Sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria.
Identifieur interne : 001550 ( Istex/Corpus ); précédent : 001549; suivant : 001551Sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria.
Auteurs : A P Hall ; E B Doberstyn ; C. Karnchanachetanee ; S. Samransamruajkit ; B. Laixuthai ; E J Pearlman ; R M Lampe ; C F Miller ; P. PhintuyothinSource :
- British Medical Journal [ 0007-1447 ] ; 1977-06-25.
English descriptors
- Teeft :
- Acta medica scandinavica, American journal, Apnoeic attacks, Asexual parasitaemia, Asexual parasites, Bacillus, Bacillus cereus, Clinical nutrition, Clinical picture, Cure rate, Diabetes mellitus, Dos, Effective treatment, Faecal streptococci, Falciparum, Falciparum malaria, Fansidar, Internal medicine, Last dose, Malaria, Medical clinics, Mefloquine, Moderate numbers, Numerous bacilli, Parasitaemia, Parasite, Parasite density, Quinine, Quinine base, Radical cure, Recrudescence, Regimen, Sequential, Sequential regimens, Sequential treatment, Severe falciparum malaria, Short course, Side effects, Single dose, Small numbers, Standard dose, Tropical medicine, World health organisation.
Abstract
Patients with falciparum malaria were studied in Thailand, an area of known chloroquine resistance. The patients were unselected and some had severe malaria, and they were randomly assigned to one of two sequential regimes. A short course of quinine (average 4 doses, equivalent to 2 g base) followed by a single dose of pyrimethamine-sulfadoxine (Fansidar) cured 92% of patients (36 out of 39), while a short course of quinine followed by a single 1-5-dose of mefloquine cured all of the 35 patients who could be followed up. Gastrointestinal side effects were minimal if at least 12 hours elapsed between the last dose of quinine and the mefloquine. Sequential quinine and mefloquine is the most effective treatment for patients with chloroquine-resistant falciparum malaria, including those with severe or complicated disease. Mefloquine, however, is not commercially available, and the similar regimen using Fansidar is almost as effective.
Url:
DOI: 10.1136/bmj.1.6077.1626
Links to Exploration step
ISTEX:514326FD351DC3E6C762624CB5DDAFD449122B51Le document en format XML
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Laixuthai</name></author><author><name sortKey="Pearlman, E J" sort="Pearlman, E J" uniqKey="Pearlman E" first="E J" last="Pearlman">E J Pearlman</name></author><author><name sortKey="Lampe, R M" sort="Lampe, R M" uniqKey="Lampe R" first="R M" last="Lampe">R M Lampe</name></author><author><name sortKey="Miller, C F" sort="Miller, C F" uniqKey="Miller C" first="C F" last="Miller">C F Miller</name></author><author><name sortKey="Phintuyothin, P" sort="Phintuyothin, P" uniqKey="Phintuyothin P" first="P" last="Phintuyothin">P. 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The patients were unselected and some had severe malaria, and they were randomly assigned to one of two sequential regimes. A short course of quinine (average 4 doses, equivalent to 2 g base) followed by a single dose of pyrimethamine-sulfadoxine (Fansidar) cured 92% of patients (36 out of 39), while a short course of quinine followed by a single 1-5-dose of mefloquine cured all of the 35 patients who could be followed up. Gastrointestinal side effects were minimal if at least 12 hours elapsed between the last dose of quinine and the mefloquine. Sequential quinine and mefloquine is the most effective treatment for patients with chloroquine-resistant falciparum malaria, including those with severe or complicated disease. Mefloquine, however, is not commercially available, and the similar regimen using Fansidar is almost as effective.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Infectious diseases</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1977-06-25">Created</change><change when="1977-06-25">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-10-17">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-RNM7DSHC-T/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="hwp">bmj</journal-id><journal-id journal-id-type="nlm-ta">BMJ</journal-id><journal-title>British Medical Journal</journal-title><abbrev-journal-title abbrev-type="publisher">Br Med J</abbrev-journal-title><issn pub-type="ppub">0007-1447</issn><issn pub-type="epub">1468-5833</issn><publisher><publisher-name>British Medical Journal Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">326337</article-id><article-id pub-id-type="other">bmj;1/6077/1626</article-id><article-id pub-id-type="doi">10.1136/bmj.1.6077.1626</article-id><article-id pub-id-type="other">1626</article-id><article-id pub-id-type="other">bmj.1.6077.1626</article-id><article-categories><subj-group subj-group-type="heading"><subject content-type="original">Research Article</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Infectious diseases</subject></subj-group></article-categories><title-group><article-title>Sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria.</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Hall</surname><given-names>A P</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Doberstyn</surname><given-names>E B</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Karnchanachetanee</surname><given-names>C</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Samransamruajkit</surname><given-names>S</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Laixuthai</surname><given-names>B</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Pearlman</surname><given-names>E J</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Lampe</surname><given-names>R M</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Miller</surname><given-names>C F</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Phintuyothin</surname><given-names>P</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>25</day><month>6</month><year>1977</year></pub-date><pub-date pub-type="epub"><day>25</day><month>6</month><year>1977</year></pub-date><volume>1</volume><volume-id pub-id-type="other">1</volume-id><volume-id pub-id-type="other">1</volume-id><issue>6077</issue><issue-id pub-id-type="other">bmj;1/6077</issue-id><issue-id pub-id-type="other">6077</issue-id><issue-id pub-id-type="other">1/6077</issue-id><fpage>1626</fpage><self-uri content-type="pdf" xlink:role="full-text" xlink:href="bmj-1-1626.pdf"></self-uri><abstract><p>Patients with falciparum malaria were studied in Thailand, an area of known chloroquine resistance. The patients were unselected and some had severe malaria, and they were randomly assigned to one of two sequential regimes. A short course of quinine (average 4 doses, equivalent to 2 g base) followed by a single dose of pyrimethamine-sulfadoxine (Fansidar) cured 92% of patients (36 out of 39), while a short course of quinine followed by a single 1-5-dose of mefloquine cured all of the 35 patients who could be followed up. Gastrointestinal side effects were minimal if at least 12 hours elapsed between the last dose of quinine and the mefloquine. Sequential quinine and mefloquine is the most effective treatment for patients with chloroquine-resistant falciparum malaria, including those with severe or complicated disease. Mefloquine, however, is not commercially available, and the similar regimen using Fansidar is almost as effective.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria.</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria.</title></titleInfo><name type="personal"><namePart type="given">A P</namePart><namePart type="family">Hall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E B</namePart><namePart type="family">Doberstyn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Karnchanachetanee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Samransamruajkit</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Laixuthai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E J</namePart><namePart type="family">Pearlman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R M</namePart><namePart type="family">Lampe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C F</namePart><namePart type="family">Miller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Phintuyothin</namePart><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>British Medical Journal Publishing Group</publisher><dateIssued encoding="w3cdtf">1977-06-25</dateIssued><dateCreated encoding="w3cdtf">1977-06-25</dateCreated><copyrightDate encoding="w3cdtf">1977</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Patients with falciparum malaria were studied in Thailand, an area of known chloroquine resistance. The patients were unselected and some had severe malaria, and they were randomly assigned to one of two sequential regimes. A short course of quinine (average 4 doses, equivalent to 2 g base) followed by a single dose of pyrimethamine-sulfadoxine (Fansidar) cured 92% of patients (36 out of 39), while a short course of quinine followed by a single 1-5-dose of mefloquine cured all of the 35 patients who could be followed up. Gastrointestinal side effects were minimal if at least 12 hours elapsed between the last dose of quinine and the mefloquine. Sequential quinine and mefloquine is the most effective treatment for patients with chloroquine-resistant falciparum malaria, including those with severe or complicated disease. Mefloquine, however, is not commercially available, and the similar regimen using Fansidar is almost as effective.</abstract><relatedItem type="host"><titleInfo><title>British Medical Journal</title></titleInfo><titleInfo type="abbreviated"><title>Br Med J</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>hwp-journal-coll</genre><topic>Infectious diseases</topic></subject><identifier type="ISSN">0007-1447</identifier><identifier type="eISSN">1468-5833</identifier><identifier type="PublisherID-hwp">bmj</identifier><identifier type="PublisherID-nlm-ta">BMJ</identifier><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><detail type="issue"><caption>no.</caption><number>6077</number></detail><extent unit="pages"><start>1626</start></extent></part></relatedItem><identifier type="istex">514326FD351DC3E6C762624CB5DDAFD449122B51</identifier><identifier type="ark">ark:/67375/NVC-RNM7DSHC-T</identifier><identifier type="DOI">10.1136/bmj.1.6077.1626</identifier><identifier type="href">bmj-1-1626.pdf</identifier><identifier type="PMID">326337</identifier><identifier type="local">bmj;1/6077/1626</identifier><accessCondition type="use and reproduction" contentType="copyright">© British Medical Journal Publishing Group</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</recordContentSource><recordOrigin>© British Medical Journal Publishing Group</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-RNM7DSHC-T/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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