Artesunate plus amodiaquine combination therapy: reviewing the evidence
Identifieur interne : 001247 ( Istex/Corpus ); précédent : 001246; suivant : 001248Artesunate plus amodiaquine combination therapy: reviewing the evidence
Auteurs : George O. Adjei ; William Kudzi ; Alexander Dodoo ; Jorgen A. L. KurtzhalsSource :
- Drug Development Research [ 0272-4391 ] ; 2010-02.
Abstract
The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed‐dose combination of artemether‐lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first‐line therapy for uncomplicated malaria by National Malaria Control Programs in sub‐Saharan Africa. In contrast to other ACT regimens in current use, on which reviews of the available evidence on safety and efficacy have been periodically published, no, or few summaries of the extensive data available on the safety and efficacy of this widely used ACT are available in the published literature. The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed. Drug Dev Res 71: 33–43, 2010. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ddr.20346
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[2008]</json:string><json:string>Mutabingwa et al., 2005</json:string><json:string>Svensson and Ashton, 1999</json:string><json:string>Martin-Carbonero et al., 2003</json:string><json:string>Martensson et al., 2005</json:string><json:string>Rhodes et al., 1986</json:string><json:string>Oyakhirome et al., 2007</json:string><json:string>Paredes et al., 2005</json:string><json:string>Parikh et al., 2007</json:string><json:string>Pussard et al., 1987</json:string><json:string>Nsobya et al., 2007</json:string><json:string>Labro and Babin-Chevaye, 1988</json:string><json:string>Grandesso et al., 2006</json:string><json:string>Owusu-Agyei et al. [2008]</json:string><json:string>German et al., 2007</json:string><json:string>Churchill et al., 1985</json:string><json:string>Hasugian et al., 2007</json:string><json:string>Winstanley et al., 1987, 1990</json:string><json:string>Holmgren et al., 2006</json:string><json:string>Thanh et al., 2009</json:string><json:string>Adjei et al. [2008]</json:string><json:string>Guthmann et al., 2006</json:string><json:string>Oyakhirome et al. [2007]</json:string><json:string>Dale and Wolff, 1973</json:string><json:string>Faye et al. [2007]</json:string><json:string>Genovese et al., 1998</json:string><json:string>Orrell et al., 2001</json:string><json:string>Oduro et al., 2008</json:string><json:string>Ruscoe et al., 1998</json:string><json:string>Panossian et al., 2005</json:string><json:string>Koram et al., 2008</json:string><json:string>WHO, 2006</json:string><json:string>Kayentao et al., 2009</json:string><json:string>Sirima et al. [2009]</json:string><json:string>Brasseur et al., 2007</json:string><json:string>Osorio et al. [2007]</json:string><json:string>Orrell et al. [2008]</json:string><json:string>Snow et al., 2005</json:string><json:string>van den Broek et al., 2006</json:string><json:string>Neftel et al., 1986</json:string><json:string>Ngouesse et al., 2001</json:string><json:string>Golenser et al., 2006</json:string><json:string>WHO, 2000</json:string><json:string>Eholie et al., 2009</json:string><json:string>Kobbe et al., 2008</json:string><json:string>Navaratnam et al., 2009</json:string><json:string>Bukirwa et al., 2006</json:string><json:string>Bonnet et al., 2007</json:string><json:string>Bonnet et al. [2007]</json:string><json:string>Van den Broek et al. [2006]</json:string><json:string>Faye et al., 2007</json:string><json:string>Martensson et al. [2005]</json:string><json:string>Thanh et al. [2009]</json:string><json:string>Humphreys et al., 2007</json:string><json:string>Ndiaye et al. [2009]</json:string><json:string>Mutabingwa et al. [2005]</json:string><json:string>Kobbe et al. [2008]</json:string><json:string>Ashton et al., 1998</json:string><json:string>Swarthout et al. [2006]</json:string><json:string>Adjei et al.</json:string><json:string>Breman et al., 2004</json:string><json:string>Swarthout et al., 2006</json:string><json:string>Grandesso et al. [2006]</json:string><json:string>Rwagacondo et al. [2004]</json:string><json:string>WHO, 2004</json:string><json:string>Guthmann et al. [2006]</json:string><json:string>Faucher et al. [2009]</json:string><json:string>Ndiaye et al., 2009</json:string><json:string>Adjuik et al., 2002</json:string><json:string>Gasasira et al., 2003</json:string><json:string>Owusu-Agyei et al., 2008</json:string><json:string>Adjuik et al. [2002]</json:string><json:string>Sirima et al., 2009</json:string><json:string>Olliaro et al., 1996</json:string><json:string>Shimizu et al., 2009</json:string><json:string>Hietala et al., 2007</json:string><json:string>Cowman et al., 1994</json:string><json:string>Gasasira et al., 2008</json:string><json:string>Taylor et al., 2006</json:string><json:string>Adjei et al., 2008a</json:string><json:string>Ong et al., 2000</json:string><json:string>Kayentao et al. [2009]</json:string><json:string>Oduro et al. [2008]</json:string><json:string>Clarke et al., 1990, 1991</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-THNGGQ4G-R</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - pharmacology & pharmacy</json:string><json:string>2 - chemistry, medicinal</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - pharmacology & pharmacy</json:string></scienceMetrix><scopus></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences 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type="division">Centre for Tropical Clinical Pharmacology and Therapeutics</orgName><orgName type="institution">University of Ghana Medical School</orgName><orgName type="institution">College of Health Sciences</orgName><orgName type="institution">University of Ghana</orgName></affiliation></author><author xml:id="author-0001"><persName><forename type="first">William</forename><surname>Kudzi</surname></persName><affiliation><orgName type="division">Centre for Tropical Clinical Pharmacology and Therapeutics</orgName><orgName type="institution">University of Ghana Medical School</orgName><orgName type="institution">College of Health Sciences</orgName><orgName type="institution">University of Ghana</orgName></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Alexander</forename><surname>Dodoo</surname></persName><affiliation><orgName type="division">Centre for Tropical Clinical Pharmacology and Therapeutics</orgName><orgName type="institution">University of Ghana Medical School</orgName><orgName type="institution">College of Health Sciences</orgName><orgName type="institution">University of Ghana</orgName></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Jorgen A.L.</forename><surname>Kurtzhals</surname></persName><affiliation><orgName type="division">Centre for Medical Parasitology at Department of Clinical Microbiology and Department of Infectious Diseases</orgName><orgName type="institution">Copenhagen University Hospital (Rigshospitalet)</orgName><orgName type="division">and Department of International Health</orgName><orgName type="department">Immunology and Microbiology</orgName><orgName type="institution">University of Copenhagen</orgName><address><addrLine>Denmark</addrLine><country key="DK" xml:lang="en">DENMARK</country></address></affiliation></author><idno type="istex">C2EE642E7B6BEBFA15EBD91499F38D4CF4DFFE2E</idno><idno type="ark">ark:/67375/WNG-THNGGQ4G-R</idno><idno 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The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed. Drug Dev Res 71: 33–43, 2010. © 2009 Wiley‐Liss, Inc.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">artemisinin combination therapy</term><term xml:id="kwd2">artesunate‐amodiaquine</term><term xml:id="kwd3">uncomplicated malaria</term></keywords><keywords rend="articleCategory"><term>Research Overview</term></keywords><keywords rend="tocHeading1"><term>Research Overviews</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-THNGGQ4G-R/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1098-2299</doi><issn type="print">0272-4391</issn><issn type="electronic">1098-2299</issn><idGroup><id type="product" value="DDR"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="DRUG DEVELOPMENT RESEARCH">Drug Development Research</title><title type="short">Drug Dev. 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Box 4236, Accra, Ghana</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:DDR.DDR20346.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="79"></count></countGroup><titleGroup><title type="main" xml:lang="en">Artesunate plus amodiaquine combination therapy: reviewing the evidence</title><title type="short" xml:lang="en">ARTESUNATE‐AMODIAQUINE COMBINATION THERAPY</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>George O.</givenNames><familyName>Adjei</familyName></personName><contactDetails><email>goadjei@chs.edu.gh</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>William</givenNames><familyName>Kudzi</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Alexander</givenNames><familyName>Dodoo</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Jorgen A.L.</givenNames><familyName>Kurtzhals</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GH" type="organization"><unparsedAffiliation>Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, College of Health Sciences, University of Ghana</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DK" type="organization"><unparsedAffiliation>Centre for Medical Parasitology at Department of Clinical Microbiology and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), and Department of International Health, Immunology and Microbiology, University of Copenhagen, Denmark</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">artemisinin combination therapy</keyword><keyword xml:id="kwd2">artesunate‐amodiaquine</keyword><keyword xml:id="kwd3">uncomplicated malaria</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed‐dose combination of artemether‐lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first‐line therapy for uncomplicated malaria by National Malaria Control Programs in sub‐Saharan Africa. In contrast to other ACT regimens in current use, on which reviews of the available evidence on safety and efficacy have been periodically published, no, or few summaries of the extensive data available on the safety and efficacy of this widely used ACT are available in the published literature. The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed. Drug Dev Res 71: 33–43, 2010. © 2009 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Artesunate plus amodiaquine combination therapy: reviewing the evidence</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>ARTESUNATE‐AMODIAQUINE COMBINATION THERAPY</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Artesunate plus amodiaquine combination therapy: reviewing the evidence</title></titleInfo><name type="personal"><namePart type="given">George O.</namePart><namePart type="family">Adjei</namePart><affiliation>Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, College of Health Sciences, University of Ghana</affiliation><affiliation>E-mail: goadjei@chs.edu.gh</affiliation><affiliation>Correspondence address: Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, College of Health Sciences, P. 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Box 4236, Accra, Ghana</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William</namePart><namePart type="family">Kudzi</namePart><affiliation>Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, College of Health Sciences, University of Ghana</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexander</namePart><namePart type="family">Dodoo</namePart><affiliation>Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, College of Health Sciences, University of Ghana</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jorgen A.L.</namePart><namePart type="family">Kurtzhals</namePart><affiliation>Centre for Medical Parasitology at Department of Clinical Microbiology and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), and Department of International Health, Immunology and Microbiology, University of Copenhagen, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-02</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">2</extent><extent unit="references">79</extent></physicalDescription><abstract lang="en">The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed‐dose combination of artemether‐lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first‐line therapy for uncomplicated malaria by National Malaria Control Programs in sub‐Saharan Africa. In contrast to other ACT regimens in current use, on which reviews of the available evidence on safety and efficacy have been periodically published, no, or few summaries of the extensive data available on the safety and efficacy of this widely used ACT are available in the published literature. The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed. Drug Dev Res 71: 33–43, 2010. © 2009 Wiley‐Liss, Inc.</abstract><subject lang="en"><genre>keywords</genre><topic>artemisinin combination therapy</topic><topic>artesunate‐amodiaquine</topic><topic>uncomplicated malaria</topic></subject><relatedItem type="host"><titleInfo><title>Drug Development Research</title></titleInfo><titleInfo type="abbreviated"><title>Drug Dev. Res.</title></titleInfo><name type="personal"><namePart type="given">David</namePart><namePart type="family">Gurwitz</namePart></name><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Overview</topic><topic>Research Overviews</topic></subject><identifier type="ISSN">0272-4391</identifier><identifier type="eISSN">1098-2299</identifier><identifier type="DOI">10.1002/(ISSN)1098-2299</identifier><identifier type="PublisherID">DDR</identifier><part><date>2010</date><detail type="title"><title>New Malaria Drugs</title></detail><detail type="volume"><caption>vol.</caption><number>71</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>33</start><end>43</end><total>11</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria</title></titleInfo><name type="personal"><namePart type="given">GO</namePart><namePart type="family">Adjei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kristensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BQ</namePart><namePart type="family">Goka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LC</namePart><namePart type="family">Hoegberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Alifrangis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">OP</namePart><namePart type="family">Rodrigues</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Kurtzhals</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Adjei GO, Kristensen K, Goka BQ, Hoegberg LC, Alifrangis M, Rodrigues OP, Kurtzhals JA. 2008a. Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria. Antimicrob Agents Chemother 52:4400–4406.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>4400</start><end>4406</end></extent></part><relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>4400</start><end>4406</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Amodiaquine‐artesunate vs artemether‐lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow‐up</title></titleInfo><name type="personal"><namePart type="given">GO</namePart><namePart type="family">Adjei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Kurtzhals</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">OP</namePart><namePart type="family">Rodrigues</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Alifrangis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LC</namePart><namePart type="family">Hoegberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ED</namePart><namePart type="family">Kitcher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EV</namePart><namePart type="family">Badoe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Lamptey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BQ</namePart><namePart type="family">Goka</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Adjei GO, Kurtzhals JA, Rodrigues OP, Alifrangis M, Hoegberg LC, Kitcher ED, Badoe EV, Lamptey R, Goka BQ. 2008b. Amodiaquine‐artesunate vs artemether‐lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow‐up. Malar J 7:127.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>127</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>127</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Amodiaquine‐artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Adjuik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Agnamey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Babiker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Borrmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Brasseur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Cisse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Cobelens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Diallo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Faucher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Garner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Gikunda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Kremsner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Krishna</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Lell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Loolpapit</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PB</namePart><namePart type="family">Matsiegui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Missinou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Mwanza</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Ntoumi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Osimbo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Rezbach</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Some</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WR</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Adjuik M, Agnamey P, Babiker A, Borrmann S, Brasseur P, Cisse M, Cobelens F, Diallo S, Faucher JF, Garner P, Gikunda S, Kremsner PG, Krishna S, Lell B, Loolpapit M, Matsiegui PB, Missinou MA, Mwanza J, Ntoumi F, Olliaro P, Osimbo P, Rezbach P, Some E, Taylor WR. 2002. Amodiaquine‐artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial. Lancet 359:1365–1372.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>359</number></detail><extent unit="pages"><start>1365</start><end>1372</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>359</number></detail><extent unit="pages"><start>1365</start><end>1372</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Amodiaquine‐induced involuntary movements</title></titleInfo><name type="personal"><namePart type="given">MO</namePart><namePart type="family">Akindele</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AO</namePart><namePart type="family">Odejide</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Akindele MO, Odejide AO. 1976. Amodiaquine‐induced involuntary movements. Br Med J 2:214–215.</note><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>214</start><end>215</end></extent></part><relatedItem type="host"><titleInfo><title>Br Med J</title></titleInfo><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>214</start><end>215</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Amodiaquine‐induced dystonic reactions: case reports and implications for policy change in Ghana</title></titleInfo><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Akpalu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PK</namePart><namePart type="family">Nyame</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ANO</namePart><namePart type="family">Dodoo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Akpalu AK, Nyame PK, Dodoo ANO. 2005. Amodiaquine‐induced dystonic reactions: case reports and implications for policy change in Ghana. Int J Risk Safety Med 17:1–4.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>1</start><end>4</end></extent></part><relatedItem type="host"><titleInfo><title>Int J Risk Safety Med</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>1</start><end>4</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Artemisinin pharmacokinetics is time‐dependent during repeated oral administration in healthy male adults</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ashton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TN</namePart><namePart type="family">Hai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ND</namePart><namePart type="family">Sy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DX</namePart><namePart type="family">Huong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Van Huong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NT</namePart><namePart type="family">Nieu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LD</namePart><namePart type="family">Cong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ashton M, Hai TN, Sy ND, Huong DX, Van Huong N, Nieu NT, Cong LD. 1998. Artemisinin pharmacokinetics is time‐dependent during repeated oral administration in healthy male adults. Drug Metab Dispos 26:25–27.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>25</start><end>27</end></extent></part><relatedItem type="host"><titleInfo><title>Drug Metab Dispos</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>25</start><end>27</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Efficacy of antimalarial treatment in Guinea: in vivo study of two artemisinin combination therapies in Dabola and molecular markers of resistance to sulphadoxine‐pyrimethamine in N'Zerekore</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Bonnet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Roper</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Felix</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Coulibaly</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GM</namePart><namePart type="family">Kankolongo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Guthmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bonnet M, Roper C, Felix M, Coulibaly L, Kankolongo GM, Guthmann JP. 2007. Efficacy of antimalarial treatment in Guinea: in vivo study of two artemisinin combination therapies in Dabola and molecular markers of resistance to sulphadoxine‐pyrimethamine in N'Zerekore. Malar J 6:54.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>54</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>54</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Senegal</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Brasseur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Agnamey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Gaye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Vaillant</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WR</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PL</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brasseur P, Agnamey P, Gaye O, Vaillant M, Taylor WR, Olliaro PL. 2007. Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Senegal. Malar J 6:150.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>150</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>150</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Conquering the intolerable burden of malaria: what's new, what's needed: a summary</title></titleInfo><name type="personal"><namePart type="given">JG</namePart><namePart type="family">Breman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MS</namePart><namePart type="family">Alilio</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Mills</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Breman JG, Alilio MS, Mills A. 2004. Conquering the intolerable burden of malaria: what's new, what's needed: a summary. Am J Trop Med Hyg 71(2 Suppl):1–15.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>71</number></detail><detail type="issue"><caption>no.</caption><number>2 Suppl</number></detail><extent unit="pages"><start>1</start><end>15</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>71</number></detail><detail type="issue"><caption>no.</caption><number>2 Suppl</number></detail><extent unit="pages"><start>1</start><end>15</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Bukirwa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Yeka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MR</namePart><namePart type="family">Kamya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Talisuna</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Banek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Bakyaita</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JB</namePart><namePart type="family">Rwakimari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Rosenthal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Wabwire‐Mangen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Dorsey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SG</namePart><namePart type="family">Staedke</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bukirwa H, Yeka A, Kamya MR, Talisuna A, Banek K, Bakyaita N, Rwakimari JB, Rosenthal PJ, Wabwire‐Mangen F, Dorsey G, Staedke SG. 2006. Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. PLoS Clin Trials 1:e7.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>e7</start></extent></part><relatedItem type="host"><titleInfo><title>PLoS Clin Trials</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>e7</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Amodiaquine as a prodrug: importance of metabolite(s) in the antimalarial effect of amodiaquine in humans</title></titleInfo><name type="personal"><namePart type="given">FC</namePart><namePart type="family">Churchill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LC</namePart><namePart type="family">Patchen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Campbell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IK</namePart><namePart type="family">Schwartz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Nguyen‐Dinh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Dickinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Churchill FC, Patchen LC, Campbell CC, Schwartz IK, Nguyen‐Dinh P, Dickinson CM. 1985. Amodiaquine as a prodrug: importance of metabolite(s) in the antimalarial effect of amodiaquine in humans. Life Sci 36:53–62.</note><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>53</start><end>62</end></extent></part><relatedItem type="host"><titleInfo><title>Life Sci</title></titleInfo><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>53</start><end>62</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Immunogenicity of amodiaquine in the rat</title></titleInfo><name type="personal"><namePart type="given">JB</namePart><namePart type="family">Clarke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Maggs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NR</namePart><namePart type="family">Kitteringham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BK</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Clarke JB, Maggs JL, Kitteringham NR, Park BK. 1990. Immunogenicity of amodiaquine in the rat. Int Arch Allergy Appl Immunol 91:335–342.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>91</number></detail><extent unit="pages"><start>335</start><end>342</end></extent></part><relatedItem type="host"><titleInfo><title>Int Arch Allergy Appl Immunol</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>91</number></detail><extent unit="pages"><start>335</start><end>342</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine</title></titleInfo><name type="personal"><namePart type="given">JB</namePart><namePart type="family">Clarke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Neftel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NR</namePart><namePart type="family">Kitteringham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BK</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Clarke JB, Neftel K, Kitteringham NR, Park BK. 1991. Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine. Int Arch Allergy Appl Immunol 95:369–375.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><extent unit="pages"><start>369</start><end>375</end></extent></part><relatedItem type="host"><titleInfo><title>Int Arch Allergy Appl Immunol</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><extent unit="pages"><start>369</start><end>375</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross‐resistance to halofantrine and quinine</title></titleInfo><name type="personal"><namePart type="given">AF</namePart><namePart type="family">Cowman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Galatis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Thompson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cowman AF, Galatis D, Thompson JK. 1994. Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross‐resistance to halofantrine and quinine. Proc Natl Acad Sci USA 91:1143–1147.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>91</number></detail><extent unit="pages"><start>1143</start><end>1147</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>91</number></detail><extent unit="pages"><start>1143</start><end>1147</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Studies of the neutropenia of acute malaria</title></titleInfo><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Dale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Wolff</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dale DC, Wolff SM. 1973. Studies of the neutropenia of acute malaria. Blood 41:197–206.</note><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>197</start><end>206</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>197</start><end>206</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Eholie SP, Bissagnene E, Girard PM. 2009. Therapeutic handbook for malaria in Africa. 1st ed. Doin Publishers. p. 46–47.</title></titleInfo><note type="citation/reference">Eholie SP, Bissagnene E, Girard PM. 2009. Therapeutic handbook for malaria in Africa. 1st ed. Doin Publishers. p. 46–47.</note><name type="personal"><namePart type="given">SP</namePart><namePart type="family">Eholie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Bissagnene</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Girard</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Doin Publishers</publisher></originInfo><part><date>2009</date><extent unit="pages"><start>46</start><end>47</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Comparison of sulfadoxine‐pyrimethamine, unsupervised artemether‐lumefantrine, and unsupervised artesunate‐amodiaquine fixed‐dose formulation for uncomplicated plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial</title></titleInfo><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Faucher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Aubouy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Adeothy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Cottrell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Doritchamou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Gourmel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Houze</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kossou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Amedome</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Massougbodji</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Cot</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Deloron</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Faucher JF, Aubouy A, Adeothy A, Cottrell G, Doritchamou J, Gourmel B, Houze P, Kossou H, Amedome H, Massougbodji A, Cot M, Deloron P. 2009. Comparison of sulfadoxine‐pyrimethamine, unsupervised artemether‐lumefantrine, and unsupervised artesunate‐amodiaquine fixed‐dose formulation for uncomplicated plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial. J Infect Dis 200:57–65.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>200</number></detail><extent unit="pages"><start>57</start><end>65</end></extent></part><relatedItem type="host"><titleInfo><title>J Infect Dis</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>200</number></detail><extent unit="pages"><start>57</start><end>65</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Faye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Ndiaye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Ndiaye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Dieng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Faye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Gaye</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Faye B, Ndiaye JL, Ndiaye D, Dieng Y, Faye O, Gaye O. 2007. Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal. Malar J 6:80.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>80</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>80</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, East Africa</title></titleInfo><name type="personal"><namePart type="given">PE</namePart><namePart type="family">Ferreira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MI</namePart><namePart type="family">Veiga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Cavaco</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Martins</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Andersson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Mushin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AS</namePart><namePart type="family">Ali</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bhattarai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Ribeiro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bjorkman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Gil</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ferreira PE, Veiga MI, Cavaco I, Martins JP, Andersson B, Mushin S, Ali AS, Bhattarai A, Ribeiro V, Bjorkman A, Gil JP. 2008. Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, East Africa. Ther Drug Monit 30:10–15.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>10</start><end>15</end></extent></part><relatedItem type="host"><titleInfo><title>Ther Drug Monit</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>10</start><end>15</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Neurotoxicity due to antimalarial therapy associated with misdiagnosis of malaria</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Franco‐Paredes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Dismukes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Nicolls</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PE</namePart><namePart type="family">Kozarsky</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Franco‐Paredes C, Dismukes R, Nicolls D, Kozarsky PE. 2005. Neurotoxicity due to antimalarial therapy associated with misdiagnosis of malaria. Clin Infect Dis 40:1710–1711.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>1710</start><end>1711</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Infect Dis</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>1710</start><end>1711</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Comparative efficacy of aminoquinoline‐antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda</title></titleInfo><name type="personal"><namePart type="given">AF</namePart><namePart type="family">Gasasira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Dorsey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Nzarubara</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SG</namePart><namePart type="family">Staedke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Nassali</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Rosenthal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MR</namePart><namePart type="family">Kamya</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gasasira AF, Dorsey G, Nzarubara B, Staedke SG, Nassali A, Rosenthal PJ, Kamya MR. 2003. Comparative efficacy of aminoquinoline‐antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg 68:127–132.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>127</start><end>132</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>127</start><end>132</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>High risk of neutropenia in HIV‐infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda</title></titleInfo><name type="personal"><namePart type="given">AF</namePart><namePart type="family">Gasasira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MR</namePart><namePart type="family">Kamya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Achan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Mebrahtu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JN</namePart><namePart type="family">Kalyango</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Ruel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Charlebois</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SG</namePart><namePart type="family">Staedke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Kekitiinwa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Rosenthal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Havlir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Dorsey</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN, Ruel T, Charlebois E, Staedke SG, Kekitiinwa A, Rosenthal PJ, Havlir D, Dorsey G. 2008. High risk of neutropenia in HIV‐infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis 46:985–991.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>985</start><end>991</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Infect Dis</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>985</start><end>991</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Behavioral and neural toxicity of arteether in rats</title></titleInfo><name type="personal"><namePart type="given">RF</namePart><namePart type="family">Genovese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DB</namePart><namePart type="family">Newman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Petras</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TG</namePart><namePart type="family">Brewer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Genovese RF, Newman DB, Petras JM, Brewer TG. 1998. Behavioral and neural toxicity of arteether in rats. Pharmacol Biochem Behav 60:449–458.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>60</number></detail><extent unit="pages"><start>449</start><end>458</end></extent></part><relatedItem type="host"><titleInfo><title>Pharmacol Biochem Behav</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>60</number></detail><extent unit="pages"><start>449</start><end>458</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">German</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Greenhouse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Coates</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Dorsey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Rosenthal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Charlebois</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Lindegardh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Havlir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FT</namePart><namePart type="family">Aweeka</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">German P, Greenhouse B, Coates C, Dorsey G, Rosenthal PJ, Charlebois E, Lindegardh N, Havlir D, Aweeka FT. 2007. Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz. Clin Infect Dis 44:889–891.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>889</start><end>891</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Infect Dis</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>889</start><end>891</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>Current perspectives on the mechanism of action of artemisinins</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Golenser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Waknine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Krugliak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NH</namePart><namePart type="family">Hunt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GE</namePart><namePart type="family">Grau</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Golenser J, Waknine JH, Krugliak M, Hunt NH, Grau GE. 2006. Current perspectives on the mechanism of action of artemisinins. Int J Parasitol 36:1427–1441.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>1427</start><end>1441</end></extent></part><relatedItem type="host"><titleInfo><title>Int J Parasitol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>1427</start><end>1441</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Grandesso</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hagerman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kamara</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Lam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Checchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Balkan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Scollo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Durand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Guthmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Grandesso F, Hagerman A, Kamara S, Lam E, Checchi F, Balkan S, Scollo G, Durand R, Guthmann JP. 2006. Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. Trop Med Int Health 11:1017–1021.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>1017</start><end>1021</end></extent></part><relatedItem type="host"><titleInfo><title>Trop Med Int Health</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>1017</start><end>1021</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Two cases of fulminant hepatitis during a curative treatment with an artesunate‐amodiaquine combination</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Guevart</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Aguemon</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Guevart E, Aguemon A. 2009. Two cases of fulminant hepatitis during a curative treatment with an artesunate‐amodiaquine combination. Med Mal Infect 39:57–60.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>57</start><end>60</end></extent></part><relatedItem type="host"><titleInfo><title>Med Mal Infect</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>57</start><end>60</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>High efficacy of two artemisinin‐based combinations (artesunate+amodiaquine and artemether+lumefantrine) in Caala, Central Angola</title></titleInfo><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Guthmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Cohuet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Rigutto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Fortes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Saraiva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Kiguli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Kyomuhendo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Francis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Noel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Mulemba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Balkan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Guthmann JP, Cohuet S, Rigutto C, Fortes F, Saraiva N, Kiguli J, Kyomuhendo J, Francis M, Noel F, Mulemba M, Balkan S. 2006. High efficacy of two artemisinin‐based combinations (artesunate+amodiaquine and artemether+lumefantrine) in Caala, Central Angola. Am J Trop Med Hyg 75:143–145.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>143</start><end>145</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>143</start><end>145</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit29"><titleInfo><title>Dihydroartemisinin‐piperaquine versus artesunate‐amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug‐resistant Plasmodium falciparum and Plasmodium vivax malaria</title></titleInfo><name type="personal"><namePart type="given">AR</namePart><namePart type="family">Hasugian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HL</namePart><namePart type="family">Purba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Kenangalem</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Wuwung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EP</namePart><namePart type="family">Ebsworth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Maristela</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Penttinen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Laihad</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NM</namePart><namePart type="family">Anstey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Tjitra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RN</namePart><namePart type="family">Price</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hasugian AR, Purba HL, Kenangalem E, Wuwung RM, Ebsworth EP, Maristela R, Penttinen PM, Laihad F, Anstey NM, Tjitra E, Price RN. 2007. Dihydroartemisinin‐piperaquine versus artesunate‐amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug‐resistant Plasmodium falciparum and Plasmodium vivax malaria. Clin Infect Dis 44:1067–1074.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>1067</start><end>1074</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Infect Dis</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>1067</start><end>1074</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit30"><titleInfo><title>Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria</title></titleInfo><name type="personal"><namePart type="given">CS</namePart><namePart type="family">Hatton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TE</namePart><namePart type="family">Peto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Bunch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Pasvol</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SJ</namePart><namePart type="family">Russell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CR</namePart><namePart type="family">Singer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Edwards</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Winstanley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hatton CS, Peto TE, Bunch C, Pasvol G, Russell SJ, Singer CR, Edwards G, Winstanley P. 1986. Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. Lancet 1:411–414.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>411</start><end>414</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>411</start><end>414</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit31"><titleInfo><title>Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">SF</namePart><namePart type="family">Hietala</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bhattarai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Msellem</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Roshammar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AS</namePart><namePart type="family">Ali</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Stromberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FW</namePart><namePart type="family">Hombhanje</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Kaneko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bjorkman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ashton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hietala SF, Bhattarai A, Msellem M, Roshammar D, Ali AS, Stromberg J, Hombhanje FW, Kaneko A, Bjorkman A, Ashton M. 2007. Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria. J Pharmacokinet Pharmacodyn 34:669–686.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>669</start><end>686</end></extent></part><relatedItem type="host"><titleInfo><title>J Pharmacokinet Pharmacodyn</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>669</start><end>686</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit32"><titleInfo><title>Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Holmgren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Gil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Ferreira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MI</namePart><namePart type="family">Veiga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CO</namePart><namePart type="family">Obonyo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bjorkman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Holmgren G, Gil JP, Ferreira PM, Veiga MI, Obonyo CO, Bjorkman A. 2006. Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y. Infect Genet Evol 6:309–314.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>309</start><end>314</end></extent></part><relatedItem type="host"><titleInfo><title>Infect Genet Evol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>309</start><end>314</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit33"><titleInfo><title>Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Holmgren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Hamrin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Svard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Martensson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Gil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bjorkman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Holmgren G, Hamrin J, Svard J, Martensson A, Gil JP, Bjorkman A. 2007. Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa. Infect Genet Evol 7:562–569.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>562</start><end>569</end></extent></part><relatedItem type="host"><titleInfo><title>Infect Genet Evol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>562</start><end>569</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit34"><titleInfo><title>Amodiaquine and artemether‐lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria</title></titleInfo><name type="personal"><namePart type="given">GS</namePart><namePart type="family">Humphreys</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Merinopoulos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Ahmed</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CJ</namePart><namePart type="family">Whitty</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TK</namePart><namePart type="family">Mutabingwa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CJ</namePart><namePart type="family">Sutherland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RL</namePart><namePart type="family">Hallett</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Humphreys GS, Merinopoulos I, Ahmed J, Whitty CJ, Mutabingwa TK, Sutherland CJ, Hallett RL. 2007. Amodiaquine and artemether‐lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria. Antimicrob Agents Chemother 51:991–997.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>51</number></detail><extent unit="pages"><start>991</start><end>997</end></extent></part><relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>51</number></detail><extent unit="pages"><start>991</start><end>997</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit35"><titleInfo><title>Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jewell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Maggs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AC</namePart><namePart type="family">Harrison</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">O'Neill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Ruscoe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BK</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jewell H, Maggs JL, Harrison AC, O'Neill PM, Ruscoe JE, Park BK. 1995. Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine. Xenobiotica 25:199–217.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>199</start><end>217</end></extent></part><relatedItem type="host"><titleInfo><title>Xenobiotica</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>199</start><end>217</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit36"><titleInfo><title>Oro‐facial dyskinesias and amodiaquine</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kamagate</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Die‐Kacou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Balayssac</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PT</namePart><namePart type="family">Daubret</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Yavo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kamagate M, Die‐Kacou H, Balayssac E, Daubret PT, Yavo JC. 2004. Oro‐facial dyskinesias and amodiaquine. Therapie 59:565–566.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><extent unit="pages"><start>565</start><end>566</end></extent></part><relatedItem type="host"><titleInfo><title>Therapie</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><extent unit="pages"><start>565</start><end>566</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit37"><titleInfo><title>Artemisinin‐based combinations versus amodiaquine plus sulphadoxine‐pyrimethamine for the treatment of uncomplicated malaria in Faladje, Mali</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kayentao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Maiga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RD</namePart><namePart type="family">Newman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">McMorrow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hoppe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Yattara</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Traore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Kone</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EA</namePart><namePart type="family">Guirou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Saye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Traore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Djimde</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">OK</namePart><namePart type="family">Doumbo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kayentao K, Maiga H, Newman RD, McMorrow ML, Hoppe A, Yattara O, Traore H, Kone Y, Guirou EA, Saye R, Traore B, Djimde A, Doumbo OK. 2009. Artemisinin‐based combinations versus amodiaquine plus sulphadoxine‐pyrimethamine for the treatment of uncomplicated malaria in Faladje, Mali. Malar J 8:5.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>5</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>5</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit38"><titleInfo><title>A randomized trial on effectiveness of artemether‐lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Kobbe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Klein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Adjei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Amemasor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WN</namePart><namePart type="family">Thompson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Heidemann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MV</namePart><namePart type="family">Nielsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Vohwinkel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Hogan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Kreuels</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Buhrlen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Loag</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Ansong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">May</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kobbe R, Klein P, Adjei S, Amemasor S, Thompson WN, Heidemann H, Nielsen MV, Vohwinkel J, Hogan B, Kreuels B, Buhrlen M, Loag W, Ansong D, May J. 2008. A randomized trial on effectiveness of artemether‐lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children. Malar J 7:261.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>261</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>261</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit39"><titleInfo><title>Efficacy of amodiaquine/artesunate combination therapy for uncomplicated malaria in children under five years in ghana</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Koram</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Quaye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Abuaku</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Koram K, Quaye L, Abuaku B. 2008. Efficacy of amodiaquine/artesunate combination therapy for uncomplicated malaria in children under five years in ghana. Ghana Med J 42:55–60.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>55</start><end>60</end></extent></part><relatedItem type="host"><titleInfo><title>Ghana Med J</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>55</start><end>60</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit40"><titleInfo><title>Effects of amodiaquine, chloroquine, and mefloquine on human polymorphonuclear neutrophil function in vitro</title></titleInfo><name type="personal"><namePart type="given">MT</namePart><namePart type="family">Labro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Babin‐Chevaye</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Labro MT, Babin‐Chevaye C. 1988. Effects of amodiaquine, chloroquine, and mefloquine on human polymorphonuclear neutrophil function in vitro. Antimicrob Agents Chemother 32:1124–1130.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>1124</start><end>1130</end></extent></part><relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>1124</start><end>1130</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit41"><titleInfo><title>Amodiaquine clearance and its metabolism to N‐desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme‐specific probe substrate</title></titleInfo><name type="personal"><namePart type="given">XQ</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bjorkman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TB</namePart><namePart type="family">Andersson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ridderstrom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Masimirembwa</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Li XQ, Bjorkman A, Andersson TB, Ridderstrom M, Masimirembwa CM. 2002. Amodiaquine clearance and its metabolism to N‐desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme‐specific probe substrate. J Pharmacol Exp Ther 300:399–407.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>300</number></detail><extent unit="pages"><start>399</start><end>407</end></extent></part><relatedItem type="host"><titleInfo><title>J Pharmacol Exp Ther</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>300</number></detail><extent unit="pages"><start>399</start><end>407</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit42"><titleInfo><title>Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro</title></titleInfo><name type="personal"><namePart type="given">ST</namePart><namePart type="family">Mariga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Gil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WH</namePart><namePart type="family">Wernsdorfer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bjorkman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mariga ST, Gil JP, Wernsdorfer WH, Bjorkman A. 2005. Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro. Acta Trop 93:221–231.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>221</start><end>231</end></extent></part><relatedItem type="host"><titleInfo><title>Acta Trop</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>221</start><end>231</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit43"><titleInfo><title>Efficacy of artesunate plus amodiaquine versus that of artemether‐lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Martensson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Stromberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Sisowath</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MI</namePart><namePart type="family">Msellem</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Gil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Montgomery</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AS</namePart><namePart type="family">Ali</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bjorkman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Martensson A, Stromberg J, Sisowath C, Msellem MI, Gil JP, Montgomery SM, Olliaro P, Ali AS, Bjorkman A. 2005. Efficacy of artesunate plus amodiaquine versus that of artemether‐lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania. Clin Infect Dis 41:1079–1086.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>1079</start><end>1086</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Infect Dis</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>1079</start><end>1086</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit44"><titleInfo><title>Incidence of liver injury after beginning antiretroviral therapy with efavirenz or nevirapine</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Martin‐Carbonero</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Nunez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Gonzalez‐Lahoz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Soriano</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Martin‐Carbonero L, Nunez M, Gonzalez‐Lahoz J, Soriano V. 2003. Incidence of liver injury after beginning antiretroviral therapy with efavirenz or nevirapine. HIV Clin Trials 4:115–120.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>115</start><end>120</end></extent></part><relatedItem type="host"><titleInfo><title>HIV Clin Trials</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>115</start><end>120</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit45"><titleInfo><title>Amodiaquine alone, amodiaquine+sulfadoxine‐pyrimethamine, amodiaquine+artesunate, and artemether‐lumefantrine for outpatient treatment of malaria in Tanzanian children: a four‐arm randomised effectiveness trial</title></titleInfo><name type="personal"><namePart type="given">TK</namePart><namePart type="family">Mutabingwa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Anthony</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Heller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Hallett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Ahmed</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Drakeley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BM</namePart><namePart type="family">Greenwood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CJ</namePart><namePart type="family">Whitty</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mutabingwa TK, Anthony D, Heller A, Hallett R, Ahmed J, Drakeley C, Greenwood BM, Whitty CJ. 2005. Amodiaquine alone, amodiaquine+sulfadoxine‐pyrimethamine, amodiaquine+artesunate, and artemether‐lumefantrine for outpatient treatment of malaria in Tanzanian children: a four‐arm randomised effectiveness trial. Lancet 365:1474–1480.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>365</number></detail><extent unit="pages"><start>1474</start><end>1480</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>365</number></detail><extent unit="pages"><start>1474</start><end>1480</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit46"><titleInfo><title>Tolerability and pharmacokinetics of non‐fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">Navaratnam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Ramanathan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MS</namePart><namePart type="family">Wahab</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Siew Hua</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Mansor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Kiechel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Vaillant</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WR</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Navaratnam V, Ramanathan S, Wahab MS, Siew Hua G, Mansor SM, Kiechel JR, Vaillant M, Taylor WR, Olliaro P. 2009. Tolerability and pharmacokinetics of non‐fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers. Eur J Clin Pharmacol 65:809–821.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>809</start><end>821</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Clin Pharmacol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>809</start><end>821</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit47"><titleInfo><title>Randomized, multicentre assessment of the efficacy and safety of ASAQ: a fixed‐dose artesunate‐amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Ndiaye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Randrianarivelojosia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Sagara</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Brasseur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Ndiaye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Faye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Randrianasolo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ratsimbasoa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Forlemu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VA</namePart><namePart type="family">Moor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Traore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Dicko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Dara</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Lameyre</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Diallo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Djimde</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Same‐Ekobo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Gaye</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ndiaye JL, Randrianarivelojosia M, Sagara I, Brasseur P, Ndiaye I, Faye B, Randrianasolo L, Ratsimbasoa A, Forlemu D, Moor VA, Traore A, Dicko Y, Dara N, Lameyre V, Diallo M, Djimde A, Same‐Ekobo A, Gaye O. 2009. Randomized, multicentre assessment of the efficacy and safety of ASAQ: a fixed‐dose artesunate‐amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria. Malar J 8:125.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>125</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>125</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit48"><titleInfo><title>Amodiaquine induced agranulocytosis and liver damage</title></titleInfo><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Neftel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Woodtly</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schmid</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Frick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Fehr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Neftel KA, Woodtly W, Schmid M, Frick PG, Fehr J. 1986. Amodiaquine induced agranulocytosis and liver damage. Br Med J (Clin Res Ed) 292:721–723.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>292</number></detail><extent unit="pages"><start>721</start><end>723</end></extent></part><relatedItem type="host"><titleInfo><title>Br Med J (Clin Res Ed)</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>292</number></detail><extent unit="pages"><start>721</start><end>723</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit49"><titleInfo><title>Cardiac effects of amodiaquine and sulfadoxine‐pyrimethamine in malaria‐infected African patients</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Ngouesse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Basco</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Ringwald</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Keundjian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KN</namePart><namePart type="family">Blackett</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ngouesse B, Basco LK, Ringwald P, Keundjian A, Blackett KN. 2001. Cardiac effects of amodiaquine and sulfadoxine‐pyrimethamine in malaria‐infected African patients. Am J Trop Med Hyg 65:711–716.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>711</start><end>716</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>711</start><end>716</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit50"><titleInfo><title>Resistance‐mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate‐amodiaquine in Uganda</title></titleInfo><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Nsobya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Dokomajilar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Joloba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Dorsey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Rosenthal</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nsobya SL, Dokomajilar C, Joloba M, Dorsey G, Rosenthal PJ. 2007. Resistance‐mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate‐amodiaquine in Uganda. Antimicrob Agents Chemother 51:3023–3025.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>51</number></detail><extent unit="pages"><start>3023</start><end>3025</end></extent></part><relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>51</number></detail><extent unit="pages"><start>3023</start><end>3025</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit51"><titleInfo><title>A randomized, comparative study of supervised and unsupervised artesunate‐amodiaquine, for the treatment of uncomplicated malaria in Ghana</title></titleInfo><name type="personal"><namePart type="given">AR</namePart><namePart type="family">Oduro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Anyorigiya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Anto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Amenga‐Etego</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NA</namePart><namePart type="family">Ansah</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Atobrah</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Ansah</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Koram</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hodgson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Oduro AR, Anyorigiya T, Anto F, Amenga‐Etego L, Ansah NA, Atobrah P, Ansah P, Koram K, Hodgson A. 2008. A randomized, comparative study of supervised and unsupervised artesunate‐amodiaquine, for the treatment of uncomplicated malaria in Ghana. Ann Trop Med Parasitol 102:565–576.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>102</number></detail><extent unit="pages"><start>565</start><end>576</end></extent></part><relatedItem type="host"><titleInfo><title>Ann Trop Med Parasitol</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>102</number></detail><extent unit="pages"><start>565</start><end>576</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit52"><titleInfo><title>Systematic review of amodiaquine treatment in uncomplicated malaria</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Nevill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">LeBras</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Ringwald</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Mussano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Garner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Brasseur</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Olliaro P, Nevill C, LeBras J, Ringwald P, Mussano P, Garner P, Brasseur P. 1996. Systematic review of amodiaquine treatment in uncomplicated malaria. Lancet 348:1196–1201.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>348</number></detail><extent unit="pages"><start>1196</start><end>1201</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>348</number></detail><extent unit="pages"><start>1196</start><end>1201</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit53"><titleInfo><title>Olumese P. 2007. Antimalarial treatment policies for P. falciparum and P. vivax by country in WHO Africa region. Antimalarial drug policies, AFRO Global AMDP Database.</title></titleInfo><note type="citation/reference">Olumese P. 2007. Antimalarial treatment policies for P. falciparum and P. vivax by country in WHO Africa region. Antimalarial drug policies, AFRO Global AMDP Database.</note><name type="personal"><namePart type="given">P</namePart><namePart type="family">Olumese</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Antimalarial drug policies, AFRO Global AMDP Database</publisher></originInfo><part><date>2007</date></part></relatedItem><relatedItem type="references" displayLabel="cit54"><titleInfo><title>The xenobiotic inhibitor profile of cytochrome P4502C8</title></titleInfo><name type="personal"><namePart type="given">CE</namePart><namePart type="family">Ong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Coulter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Birkett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CR</namePart><namePart type="family">Bhasker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JO</namePart><namePart type="family">Miners</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ong CE, Coulter S, Birkett DJ, Bhasker CR, Miners JO. 2000. The xenobiotic inhibitor profile of cytochrome P4502C8. Br J Clin Pharmacol 50:573–580.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>573</start><end>580</end></extent></part><relatedItem type="host"><titleInfo><title>Br J Clin Pharmacol</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>573</start><end>580</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit55"><titleInfo><title>Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Orrell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WR</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Orrell C, Taylor WR, Olliaro P. 2001. Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate. Trans R Soc Trop Med Hyg 95:517–518.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><extent unit="pages"><start>517</start><end>518</end></extent></part><relatedItem type="host"><titleInfo><title>Trans R Soc Trop Med Hyg</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><extent unit="pages"><start>517</start><end>518</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit56"><titleInfo><title>Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Orrell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Little</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Folb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KI</namePart><namePart type="family">Barnes</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Orrell C, Little F, Smith P, Folb P, Taylor W, Olliaro P, Barnes KI. 2008. Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers. Eur J Clin Pharmacol 64:683–690.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>64</number></detail><extent unit="pages"><start>683</start><end>690</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Clin Pharmacol</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>64</number></detail><extent unit="pages"><start>683</start><end>690</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit57"><titleInfo><title>Artemisinin‐based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Osorio</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Gonzalez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WR</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Osorio L, Gonzalez I, Olliaro P, Taylor WR. 2007. Artemisinin‐based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia. Malar J 6:25.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>25</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>25</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit58"><titleInfo><title>An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil‐dapsone and artemether‐lumefantrine for the treatment of uncomplicated malaria</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Owusu‐Agyei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KP</namePart><namePart type="family">Asante</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Owusu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Adjuik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Amenga‐Etego</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DK</namePart><namePart type="family">Dosoo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Gyapong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Greenwood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Chandramohan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Owusu‐Agyei S, Asante KP, Owusu R, Adjuik M, Amenga‐Etego S, Dosoo DK, Gyapong J, Greenwood B, Chandramohan D. 2008. An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil‐dapsone and artemether‐lumefantrine for the treatment of uncomplicated malaria. PLoS ONE 3:e2530.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>e2530</start></extent></part><relatedItem type="host"><titleInfo><title>PLoS ONE</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>e2530</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit59"><titleInfo><title>Artesunate‐amodiaquine combination therapy for falciparum malaria in young Gabonese children</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Oyakhirome</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Potschke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NG</namePart><namePart type="family">Schwarz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Dornemann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Laengin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CO</namePart><namePart type="family">Salazar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Lell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Kun</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Kremsner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MP</namePart><namePart type="family">Grobusch</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Oyakhirome S, Potschke M, Schwarz NG, Dornemann J, Laengin M, Salazar CO, Lell B, Kun JF, Kremsner PG, Grobusch MP. 2007. Artesunate‐amodiaquine combination therapy for falciparum malaria in young Gabonese children. Malar J 6:29.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>29</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>29</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit60"><titleInfo><title>Toxic brainstem encephalopathy after artemisinin treatment for breast cancer</title></titleInfo><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Panossian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NI</namePart><namePart type="family">Garga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Pelletier</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Panossian LA, Garga NI, Pelletier D. 2005. Toxic brainstem encephalopathy after artemisinin treatment for breast cancer. Ann Neurol 58:812–813.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>58</number></detail><extent unit="pages"><start>812</start><end>813</end></extent></part><relatedItem type="host"><titleInfo><title>Ann Neurol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>58</number></detail><extent unit="pages"><start>812</start><end>813</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit61"><titleInfo><title>Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Parikh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JB</namePart><namePart type="family">Ouedraogo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Goldstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Rosenthal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DL</namePart><namePart type="family">Kroetz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Parikh S, Ouedraogo JB, Goldstein JA, Rosenthal PJ, Kroetz DL. 2007. Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther 82:197–203.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>82</number></detail><extent unit="pages"><start>197</start><end>203</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Pharmacol Ther</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>82</number></detail><extent unit="pages"><start>197</start><end>203</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit62"><titleInfo><title>Serious adverse drug reactions to pyrimethamine‐sulphadoxine, pyrimethamine‐dapsone and to amodiaquine</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Philips‐Howard</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Philips‐Howard P. 1990. Serious adverse drug reactions to pyrimethamine‐sulphadoxine, pyrimethamine‐dapsone and to amodiaquine. J R Soc Med 83:82–85.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>82</start><end>85</end></extent></part><relatedItem type="host"><titleInfo><title>J R Soc Med</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>82</start><end>85</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit63"><titleInfo><title>Disposition of monodesethylamodiaquine after a single oral dose of amodiaquine and three regimens for prophylaxis against Plasmodium falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Pussard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Verdier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Faurisson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Scherrmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Le Bras</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MC</namePart><namePart type="family">Blayo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pussard E, Verdier F, Faurisson F, Scherrmann JM, Le Bras J, Blayo MC. 1987. Disposition of monodesethylamodiaquine after a single oral dose of amodiaquine and three regimens for prophylaxis against Plasmodium falciparum malaria. Eur J Clin Pharmacol 33:409–414.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>409</start><end>414</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Clin Pharmacol</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>409</start><end>414</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit64"><titleInfo><title>Position of WHO's RBM Department on malaria treatment policy statement</title></titleInfo><name type="corporate"><namePart>RBM/WHO</namePart></name><genre>other</genre><part><date>2004</date></part></relatedItem><relatedItem type="references" displayLabel="cit65"><titleInfo><title>Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">EG</namePart><namePart type="family">Rhodes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Ball</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IM</namePart><namePart type="family">Franklin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rhodes EG, Ball J, Franklin IM. 1986. Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents. Br Med J (Clin Res Ed) 292:717–718.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>292</number></detail><extent unit="pages"><start>717</start><end>718</end></extent></part><relatedItem type="host"><titleInfo><title>Br Med J (Clin Res Ed)</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>292</number></detail><extent unit="pages"><start>717</start><end>718</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit66"><titleInfo><title>Effect of disposition of mannich antimalarial agents on their pharmacology and toxicology</title></titleInfo><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Ruscoe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MD</namePart><namePart type="family">Tingle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">O'Neill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Ward</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BK</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ruscoe JE, Tingle MD, O'Neill PM, Ward SA, Park BK. 1998. Effect of disposition of mannich antimalarial agents on their pharmacology and toxicology. Antimicrob Agents Chemother 42:2410–2416.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>2410</start><end>2416</end></extent></part><relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>2410</start><end>2416</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit67"><titleInfo><title>Metabolism‐dependent hepatotoxicity of amodiaquine in glutathione‐depleted mice</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Shimizu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Atsumi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Itokawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Iwasaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Aoki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Ono</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Izumi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Sudo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Okazaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shimizu S, Atsumi R, Itokawa K, Iwasaki M, Aoki T, Ono C, Izumi T, Sudo K, Okazaki O. 2009. Metabolism‐dependent hepatotoxicity of amodiaquine in glutathione‐depleted mice. Arch Toxicol 83:701–707.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>701</start><end>707</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Toxicol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>701</start><end>707</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit68"><titleInfo><title>The efficacy and safety of a new fixed‐dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum</title></titleInfo><name type="personal"><namePart type="given">SB</namePart><namePart type="family">Sirima</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AB</namePart><namePart type="family">Tiono</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Gansane</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Diarra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ouedraogo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AT</namePart><namePart type="family">Konate</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Kiechel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Morgan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PL</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WR</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sirima SB, Tiono AB, Gansane A, Diarra A, Ouedraogo A, Konate AT, Kiechel JR, Morgan CC, Olliaro PL, Taylor WR. 2009. The efficacy and safety of a new fixed‐dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum. Malar J 8:48.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>48</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>48</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit69"><titleInfo><title>The global distribution of clinical episodes of Plasmodium falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">RW</namePart><namePart type="family">Snow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Guerra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Noor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HY</namePart><namePart type="family">Myint</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SI</namePart><namePart type="family">Hay</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI. 2005. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434:214–217.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>434</number></detail><extent unit="pages"><start>214</start><end>217</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>434</number></detail><extent unit="pages"><start>214</start><end>217</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit70"><titleInfo><title>Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin</title></titleInfo><name type="personal"><namePart type="given">US</namePart><namePart type="family">Svensson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ashton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Svensson US, Ashton M. 1999. Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin. Br J Clin Pharmacol 48:528–535.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>528</start><end>535</end></extent></part><relatedItem type="host"><titleInfo><title>Br J Clin Pharmacol</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>528</start><end>535</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit71"><titleInfo><title>Artesunate+amodiaquine and artesunate+sulphadoxine‐pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine‐resistant haplotypes</title></titleInfo><name type="personal"><namePart type="given">TD</namePart><namePart type="family">Swarthout</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IV</namePart><namePart type="family">van den Broek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Kayembe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Montgomery</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Pota</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Roper</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Swarthout TD, van den Broek IV, Kayembe G, Montgomery J, Pota H, Roper C. 2006. Artesunate+amodiaquine and artesunate+sulphadoxine‐pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine‐resistant haplotypes. Trop Med Int Health 11:1503–1511.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>1503</start><end>1511</end></extent></part><relatedItem type="host"><titleInfo><title>Trop Med Int Health</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>1503</start><end>1511</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit72"><titleInfo><title>Use of weight‐for‐age‐data to optimize tablet strength and dosing regimens for a new fixed‐dose artesunate‐amodiaquine combination for treating falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">WR</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Terlouw</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PL</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Brasseur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FO</namePart><namePart type="family">ter Kuile</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Taylor WR, Terlouw DJ, Olliaro PL, White NJ, Brasseur P, ter Kuile FO. 2006. Use of weight‐for‐age‐data to optimize tablet strength and dosing regimens for a new fixed‐dose artesunate‐amodiaquine combination for treating falciparum malaria. Bull World Health Organ 84:956–964.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>956</start><end>964</end></extent></part><relatedItem type="host"><titleInfo><title>Bull World Health Organ</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>956</start><end>964</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit73"><titleInfo><title>Open label randomized comparison of dihydroartemisinin‐piperaquine and artesunate‐amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam</title></titleInfo><name type="personal"><namePart type="given">NX</namePart><namePart type="family">Thanh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TN</namePart><namePart type="family">Trung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NC</namePart><namePart type="family">Phong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NX</namePart><namePart type="family">Thien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Dai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Dennis Shanks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Chavchich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MD</namePart><namePart type="family">Edstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Thanh NX, Trung TN, Phong NC, Thien NX, Dai B, Dennis Shanks G, Chavchich M, Edstein MD. 2009. Open label randomized comparison of dihydroartemisinin‐piperaquine and artesunate‐amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam. Trop Med Int Health.</note><part><date>2009</date></part><relatedItem type="host"><titleInfo><title>Trop Med Int Health</title></titleInfo><part><date>2009</date></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit74"><titleInfo><title>Efficacy of three artemisinin combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in the Republic of Congo</title></titleInfo><name type="personal"><namePart type="given">I</namePart><namePart type="family">van den Broek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Kitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Al Attas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Libama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Balasegaram</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Guthmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">van den Broek I, Kitz C, Al Attas S, Libama F, Balasegaram M, Guthmann JP. 2006. Efficacy of three artemisinin combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in the Republic of Congo. Malar J 5:113.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>113</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>113</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit75"><titleInfo><title>A molecular marker for chloroquine‐resistant falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Warhurst</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Warhurst DC. 2001. A molecular marker for chloroquine‐resistant falciparum malaria. N Engl J Med 344:299–302.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>344</number></detail><extent unit="pages"><start>299</start><end>302</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>344</number></detail><extent unit="pages"><start>299</start><end>302</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit76"><titleInfo><title>WHO. 2000. The use of antimalarial drugs. Report of a WHO informal consultation 13–17 November 2000. Geneva: World Health Organisation.</title></titleInfo><name type="corporate"><namePart>WHO</namePart></name><note type="citation/reference">WHO. 2000. The use of antimalarial drugs. Report of a WHO informal consultation 13–17 November 2000. Geneva: World Health Organisation.</note><genre>book</genre><originInfo><publisher>World Health Organisation</publisher><place><placeTerm type="text">Geneva</placeTerm></place></originInfo><part><date>2000</date></part></relatedItem><relatedItem type="references" displayLabel="cit77"><titleInfo><title>WHO. 2006. World Health Organisation and World. Guidelines for the treatment of Malaria. Global malaria programme. Geneva: World Health Organisation.</title></titleInfo><name type="corporate"><namePart>WHO</namePart></name><note type="citation/reference">WHO. 2006. World Health Organisation and World. Guidelines for the treatment of Malaria. Global malaria programme. Geneva: World Health Organisation.</note><genre>book</genre><originInfo><publisher>World Health Organisation</publisher><place><placeTerm type="text">Geneva</placeTerm></place></originInfo><part><date>2006</date></part></relatedItem><relatedItem type="references" displayLabel="cit78"><titleInfo><title>Effect of dose size on amodiaquine pharmacokinetics after oral administration</title></titleInfo><name type="personal"><namePart type="given">PA</namePart><namePart type="family">Winstanley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Edwards</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Orme</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Breckenridge</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Winstanley PA, Edwards G, Orme ML, Breckenridge AM. 1987. Effect of dose size on amodiaquine pharmacokinetics after oral administration. Eur J Clin Pharmacol 33:331–333.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>331</start><end>333</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Clin Pharmacol</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>331</start><end>333</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit79"><titleInfo><title>The disposition of amodiaquine in Zambians and Nigerians with malaria</title></titleInfo><name type="personal"><namePart type="given">PA</namePart><namePart type="family">Winstanley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Simooya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Kofi‐Ekue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Walker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Salako</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Edwards</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Orme</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Breckenridge</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Winstanley PA, Simooya O, Kofi‐Ekue JM, Walker O, Salako LA, Edwards G, Orme ML, Breckenridge AM. 1990. The disposition of amodiaquine in Zambians and Nigerians with malaria. Br J Clin Pharmacol 29:695–701.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>695</start><end>701</end></extent></part><relatedItem type="host"><titleInfo><title>Br J Clin Pharmacol</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>695</start><end>701</end></extent></part></relatedItem></relatedItem><identifier type="istex">C2EE642E7B6BEBFA15EBD91499F38D4CF4DFFE2E</identifier><identifier type="ark">ark:/67375/WNG-THNGGQ4G-R</identifier><identifier type="DOI">10.1002/ddr.20346</identifier><identifier type="ArticleID">DDR20346</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2009 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-14</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-THNGGQ4G-R/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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