of the drug-loading micelle systems to current efforts to establish a gene delivery
  system with a polyion complex (PIC) micelle, one of the most attractive topics in nanomedicine.
  </Para>
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<KeywordGroup Language="En"><Keyword>Block copolymer</Keyword>
<Keyword>Poly(ethylene glycol)</Keyword>
<Keyword>Polyion complex</Keyword>
<Keyword>Polymeric micelle</Keyword>
<Keyword>Non-viral gene vector</Keyword>
</KeywordGroup>
<AbbreviationGroup><Heading>Abbreviations</Heading>
<DefinitionList><DefinitionListEntry><Term>EPR effect</Term>
<Description><Para>enhanced permeability and retention effect</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>RES</Term>
<Description><Para>reticuloendothelial system</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PEG</Term>
<Description><Para>poly(ethylene glycol)</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>NCA</Term>
<Description><Para>amino acid <Emphasis Type="Italic">N</Emphasis>
-carboxyanhydride</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PLL</Term>
<Description><Para>poly(<Emphasis Type="SmallCaps">l</Emphasis>
-lysine)</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PAsp</Term>
<Description><Para>poly(α,β-aspartic acid)</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PBLA</Term>
<Description><Para>poly(β-benzyl-<Emphasis Type="SmallCaps">l</Emphasis>
-aspartate)</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PGlu</Term>
<Description><Para>poly(<Emphasis Type="SmallCaps">l</Emphasis>
-glutamic acid)</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PEG-PAsp(DPT)</Term>
<Description><Para>poly(ethylene glycol)-<Emphasis Type="Italic">b</Emphasis>
-poly(3-[(3-aminopropyl)amino]propylaspartamide)</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PEG-PAsp(DMAPA)</Term>
<Description><Para>PEG-poly(3-dimethylamino)propyl aspartamide</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PAsp(MPA)</Term>
<Description><Para>poly[(3-morpholinopropyl) aspartamide]</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PEG-PAsp(MPA)-PLL</Term>
<Description><Para>PEG-<Emphasis Type="Italic">b</Emphasis>
-poly[(3-morpholinopropyl) aspartamide]-<Emphasis Type="Italic">b</Emphasis>
-PLL</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PEG-PAMA</Term>
<Description><Para>PEG-<Emphasis Type="Italic">b</Emphasis>
-poly(2-(dimethylamino)ethyl methacrylate))</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PEI</Term>
<Description><Para>poly(ethyleneimine)</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>Dox</Term>
<Description><Para>doxorubicin</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>PIC micelle</Term>
<Description><Para>polyion complex micelle</Para>
</Description>
</DefinitionListEntry>
<DefinitionListEntry><Term>N/P ratio</Term>
<Description><Para>ratio of [amino group in polycation]/[phosphate group in polynucleic acid]</Para>
</Description>
</DefinitionListEntry>
</DefinitionList>
</AbbreviationGroup>
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<affiliation>Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Tokyo, Japan</affiliation>
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<affiliation>Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Tokyo, Japan</affiliation>
<affiliation>Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan</affiliation>
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<abstract lang="en">Abstract: Recently, polypeptide hybrid polymers, particularly poly(ethylene glycol) (PEG)-polypeptide block copolymers, have been attracting significant interest for polymeric therapeutics, such as drug and gene delivery systems, utilizing their most relevant feature, that is the formation of micelles with a distinguished core-shell architecture. Of particular interest in the polypeptides is that a variety of functional groups, such as carboxyl groups and amino groups, are available as a side chain, and that they have propensities of low toxicity and biodegradability. The segregated polypeptide core of the micelle embedded in the hydrophilic palisade serves as a reservoir for a variety of drugs as well as of genes with diverse characteristics. The micelles have been developed with various functions, such as biocompatibility, stimuli- and environment-sensitivity, and targetability, aimed at their clinical use. Smart micelles have emerged as promising carriers that enhance the effect of drugs and genes with minimal side effects. In this review, recent advances in drug and gene delivery by polypeptide hybrid micelles, mostly accomplished in our group, are comprehensively described. Focus is placed on the design of PEG-polypeptide hybrid block copolymers, starting from the development of the drug-loading micelle systems to current efforts to establish a gene delivery system with a polyion complex (PIC) micelle, one of the most attractive topics in nanomedicine.</abstract>
<subject lang="en"><topic>Block copolymer</topic>
<topic>Poly(ethylene glycol)</topic>
<topic>Polyion complex</topic>
<topic>Polymeric micelle</topic>
<topic>Non-viral gene vector</topic>
</subject>
<subject><genre>Abbreviations</genre>
<topic>EPR effect : enhanced permeability and retention effect</topic>
<topic>RES : reticuloendothelial system</topic>
<topic>PEG : poly(ethylene glycol)</topic>
<topic>NCA : amino acid N-carboxyanhydride</topic>
<topic>PLL : poly(l-lysine)</topic>
<topic>PAsp : poly(α,β-aspartic acid)</topic>
<topic>PBLA : poly(β-benzyl-l-aspartate)</topic>
<topic>PGlu : poly(l-glutamic acid)</topic>
<topic>PEG-PAsp(DPT) : poly(ethylene glycol)-b-poly(3-[(3-aminopropyl)amino]propylaspartamide)</topic>
<topic>PEG-PAsp(DMAPA) : PEG-poly(3-dimethylamino)propyl aspartamide</topic>
<topic>PAsp(MPA) : poly[(3-morpholinopropyl) aspartamide]</topic>
<topic>PEG-PAsp(MPA)-PLL : PEG-b-poly[(3-morpholinopropyl) aspartamide]-b-PLL</topic>
<topic>PEG-PAMA : PEG-b-poly(2-(dimethylamino)ethyl methacrylate))</topic>
<topic>PEI : poly(ethyleneimine)</topic>
<topic>Dox : doxorubicin</topic>
<topic>PIC micelle : polyion complex micelle</topic>
<topic>N/P ratio : ratio of [amino group in polycation]/[phosphate group in polynucleic acid]</topic>
</subject>
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Drug and Gene Delivery Based on Supramolecular Assembly of PEG-Polypeptide Hybrid Block Copolymers

Drug and Gene Delivery Based on Supramolecular Assembly of PEG-Polypeptide Hybrid Block Copolymers

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