Artesunate plus amodiaquine combination therapy: reviewing the evidence
Identifieur interne : 001247 ( Istex/Corpus ); précédent : 001246; suivant : 001248Artesunate plus amodiaquine combination therapy: reviewing the evidence
Auteurs : George O. Adjei ; William Kudzi ; Alexander Dodoo ; Jorgen A. L. KurtzhalsSource :
- Drug Development Research [ 0272-4391 ] ; 2010-02.
Abstract
The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed‐dose combination of artemether‐lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first‐line therapy for uncomplicated malaria by National Malaria Control Programs in sub‐Saharan Africa. In contrast to other ACT regimens in current use, on which reviews of the available evidence on safety and efficacy have been periodically published, no, or few summaries of the extensive data available on the safety and efficacy of this widely used ACT are available in the published literature. The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed. Drug Dev Res 71: 33–43, 2010. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ddr.20346
Links to Exploration step
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<front><div type="abstract" xml:lang="en">The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed‐dose combination of artemether‐lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first‐line therapy for uncomplicated malaria by National Malaria Control Programs in sub‐Saharan Africa. In contrast to other ACT regimens in current use, on which reviews of the available evidence on safety and efficacy have been periodically published, no, or few summaries of the extensive data available on the safety and efficacy of this widely used ACT are available in the published literature. The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed. Drug Dev Res 71: 33–43, 2010. © 2009 Wiley‐Liss, Inc.</div>
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<abstract lang="en">The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed‐dose combination of artemether‐lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first‐line therapy for uncomplicated malaria by National Malaria Control Programs in sub‐Saharan Africa. In contrast to other ACT regimens in current use, on which reviews of the available evidence on safety and efficacy have been periodically published, no, or few summaries of the extensive data available on the safety and efficacy of this widely used ACT are available in the published literature. The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed. Drug Dev Res 71: 33–43, 2010. © 2009 Wiley‐Liss, Inc.</abstract>
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<relatedItem type="references" displayLabel="cit1"><titleInfo><title>Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria</title>
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<name type="personal"><namePart type="given">GO</namePart>
<namePart type="family">Adjei</namePart>
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<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Kristensen</namePart>
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<note type="citation/reference">Adjei GO, Kristensen K, Goka BQ, Hoegberg LC, Alifrangis M, Rodrigues OP, Kurtzhals JA. 2008a. Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria. Antimicrob Agents Chemother 52:4400–4406.</note>
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<relatedItem type="references" displayLabel="cit2"><titleInfo><title>Amodiaquine‐artesunate vs artemether‐lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow‐up</title>
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<note type="citation/reference">Adjei GO, Kurtzhals JA, Rodrigues OP, Alifrangis M, Hoegberg LC, Kitcher ED, Badoe EV, Lamptey R, Goka BQ. 2008b. Amodiaquine‐artesunate vs artemether‐lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow‐up. Malar J 7:127.</note>
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<relatedItem type="references" displayLabel="cit3"><titleInfo><title>Amodiaquine‐artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial</title>
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