ChloroquineV1, Istex, Corpus, bibRecord, 000C99

Electrocardiographic monitoring in severe falciparum malaria

Identifieur interne : 000C99 ( Istex/Corpus ); précédent : 000C98; suivant : 000D00

Electrocardiographic monitoring in severe falciparum malaria

Auteurs : Delia B. Bethell ; Pham Tung Phuong ; Cao Xuan Thanh Phuong ; François Nosten ; Deborah Waller ; Timothy M. E. Davis ; Nicholas P. J. Day ; Jane Crawley ; David Brewster ; Sasithon Pukrittayakamee ; Nicholas J. White

Source :

Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1996.

RBID : ISTEX:690508B2080B1B8E179DAE11BBB05B33B49A8189

Abstract

Electrocardiographic monitoring over 24 h was performed with 53 patients with severe Plasmodium falciparum malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated P. falciparum malaria is questionable.

Url:

https://api.istex.fr/ark:/67375/HXZ-0465DSXR-6/fulltext.pdf

DOI: 10.1016/S0035-9203(96)90241-2

Links to Exploration step

ISTEX:690508B2080B1B8E179DAE11BBB05B33B49A8189

Le document en format XML

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<front><div type="abstract">Electrocardiographic monitoring over 24 h was performed with 53 patients with severe Plasmodium falciparum malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated P. falciparum malaria is questionable.</div>
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<abstract>Electrocardiographic monitoring over 24 h was performed with 53 patients with severe Plasmodium falciparum malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated P. falciparum malaria is questionable.</abstract>
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<p>Current address: Jane Crawley, Wellcome Trust Laboratories, P.O. Box 230, Kilifi, Kenya.</p>
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<p>Current address: David Brewster, Paediatric Department, Royal Darwin Hospital, P.O. Box 41326, Casuarina, NT 0811, Australia.</p>
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<p>Electrocardiographic monitoring over 24 h was performed with 53 patients with severe <hi rend="italic">Plasmodium falciparum</hi>
 malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated <hi rend="italic">P. falciparum</hi>
 malaria is questionable.</p>
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<article-title>Electrocardiographic monitoring in severe falciparum malaria</article-title>

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<contrib-group>

<contrib contrib-type="author">

<name>

<surname>Bethell</surname>

<given-names>Delia B.</given-names>
</name>
<xref ref-type="corresp" rid="COR1"><sup>∗</sup>
</xref>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="AFF2"><sup>2</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Phuong</surname>

<given-names>Pham Tung</given-names>
</name>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Phuong</surname>

<given-names>Cao Xuan Thanh</given-names>
</name>
<xref ref-type="aff" rid="AFF3"><sup>3</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Nosten</surname>

<given-names>François</given-names>
</name>
<xref ref-type="aff" rid="AFF4"><sup>4</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Waller</surname>

<given-names>Deborah</given-names>
</name>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="AFF2"><sup>2</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Davis</surname>

<given-names>Timothy M.E.</given-names>
</name>
<xref ref-type="aff" rid="AFF5"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="AFF2"><sup>2</sup>
</xref>
<xref ref-type="fn" rid="FN1"><sup>∗1</sup>
</xref>

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<contrib contrib-type="author">

<name>

<surname>Day</surname>

<given-names>Nicholas P.J.</given-names>
</name>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="AFF2"><sup>2</sup>
</xref>

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<contrib contrib-type="author">

<name>

<surname>Crawley</surname>

<given-names>Jane</given-names>
</name>
<xref ref-type="aff" rid="AFF2"><sup>2</sup>
</xref>
<xref ref-type="fn" rid="FN2"><sup>∗2</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Brewster</surname>

<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="AFF5"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="AFF6"><sup>6</sup>
</xref>
<xref ref-type="fn" rid="FN3"><sup>∗3</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Pukrittayakamee</surname>

<given-names>Sasithon</given-names>
</name>
<xref ref-type="aff" rid="AFF7"><sup>7</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>White</surname>

<given-names>Nicholas J.</given-names>
</name>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="AFF2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="AFF7"><sup>7</sup>
</xref>

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<aff id="AFF1">

<label>1</label>
Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</aff>

<aff id="AFF2">

<label>2</label>
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</aff>

<aff id="AFF3">

<label>3</label>
Dong Nai Paediatric Centre, Bien Hoa, Viet Nam</aff>

<aff id="AFF4">

<label>4</label>
Shoklo Malaria Research Unit, Mae Sot, Thailand</aff>

<aff id="AFF5">

<label>5</label>
Royal Victoria Hospital, Banjul, The Gambia</aff>

<aff id="AFF6">

<label>6</label>
Medical Research Council Laboratories, Fajara, The Gambia</aff>

<aff id="AFF7">

<label>7</label>
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</aff>
</contrib-group>

<author-notes>

<corresp id="COR1">

<label>∗</label>
Address for correspondence: Delia Bethell, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Level 7, John Radcliffe Hospital, Oxford, OX3 9DU, UK.</corresp>

<fn fn-type="other" id="FN1">

<label>∗1</label>

<p>Current address: Timothy M. E. Davis, University of Western Australia, Dept of Medicine, Fremantle Hospital, Fremantle, Australia.</p>
</fn>

<fn fn-type="other" id="FN2">

<label>∗2</label>

<p>Current address: Jane Crawley, Wellcome Trust Laboratories, P.O. Box 230, Kilifi, Kenya.</p>
</fn>

<fn fn-type="other" id="FN3">

<label>∗3</label>

<p>Current address: David Brewster, Paediatric Department, Royal Darwin Hospital, P.O. Box 41326, Casuarina, NT 0811, Australia.</p>
</fn>
</author-notes>

<pub-date pub-type="ppub">

<month>6</month>

<year>1996</year>
</pub-date>

<volume>90</volume>

<issue>3</issue>

<fpage>266</fpage>

<lpage>269</lpage>

<history><date date-type="received"><day>18</day>

<month>12</month>

<year>1995</year>
</date>
<date date-type="rev-recd"><day>3</day>

<month>1</month>

<year>1996</year>
</date>
<date date-type="accepted"><day>4</day>

<month>1</month>

<year>1996</year>
</date>
</history>

<permissions><copyright-year>1996</copyright-year>
</permissions>

<abstract>

<title>Abstract</title>

<p>Electrocardiographic monitoring over 24 h was performed with 53 patients with severe <italic>Plasmodium falciparum</italic>
 malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated <italic>P. falciparum</italic>
 malaria is questionable.</p>
</abstract>

<kwd-group xml:lang="en">

<title>Keywords</title>

<kwd>malaria</kwd>

<kwd><italic>Plasmodium falciparum</italic>
</kwd>

<kwd>electrocardiography</kwd>
</kwd-group>

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<back>

<ref-list>

<title>References</title>

<ref id="BIB1">

<label>Brewer et al., 1994a</label>

<nlm-citation citation-type="journal">

<person-group person-group-type="author">

<name>

<surname>Brewer</surname>

<given-names>T.G.</given-names>
</name>

<name>

<surname>Peggins</surname>

<given-names>J.O.</given-names>
</name>

<name>

<surname>Grate</surname>

<given-names>S.J.</given-names>
</name>

<name>

<surname>Petras</surname>

<given-names>J.M.</given-names>
</name>

<name>

<surname>Levine</surname>

<given-names>B.S.</given-names>
</name>

<name>

<surname>Weina</surname>

<given-names>P.J.</given-names>
</name>

<name>

<surname>Swearengen</surname>

<given-names>J.</given-names>
</name>

<name>

<surname>Heiffer</surname>

<given-names>M.H.</given-names>
</name>

<name>

<surname>Schuster</surname>

<given-names>B.G.</given-names>
</name>

</person-group>

<article-title>Neurotoxicity in animals due to arteether and artemether</article-title>

<source>Transactions of the Royal Society of Tropical Medicine and Hygiene</source>

<year>1994</year>

<volume>88</volume>

<issue>supplement 1</issue>

<fpage>S1/33</fpage>

<lpage>S1/36</lpage>

</nlm-citation>

</ref>

<ref id="BIB2">

<label>Brewer et al., 1994b</label>

<nlm-citation citation-type="journal">

<person-group person-group-type="author">

<name>

<surname>Brewer</surname>

<given-names>T.G.</given-names>
</name>

<name>

<surname>Grate</surname>

<given-names>S.J.</given-names>
</name>

<name>

<surname>Peggins</surname>

<given-names>J.O.</given-names>
</name>

<name>

<surname>Weina</surname>

<given-names>P.J.</given-names>
</name>

<name>

<surname>Petras</surname>

<given-names>J.M.</given-names>
</name>

<name>

<surname>Levine</surname>

<given-names>B.S.</given-names>
</name>

<name>

<surname>Heiffer</surname>

<given-names>M.H.</given-names>
</name>

<name>

<surname>Schuster</surname>

<given-names>B.G.</given-names>
</name>

</person-group>

<article-title>Fatal neurotoxicity of arteether and artemether</article-title>

<source>American Journal of Tropical Medicine and Hygiene</source>

<year>1994</year>

<volume>51</volume>

<fpage>251</fpage>

<lpage>259</lpage>

</nlm-citation>

</ref>

<ref id="BIB3">

<label>Butler and Weber, 1973</label>

<nlm-citation citation-type="journal">

<person-group person-group-type="author">

<name>

<surname>Butler</surname>

<given-names>T.</given-names>
</name>

<name>

<surname>Weber</surname>

<given-names>D.M.</given-names>
</name>

</person-group>

<article-title>On the nature of orthostatic hypotension in acute malaria</article-title>

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</article>
</istex:document>
</istex:metadataXml>
<mods version="3.6"><titleInfo><title>Electrocardiographic monitoring in severe falciparum malaria</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA"><title>Electrocardiographic monitoring in severe falciparum malaria</title>
</titleInfo>
<name type="personal"><namePart type="given">Delia B.</namePart>
<namePart type="family">Bethell</namePart>
<affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation>
<affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</affiliation>
<affiliation>Address for correspondence: Delia Bethell, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Level 7, John Radcliffe Hospital, Oxford, OX3 9DU, UK.</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Pham Tung</namePart>
<namePart type="family">Phuong</namePart>
<affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Cao Xuan Thanh</namePart>
<namePart type="family">Phuong</namePart>
<affiliation>Dong Nai Paediatric Centre, Bien Hoa, Viet Nam</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">François</namePart>
<namePart type="family">Nosten</namePart>
<affiliation>Shoklo Malaria Research Unit, Mae Sot, Thailand</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Deborah</namePart>
<namePart type="family">Waller</namePart>
<affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation>
<affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Timothy M.E.</namePart>
<namePart type="family">Davis</namePart>
<affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</affiliation>
<affiliation>Royal Victoria Hospital, Banjul, The Gambia</affiliation>
<description>∗1 Current address: Timothy M. E. Davis, University of Western Australia, Dept of Medicine, Fremantle Hospital, Fremantle, Australia.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Nicholas P.J.</namePart>
<namePart type="family">Day</namePart>
<affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation>
<affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Jane</namePart>
<namePart type="family">Crawley</namePart>
<affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</affiliation>
<description>∗2 Current address: Jane Crawley, Wellcome Trust Laboratories, P.O. Box 230, Kilifi, Kenya.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">David</namePart>
<namePart type="family">Brewster</namePart>
<affiliation>Royal Victoria Hospital, Banjul, The Gambia</affiliation>
<affiliation>Medical Research Council Laboratories, Fajara, The Gambia</affiliation>
<description>∗3 Current address: David Brewster, Paediatric Department, Royal Darwin Hospital, P.O. Box 41326, Casuarina, NT 0811, Australia.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Sasithon</namePart>
<namePart type="family">Pukrittayakamee</namePart>
<affiliation>Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Nicholas J.</namePart>
<namePart type="family">White</namePart>
<affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation>
<affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</affiliation>
<affiliation>Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre>
<originInfo><publisher>Royal Society of Tropical Medicine and Hygiene</publisher>
<dateIssued encoding="w3cdtf">1996-06</dateIssued>
<dateCreated encoding="w3cdtf">1996-01-04</dateCreated>
<copyrightDate encoding="w3cdtf">1996</copyrightDate>
</originInfo>
<abstract>Electrocardiographic monitoring over 24 h was performed with 53 patients with severe Plasmodium falciparum malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated P. falciparum malaria is questionable.</abstract>
<note type="footnotes">Current address: Timothy M. E. Davis, University of Western Australia, Dept of Medicine, Fremantle Hospital, Fremantle, Australia.</note>
<note type="author-notes">∗Address for correspondence: Delia Bethell, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Level 7, John Radcliffe Hospital, Oxford, OX3 9DU, UK.</note>
<subject lang="en"><genre>Keywords</genre>
<topic>malaria</topic>
<topic>electrocardiography</topic>
</subject>
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<identifier type="eISSN">1878-3503</identifier>
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Electrocardiographic monitoring in severe falciparum malaria

Electrocardiographic monitoring in severe falciparum malaria

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