Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy
Identifieur interne : 001553 ( Istex/Corpus ); précédent : 001552; suivant : 001554Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy
Auteurs : Ian S. Blagbrough ; Simon Carrington ; Andrew J. GeallSource :
- Pharmacy and Pharmacology Communications [ 1460-8081 ] ; 1997-05-06.
Abstract
The family of polyamines and polyamine amides, especially unsymmetrical synthetic members, is critically assessed with respect to chemical structure and pharmacological activity. Naturally occurring polyamines (and diamines) and mono‐ (and di‐) acylated polyamines (polyamine amides) are blockers of cation channels that are receptor‐ or voltage‐gated. Such compounds are leads for the design of novel therapeutic agents. Furthermore, polyamines and polyamine amides are templates for the design of synthetic vectors with potential application in gene therapy. Natural di‐ and polyamines, spider and wasp venom polyamine amide toxins and their analogues, and totally synthetic polyamines, are potent cation‐channel blockers with uses as selective receptor probes for nicotinic acetylcholine and glutamate (NMDA and non‐NMDA) receptors, sodium and calcium channels. Therefore, as receptor probes, they may help us to understand the molecular mechanisms of neurodegeneration, and ultimately to design drugs for the treatment of neurodegenerative diseases, especially stroke. Polyamine conjugates are also novel therapeutic lead compounds for possible treatments of cancer, diarrhoea, malaria and haemochromatosis (β‐thalassaemia). The metal chelating properties of (poly‐) ethylenediamines have led to their incorporation in ion chelators which are synthetic RNase and DNase enzymes. Synthetic polyamines and polyamine amides have potential as novel vectors in gene delivery. Such compounds can condense DNA to form toroidal particles which may be incorporated in a non‐viral gene delivery system. The applications of polylysine, polyethylenimine, Starburst polyamidoamine dendrimers, Transfectam (DOGS), cholic acid, and cholesterol conjugates to gene therapy are compared as a function of structure and pKa. This assessment of polyamines and polyamine amides stresses the basicity of the amine functional groups. The pKa's of these functionalities are a major determinant in their binding to biological macromolecules. Selectivity of pharmacological action also encompasses contributions from solution conformation and lipophilicity as well as amine pKa. The use of these compounds as leads for the design of novel therapeutics or gene medicines is demonstrated to be practical as well as theoretically possible.
Url:
DOI: 10.1111/j.2042-7158.1997.tb00258.x
Links to Exploration step
ISTEX:387646E2F0E6D32C59D1D26510CA94142513B184Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy</title><author><name sortKey="Blagbrough, Ian S" sort="Blagbrough, Ian S" uniqKey="Blagbrough I" first="Ian S." last="Blagbrough">Ian S. Blagbrough</name><affiliation><mods:affiliation>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.</mods:affiliation></affiliation></author><author><name sortKey="Carrington, Simon" sort="Carrington, Simon" uniqKey="Carrington S" first="Simon" last="Carrington">Simon Carrington</name><affiliation><mods:affiliation>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</mods:affiliation></affiliation></author><author><name sortKey="Geall, Andrew J" sort="Geall, Andrew J" uniqKey="Geall A" first="Andrew J." last="Geall">Andrew J. Geall</name><affiliation><mods:affiliation>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:387646E2F0E6D32C59D1D26510CA94142513B184</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1111/j.2042-7158.1997.tb00258.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-ZCL4DBCZ-X/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001553</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001553</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy</title><author><name sortKey="Blagbrough, Ian S" sort="Blagbrough, Ian S" uniqKey="Blagbrough I" first="Ian S." last="Blagbrough">Ian S. Blagbrough</name><affiliation><mods:affiliation>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.</mods:affiliation></affiliation></author><author><name sortKey="Carrington, Simon" sort="Carrington, Simon" uniqKey="Carrington S" first="Simon" last="Carrington">Simon Carrington</name><affiliation><mods:affiliation>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</mods:affiliation></affiliation></author><author><name sortKey="Geall, Andrew J" sort="Geall, Andrew J" uniqKey="Geall A" first="Andrew J." last="Geall">Andrew J. Geall</name><affiliation><mods:affiliation>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pharmacy and Pharmacology Communications</title><title level="j" type="alt">PHARMACY AND PHARMACOLOGY COMMUNICATIONS</title><idno type="ISSN">1460-8081</idno><idno type="eISSN">2042-7158</idno><imprint><biblScope unit="vol">3</biblScope><biblScope unit="issue">5‐6</biblScope><biblScope unit="page" from="223">223</biblScope><biblScope unit="page" to="233">233</biblScope><biblScope unit="page-count">11</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1997-05-06">1997-05-06</date></imprint><idno type="ISSN">1460-8081</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1460-8081</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The family of polyamines and polyamine amides, especially unsymmetrical synthetic members, is critically assessed with respect to chemical structure and pharmacological activity. Naturally occurring polyamines (and diamines) and mono‐ (and di‐) acylated polyamines (polyamine amides) are blockers of cation channels that are receptor‐ or voltage‐gated. Such compounds are leads for the design of novel therapeutic agents. Furthermore, polyamines and polyamine amides are templates for the design of synthetic vectors with potential application in gene therapy. Natural di‐ and polyamines, spider and wasp venom polyamine amide toxins and their analogues, and totally synthetic polyamines, are potent cation‐channel blockers with uses as selective receptor probes for nicotinic acetylcholine and glutamate (NMDA and non‐NMDA) receptors, sodium and calcium channels. Therefore, as receptor probes, they may help us to understand the molecular mechanisms of neurodegeneration, and ultimately to design drugs for the treatment of neurodegenerative diseases, especially stroke. Polyamine conjugates are also novel therapeutic lead compounds for possible treatments of cancer, diarrhoea, malaria and haemochromatosis (β‐thalassaemia). The metal chelating properties of (poly‐) ethylenediamines have led to their incorporation in ion chelators which are synthetic RNase and DNase enzymes. Synthetic polyamines and polyamine amides have potential as novel vectors in gene delivery. Such compounds can condense DNA to form toroidal particles which may be incorporated in a non‐viral gene delivery system. The applications of polylysine, polyethylenimine, Starburst polyamidoamine dendrimers, Transfectam (DOGS), cholic acid, and cholesterol conjugates to gene therapy are compared as a function of structure and pKa. This assessment of polyamines and polyamine amides stresses the basicity of the amine functional groups. The pKa's of these functionalities are a major determinant in their binding to biological macromolecules. Selectivity of pharmacological action also encompasses contributions from solution conformation and lipophilicity as well as amine pKa. The use of these compounds as leads for the design of novel therapeutics or gene medicines is demonstrated to be practical as well as theoretically possible.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>polyamine</json:string><json:string>polyamines</json:string><json:string>spermine</json:string><json:string>chem</json:string><json:string>blagbrough</json:string><json:string>spermidine</json:string><json:string>cationic</json:string><json:string>lipid</json:string><json:string>bergeron</json:string><json:string>amide</json:string><json:string>moiety</json:string><json:string>polyamine amide</json:string><json:string>tabor</json:string><json:string>receptor</json:string><json:string>amine</json:string><json:string>behr</json:string><json:string>biochem</json:string><json:string>proc</json:string><json:string>analogue</json:string><json:string>transfection</json:string><json:string>acad</json:string><json:string>synthetic vector</json:string><json:string>natl</json:string><json:string>natl acad</json:string><json:string>cytotoxic</json:string><json:string>dendrimers</json:string><json:string>lett</json:string><json:string>synthetic polyamines</json:string><json:string>cationic lipid</json:string><json:string>calcium channel</json:string><json:string>gene therapy</json:string><json:string>gene delivery</json:string><json:string>toxin</json:string><json:string>polyamine biosynthesis</json:string><json:string>novel therapeutic</json:string><json:string>unsymmetrical polyamine amide</json:string><json:string>academic press</json:string><json:string>starburst polyamidoamine dendrimers</json:string><json:string>murine melanoma cell</json:string><json:string>tabor tabor</json:string><json:string>certain spider</json:string><json:string>glutamate receptor</json:string><json:string>polyamine conjugate</json:string><json:string>tetrahedron lett</json:string><json:string>efficient gene transfer</json:string><json:string>polyamine transporter</json:string><json:string>spermine analogue</json:string><json:string>synthetic analogue</json:string><json:string>cellular uptake</json:string><json:string>mammalian cell</json:string><json:string>spider</json:string><json:string>primary amine</json:string><json:string>cerebellar purkinje cell</json:string><json:string>gating molecule</json:string><json:string>polynucleic acid</json:string><json:string>polynucleotide delivery</json:string><json:string>synthetic rnase</json:string><json:string>cytotoxic agent</json:string><json:string>dnase enzyme</json:string><json:string>selective receptor probe</json:string><json:string>positive charge</json:string><json:string>polyamine moiety</json:string><json:string>profound effect</json:string><json:string>chronic toxicity</json:string><json:string>complete cure</json:string><json:string>methylene group</json:string><json:string>microbial siderophores</json:string><json:string>albert serjeant</json:string><json:string>metal chelating moiety</json:string><json:string>physiological condition</json:string><json:string>stewart gray</json:string><json:string>gene delivery system</json:string><json:string>fusogenic lipid</json:string><json:string>cationic facial amphiphiles</json:string><json:string>nucleic acid</json:string><json:string>compact particle</json:string><json:string>pharmaceutical science</json:string><json:string>cationic liposome</json:string><json:string>blagbrough usherwood</json:string><json:string>diamine putrescine</json:string><json:string>such compound</json:string><json:string>cholic acid</json:string><json:string>endogenous polyamines</json:string><json:string>marton pegg</json:string><json:string>physiological polyamines</json:string><json:string>cleaving activity</json:string><json:string>further study</json:string><json:string>polyamine toxin</json:string><json:string>gene transfer</json:string><json:string>biological property</json:string></teeft></keywords><author><json:item><name>IAN S. BLAGBROUGH</name><affiliations><json:string>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</json:string><json:string>Correspondence address: School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.</json:string></affiliations></json:item><json:item><name>SIMON CARRINGTON</name><affiliations><json:string>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</json:string></affiliations></json:item><json:item><name>ANDREW J. GEALL</name><affiliations><json:string>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</json:string></affiliations></json:item></author><articleId><json:string>JPHP258</json:string></articleId><arkIstex>ark:/67375/WNG-ZCL4DBCZ-X</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The family of polyamines and polyamine amides, especially unsymmetrical synthetic members, is critically assessed with respect to chemical structure and pharmacological activity. Naturally occurring polyamines (and diamines) and mono‐ (and di‐) acylated polyamines (polyamine amides) are blockers of cation channels that are receptor‐ or voltage‐gated. Such compounds are leads for the design of novel therapeutic agents. Furthermore, polyamines and polyamine amides are templates for the design of synthetic vectors with potential application in gene therapy. Natural di‐ and polyamines, spider and wasp venom polyamine amide toxins and their analogues, and totally synthetic polyamines, are potent cation‐channel blockers with uses as selective receptor probes for nicotinic acetylcholine and glutamate (NMDA and non‐NMDA) receptors, sodium and calcium channels. Therefore, as receptor probes, they may help us to understand the molecular mechanisms of neurodegeneration, and ultimately to design drugs for the treatment of neurodegenerative diseases, especially stroke. Polyamine conjugates are also novel therapeutic lead compounds for possible treatments of cancer, diarrhoea, malaria and haemochromatosis (β‐thalassaemia). The metal chelating properties of (poly‐) ethylenediamines have led to their incorporation in ion chelators which are synthetic RNase and DNase enzymes. Synthetic polyamines and polyamine amides have potential as novel vectors in gene delivery. Such compounds can condense DNA to form toroidal particles which may be incorporated in a non‐viral gene delivery system. The applications of polylysine, polyethylenimine, Starburst polyamidoamine dendrimers, Transfectam (DOGS), cholic acid, and cholesterol conjugates to gene therapy are compared as a function of structure and pKa. This assessment of polyamines and polyamine amides stresses the basicity of the amine functional groups. The pKa's of these functionalities are a major determinant in their binding to biological macromolecules. Selectivity of pharmacological action also encompasses contributions from solution conformation and lipophilicity as well as amine pKa. The use of these compounds as leads for the design of novel therapeutics or gene medicines is demonstrated to be practical as well as theoretically possible.</abstract><qualityIndicators><score>10</score><pdfWordCount>6654</pdfWordCount><pdfCharCount>43348</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>576 x 856.559 pts</pdfPageSize><pdfWordsPerPage>605</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>316</abstractWordCount><abstractCharCount>2312</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy</title><genre><json:string>article</json:string></genre><host><title>Pharmacy and Pharmacology Communications</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)2042-7158a</json:string></doi><issn><json:string>1460-8081</json:string></issn><eissn><json:string>2042-7158</json:string></eissn><publisherId><json:string>JPHP</json:string></publisherId><volume>3</volume><issue>5‐6</issue><pages><first>223</first><last>233</last><total>11</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1997</json:string></date><geogName></geogName><orgName><json:string>H CO</json:string><json:string>H H CO</json:string><json:string>UK Abstract The</json:string><json:string>University of Bath</json:string><json:string>Nuffield Foundation Science Lecturer</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Studies</json:string><json:string>Bergeron</json:string></persName><placeName><json:string>COS</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Breslow 1995</json:string><json:string>Albert & Serjeant 1984</json:string><json:string>Behr 1986</json:string><json:string>Tabor & Tabor 1984</json:string><json:string>Fischer & Bohn 1957</json:string><json:string>Tabor ( 1964)</json:string><json:string>Walker et al 1996</json:string><json:string>Porter et a1 1982, 1985</json:string><json:string>1987, 1989</json:string><json:string>Stewart & Gray 1992</json:string><json:string>Cohen & Smith 1990</json:string><json:string>Moya & Blagbrough 1994</json:string><json:string>Fairlamb & Cerami 1992</json:string><json:string>Gilbo & Coles 1964</json:string><json:string>Blagbrough & Moya 1994</json:string><json:string>Rodger et a1 1994, 1995</json:string><json:string>Seiler & Dezeure 1990</json:string><json:string>Behr 1993</json:string><json:string>Bergeron 1984</json:string><json:string>Temin 1990</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-ZCL4DBCZ-X</json:string></ark><categories><wos></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - pharmacology & pharmacy</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Pharmaceutical Science</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Pharmacology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>1997</publicationDate><copyrightDate>1997</copyrightDate><doi><json:string>10.1111/j.2042-7158.1997.tb00258.x</json:string></doi><id>387646E2F0E6D32C59D1D26510CA94142513B184</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-ZCL4DBCZ-X/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-ZCL4DBCZ-X/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-ZCL4DBCZ-X/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>1997 Royal Pharmaceutical Society of Great Britain</licence></availability><date type="published" when="1997-05-06"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">IAN S.</forename><surname>BLAGBROUGH</surname></persName><affiliation><orgName type="department">School of Pharmacy and Pharmacology</orgName><orgName type="institution">University of Bath</orgName><address><addrLine>Bath BA2 7AY</addrLine><addrLine>UK</addrLine><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">SIMON</forename><surname>CARRINGTON</surname></persName><affiliation><orgName type="department">School of Pharmacy and Pharmacology</orgName><orgName type="institution">University of Bath</orgName><address><addrLine>Bath BA2 7AY</addrLine><addrLine>UK</addrLine><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">ANDREW J.</forename><surname>GEALL</surname></persName><affiliation><orgName type="department">School of Pharmacy and Pharmacology</orgName><orgName type="institution">University of Bath</orgName><address><addrLine>Bath BA2 7AY</addrLine><addrLine>UK</addrLine><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><idno type="istex">387646E2F0E6D32C59D1D26510CA94142513B184</idno><idno type="ark">ark:/67375/WNG-ZCL4DBCZ-X</idno><idno type="DOI">10.1111/j.2042-7158.1997.tb00258.x</idno><idno type="unit">JPHP258</idno><idno type="toTypesetVersion">file:JPHP.JPHP258.pdf</idno></analytic><monogr><title level="j" type="main">Pharmacy and Pharmacology Communications</title><title level="j" type="alt">PHARMACY AND PHARMACOLOGY COMMUNICATIONS</title><idno type="pISSN">1460-8081</idno><idno type="eISSN">2042-7158</idno><idno type="book-DOI">10.1111/(ISSN)2042-7158a</idno><idno type="book-part-DOI">10.1111/jphp.1997.3.issue-5-6</idno><idno type="product">JPHP</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">3</biblScope><biblScope unit="issue">5‐6</biblScope><biblScope unit="page" from="223">223</biblScope><biblScope unit="page" to="233">233</biblScope><biblScope unit="page-count">11</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1997-05-06"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>The family of polyamines and polyamine amides, especially unsymmetrical synthetic members, is critically assessed with respect to chemical structure and pharmacological activity. Naturally occurring polyamines (and diamines) and mono‐ (and di‐) acylated polyamines (polyamine amides) are blockers of cation channels that are receptor‐ or voltage‐gated. Such compounds are leads for the design of novel therapeutic agents. Furthermore, polyamines and polyamine amides are templates for the design of synthetic vectors with potential application in gene therapy.</p><p>Natural di‐ and polyamines, spider and wasp venom polyamine amide toxins and their analogues, and totally synthetic polyamines, are potent cation‐channel blockers with uses as selective receptor probes for nicotinic acetylcholine and glutamate (NMDA and non‐NMDA) receptors, sodium and calcium channels. Therefore, as receptor probes, they may help us to understand the molecular mechanisms of neurodegeneration, and ultimately to design drugs for the treatment of neurodegenerative diseases, especially stroke. Polyamine conjugates are also novel therapeutic lead compounds for possible treatments of cancer, diarrhoea, malaria and haemochromatosis (β‐thalassaemia). The metal chelating properties of (poly‐) ethylenediamines have led to their incorporation in ion chelators which are synthetic RNase and DNase enzymes. Synthetic polyamines and polyamine amides have potential as novel vectors in gene delivery. Such compounds can condense DNA to form toroidal particles which may be incorporated in a non‐viral gene delivery system. The applications of polylysine, polyethylenimine, Starburst polyamidoamine dendrimers, Transfectam (DOGS), cholic acid, and cholesterol conjugates to gene therapy are compared as a function of structure and pKa.</p><p>This assessment of polyamines and polyamine amides stresses the basicity of the amine functional groups. The pKa's of these functionalities are a major determinant in their binding to biological macromolecules. Selectivity of pharmacological action also encompasses contributions from solution conformation and lipophilicity as well as amine pKa. The use of these compounds as leads for the design of novel therapeutics or gene medicines is demonstrated to be practical as well as theoretically possible.</p></abstract><textClass><keywords rend="tocHeading1"><term>Original Article</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-ZCL4DBCZ-X/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)2042-7158a</doi><issn type="print">1460-8081</issn><issn type="electronic">2042-7158</issn><idGroup><id type="product" value="JPHP"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="PHARMACY AND PHARMACOLOGY COMMUNICATIONS">Pharmacy and Pharmacology Communications</title></titleGroup></publicationMeta><publicationMeta level="part" position="05105"><doi origin="wiley">10.1111/jphp.1997.3.issue-5-6</doi><numberingGroup><numbering type="journalVolume" number="3">3</numbering><numbering type="journalIssue">5‐6</numbering></numberingGroup><coverDate startDate="1997-05-06">May‐June 1997</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="4" status="forIssue"><doi origin="wiley">10.1111/j.2042-7158.1997.tb00258.x</doi><idGroup><id type="unit" value="JPHP258"></id></idGroup><countGroup><count type="pageTotal" number="11"></count></countGroup><titleGroup><title type="tocHeading1">Original Article</title></titleGroup><copyright>1997 Royal Pharmaceutical Society of Great Britain</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.4.7 mode:FullText" date="2011-03-10"></event><event type="firstOnline" date="2011-03-11"></event><event type="publishedOnlineFinalForm" date="2011-03-11"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-03"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="223">223</numbering><numbering type="pageLast" number="233">233</numbering></numberingGroup><correspondenceTo>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JPHP.JPHP258.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="referenceTotal" number="82"></count><count type="linksCrossRef" number="4"></count></countGroup><titleGroup><title type="main">Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>IAN S.</givenNames><familyName>BLAGBROUGH</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>SIMON</givenNames><familyName>CARRINGTON</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>ANDREW J.</givenNames><familyName>GEALL</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="GB"><unparsedAffiliation>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The family of polyamines and polyamine amides, especially unsymmetrical synthetic members, is critically assessed with respect to chemical structure and pharmacological activity. Naturally occurring polyamines (and diamines) and mono‐ (and di‐) acylated polyamines (polyamine amides) are blockers of cation channels that are receptor‐ or voltage‐gated. Such compounds are leads for the design of novel therapeutic agents. Furthermore, polyamines and polyamine amides are templates for the design of synthetic vectors with potential application in gene therapy.</p><p>Natural di‐ and polyamines, spider and wasp venom polyamine amide toxins and their analogues, and totally synthetic polyamines, are potent cation‐channel blockers with uses as selective receptor probes for nicotinic acetylcholine and glutamate (NMDA and non‐NMDA) receptors, sodium and calcium channels. Therefore, as receptor probes, they may help us to understand the molecular mechanisms of neurodegeneration, and ultimately to design drugs for the treatment of neurodegenerative diseases, especially stroke. Polyamine conjugates are also novel therapeutic lead compounds for possible treatments of cancer, diarrhoea, malaria and haemochromatosis (β‐thalassaemia). The metal chelating properties of (poly‐) ethylenediamines have led to their incorporation in ion chelators which are synthetic RNase and DNase enzymes. Synthetic polyamines and polyamine amides have potential as novel vectors in gene delivery. Such compounds can condense DNA to form toroidal particles which may be incorporated in a non‐viral gene delivery system. The applications of polylysine, polyethylenimine, Starburst polyamidoamine dendrimers, Transfectam (DOGS), cholic acid, and cholesterol conjugates to gene therapy are compared as a function of structure and pKa.</p><p>This assessment of polyamines and polyamine amides stresses the basicity of the amine functional groups. The pKa's of these functionalities are a major determinant in their binding to biological macromolecules. Selectivity of pharmacological action also encompasses contributions from solution conformation and lipophilicity as well as amine pKa. The use of these compounds as leads for the design of novel therapeutics or gene medicines is demonstrated to be practical as well as theoretically possible.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy</title></titleInfo><name type="personal"><namePart type="given">IAN S.</namePart><namePart type="family">BLAGBROUGH</namePart><affiliation>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</affiliation><affiliation>Correspondence address: School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SIMON</namePart><namePart type="family">CARRINGTON</namePart><affiliation>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ANDREW J.</namePart><namePart type="family">GEALL</namePart><affiliation>School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1997-05-06</dateIssued><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">82</extent><extent unit="linksCrossRef">4</extent></physicalDescription><abstract lang="en">The family of polyamines and polyamine amides, especially unsymmetrical synthetic members, is critically assessed with respect to chemical structure and pharmacological activity. Naturally occurring polyamines (and diamines) and mono‐ (and di‐) acylated polyamines (polyamine amides) are blockers of cation channels that are receptor‐ or voltage‐gated. Such compounds are leads for the design of novel therapeutic agents. Furthermore, polyamines and polyamine amides are templates for the design of synthetic vectors with potential application in gene therapy. Natural di‐ and polyamines, spider and wasp venom polyamine amide toxins and their analogues, and totally synthetic polyamines, are potent cation‐channel blockers with uses as selective receptor probes for nicotinic acetylcholine and glutamate (NMDA and non‐NMDA) receptors, sodium and calcium channels. Therefore, as receptor probes, they may help us to understand the molecular mechanisms of neurodegeneration, and ultimately to design drugs for the treatment of neurodegenerative diseases, especially stroke. Polyamine conjugates are also novel therapeutic lead compounds for possible treatments of cancer, diarrhoea, malaria and haemochromatosis (β‐thalassaemia). The metal chelating properties of (poly‐) ethylenediamines have led to their incorporation in ion chelators which are synthetic RNase and DNase enzymes. Synthetic polyamines and polyamine amides have potential as novel vectors in gene delivery. Such compounds can condense DNA to form toroidal particles which may be incorporated in a non‐viral gene delivery system. The applications of polylysine, polyethylenimine, Starburst polyamidoamine dendrimers, Transfectam (DOGS), cholic acid, and cholesterol conjugates to gene therapy are compared as a function of structure and pKa. This assessment of polyamines and polyamine amides stresses the basicity of the amine functional groups. The pKa's of these functionalities are a major determinant in their binding to biological macromolecules. Selectivity of pharmacological action also encompasses contributions from solution conformation and lipophilicity as well as amine pKa. The use of these compounds as leads for the design of novel therapeutics or gene medicines is demonstrated to be practical as well as theoretically possible.</abstract><relatedItem type="host"><titleInfo><title>Pharmacy and Pharmacology Communications</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1460-8081</identifier><identifier type="eISSN">2042-7158</identifier><identifier type="DOI">10.1111/(ISSN)2042-7158a</identifier><identifier type="PublisherID">JPHP</identifier><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><detail type="issue"><caption>no.</caption><number>5‐6</number></detail><extent unit="pages"><start>223</start><end>233</end><total>11</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Multiple binding modes with DNA of anthracene‐9‐carbonyl‐N1‐spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine</title></titleInfo><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Adlam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. C.</namePart><namePart type="family">Latham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Haworth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rodger</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Adlam, G., Blagbrough, I. S., Taylor, S., Latham, H. C., Haworth, I. S., Rodger, A. (1994) Multiple binding modes with DNA of anthracene‐9‐carbonyl‐N1‐spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine. Bioorg. Med. Chem. Lett. 4: 2435–2440.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>2435</start><end>2440</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg. Med. Chem. Lett.</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>2435</start><end>2440</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Albert, A., Serjeant, E. P. (1984) The Determination of Ionization Constants. 3rd edn, Chapman and Hall, London, pp 138–139.</title></titleInfo><note type="citation/reference">Albert, A., Serjeant, E. P. (1984) The Determination of Ionization Constants. 3rd edn, Chapman and Hall, London, pp 138–139.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Albert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. P.</namePart><namePart type="family">Serjeant</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Chapman and Hall</publisher></originInfo><part><date>1984</date><extent unit="pages"><start>138</start><end>139</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Structure of viral DNA condensed by simple triamines: a light‐scattering and electron microscope study</title></titleInfo><name type="personal"><namePart type="given">S. A.</namePart><namePart type="family">Allison</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. C.</namePart><namePart type="family">Herr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Schurr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Allison, S. A., Herr, J. C., Schurr, J. M. (1981) Structure of viral DNA condensed by simple triamines: a light‐scattering and electron microscope study. Biopolymers 20: 469–488.</note><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>469</start><end>488</end></extent></part><relatedItem type="host"><titleInfo><title>Biopolymers</title></titleInfo><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>469</start><end>488</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Effects of the ornithine decarboxylase inhibitors DL‐α‐difluoromethylornithine and α‐monofluoromethyldehydroornithine methyl‐ester alone and in combination with suramin against Trypanosoma‐brucei‐brucei central nervous system models</title></titleInfo><name type="personal"><namePart type="given">C. J.</namePart><namePart type="family">Bacchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. C.</namePart><namePart type="family">Nathan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. B.</namePart><namePart type="family">Clarkson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. J.</namePart><namePart type="family">Bienen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Bitonti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. P.</namePart><namePart type="family">McCann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Sjoerdsma</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bacchi, C. J., Nathan, H. C., Clarkson, A. B., Bienen, E. J., Bitonti, A. J., McCann, P. P., Sjoerdsma, A. (1987) Effects of the ornithine decarboxylase inhibitors DL‐α‐difluoromethylornithine and α‐monofluoromethyldehydroornithine methyl‐ester alone and in combination with suramin against Trypanosoma‐brucei‐brucei central nervous system models. Am. J. Trop. Med. Hyg. 36: 46–52.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>46</start><end>52</end></extent></part><relatedItem type="host"><titleInfo><title>Am. J. Trop. Med. Hyg.</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>46</start><end>52</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Effect of polyamine depletion on chromatin structure in U‐87 MG human brain‐tumour cells</title></titleInfo><name type="personal"><namePart type="given">H. S.</namePart><namePart type="family">Basu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. C. J. M.</namePart><namePart type="family">Sturkenboom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.‐G.</namePart><namePart type="family">Delcros</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. P.</namePart><namePart type="family">Csokan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Szollosi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. G.</namePart><namePart type="family">Feuerstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. J.</namePart><namePart type="family">Marton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Basu, H. S., Sturkenboom, M. C. J. M., Delcros, J.‐G., Csokan, P. P., Szollosi, J., Feuerstein, B. G., Marton, L. J. (1992) Effect of polyamine depletion on chromatin structure in U‐87 MG human brain‐tumour cells. Biochem. J. 282: 723–727.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>282</number></detail><extent unit="pages"><start>723</start><end>727</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem. J.</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>282</number></detail><extent unit="pages"><start>723</start><end>727</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>DNA strongly binds to micelles and vesicles containing lipopolyamines or lipointercalants</title></titleInfo><name type="personal"><namePart type="given">J.‐P.</namePart><namePart type="family">Behr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Behr, J.‐P. (1986) DNA strongly binds to micelles and vesicles containing lipopolyamines or lipointercalants. Tetrahedron Lett. 27: 5861–5864.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>5861</start><end>5864</end></extent></part><relatedItem type="host"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>5861</start><end>5864</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Synthetic gene‐transfer vectors</title></titleInfo><name type="personal"><namePart type="given">J.‐P.</namePart><namePart type="family">Behr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Behr, J.‐P. (1993) Synthetic gene‐transfer vectors. Acc. Chem. Res. 26: 274–278.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>274</start><end>278</end></extent></part><relatedItem type="host"><titleInfo><title>Acc. Chem. Res.</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>274</start><end>278</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine‐coated DNA</title></titleInfo><name type="personal"><namePart type="given">J.‐P.</namePart><namePart type="family">Behr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Demeneix</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.‐P.</namePart><namePart type="family">Loeffler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Perez‐Mutul</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Behr, J.‐P., Demeneix, B., Loeffler, J.‐P., Perez‐Mutul, J. (1989) Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine‐coated DNA. Proc. Natl Acad. Sci. USA 86: 6982–6986.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>86</number></detail><extent unit="pages"><start>6982</start><end>6986</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl Acad. Sci. USA</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>86</number></detail><extent unit="pages"><start>6982</start><end>6986</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Effects of spermine and spermidine on gastric emptying in rats</title></titleInfo><name type="personal"><namePart type="given">E. J.</namePart><namePart type="family">Belair</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. R.</namePart><namePart type="family">Carlson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Melamed</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. N.</namePart><namePart type="family">Moss</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. F.</namePart><namePart type="family">Tansy</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Belair, E. J., Carlson, G. R., Melamed, S., Moss, J. N., Tansy, M. F. (1981) Effects of spermine and spermidine on gastric emptying in rats. J. Pharm. Sci. 70: 347.</note><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><extent unit="pages"><start>347</start></extent></part><relatedItem type="host"><titleInfo><title>J. Pharm. Sci.</title></titleInfo><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><extent unit="pages"><start>347</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Synthesis and solution structure of microbial siderophores</title></titleInfo><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Bergeron</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bergeron, R. J. (1984) Synthesis and solution structure of microbial siderophores. Chem. Rev. 84: 587–602.</note><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>587</start><end>602</end></extent></part><relatedItem type="host"><titleInfo><title>Chem. Rev.</title></titleInfo><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>587</start><end>602</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Synthetic polyamine analogues as antineoplastics</title></titleInfo><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Bergeron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. H.</namePart><namePart type="family">Neims</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. S.</namePart><namePart type="family">McManis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. R.</namePart><namePart type="family">Hawthorne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. R. T.</namePart><namePart type="family">Vinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Bortell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Ingeno</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bergeron, R. J., Neims, A. H., McManis, J. S., Hawthorne, T. R., Vinson, J. R. T., Bortell, R., Ingeno, M. J. (1987) Synthetic polyamine analogues as antineoplastics. J. Med. Chem. 31: 1183–1190.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>1183</start><end>1190</end></extent></part><relatedItem type="host"><titleInfo><title>J. Med. Chem.</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>1183</start><end>1190</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells</title></titleInfo><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Bergeron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. R.</namePart><namePart type="family">Hawthorne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. R. T.</namePart><namePart type="family">Vinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. E.</namePart><namePart type="family">Beck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Ingeno</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bergeron, R. J., Hawthorne, T. R., Vinson, J. R. T., Beck, D. E., Ingeno, M. J. (1989) Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells. Cancer Res. 49: 2959–2964.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>2959</start><end>2964</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Res.</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>2959</start><end>2964</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Metabolically programmed polyamine analogue antidiarrhoeals</title></titleInfo><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Bergeron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. W.</namePart><namePart type="family">Yao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Yao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. R.</namePart><namePart type="family">Weimar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. A.</namePart><namePart type="family">Sninsky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Raisler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Feng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bergeron, R. J., Yao, G. W., Yao, H., Weimar, W. R., Sninsky, C. A., Raisler, B., Feng, Y., Wu, Q., Gao, F. (1996) Metabolically programmed polyamine analogue antidiarrhoeals. J. Med. Chem. 39: 2461–2471.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>2461</start><end>2471</end></extent></part><relatedItem type="host"><titleInfo><title>J. Med. Chem.</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>2461</start><end>2471</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Bis(benzyl)polyamine analogs inhibit the growth of chloroquine‐resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with α‐difluoromethylornithine cure murine malaria</title></titleInfo><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Bitonti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Dumont</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. L.</namePart><namePart type="family">Bush</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Edwards</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. M.</namePart><namePart type="family">Stemerick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. P.</namePart><namePart type="family">McCann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Sjoerdsma</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bitonti, A. J., Dumont, J. A., Bush, T. L., Edwards, M. L., Stemerick, D. M., McCann, P. P., Sjoerdsma, A. (1989) Bis(benzyl)polyamine analogs inhibit the growth of chloroquine‐resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with α‐difluoromethylornithine cure murine malaria. Proc. Natl Acad. Sci. USA 86: 651–655.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>86</number></detail><extent unit="pages"><start>651</start><end>655</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl Acad. Sci. USA</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>86</number></detail><extent unit="pages"><start>651</start><end>655</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Practical synthesis of the putative polyamine spider toxin FTX: a proposed blocker of voltage‐sensitive calcium channels</title></titleInfo><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Moya</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Blagbrough, I. S., Moya, E. (1994) Practical synthesis of the putative polyamine spider toxin FTX: a proposed blocker of voltage‐sensitive calcium channels. Tetrahedron Lett. 35: 2057–2060.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>2057</start><end>2060</end></extent></part><relatedItem type="host"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>2057</start><end>2060</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Polyamine amide toxins as pharmacological tools and pharmaceutical agents</title></titleInfo><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. N. R.</namePart><namePart type="family">Usherwood</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Blagbrough, I. S., Usherwood, P. N. R. (1992) Polyamine amide toxins as pharmacological tools and pharmaceutical agents. Proc. R. Soc. Edin. 99B: 67–81.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>99B</number></detail><extent unit="pages"><start>67</start><end>81</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. R. Soc. Edin.</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>99B</number></detail><extent unit="pages"><start>67</start><end>81</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>A versatile vector for gene and oligonucleotide transfer into cells in culture and in‐vivo: polyethylenimine</title></titleInfo><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Boussif</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Lezoualc'h</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Zanta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. D.</namePart><namePart type="family">Mergny</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Scherman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Demeneix</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. P.</namePart><namePart type="family">Behr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., Behr, J. P. (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in‐vivo: polyethylenimine. Proc. Natl Acad. Sci. USA 92: 7297–7301.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>92</number></detail><extent unit="pages"><start>7297</start><end>7301</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl Acad. Sci. USA</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>92</number></detail><extent unit="pages"><start>7297</start><end>7301</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Biomimetic chemistry and artificial enzymes: catalysis by design</title></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Breslow</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Breslow, R. (1995) Biomimetic chemistry and artificial enzymes: catalysis by design. Acc. Chem. Res. 28: 146–153.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>146</start><end>153</end></extent></part><relatedItem type="host"><titleInfo><title>Acc. Chem. Res.</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>146</start><end>153</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Inhibition of the growth of B16 murine melanoma cells by novel spermine analogues</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Carrington</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Qarawi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. H.</namePart><namePart type="family">Moss</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. W.</namePart><namePart type="family">Pouton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Carrington, S., Qarawi, M. A., Blagbrough, I. S., Moss, S. H., Pouton, C. W. (1996) Inhibition of the growth of B16 murine melanoma cells by novel spermine analogues. Pharm. Sci. 2: 25–27.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>25</start><end>27</end></extent></part><relatedItem type="host"><titleInfo><title>Pharm. Sci.</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>25</start><end>27</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Carter, C. (1995) The Neuropharmacology of Polyamines. Academic Press, San Diego.</title></titleInfo><note type="citation/reference">Carter, C. (1995) The Neuropharmacology of Polyamines. Academic Press, San Diego.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Carter</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Academic Press</publisher></originInfo><part><date>1995</date></part></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Potential therapeutic exploitation of the pulmonary polyamine uptake system</title></titleInfo><name type="personal"><namePart type="given">G. M.</namePart><namePart type="family">Cohen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. L.</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cohen, G. M., Smith, L. L. (1990) Potential therapeutic exploitation of the pulmonary polyamine uptake system. Biochem. Soc. Trans. 18: 743–745.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>743</start><end>745</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem. Soc. Trans.</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>743</start><end>745</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>Targeting of cytotoxic agents by polyamines: synthesis of a chlorambucil‐spermidine conjugate</title></titleInfo><name type="personal"><namePart type="given">G. M.</namePart><namePart type="family">Cohen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. M.</namePart><namePart type="family">Cullis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Hartley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Mather</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. C. R.</namePart><namePart type="family">Symons</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. T.</namePart><namePart type="family">Wheelhouse</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cohen, G. M., Cullis, P. M., Hartley, J. A., Mather, A., Symons, M. C. R., Wheelhouse, R. T. (1992) Targeting of cytotoxic agents by polyamines: synthesis of a chlorambucil‐spermidine conjugate. J. Chem. Soc. Chem. Comm. 298–300.</note><part><date>1992</date><extent unit="pages"><start>298</start><end>300</end></extent></part><relatedItem type="host"><titleInfo><title>J. Chem. Soc. Chem. Comm.</title></titleInfo><part><date>1992</date><extent unit="pages"><start>298</start><end>300</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Transferrin polycation‐mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Cotten</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Längle‐Rouault</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Kirlappos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Wagner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Mechtler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Zenke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Beug</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Birnstiel</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cotten, M., Längle‐Rouault, F., Kirlappos, H., Wagner, E., Mechtler, K., Zenke, M., Beug, H., Birnstiel, M. L. (1990) Transferrin polycation‐mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc. Natl Acad. Sci. USA 87: 4033–4037.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>4033</start><end>4037</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl Acad. Sci. USA</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>4033</start><end>4037</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Conjugation of a polyamine to the bifunctional alkylating agent chlorambucil does not alter the preferred cross‐linking site in duplex DNA</title></titleInfo><name type="personal"><namePart type="given">P. M.</namePart><namePart type="family">Cullis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Merson‐Davies</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Weaver</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cullis, P. M., Merson‐Davies, L., Weaver, R. (1995) Conjugation of a polyamine to the bifunctional alkylating agent chlorambucil does not alter the preferred cross‐linking site in duplex DNA. J. Am. Chem. Soc. 117: 8033–8034.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>117</number></detail><extent unit="pages"><start>8033</start><end>8034</end></extent></part><relatedItem type="host"><titleInfo><title>J. Am. Chem. Soc.</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>117</number></detail><extent unit="pages"><start>8033</start><end>8034</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>Antitumour acridines.</title></titleInfo><name type="personal"><namePart type="given">W. A.</namePart><namePart type="family">Denny</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. C.</namePart><namePart type="family">Baguley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. F.</namePart><namePart type="family">Cain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Waring</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>Molecular Aspects of Anti‐Cancer Drug Design</title></titleInfo><originInfo><publisher>Macmillan</publisher></originInfo><part><date>1983</date><extent unit="pages"><start>1</start><end>34</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Differential inhibition of Ca2+ channels in mature rat cerebellar purkinje cells by sFTX‐3.3 and FTX‐3.3</title></titleInfo><name type="personal"><namePart type="given">J. R. B.</namePart><namePart type="family">Dupere</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Moya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. M.</namePart><namePart type="family">Usowicz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dupere, J. R. B., Moya, E., Blagbrough, I. S., Usowicz, M. M. (1996) Differential inhibition of Ca2+ channels in mature rat cerebellar purkinje cells by sFTX‐3.3 and FTX‐3.3. Neuropharmacology 35: 1–11.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>1</start><end>11</end></extent></part><relatedItem type="host"><titleInfo><title>Neuropharmacology</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>1</start><end>11</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Antimalarial polyamine analogs</title></titleInfo><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Edwards</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. M.</namePart><namePart type="family">Stemerick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Bitonti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Dumont</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. P.</namePart><namePart type="family">McCann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Bey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Sjoerdsma</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Edwards, M. L., Stemerick, D. M., Bitonti, A. J., Dumont, J. A., McCann, P. P., Bey, P., Sjoerdsma, A. (1991) Antimalarial polyamine analogs. J. Med. Chem. 34: 569–574.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>569</start><end>574</end></extent></part><relatedItem type="host"><titleInfo><title>J. Med. Chem.</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>569</start><end>574</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>Metabolism and functions of trypanothione in the kinetoplastida</title></titleInfo><name type="personal"><namePart type="given">A. H.</namePart><namePart type="family">Fairlamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Cerami</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Fairlamb, A. H., Cerami, A. (1992) Metabolism and functions of trypanothione in the kinetoplastida. Ann. Rev. Microbiol. 46: 695–729.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>695</start><end>729</end></extent></part><relatedItem type="host"><titleInfo><title>Ann. Rev. Microbiol.</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>695</start><end>729</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit29"><titleInfo><title>Lipofection: A highly efficient lipid‐mediated DNA‐transfection procedure</title></titleInfo><name type="personal"><namePart type="given">P. L.</namePart><namePart type="family">Felgner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. R.</namePart><namePart type="family">Gadek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Holm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Roman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. W.</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Wenz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. P.</namePart><namePart type="family">Northrop</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. M.</namePart><namePart type="family">Ringold</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Danielsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., Ringold, G. M., Danielsen, M. (1987) Lipofection: A highly efficient lipid‐mediated DNA‐transfection procedure. Proc. Natl Acad. Sci. USA 84: 7413–7417.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>7413</start><end>7417</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl Acad. Sci. USA</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>7413</start><end>7417</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit30"><titleInfo><title>Molecular mechanics of the interactions of spermine with DNA: DNA bending as a result of ligand binding</title></titleInfo><name type="personal"><namePart type="given">B. G.</namePart><namePart type="family">Feuerstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Pattabiraman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. J.</namePart><namePart type="family">Marton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Feuerstein, B. G., Pattabiraman, N., Marton, L. J. (1990) Molecular mechanics of the interactions of spermine with DNA: DNA bending as a result of ligand binding. Nucleic Acids Res. 18: 1271–1282.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>1271</start><end>1282</end></extent></part><relatedItem type="host"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>1271</start><end>1282</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit31"><titleInfo><title>Spermine and spermidine as gating molecules for inward rectifier K+ channels</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Ficker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Taglialatela</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. A.</namePart><namePart type="family">Wible</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. M.</namePart><namePart type="family">Henly</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. M.</namePart><namePart type="family">Brown</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ficker E., Taglialatela, M., Wible, B. A., Henly, C. M., Brown, A. M. (1994) Spermine and spermidine as gating molecules for inward rectifier K+ channels. Science 266: 1068–1072.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>266</number></detail><extent unit="pages"><start>1068</start><end>1072</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>266</number></detail><extent unit="pages"><start>1068</start><end>1072</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit32"><titleInfo><title>Die giftsekrete der Volgenspinnen</title></titleInfo><name type="personal"><namePart type="given">F. G.</namePart><namePart type="family">Fischer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Bohn</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Fischer, F. G., Bohn, H. (1957) Die giftsekrete der Volgenspinnen. Justus Liebigs Annalen der Chemie 603: 232–250.</note><part><date>1957</date><detail type="volume"><caption>vol.</caption><number>603</number></detail><extent unit="pages"><start>232</start><end>250</end></extent></part><relatedItem type="host"><titleInfo><title>Justus Liebigs Annalen der Chemie</title></titleInfo><part><date>1957</date><detail type="volume"><caption>vol.</caption><number>603</number></detail><extent unit="pages"><start>232</start><end>250</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit33"><titleInfo><title>An investigation of certain components of the venom of the female Sydney funnel web spider, Atrax robustus CAMBR</title></titleInfo><name type="personal"><namePart type="given">C. M.</namePart><namePart type="family">Gilbo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. W.</namePart><namePart type="family">Coles</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gilbo, C. M., Coles, N. W. (1964) An investigation of certain components of the venom of the female Sydney funnel web spider, Atrax robustus CAMBR. Aust. J. Biol. Sci. 17: 758–763.</note><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>758</start><end>763</end></extent></part><relatedItem type="host"><titleInfo><title>Aust. J. Biol. Sci.</title></titleInfo><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>758</start><end>763</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit34"><titleInfo><title>S‐(5′‐Deoxy‐5′‐adenosyl)‐1‐aminoxy‐4‐(methylsulfonio)‐2‐cyclopentene (ADOMAO) ‐ an irreversible inhibitor of S‐adenosylmethioninedecarboxylase with potent in vitro antitrypanosomal activity</title></titleInfo><name type="personal"><namePart type="given">J. Q.</namePart><namePart type="family">Guo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y. Q.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Rattendi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. J.</namePart><namePart type="family">Bacchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. M.</namePart><namePart type="family">Woster</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Guo, J. Q., Wu, Y. Q., Rattendi, D., Bacchi, C. J., Woster, P. M. (1995) S‐(5′‐Deoxy‐5′‐adenosyl)‐1‐aminoxy‐4‐(methylsulfonio)‐2‐cyclopentene (ADOMAO) ‐ an irreversible inhibitor of S‐adenosylmethioninedecarboxylase with potent in vitro antitrypanosomal activity. J. Med. Chem. 38: 1770–1777.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>1770</start><end>1777</end></extent></part><relatedItem type="host"><titleInfo><title>J. Med. Chem.</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>1770</start><end>1777</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit35"><titleInfo><title>Novel polyaminolipids enhance the cellular uptake of oligonucleotides</title></titleInfo><name type="personal"><namePart type="given">J. K.</namePart><namePart type="family">Guy‐Caffey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Bodepudi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. S.</namePart><namePart type="family">Bishop</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Jayaraman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Chaudhary</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Guy‐Caffey, J. K., Bodepudi, V., Bishop, J. S., Jayaraman, K., Chaudhary, N. (1995) Novel polyaminolipids enhance the cellular uptake of oligonucleotides. J. Biol. Chem. 270: 31391–31396.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>270</number></detail><extent unit="pages"><start>31391</start><end>31396</end></extent></part><relatedItem type="host"><titleInfo><title>J. Biol. Chem.</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>270</number></detail><extent unit="pages"><start>31391</start><end>31396</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit36"><titleInfo><title>Molecular genetics of polyamine synthesis in eukaryotic cells</title></titleInfo><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Heby</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Persson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Heby, O., Persson, L. (1990) Molecular genetics of polyamine synthesis in eukaryotic cells. Trends Bio. Sci. 15: 153–158.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>153</start><end>158</end></extent></part><relatedItem type="host"><titleInfo><title>Trends Bio. Sci.</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>153</start><end>158</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit37"><titleInfo><title>DNA intercalators bearing metal chelating moiety. Ternary complexes of polyamine containing anthraquinone derivative‐DNA‐Cu(II) and its DNA cleaving activity</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Ihara</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Inenaga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Takagi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ihara, T., Inenaga, A., Takagi, M. (1994) DNA intercalators bearing metal chelating moiety. Ternary complexes of polyamine containing anthraquinone derivative‐DNA‐Cu(II) and its DNA cleaving activity. Chem. Lett. 1053–1056.</note><part><date>1994</date><extent unit="pages"><start>1053</start><end>1056</end></extent></part><relatedItem type="host"><titleInfo><title>Chem. Lett.</title></titleInfo><part><date>1994</date><extent unit="pages"><start>1053</start><end>1056</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit38"><titleInfo><title>Neuroactive polyamine wasp toxins: nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin‐343</title></titleInfo><name type="personal"><namePart type="given">J. W.</namePart><namePart type="family">Jaroszewski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Matzen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Frolund</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Krogsgaard‐Larsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jaroszewski, J. W., Matzen, L., Frolund B., Krogsgaard‐Larsen, P. (1996) Neuroactive polyamine wasp toxins: nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin‐343. J. Med. Chem. 39: 515–521.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>515</start><end>521</end></extent></part><relatedItem type="host"><titleInfo><title>J. Med. Chem.</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>515</start><end>521</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit39"><titleInfo><title>Efficient transfer of genetic material into mammalian cells using starburst polyamidoamine dendrimers</title></titleInfo><name type="personal"><namePart type="given">J. F.</namePart><namePart type="family">Kukowska‐Latallo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. U.</namePart><namePart type="family">Bielinska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Johnson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Spindler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. A.</namePart><namePart type="family">Tomalia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. R.</namePart><namePart type="family">Baker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kukowska‐Latallo, J. F., Bielinska, A. U., Johnson, J., Spindler, R., Tomalia, D. A., Baker, J. R. (1996) Efficient transfer of genetic material into mammalian cells using starburst polyamidoamine dendrimers. Proc. Natl Acad. Sci. USA 93: 4897–4902.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>4897</start><end>4902</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl Acad. Sci. USA</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>4897</start><end>4902</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit40"><titleInfo><title>Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung</title></titleInfo><name type="personal"><namePart type="given">E. R.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Marshall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. S.</namePart><namePart type="family">Siegel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Jiang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. S.</namePart><namePart type="family">Yew</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. R.</namePart><namePart type="family">Nichols</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lee, E. R., Marshall, J., Siegel, C. S., Jiang, C., Yew, N. S., Nichols, M. R. (1996) Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung. Hum. Gene Ther. 7: 1701–1717.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>1701</start><end>1717</end></extent></part><relatedItem type="host"><titleInfo><title>Hum. Gene Ther.</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>1701</start><end>1717</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit41"><titleInfo><title>Synthesis and antitumor evaluation of a highly potent cytotoxic DNA crosslinking polyamine analog *1, 12‐diaziridinyl‐4, 9‐diazododecane</title></titleInfo><name type="personal"><namePart type="given">Y. L.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. L.</namePart><namePart type="family">Eiseman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. L.</namePart><namePart type="family">Sentz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. A.</namePart><namePart type="family">Rogers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. S.</namePart><namePart type="family">Pan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. T.</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Egorin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. S.</namePart><namePart type="family">Callery</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Li, Y. L., Eiseman, J. L., Sentz, D. L., Rogers, F. A., Pan, S. S., Hu, L. T., Egorin, M. J., Callery, P. S. (1996) Synthesis and antitumor evaluation of a highly potent cytotoxic DNA crosslinking polyamine analog *1, 12‐diaziridinyl‐4, 9‐diazododecane. J. Med. Chem. 39: 339–341.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>339</start><end>341</end></extent></part><relatedItem type="host"><titleInfo><title>J. Med. Chem.</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>339</start><end>341</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit42"><titleInfo><title>Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification</title></titleInfo><name type="personal"><namePart type="given">A. N.</namePart><namePart type="family">Lopatin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. N.</namePart><namePart type="family">Makhina</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. G.</namePart><namePart type="family">Nichols</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lopatin, A. N., Makhina, E. N., Nichols, C. G. (1994) Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 372: 366–369.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>372</number></detail><extent unit="pages"><start>366</start><end>369</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>372</number></detail><extent unit="pages"><start>366</start><end>369</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit43"><titleInfo><title>Thermodynamics of cation induced DNA condensation</title></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Marquet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Houssier</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Marquet, R., Houssier, C. (1991) Thermodynamics of cation induced DNA condensation. J. Biomol. Struct. Dyn. 9: 159–167.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>159</start><end>167</end></extent></part><relatedItem type="host"><titleInfo><title>J. Biomol. Struct. Dyn.</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>159</start><end>167</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit44"><titleInfo><title>Polyamines as targets for therapeutic intervention</title></titleInfo><name type="personal"><namePart type="given">L. J.</namePart><namePart type="family">Marton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. E.</namePart><namePart type="family">Pegg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Marton, L. J., Pegg, A. E. (1995) Polyamines as targets for therapeutic intervention. Annu. Rev. Pharmacol. Toxicol. 35: 55–91.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>55</start><end>91</end></extent></part><relatedItem type="host"><titleInfo><title>Annu. Rev. Pharmacol. Toxicol.</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>55</start><end>91</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit45"><titleInfo><title>Total synthesis of 2′‐deoxymugenic acid and nicotianamine</title></titleInfo><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Matsuura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Hamada</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Shioiri</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Matsuura, F., Hamada, Y., Shioiri, T. (1994) Total synthesis of 2′‐deoxymugenic acid and nicotianamine. Tetrahedron 50: 9457–9470.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>9457</start><end>9470</end></extent></part><relatedItem type="host"><titleInfo><title>Tetrahedron</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>9457</start><end>9470</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit46"><titleInfo><title>GI pharmacology of polyethyleneimine I: effects on gastric emptying in rats</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Melamed</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. R.</namePart><namePart type="family">Carlson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. N.</namePart><namePart type="family">Moss</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. J.</namePart><namePart type="family">Belair</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. F.</namePart><namePart type="family">Tansy</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Melamed, S., Carlson, G. R., Moss, J. N., Belair, E. J., Tansy, M. F. (1977) GI pharmacology of polyethyleneimine I: effects on gastric emptying in rats. J. Pharm. Sci. 66: 899–901.</note><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>899</start><end>901</end></extent></part><relatedItem type="host"><titleInfo><title>J. Pharm. Sci.</title></titleInfo><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>899</start><end>901</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit47"><titleInfo><title>Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C. 4.1.1.17) by substrate and product analogues</title></titleInfo><name type="personal"><namePart type="given">B. W.</namePart><namePart type="family">Metcalf</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Bey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Danzin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Jung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Casara</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. P.</namePart><namePart type="family">Vevert</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Metcalf, B. W., Bey, P., Danzin, C., Jung, M. J., Casara, P., Vevert, J. P. (1978) Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C. 4.1.1.17) by substrate and product analogues. J. Am. Chem. Soc. 100: 2551–2553.</note><part><date>1978</date><detail type="volume"><caption>vol.</caption><number>100</number></detail><extent unit="pages"><start>2551</start><end>2553</end></extent></part><relatedItem type="host"><titleInfo><title>J. Am. Chem. Soc.</title></titleInfo><part><date>1978</date><detail type="volume"><caption>vol.</caption><number>100</number></detail><extent unit="pages"><start>2551</start><end>2553</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit48"><titleInfo><title>Efficient gene transfer into mammalian cells with cholesteryl‐spermidine</title></titleInfo><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Moradpour</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. I.</namePart><namePart type="family">Schauer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. R.</namePart><namePart type="family">Zurawski Jr.</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. R.</namePart><namePart type="family">Wands</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. H.</namePart><namePart type="family">Boutin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Moradpour, D., Schauer, J. I., Zurawski, Jr. V. R., Wands, J. R., Boutin, R. H. (1996) Efficient gene transfer into mammalian cells with cholesteryl‐spermidine. Biochem. Biophys. Res. Commun. 221: 82–88.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>221</number></detail><extent unit="pages"><start>82</start><end>88</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem. Biophys. Res. Commun.</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>221</number></detail><extent unit="pages"><start>82</start><end>88</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit49"><titleInfo><title>Rapid practical syntheses of the arginyl polyamine sFTX‐3.3: a blocker of voltage‐sensitive calcium channels</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Moya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Moya, E., Blagbrough, I. S. (1994) Rapid practical syntheses of the arginyl polyamine sFTX‐3.3: a blocker of voltage‐sensitive calcium channels. Tetrahedron Lett. 35: 2061–2062.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>2061</start><end>2062</end></extent></part><relatedItem type="host"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>2061</start><end>2062</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit50"><titleInfo><title>Pharmacology of polyamine toxins from spiders and wasps.</title></titleInfo><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Mueller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Roeloffs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Jackson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>The Alkaloids</title></titleInfo><originInfo><publisher>Academic Press</publisher></originInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>63</start><end>94</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit51"><titleInfo><title>Block of high‐threshold calcium channels by the synthetic polyamines sFTX‐3.3 and FTX‐3.3</title></titleInfo><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Norris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Moya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. E.</namePart><namePart type="family">Adams</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Norris, T. M., Moya, E., Blagbrough, I. S., Adams, M. E. (1996) Block of high‐threshold calcium channels by the synthetic polyamines sFTX‐3.3 and FTX‐3.3. Mol. Pharmacol. 50: 939–946.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>939</start><end>946</end></extent></part><relatedItem type="host"><titleInfo><title>Mol. Pharmacol.</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>939</start><end>946</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit52"><titleInfo><title>Chromatin models. The ionic strength dependence of model histone‐DNA interactions: circular dichroism studies of lysine‐leucine polypeptide‐DNA complexes</title></titleInfo><name type="personal"><namePart type="given">E. C.</namePart><namePart type="family">Ong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Snell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. D.</namePart><namePart type="family">Fasman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ong, E. C., Snell, C., Fasman, G. D. (1976) Chromatin models. The ionic strength dependence of model histone‐DNA interactions: circular dichroism studies of lysine‐leucine polypeptide‐DNA complexes. Biochemistry 15: 468–476.</note><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>468</start><end>476</end></extent></part><relatedItem type="host"><titleInfo><title>Biochemistry</title></titleInfo><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>468</start><end>476</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit53"><titleInfo><title>Chelating properties of linear aliphatic tetra‐amines with some bivalent transition metal ions. 1, 5, 8, 12‐Tetraazadodecane (3, 2, 3‐tet)</title></titleInfo><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Paoletti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Fabbrizzi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Barbucci</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Paoletti, P., Fabbrizzi, L., Barbucci, R. (1973) Chelating properties of linear aliphatic tetra‐amines with some bivalent transition metal ions. 1, 5, 8, 12‐Tetraazadodecane (3, 2, 3‐tet). Inorg. Chem. 12: 1861–1864.</note><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1861</start><end>1864</end></extent></part><relatedItem type="host"><titleInfo><title>Inorg. Chem.</title></titleInfo><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1861</start><end>1864</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit54"><titleInfo><title>Arylamine toxins from funnel‐web spider (Agelenopsis aperta) venom antagonize N‐methyl‐D‐aspartate receptor function in mammalian brain</title></titleInfo><name type="personal"><namePart type="given">T. N.</namePart><namePart type="family">Parks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Mueller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. D.</namePart><namePart type="family">Artman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. C.</namePart><namePart type="family">Albensi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. F.</namePart><namePart type="family">Nemeth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Jackson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. J.</namePart><namePart type="family">Jasys</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. A.</namePart><namePart type="family">Saccomano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Volkmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Parks, T. N., Mueller, A. L., Artman, L. D., Albensi, B. C., Nemeth, E. F., Jackson, H., Jasys, V. J., Saccomano, N. A., Volkmann, R. A. (1991) Arylamine toxins from funnel‐web spider (Agelenopsis aperta) venom antagonize N‐methyl‐D‐aspartate receptor function in mammalian brain. J. Biol. Chem. 266: 21523–21529.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>266</number></detail><extent unit="pages"><start>21523</start><end>21529</end></extent></part><relatedItem type="host"><titleInfo><title>J. Biol. Chem.</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>266</number></detail><extent unit="pages"><start>21523</start><end>21529</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit55"><titleInfo><title>Ornithine decarboxylase as a target for chemoprevention</title></titleInfo><name type="personal"><namePart type="given">A. E.</namePart><namePart type="family">Pegg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. M.</namePart><namePart type="family">Shantz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. S.</namePart><namePart type="family">Coleman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pegg, A. E., Shantz, L. M., Coleman, C. S. (1995) Ornithine decarboxylase as a target for chemoprevention. J. Cell. Biochem. S22: 132–138.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>S22</number></detail><extent unit="pages"><start>132</start><end>138</end></extent></part><relatedItem type="host"><titleInfo><title>J. Cell. Biochem.</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>S22</number></detail><extent unit="pages"><start>132</start><end>138</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit56"><titleInfo><title>An evalutaion of receptor‐mediated gene transfer using synthetic DNA‐ligand complexes</title></titleInfo><name type="personal"><namePart type="given">J. C.</namePart><namePart type="family">Perales</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Ferkol</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Molas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. W.</namePart><namePart type="family">Hanson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Perales, J. C., Ferkol, T., Molas, M., Hanson, R. W. (1994) An evalutaion of receptor‐mediated gene transfer using synthetic DNA‐ligand complexes. Eur. J. Biochem. 226: 255–266.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>226</number></detail><extent unit="pages"><start>255</start><end>266</end></extent></part><relatedItem type="host"><titleInfo><title>Eur. J. Biochem.</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>226</number></detail><extent unit="pages"><start>255</start><end>266</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit57"><titleInfo><title>Condensation of DNA by trivalent cations: effects of cationic structure</title></titleInfo><name type="personal"><namePart type="given">G. E.</namePart><namePart type="family">Plum</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. G.</namePart><namePart type="family">Arscott</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Bloomfield</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Plum, G. E., Arscott, P. G., Bloomfield, V. A. (1990) Condensation of DNA by trivalent cations: effects of cationic structure. Biopolymers 30: 631–643.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>631</start><end>643</end></extent></part><relatedItem type="host"><titleInfo><title>Biopolymers</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>631</start><end>643</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit58"><titleInfo><title>Biological properties of N4‐spermidine derivatives and their potential in anticancer chemotherapy</title></titleInfo><name type="personal"><namePart type="given">C. W.</namePart><namePart type="family">Porter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Bergeron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. J.</namePart><namePart type="family">Stolowich</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Porter, C. W., Bergeron, R. J., Stolowich, N. J. (1982) Biological properties of N4‐spermidine derivatives and their potential in anticancer chemotherapy. Cancer Res. 42: 4072–4078.</note><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>4072</start><end>4078</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Res.</title></titleInfo><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>4072</start><end>4078</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit59"><titleInfo><title>Biological properties of N4— and N1, N8— spermidine derivatives in cultured L1210 leukemia cells</title></titleInfo><name type="personal"><namePart type="given">C. W.</namePart><namePart type="family">Porter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. F.</namePart><namePart type="family">Cavanaugh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. J.</namePart><namePart type="family">Stolowich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Kelly</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Bergeron</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Porter, C. W., Cavanaugh, P. F., Stolowich, N. J., Kelly, E., Bergeron, R. J. (1985) Biological properties of N4— and N1, N8— spermidine derivatives in cultured L1210 leukemia cells. Cancer Res. 45: 2050–2057.</note><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>2050</start><end>2057</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Res.</title></titleInfo><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>2050</start><end>2057</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit60"><titleInfo><title>Relative abilities of bis(ethyl) derivatives of putrescine, spermidine and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth</title></titleInfo><name type="personal"><namePart type="given">C. W.</namePart><namePart type="family">Porter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. S.</namePart><namePart type="family">McManis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Casero</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Bergeron</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Porter, C. W., McManis, J. S., Casero, R. A., Bergeron, R. J. (1987) Relative abilities of bis(ethyl) derivatives of putrescine, spermidine and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth. Cancer Res. 47: 2821–2825.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>2821</start><end>2825</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Res.</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>2821</start><end>2825</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit61"><titleInfo><title>Optimization of the MTT assay for B16 murine melanoma cells and its application in assessing the growth inhibition by polyamines and by novel polyamine conjugates</title></titleInfo><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Qarawi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Carrington</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. H.</namePart><namePart type="family">Moss</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. W.</namePart><namePart type="family">Pouton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Qarawi, M. A., Carrington, S., Blagbrough, I. S., Moss, S. H., Pouton, C. W. (1997) Optimization of the MTT assay for B16 murine melanoma cells and its application in assessing the growth inhibition by polyamines and by novel polyamine conjugates. Pharm. Sci. 3: 235–240.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>235</start><end>240</end></extent></part><relatedItem type="host"><titleInfo><title>Pharm. Sci.</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>235</start><end>240</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit62"><titleInfo><title>Gene transfer with a series of lipophilic DNA‐binding molecules</title></titleInfo><name type="personal"><namePart type="given">J.‐S.</namePart><namePart type="family">Remy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Sirlin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Vierling</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.‐P.</namePart><namePart type="family">Behr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Remy, J.‐S., Sirlin, C., Vierling, P., Behr, J.‐P. (1994) Gene transfer with a series of lipophilic DNA‐binding molecules. Bioconjugate Chem. 5: 647–654.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>647</start><end>654</end></extent></part><relatedItem type="host"><titleInfo><title>Bioconjugate Chem.</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>647</start><end>654</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit63"><titleInfo><title>DNA binding of spermine derivative: spectroscopic study of anthracene‐9‐carbonyl‐N1‐spermine with poly[d(G‐C).d(G‐C)] and poly[d(A‐T).d(A‐T)]</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rodger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Adlam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Carpenter</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rodger, A., Adlam, G., Blagbrough, I. S., Carpenter, M. L. (1994) DNA binding of spermine derivative: spectroscopic study of anthracene‐9‐carbonyl‐N1‐spermine with poly[d(G‐C).d(G‐C)] and poly[d(A‐T).d(A‐T)]. Biopolymers 34: 1583–1593.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>1583</start><end>1593</end></extent></part><relatedItem type="host"><titleInfo><title>Biopolymers</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>1583</start><end>1593</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit64"><titleInfo><title>Multiple DNA binding modes of anthracene‐9‐carbonyl‐N1‐spermine</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rodger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Adlam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Haworth</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rodger, A., Taylor, S., Adlam, G., Blagbrough, I. S., Haworth, I. S. (1995) Multiple DNA binding modes of anthracene‐9‐carbonyl‐N1‐spermine. Bioorg. Med. Chem. 3: 861–872.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>861</start><end>872</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg. Med. Chem.</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>861</start><end>872</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit65"><titleInfo><title>The binding of spermine and magnesium to DNA</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Rowatt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. J. P.</namePart><namePart type="family">Williams</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rowatt, E., Williams, R. J. P. (1992) The binding of spermine and magnesium to DNA. J. Inorg. Biochem. 46: 87–97.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>87</start><end>97</end></extent></part><relatedItem type="host"><titleInfo><title>J. Inorg. Biochem.</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>87</start><end>97</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit66"><titleInfo><title>Polyamine toxins from spiders and wasps.</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Schäfer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Benz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Fiedler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Guggisberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Bienz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hesse</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>The Alkaloids</title></titleInfo><originInfo><publisher>Academic Press</publisher></originInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>1</start><end>125</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit67"><titleInfo><title>Nicotianamine ‐ a common constituent of strategy‐I and strategy‐II of iron acquisition by plants ‐ a review</title></titleInfo><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Scholz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Becker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Pich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U. W.</namePart><namePart type="family">Stephan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Scholz, G., Becker, R., Pich, A., Stephan, U. W. (1992) Nicotianamine ‐ a common constituent of strategy‐I and strategy‐II of iron acquisition by plants ‐ a review. J. Plant Nutrit. 15: 1647–1665.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>1647</start><end>1665</end></extent></part><relatedItem type="host"><titleInfo><title>J. Plant Nutrit.</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>1647</start><end>1665</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit68"><titleInfo><title>Polyamine transport in mammalian cells</title></titleInfo><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Seiler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Dezeure</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Seiler, N., Dezeure, F. (1990) Polyamine transport in mammalian cells. Int. J. Biochem. 22: 211.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>211</start></extent></part><relatedItem type="host"><titleInfo><title>Int. J. Biochem.</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>211</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit69"><titleInfo><title>Endogenous and exogenous polyamine in support of tumor growth</title></titleInfo><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Seiler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Sarhan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Grauffel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Jones</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Knodgen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. P.</namePart><namePart type="family">Moulinoux</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Seiler, N., Sarhan, S., Grauffel, C., Jones, R., Knodgen, B., Moulinoux, J. P. (1990) Endogenous and exogenous polyamine in support of tumor growth. Cancer Res. 50: 5077–5083.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>5077</start><end>5083</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Res.</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>5077</start><end>5083</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit70"><titleInfo><title>Synthesis and RNA cleaving activities of polyamine derived novel artificial ribonuclease</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Shinozuka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Shimizu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Nakashima</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Sawai</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shinozuka, K., Shimizu, K., Nakashima, Y., Sawai, H. (1994) Synthesis and RNA cleaving activities of polyamine derived novel artificial ribonuclease. Bioorg. Med. Chem. Lett. 4: 1979–1982.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>1979</start><end>1982</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg. Med. Chem. Lett.</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>1979</start><end>1982</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit71"><titleInfo><title>Survey of the DNA binding properties of natural and synthetic polyamino compounds</title></titleInfo><name type="personal"><namePart type="given">K. D.</namePart><namePart type="family">Stewart</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Gray</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Stewart, K. D., Gray, T. A. (1992) Survey of the DNA binding properties of natural and synthetic polyamino compounds. J. Phys. Org. Chem. 5: 461–466.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>461</start><end>466</end></extent></part><relatedItem type="host"><titleInfo><title>J. Phys. Org. Chem.</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>461</start><end>466</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit72"><titleInfo><title>Spermidine, spermine and related amines</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Tabor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. W.</namePart><namePart type="family">Tabor</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tabor, H., Tabor, C. W. (1964) Spermidine, spermine and related amines. Pharmacol. Rev. 16: 245–300.</note><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>245</start><end>300</end></extent></part><relatedItem type="host"><titleInfo><title>Pharmacol. Rev.</title></titleInfo><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>245</start><end>300</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit73"><titleInfo><title>Polyamines</title></titleInfo><name type="personal"><namePart type="given">C. W.</namePart><namePart type="family">Tabor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Tabor</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tabor, C. W., Tabor, H. (1984) Polyamines. Ann. Rev. Biochem. 53: 749–790.</note><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>749</start><end>790</end></extent></part><relatedItem type="host"><titleInfo><title>Ann. Rev. Biochem.</title></titleInfo><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>749</start><end>790</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit74"><titleInfo><title>Determination of protonation sites in thermospermine and in some other polyamines by 15N and 13C nuclear magnetic resonance spectroscopy</title></titleInfo><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Takeda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Samejima</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Nagano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Sugeta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Kyoguku</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Takeda, Y., Samejima, K., Nagano, K., Watanabe, M., Sugeta, H., Kyoguku, Y. (1983) Determination of protonation sites in thermospermine and in some other polyamines by 15N and 13C nuclear magnetic resonance spectroscopy. Eur. J. Biochem. 130: 383–389.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>130</number></detail><extent unit="pages"><start>383</start><end>389</end></extent></part><relatedItem type="host"><titleInfo><title>Eur. J. Biochem.</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>130</number></detail><extent unit="pages"><start>383</start><end>389</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit75"><titleInfo><title>GI pharmacology of polyethyleneimine II: motor activity in anesthetised dogs</title></titleInfo><name type="personal"><namePart type="given">M. F.</namePart><namePart type="family">Tansy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. S.</namePart><namePart type="family">Martin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. L.</namePart><namePart type="family">Innes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. M.</namePart><namePart type="family">Kendall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Melamed</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. N.</namePart><namePart type="family">Moss</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tansy, M. F., Martin, J. S., Innes, D. L., Kendall F. M., Melamed, S., Moss, J. N. (1977) GI pharmacology of polyethyleneimine II: motor activity in anesthetised dogs. J. Pharm. Sci. 66: 902–904.</note><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>902</start><end>904</end></extent></part><relatedItem type="host"><titleInfo><title>J. Pharm. Sci.</title></titleInfo><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>902</start><end>904</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit76"><titleInfo><title>Safety considerations in somatic gene therapy of human disease with retrovirus vectors</title></titleInfo><name type="personal"><namePart type="given">H. M.</namePart><namePart type="family">Temin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Temin, H. M. (1990) Safety considerations in somatic gene therapy of human disease with retrovirus vectors. Hum. Gene Ther. 1: 111–123.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>111</start><end>123</end></extent></part><relatedItem type="host"><titleInfo><title>Hum. Gene Ther.</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>111</start><end>123</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit77"><titleInfo><title>Starburst dendrimers ‐ molecular‐level control of size, shape, surface‐chemistry, topology, and flexibility from atoms to macroscopic matter</title></titleInfo><name type="personal"><namePart type="given">D. A.</namePart><namePart type="family">Tomalia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. M.</namePart><namePart type="family">Naylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. A.</namePart><namePart type="family">Goddard</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tomalia, D. A., Naylor, A. M., Goddard, W. A. (1990) Starburst dendrimers ‐ molecular‐level control of size, shape, surface‐chemistry, topology, and flexibility from atoms to macroscopic matter. Angew. Chem. Int. Ed. UK 29: 138–175.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>138</start><end>175</end></extent></part><relatedItem type="host"><titleInfo><title>Angew. Chem. Int. Ed. UK</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>138</start><end>175</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit78"><titleInfo><title>Spider toxins affecting glutamate receptors: polyamines in therapeutic neurochemistry</title></titleInfo><name type="personal"><namePart type="given">P. N. R.</namePart><namePart type="family">Usherwood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Blagbrough</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Usherwood, P. N. R., Blagbrough, I. S. (1991) Spider toxins affecting glutamate receptors: polyamines in therapeutic neurochemistry. Pharmacol. Ther. 52: 245–268.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>245</start><end>268</end></extent></part><relatedItem type="host"><titleInfo><title>Pharmacol. Ther.</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>245</start><end>268</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit79"><titleInfo><title>Coupling of adenovirus to transferrin‐polylysine/DNA complexes greatly enhances receptor‐mediated gene delivery and expression of transfected genes</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Wagner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Zatloukal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Cotton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Kirlappos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Mechtler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. T.</namePart><namePart type="family">Curiel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Birnstiel</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wagner, E., Zatloukal, K., Cotton, M., Kirlappos, H., Mechtler, K., Curiel, D. T., Birnstiel, M. L. (1992) Coupling of adenovirus to transferrin‐polylysine/DNA complexes greatly enhances receptor‐mediated gene delivery and expression of transfected genes. Proc. Natl Acad. Sci. USA 89: 6099–6103.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>89</number></detail><extent unit="pages"><start>6099</start><end>6103</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl Acad. Sci. USA</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>89</number></detail><extent unit="pages"><start>6099</start><end>6103</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit80"><titleInfo><title>Cationic facial amphiphiles: a promising class of transfection agents</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Walker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Sofia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Kakarla</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. A.</namePart><namePart type="family">Kogan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Wierichs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. B.</namePart><namePart type="family">Longley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Bruker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. R.</namePart><namePart type="family">Axelrod</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Midha</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Babu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Kahne</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Walker, S., Sofia, M. J., Kakarla, R., Kogan, N. A., Wierichs, L., Longley, C. B., Bruker, K., Axelrod, H. R., Midha, S., Babu, S., Kahne, D. (1996) Cationic facial amphiphiles: a promising class of transfection agents. Proc. Natl Acad. Sci. USA 93: 1585–1590.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>1585</start><end>1590</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl Acad. Sci. USA</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>1585</start><end>1590</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit81"><titleInfo><title>Metal‐chelate‐dendrimer‐antibody constructs for use in radio‐immunotherapy and imaging</title></titleInfo><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. W.</namePart><namePart type="family">Brechbiel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. W.</namePart><namePart type="family">Kozak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O. A.</namePart><namePart type="family">Gansow</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wu, C., Brechbiel. M. W., Kozak, R. W., Gansow, O. A. (1994) Metal‐chelate‐dendrimer‐antibody constructs for use in radio‐immunotherapy and imaging. Bioorg. Med. Chem. Lett. 4: 449–454.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>449</start><end>454</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg. Med. Chem. Lett.</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>449</start><end>454</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit82"><titleInfo><title>Oligoamines as simple and efficient catalysts for RNA hydrolysis</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Yoshinari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Yamazaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Komiyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yoshinari, K., Yamazaki, K., Komiyama, M. (1991) Oligoamines as simple and efficient catalysts for RNA hydrolysis. J. Am. Chem. Soc. 113: 5899–5901.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><extent unit="pages"><start>5899</start><end>5901</end></extent></part><relatedItem type="host"><titleInfo><title>J. Am. Chem. Soc.</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><extent unit="pages"><start>5899</start><end>5901</end></extent></part></relatedItem></relatedItem><identifier type="istex">387646E2F0E6D32C59D1D26510CA94142513B184</identifier><identifier type="ark">ark:/67375/WNG-ZCL4DBCZ-X</identifier><identifier type="DOI">10.1111/j.2042-7158.1997.tb00258.x</identifier><identifier type="ArticleID">JPHP258</identifier><accessCondition type="use and reproduction" contentType="copyright">1997 Royal Pharmaceutical Society of Great Britain</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-ZCL4DBCZ-X/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001553 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001553 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:387646E2F0E6D32C59D1D26510CA94142513B184
|texte= Polyamines and Polyamine Amides as Potent Selective Receptor Probes, Novel Therapeutic Lead Compounds and Synthetic Vectors in Gene Therapy
}}
| This area was generated with Dilib version V0.6.33. |  |