Altered drug metabolism in parasitic diseases
Identifieur interne : 001204 ( Istex/Corpus ); précédent : 001203; suivant : 001205Altered drug metabolism in parasitic diseases
Auteurs : B. L. Tekwanl ; O. P. Shukla ; S. GhatakSource :
- Parasitology Today [ 0169-4758 ] ; 1988.
English descriptors
- Teeft :
- Active compounds, Active substances, Aniline hydroxylase, Antimalarial drugs, Cerebral tissues, Chloroquine, Corresponding decrease, Cytochrome, Cytochrome reductase, Cytochrome reductase activity, Drug metabolism, Drugmetabolizing enzymes, Endoplasmic reticulum, Falciparum, Falciparum malaria, Fascioliasis, Function oxidase system, Functional group, Hepatic, Hepatic amoebiasis, Hepatica, Hepatica infection, Hepatocellular proliferation, Hexobarbital metabolism, Hexobarbital oxidase, Hydroxylase, Impairment, Infection, Lesser extent, Lipid bilayer, Liver pathology, Main line, Malaria, Metabolism, Microsomal, Microsomal cytochrome, Microsomal membranes, Parasite, Parasitic, Parasitic infection, Parasitic infections, Parasitology today, Patent phase, Pharmacol, Reductase, Schistosomiasis, Severe falciparum malaria, Target molecule, Uncomplicated malaria, Zoxazolamine hydroxylase.
Abstract
Abstract: While the immune system represents the main line of host defence against parasite infections, mixed function oxidase (MFO) systems (Box 1) offer the main line of defence against drugs and other biologically active substances. But, as this review shows, many parasites can exert a profound effect on the host MFO system by altering the microsomal drug-metabolizing enzymes and electron transport carriers such as cytochrome P-450. This can markedly affect the host's ability to metabolize biologically active compounds, often with adverse physiological, pharmacological and toxicological consequences.In mammals, drug metabolism occurs predominantly in the liver, and to a lesser extent in the spleen, lungs, kidneys, intestine and cerebral tissues. Thus those parasites that occupy sites in these tissues - such as amoebae, Fasciola, schistosomes and malaria - tend to be those with greatest effects on the host's ability to metabolize drugs. The effects can modify the host response to substances unrelated to the infection, and to drugs which may be administered under a chemotherapeutic regime.
Url:
DOI: 10.1016/0169-4758(88)90047-6
Links to Exploration step
ISTEX:194DAD98705CAD7DDBB61EF324503833A8EC6F59Le document en format XML
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Tekwanl</name><affiliation><mods:affiliation>Laboratory of Parasite Biochemistry, Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001, India</mods:affiliation></affiliation></author><author><name sortKey="Shukla, O P" sort="Shukla, O P" uniqKey="Shukla O" first="O. P." last="Shukla">O. P. Shukla</name><affiliation><mods:affiliation>Laboratory of Parasite Biochemistry, Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001, India</mods:affiliation></affiliation></author><author><name sortKey="Ghatak, S" sort="Ghatak, S" uniqKey="Ghatak S" first="S." last="Ghatak">S. 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But, as this review shows, many parasites can exert a profound effect on the host MFO system by altering the microsomal drug-metabolizing enzymes and electron transport carriers such as cytochrome P-450. This can markedly affect the host's ability to metabolize biologically active compounds, often with adverse physiological, pharmacological and toxicological consequences.In mammals, drug metabolism occurs predominantly in the liver, and to a lesser extent in the spleen, lungs, kidneys, intestine and cerebral tissues. Thus those parasites that occupy sites in these tissues - such as amoebae, Fasciola, schistosomes and malaria - tend to be those with greatest effects on the host's ability to metabolize drugs. 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But, as this review shows, many parasites can exert a profound effect on the host MFO system by altering the microsomal drug-metabolizing enzymes and electron transport carriers such as cytochrome P-450. This can markedly affect the host's ability to metabolize biologically active compounds, often with adverse physiological, pharmacological and toxicological consequences.In mammals, drug metabolism occurs predominantly in the liver, and to a lesser extent in the spleen, lungs, kidneys, intestine and cerebral tissues. Thus those parasites that occupy sites in these tissues - such as amoebae, Fasciola, schistosomes and malaria - tend to be those with greatest effects on the host's ability to metabolize drugs. The effects can modify the host response to substances unrelated to the infection, and to drugs which may be administered under a chemotherapeutic regime.</p></abstract></profileDesc><revisionDesc><change when="1988">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-KVCX4W2B-P/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="rev"><item-info><jid>PARTOD</jid><aid>88900476</aid><ce:pii>0169-4758(88)90047-6</ce:pii><ce:doi>10.1016/0169-4758(88)90047-6</ce:doi><ce:copyright type="unknown" year="1988"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Review</ce:textfn></ce:dochead><ce:title>Altered drug metabolism in parasitic diseases</ce:title><ce:author-group><ce:author><ce:given-name>B.L.</ce:given-name><ce:surname>Tekwanl</ce:surname></ce:author><ce:author><ce:given-name>O.P.</ce:given-name><ce:surname>Shukla</ce:surname></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Ghatak</ce:surname></ce:author><ce:affiliation><ce:textfn>Laboratory of Parasite Biochemistry, Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001, India</ce:textfn></ce:affiliation></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>While the immune system represents the main line of host defence against parasite infections, mixed function oxidase (MFO) systems (Box 1) offer the main line of defence against drugs and other biologically active substances. But, as this review shows, many parasites can exert a profound effect on the host MFO system by altering the microsomal drug-metabolizing enzymes and electron transport carriers such as cytochrome P-450. This can markedly affect the host's ability to metabolize biologically active compounds, often with adverse physiological, pharmacological and toxicological consequences.</ce:simple-para><ce:simple-para>In mammals, drug metabolism occurs predominantly in the liver, and to a lesser extent in the spleen, lungs, kidneys, intestine and cerebral tissues. Thus those parasites that occupy sites in these tissues - such as amoebae, <ce:italic>Fasciola</ce:italic>, schistosomes and malaria - tend to be those with greatest effects on the host's ability to metabolize drugs. The effects can modify the host response to substances unrelated to the infection, and to drugs which may be administered under a chemotherapeutic regime.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Altered drug metabolism in parasitic diseases</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Altered drug metabolism in parasitic diseases</title></titleInfo><name type="personal"><namePart type="given">B.L.</namePart><namePart type="family">Tekwanl</namePart><affiliation>Laboratory of Parasite Biochemistry, Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.P.</namePart><namePart type="family">Shukla</namePart><affiliation>Laboratory of Parasite Biochemistry, Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Ghatak</namePart><affiliation>Laboratory of Parasite Biochemistry, Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="Review article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1988</dateIssued><copyrightDate encoding="w3cdtf">1988</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: While the immune system represents the main line of host defence against parasite infections, mixed function oxidase (MFO) systems (Box 1) offer the main line of defence against drugs and other biologically active substances. But, as this review shows, many parasites can exert a profound effect on the host MFO system by altering the microsomal drug-metabolizing enzymes and electron transport carriers such as cytochrome P-450. This can markedly affect the host's ability to metabolize biologically active compounds, often with adverse physiological, pharmacological and toxicological consequences.In mammals, drug metabolism occurs predominantly in the liver, and to a lesser extent in the spleen, lungs, kidneys, intestine and cerebral tissues. Thus those parasites that occupy sites in these tissues - such as amoebae, Fasciola, schistosomes and malaria - tend to be those with greatest effects on the host's ability to metabolize drugs. 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