Acute sickle cell syndromes in Nigerian adults
Identifieur interne : 001147 ( Istex/Corpus ); précédent : 001146; suivant : 001148Acute sickle cell syndromes in Nigerian adults
Auteurs : M. O. Ibidapo ; O. O. AkinyanjuSource :
- Clinical & Laboratory Haematology [ 0141-9854 ] ; 2000-06.
English descriptors
- Teeft :
- Acute admissions, Acute chest syndrome, Acute illness, Akinyanju, Akinyanju johnson, American journal, Anaemia, Anaemia crises, Anaemia crisis, Bacterial infection, Bacterial infections, Blackwell science, Blood cultures, Brozovic, Cell syndromes, Clinical manifestations, Clinical signs, Dacie lewis, Davies brownwell, Davies henthorn, Emergency unit, Girdle syndrome, Haemoglobin concentration, Hendrickse collard, High mortality rate, Higher incidence, Jellife humphreys, Lagos, Malaria, Mallouh salamah, Nigeria, Nigerian, Nigerian children, Pain crises, Pain crisis, Present patients, Same hospital, Sickle, Sickle cell anaemia, Sickle cell anemia, Sickle cell crises, Sickle cell disease, Sickle cell trait, Sickle gene, Syndrome, Tropical medicine, Tropical paediatrics, Uncomplicated pain crisis, Undetermined origin, Walters lehmann, Younger patients.
Abstract
The pattern of acute illness was determined in 102 adolescents and adults with sickle cell anaemia who presented to the emergency unit of a Lagos hospital. The patients had a mean age of 20.5 years ( sd 13.1) and a male–female ratio of 1.5. The symptoms included fever (72%), fatigue and weakness (59%), anorexia (59%) and pain (57.5%) while major clinical signs were pallor (100%), jaundice (71%) and hepatomegaly (68%). Sixty‐eight per cent of patients had sickle cell crises, including one with hemiplegic stroke, 10% with combined anaemia and pain crises, 33% with anaemia crises only and 23.5% with pain crises only. Sixty‐three per cent had infection which was malaria in 24.5%, bacterial in 17% and viral in 6%. Of 16 patients with pyrexia of unknown origin, seven responded to treatment with chloroquine and eight to antibiotics. Infection was detected in 50% of the patients with sickle cell crises. The association between anaemia crises and malaria was significant (P < 0.05). Of the eight deaths, seven (88%) had anaemia crises. In contrast to studies conducted two decades ago in the same hospital, the prevalence of anaemia crises now exceeds that of pain crises and malaria now exceeds that of bacterial infection. Severe symptomatic anaemia (anaemia crisis) was more frequently associated with infection (mostly malaria) than was bone pain crisis. The Girdle pain crisis more frequently resulted in a fatal outcome than the uncomplicated bone pain crisis.
Url:
DOI: 10.1046/j.1365-2257.2000.00292.x
Links to Exploration step
ISTEX:1E9A18BA51767151D3BF9797030FD0F063684BE7Le document en format XML
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The patients had a mean age of 20.5 years ( sd 13.1) and a male–female ratio of 1.5. The symptoms included fever (72%), fatigue and weakness (59%), anorexia (59%) and pain (57.5%) while major clinical signs were pallor (100%), jaundice (71%) and hepatomegaly (68%). Sixty‐eight per cent of patients had sickle cell crises, including one with hemiplegic stroke, 10% with combined anaemia and pain crises, 33% with anaemia crises only and 23.5% with pain crises only. Sixty‐three per cent had infection which was malaria in 24.5%, bacterial in 17% and viral in 6%. Of 16 patients with pyrexia of unknown origin, seven responded to treatment with chloroquine and eight to antibiotics. Infection was detected in 50% of the patients with sickle cell crises. The association between anaemia crises and malaria was significant (P < 0.05). Of the eight deaths, seven (88%) had anaemia crises. In contrast to studies conducted two decades ago in the same hospital, the prevalence of anaemia crises now exceeds that of pain crises and malaria now exceeds that of bacterial infection. Severe symptomatic anaemia (anaemia crisis) was more frequently associated with infection (mostly malaria) than was bone pain crisis. 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Ibidapo</name><affiliations><json:string>Department of Medicine, College of Medicine of the University of Lagos, Lagos, Nigeria</json:string></affiliations></json:item><json:item><name>O.O. 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The patients had a mean age of 20.5 years ( sd 13.1) and a male–female ratio of 1.5. The symptoms included fever (72%), fatigue and weakness (59%), anorexia (59%) and pain (57.5%) while major clinical signs were pallor (100%), jaundice (71%) and hepatomegaly (68%). Sixty‐eight per cent of patients had sickle cell crises, including one with hemiplegic stroke, 10% with combined anaemia and pain crises, 33% with anaemia crises only and 23.5% with pain crises only. Sixty‐three per cent had infection which was malaria in 24.5%, bacterial in 17% and viral in 6%. Of 16 patients with pyrexia of unknown origin, seven responded to treatment with chloroquine and eight to antibiotics. Infection was detected in 50% of the patients with sickle cell crises. The association between anaemia crises and malaria was significant (P > 0.05). Of the eight deaths, seven (88%) had anaemia crises. In contrast to studies conducted two decades ago in the same hospital, the prevalence of anaemia crises now exceeds that of pain crises and malaria now exceeds that of bacterial infection. Severe symptomatic anaemia (anaemia crisis) was more frequently associated with infection (mostly malaria) than was bone pain crisis. The Girdle pain crisis more frequently resulted in a fatal outcome than the uncomplicated bone pain crisis.</abstract><qualityIndicators><score>7.091</score><pdfWordCount>2295</pdfWordCount><pdfCharCount>14640</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><pdfWordsPerPage>459</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>233</abstractWordCount><abstractCharCount>1471</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Acute sickle cell syndromes in Nigerian adults</title><pmid><json:string>10931163</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Clinical & Laboratory Haematology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1365-2257</json:string></doi><issn><json:string>0141-9854</json:string></issn><eissn><json:string>1365-2257</json:string></eissn><publisherId><json:string>IJLH</json:string></publisherId><volume>22</volume><issue>3</issue><pages><first>151</first><last>155</last><total>5</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2000</json:string><json:string>1992</json:string></date><geogName></geogName><orgName><json:string>Blackwell Science Ltd.</json:string><json:string>Bayer Diagnostics, Germany</json:string><json:string>Lagos University</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>O. 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<email>oluphysic@cyberspace.net.ng</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:IJLH.IJLH292.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 23 February 2000</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="4"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="16"></count><count type="wordTotal" number="2686"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Acute sickle cell syndromes in Nigerian adults</title><title type="shortAuthors">M. O. Ibidapo & O. O. Akinyanju</title><title type="short">Acute sickle cell syndromes in Nigerian adults</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>M.O.</givenNames><familyName>Ibidapo</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>O.O.</givenNames><familyName>Akinyanju</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Medicine, College of Medicine of the University of Lagos, Lagos, Nigeria</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Acute illness</keyword><keyword xml:id="k2">anaemia</keyword><keyword xml:id="k3">infection</keyword><keyword xml:id="k4">pain</keyword><keyword xml:id="k5">sickle cell crises</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p>The pattern of acute illness was determined in 102 adolescents and adults with sickle cell anaemia who presented to the emergency unit of a Lagos hospital. The patients had a mean age of 20.5 years ( <sc>sd</sc> 13.1) and a male–female ratio of 1.5. The symptoms included fever (72%), fatigue and weakness (59%), anorexia (59%) and pain (57.5%) while major clinical signs were pallor (100%), jaundice (71%) and hepatomegaly (68%). Sixty‐eight per cent of patients had sickle cell crises, including one with hemiplegic stroke, 10% with combined anaemia and pain crises, 33% with anaemia crises only and 23.5% with pain crises only. Sixty‐three per cent had infection which was malaria in 24.5%, bacterial in 17% and viral in 6%. Of 16 patients with pyrexia of unknown origin, seven responded to treatment with chloroquine and eight to antibiotics. Infection was detected in 50% of the patients with sickle cell crises. The association between anaemia crises and malaria was significant (<i>P</i> < 0.05). Of the eight deaths, seven (88%) had anaemia crises. In contrast to studies conducted two decades ago in the same hospital, the prevalence of anaemia crises now exceeds that of pain crises and malaria now exceeds that of bacterial infection. Severe symptomatic anaemia (anaemia crisis) was more frequently associated with infection (mostly malaria) than was bone pain crisis. The Girdle pain crisis more frequently resulted in a fatal outcome than the uncomplicated bone pain crisis.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Acute sickle cell syndromes in Nigerian adults</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Acute sickle cell syndromes in Nigerian adults</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Acute sickle cell syndromes in Nigerian adults</title></titleInfo><name type="personal"><namePart type="given">M.O.</namePart><namePart type="family">Ibidapo</namePart><affiliation>Department of Medicine, College of Medicine of the University of Lagos, Lagos, Nigeria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.O.</namePart><namePart type="family">Akinyanju</namePart><affiliation>Department of Medicine, College of Medicine of the University of Lagos, Lagos, Nigeria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Science Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2000-06</dateIssued><edition>Accepted for publication 23 February 2000</edition><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">4</extent><extent unit="formulas">0</extent><extent unit="references">16</extent><extent unit="linksCrossRef">0</extent><extent unit="words">2686</extent></physicalDescription><abstract lang="en">The pattern of acute illness was determined in 102 adolescents and adults with sickle cell anaemia who presented to the emergency unit of a Lagos hospital. The patients had a mean age of 20.5 years ( sd 13.1) and a male–female ratio of 1.5. The symptoms included fever (72%), fatigue and weakness (59%), anorexia (59%) and pain (57.5%) while major clinical signs were pallor (100%), jaundice (71%) and hepatomegaly (68%). Sixty‐eight per cent of patients had sickle cell crises, including one with hemiplegic stroke, 10% with combined anaemia and pain crises, 33% with anaemia crises only and 23.5% with pain crises only. Sixty‐three per cent had infection which was malaria in 24.5%, bacterial in 17% and viral in 6%. Of 16 patients with pyrexia of unknown origin, seven responded to treatment with chloroquine and eight to antibiotics. Infection was detected in 50% of the patients with sickle cell crises. The association between anaemia crises and malaria was significant (P < 0.05). Of the eight deaths, seven (88%) had anaemia crises. In contrast to studies conducted two decades ago in the same hospital, the prevalence of anaemia crises now exceeds that of pain crises and malaria now exceeds that of bacterial infection. Severe symptomatic anaemia (anaemia crisis) was more frequently associated with infection (mostly malaria) than was bone pain crisis. The Girdle pain crisis more frequently resulted in a fatal outcome than the uncomplicated bone pain crisis.</abstract><subject lang="en"><genre>keywords</genre><topic>Acute illness</topic><topic>anaemia</topic><topic>infection</topic><topic>pain</topic><topic>sickle cell crises</topic></subject><relatedItem type="host"><titleInfo><title>Clinical & Laboratory Haematology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0141-9854</identifier><identifier type="eISSN">1365-2257</identifier><identifier type="DOI">10.1111/(ISSN)1365-2257</identifier><identifier type="PublisherID">IJLH</identifier><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>151</start><end>155</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Osteomyelitis in sickle cell disease in Lagos</title></titleInfo><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Akinyanju</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Akinyanju O. 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