ChloroquineV1, Istex, Corpus, bibRecord, 000E25

ADULT- AND CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPARISON OF ONSET, CLINICAL FEATURES, SEROLOGY, AND OUTCOME

Identifieur interne : 000E25 ( Istex/Corpus ); précédent : 000E24; suivant : 000E26

ADULT- AND CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPARISON OF ONSET, CLINICAL FEATURES, SEROLOGY, AND OUTCOME

Auteurs : L. B. Tucker ; S. Menon ; J. G. Schaller ; D. A. Isenberg

Source :

Rheumatology [ 1462-0324 ] ; 1995.

RBID : ISTEX:0F99AC07C9D80153EAAB63C3A77EFDBD72E0BB96

Abstract

This study examines the differences which may distinguish systemic lupus erythematosus (SLE) presenting in adult life or childhood. A common database was established, with analysis of clinical, serological and outcome features of a cohert of patients with SLE, with disease diagnosed before the age of 16 (n = 39) or after the age of 16 (n = 165). Disease onset was generally more severe in the childhood-onset patients. Cardiopulmonary disease was more common in the older-onset group, but major haematological manifestations were more frequent in the childhood-onset group. Serologically, anti-DNA, anti-Sm and anti-RNP antibodies and a low C3 were all found more frequently in the younger patients. Twice as many adult-onset cases had died at the time of the last follow-up (10 vs 5%), but this group had been followed for a longer period (average 7.5 yr, S.D. 3.9 for adults vs average 4.8 yr, S.D. 3.2 for children). However, the younger patients were twice as likely (82 vs 40%) to require high-dose prednisone, although the requirement for immunosuppressive agents was similar in the two groups. Clinicians should anticipate that children with SLE have a more severe disease onset than adults in general.

Url:

https://api.istex.fr/ark:/67375/HXZ-NZJKVJD5-Q/fulltext.pdf

DOI: 10.1093/rheumatology/34.9.866

Links to Exploration step

ISTEX:0F99AC07C9D80153EAAB63C3A77EFDBD72E0BB96

Le document en format XML

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<profileDesc><abstract><p>This study examines the differences which may distinguish systemic lupus erythematosus (SLE) presenting in adult life or childhood. A common database was established, with analysis of clinical, serological and outcome features of a cohert of patients with SLE, with disease diagnosed before the age of 16 (<hi rend="italic">n</hi>
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<journal-id journal-id-type="pmc">rheumatology</journal-id>

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<article-title>ADULT- AND CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPARISON OF ONSET, CLINICAL FEATURES, SEROLOGY, AND OUTCOME</article-title>

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<name><surname>TUCKER</surname>
<given-names>L. B.</given-names>
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<xref ref-type="aff" rid="au1"><sup>*</sup>
</xref>
<xref ref-type="corresp" rid="cor1"></xref>

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<name><surname>MENON</surname>
<given-names>S.</given-names>
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<xref ref-type="aff" rid="au2"><sup>†</sup>
</xref>

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<name><surname>SCHALLER</surname>
<given-names>J. G.</given-names>
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<xref ref-type="aff" rid="au1"><sup>*</sup>
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<contrib contrib-type="author">

<name><surname>ISENBERG</surname>
<given-names>D. A.</given-names>
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<xref ref-type="aff" rid="au2"><sup>†</sup>
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<institution>Division of Pediatric Rheumatology, The Floating Hospital, New England Medical Center and Tufts University School of Medicine</institution>
 <addr-line>Boston, MA, USA</addr-line>
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<aff id="au2"><sup>†</sup>
<institution>The Bloomsbury Rheumatology Unit, Department of Medicine, University College</institution>
 <addr-line>London</addr-line>
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<corresp id="cor1">Correspondence to: L. B. Tucker, Division of Pediatric Rheumatology, Box 286, New England Medical Center, 750 Washington Street, Boston, MA 02111, USA.</corresp>

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<pub-date pub-type="ppub">

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<day>19</day>

<month>1</month>

<year>1995</year>

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<date date-type="accepted">

<day>09</day>

<month>5</month>

<year>1995</year>

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<copyright-statement>© 1995 British Society of Rheumatology</copyright-statement>

<copyright-year>1995</copyright-year>

<abstract>

<p>This study examines the differences which may distinguish systemic lupus erythematosus (SLE) presenting in adult life or childhood. A common database was established, with analysis of clinical, serological and outcome features of a cohert of patients with SLE, with disease diagnosed before the age of 16 (<italic>n</italic>
 = 39) or after the age of 16 (<italic>n</italic>
 = 165). Disease onset was generally more severe in the childhood-onset patients. Cardiopulmonary disease was more common in the older-onset group, but major haematological manifestations were more frequent in the childhood-onset group. Serologically, anti-DNA, anti-Sm and anti-RNP antibodies and a low C3 were all found more frequently in the younger patients. Twice as many adult-onset cases had died at the time of the last follow-up (10 <italic>vs</italic>
 5%), but this group had been followed for a longer period (average 7.5 yr, S.D. 3.9 for adults <italic>vs</italic>
 average 4.8 yr, S.D. 3.2 for children). However, the younger patients were twice as likely (82 <italic>vs</italic>
 40%) to require high-dose prednisone, although the requirement for immunosuppressive agents was similar in the two groups. Clinicians should anticipate that children with SLE have a more severe disease onset than adults in general.</p>

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<note type="author-notes">Correspondence to: L. B. Tucker, Division of Pediatric Rheumatology, Box 286, New England Medical Center, 750 Washington Street, Boston, MA 02111, USA.</note>
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ADULT- AND CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPARISON OF ONSET, CLINICAL FEATURES, SEROLOGY, AND OUTCOME

ADULT- AND CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPARISON OF ONSET, CLINICAL FEATURES, SEROLOGY, AND OUTCOME

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