Macrophages in host defense against Histoplasma capsulatum
Identifieur interne : 001482 ( Istex/Corpus ); précédent : 001481; suivant : 001483Macrophages in host defense against Histoplasma capsulatum
Auteurs : Simon L. NewmanSource :
- Trends in Microbiology [ 0966-842X ] ; 1999.
English descriptors
- Teeft :
- Capsulatum, Capsulatum yeasts, Cytokine, Ferric ions, Histoplasma, Host defense, Human macrophages, Immun, Immunol, Intracellular, Intraphagosomal, Macrophage, Macrophage factor, Microbiology, Microorganism, Monocyte, Murine, Murine macrophages, Phagocytosis, Phagosome, Phagosomes, Receptor, Respiratory burst, Strasser, Transferrin, Yeast.
Abstract
Abstract: Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs. Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host.
Url:
DOI: 10.1016/S0966-842X(98)01431-0
Links to Exploration step
ISTEX:E5468F1283CCB1DDF8430C38B228A8C8BD509C78Le document en format XML
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Newman</name><affiliation><mods:affiliation>Division of Infectious Diseases, University of Cincinnati College of Medicine, PO Box 670560, Cincinnati, OH 45267-0560, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: newmansl@email.uc.edu</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E5468F1283CCB1DDF8430C38B228A8C8BD509C78</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0966-842X(98)01431-0</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-FDCBGHF7-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001482</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001482</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Macrophages in host defense against Histoplasma capsulatum</title><author><name sortKey="Newman, Simon L" sort="Newman, Simon L" uniqKey="Newman S" first="Simon L" last="Newman">Simon L. Newman</name><affiliation><mods:affiliation>Division of Infectious Diseases, University of Cincinnati College of Medicine, PO Box 670560, Cincinnati, OH 45267-0560, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: newmansl@email.uc.edu</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Trends in Microbiology</title><title level="j" type="abbrev">TIMI</title><idno type="ISSN">0966-842X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">7</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="67">67</biblScope><biblScope unit="page" to="71">71</biblScope></imprint><idno type="ISSN">0966-842X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0966-842X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Capsulatum</term><term>Capsulatum yeasts</term><term>Cytokine</term><term>Ferric ions</term><term>Histoplasma</term><term>Host defense</term><term>Human macrophages</term><term>Immun</term><term>Immunol</term><term>Intracellular</term><term>Intraphagosomal</term><term>Macrophage</term><term>Macrophage factor</term><term>Microbiology</term><term>Microorganism</term><term>Monocyte</term><term>Murine</term><term>Murine macrophages</term><term>Phagocytosis</term><term>Phagosome</term><term>Phagosomes</term><term>Receptor</term><term>Respiratory burst</term><term>Strasser</term><term>Transferrin</term><term>Yeast</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs. Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>macrophage</json:string><json:string>capsulatum</json:string><json:string>murine</json:string><json:string>capsulatum yeasts</json:string><json:string>phagosome</json:string><json:string>human macrophages</json:string><json:string>phagocytosis</json:string><json:string>cytokine</json:string><json:string>intracellular</json:string><json:string>immunol</json:string><json:string>receptor</json:string><json:string>phagosomes</json:string><json:string>transferrin</json:string><json:string>immun</json:string><json:string>monocyte</json:string><json:string>respiratory burst</json:string><json:string>intraphagosomal</json:string><json:string>histoplasma</json:string><json:string>microbiology</json:string><json:string>strasser</json:string><json:string>yeast</json:string><json:string>microorganism</json:string><json:string>host defense</json:string><json:string>ferric ions</json:string><json:string>murine macrophages</json:string><json:string>macrophage factor</json:string></teeft></keywords><author><json:item><name>Simon L Newman</name><affiliations><json:string>Division of Infectious Diseases, University of Cincinnati College of Medicine, PO Box 670560, Cincinnati, OH 45267-0560, USA</json:string><json:string>E-mail: newmansl@email.uc.edu</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>macrophages</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Histoplasma capsulatum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fungi</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>interferon gamma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>phagolysosomal fusion</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>vacuolar APTase</value></json:item></subject><arkIstex>ark:/67375/6H6-FDCBGHF7-8</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Review article</json:string></originalGenre><abstract>Abstract: Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs. 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Strasser et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-FDCBGHF7-8</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - microbiology</json:string><json:string>2 - biochemistry & molecular biology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - microbiology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Microbiology (medical)</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Microbiology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1016/S0966-842X(98)01431-0</json:string></doi><id>E5468F1283CCB1DDF8430C38B228A8C8BD509C78</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FDCBGHF7-8/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FDCBGHF7-8/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-FDCBGHF7-8/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Macrophages in host defense against Histoplasma capsulatum</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©1999 Elsevier Science Ltd</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1999</date></publicationStmt><notesStmt><note type="review-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Section title: Review</note><note type="content">Fig. 1.: Differences in the interactions between Histoplasma capsulatum yeasts and human and murine macrophages. (a) Upon phagocytosis of H. capsulatum yeasts by human macrophages, there is a vigorous production of reactive oxygen intermediates (ROI) but no phagolysosomal (PL) fusion. (b) In contrast, in murine macrophages, PL fusion does occur, but there is no production of ROI. Most intriguing is the fact that human macrophages cannot be activated by interferon γ (IFN-γ) to inhibit the growth of H. capsulatum yeasts. Abbreviations: IL-3, interleukin 3; GM-CSF, granulocyte–macrophage colony-stimulating factor; M-CSF, macrophage colony-stimulating factor.</note><note type="content">Fig. 2.: Electron micrograph of Histoplasma capsulatum yeasts in a human macrophage. Note the thick electron-translucent cell wall of the yeasts, which characterizes this species of Histoplasma. Scale bar = 1 μm.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Macrophages in host defense against Histoplasma capsulatum</title><author xml:id="author-0000"><persName><forename type="first">Simon L</forename><surname>Newman</surname></persName><email>newmansl@email.uc.edu</email><note type="biography">tel: +1 513 558 4704, fax:+1 513 558 2089</note><affiliation>tel: +1 513 558 4704, fax:+1 513 558 2089</affiliation><affiliation>Division of Infectious Diseases, University of Cincinnati College of Medicine, PO Box 670560, Cincinnati, OH 45267-0560, USA</affiliation></author><idno type="istex">E5468F1283CCB1DDF8430C38B228A8C8BD509C78</idno><idno type="ark">ark:/67375/6H6-FDCBGHF7-8</idno><idno type="DOI">10.1016/S0966-842X(98)01431-0</idno><idno type="PII">S0966-842X(98)01431-0</idno></analytic><monogr><title level="j">Trends in Microbiology</title><title level="j" type="abbrev">TIMI</title><idno type="pISSN">0966-842X</idno><idno type="PII">S0966-842X(00)X0038-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">7</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="67">67</biblScope><biblScope unit="page" to="71">71</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs. Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>macrophages</term></item><item><term>Histoplasma capsulatum</term></item><item><term>fungi</term></item><item><term>interferon gamma</term></item><item><term>phagolysosomal fusion</term></item><item><term>vacuolar APTase</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FDCBGHF7-8/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="gr2"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="rev"><item-info><jid>TIMI</jid><aid>1431</aid><ce:pii>S0966-842X(98)01431-0</ce:pii><ce:doi>10.1016/S0966-842X(98)01431-0</ce:doi><ce:copyright type="full-transfer" year="1999">Elsevier Science Ltd</ce:copyright></item-info><head><ce:dochead><ce:textfn>Review</ce:textfn></ce:dochead><ce:title>Macrophages in host defense against <ce:italic>Histoplasma capsulatum</ce:italic></ce:title><ce:author-group><ce:author><ce:given-name>Simon L</ce:given-name><ce:surname>Newman</ce:surname><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:e-address>newmansl@email.uc.edu</ce:e-address></ce:author><ce:affiliation><ce:textfn>Division of Infectious Diseases, University of Cincinnati College of Medicine, PO Box 670560, Cincinnati, OH 45267-0560, USA</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>tel: +1 513 558 4704, fax:+1 513 558 2089</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen <ce:italic>Histoplasma capsulatum</ce:italic> multiplies and disseminates from the lung to other organs. Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>macrophages</ce:text></ce:keyword><ce:keyword><ce:text>Histoplasma capsulatum</ce:text></ce:keyword><ce:keyword><ce:text>fungi</ce:text></ce:keyword><ce:keyword><ce:text>interferon gamma</ce:text></ce:keyword><ce:keyword><ce:text>phagolysosomal fusion</ce:text></ce:keyword><ce:keyword><ce:text>vacuolar APTase</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Macrophages in host defense against Histoplasma capsulatum</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Macrophages in host defense against</title></titleInfo><name type="personal"><namePart type="given">Simon L</namePart><namePart type="family">Newman</namePart><affiliation>Division of Infectious Diseases, University of Cincinnati College of Medicine, PO Box 670560, Cincinnati, OH 45267-0560, USA</affiliation><affiliation>E-mail: newmansl@email.uc.edu</affiliation><description>tel: +1 513 558 4704, fax:+1 513 558 2089</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="Review article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs. Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host.</abstract><note type="content">Section title: Review</note><note type="content">Fig. 1.: Differences in the interactions between Histoplasma capsulatum yeasts and human and murine macrophages. (a) Upon phagocytosis of H. capsulatum yeasts by human macrophages, there is a vigorous production of reactive oxygen intermediates (ROI) but no phagolysosomal (PL) fusion. (b) In contrast, in murine macrophages, PL fusion does occur, but there is no production of ROI. Most intriguing is the fact that human macrophages cannot be activated by interferon γ (IFN-γ) to inhibit the growth of H. capsulatum yeasts. Abbreviations: IL-3, interleukin 3; GM-CSF, granulocyte–macrophage colony-stimulating factor; M-CSF, macrophage colony-stimulating factor.</note><note type="content">Fig. 2.: Electron micrograph of Histoplasma capsulatum yeasts in a human macrophage. Note the thick electron-translucent cell wall of the yeasts, which characterizes this species of Histoplasma. Scale bar = 1 μm.</note><subject><genre>Keywords</genre><topic>macrophages</topic><topic>Histoplasma capsulatum</topic><topic>fungi</topic><topic>interferon gamma</topic><topic>phagolysosomal fusion</topic><topic>vacuolar APTase</topic></subject><relatedItem type="host"><titleInfo><title>Trends in Microbiology</title></titleInfo><titleInfo type="abbreviated"><title>TIMI</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued></originInfo><identifier type="ISSN">0966-842X</identifier><identifier type="PII">S0966-842X(00)X0038-8</identifier><part><date>1999</date><detail type="volume"><number>7</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue-pages"><start>55</start><end>92</end></extent><extent unit="pages"><start>67</start><end>71</end></extent></part></relatedItem><identifier type="istex">E5468F1283CCB1DDF8430C38B228A8C8BD509C78</identifier><identifier type="ark">ark:/67375/6H6-FDCBGHF7-8</identifier><identifier type="DOI">10.1016/S0966-842X(98)01431-0</identifier><identifier type="PII">S0966-842X(98)01431-0</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 Elsevier Science Ltd</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Elsevier Science Ltd, ©1999</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FDCBGHF7-8/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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