Drug concentrations in post‐mortem femoral blood compared with therapeutic concentrations in plasma
Identifieur interne : 000B33 ( Istex/Corpus ); précédent : 000B32; suivant : 000B34Drug concentrations in post‐mortem femoral blood compared with therapeutic concentrations in plasma
Auteurs : Terhi Launiainen ; Ilkka OjanperSource :
- Drug Testing and Analysis [ 1942-7603 ] ; 2014-04.
Abstract
Therapeutic drug concentrations measured in plasma are of limited value as reference intervals for interpretation in post‐mortem (PM) toxicology. In this study, drug concentration distributions were studied in PM femoral venous blood from 57 903 Finnish autopsy cases representing all causes of death during an 11‐year period. Cause‐of‐death information was obtained from death certificates issued by forensic pathologists. Median, mean, and upper percentile (90th, 95th, 97.5th) concentrations were calculated for 129 drugs. To illustrate how PM median concentrations relate to established therapeutic ranges in plasma, a PM blood/plasma relationship was calculated for each drug. Males represented 75% of the subjects and showed a lower median age (55 yrs) than females (59 yrs). In 43% of these cases, blood alcohol concentration was higher than 0.2‰, and the median was 1.8‰. Sixty‐one (47%) of the 129 drugs showed a PM blood/plasma relationship of 1. For 22 drugs (17%), the relationship was <1, and for 46 drugs (35%), the relationship was >1. No marked correlation was found between the PM blood/plasma relationship and the volume of distribution (Vd). For 36 drugs, more than 10% of cases were fatal poisonings attributed to this drug as the main finding. These drug concentration distributions based on a large database provide a helpful reference not only to forensic toxicologists and pathologists but also to clinical pharmacologists in charge of interpreting drug concentrations in PM cases. © 2013 The Authors. Drug Testing and Analysis published by John Wiley & Sons, Ltd.
Drug concentration distributions were studied in post‐mortem (PM) femoral venous blood from 57 903 Finnish autopsy cases representing all causes of death during an eleven‐year period. Median, mean, and upper percentile (90th, 95th, 97.5th) concentrations were calculated for 129 drugs and a PM blood/plasma relationship was calculated for each drug. These drug concentration distributions provide a helpful reference not only to forensic toxicologists and pathologists but also to clinical pharmacologists in charge of interpreting drug concentrations in PM cases.
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DOI: 10.1002/dta.1507
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In this study, drug concentration distributions were studied in PM femoral venous blood from 57 903 Finnish autopsy cases representing all causes of death during an 11‐year period. Cause‐of‐death information was obtained from death certificates issued by forensic pathologists. Median, mean, and upper percentile (90th, 95th, 97.5th) concentrations were calculated for 129 drugs. To illustrate how PM median concentrations relate to established therapeutic ranges in plasma, a PM blood/plasma relationship was calculated for each drug. Males represented 75% of the subjects and showed a lower median age (55 yrs) than females (59 yrs). In 43% of these cases, blood alcohol concentration was higher than 0.2‰, and the median was 1.8‰. Sixty‐one (47%) of the 129 drugs showed a PM blood/plasma relationship of 1. For 22 drugs (17%), the relationship was <1, and for 46 drugs (35%), the relationship was >1. No marked correlation was found between the PM blood/plasma relationship and the volume of distribution (Vd). For 36 drugs, more than 10% of cases were fatal poisonings attributed to this drug as the main finding. These drug concentration distributions based on a large database provide a helpful reference not only to forensic toxicologists and pathologists but also to clinical pharmacologists in charge of interpreting drug concentrations in PM cases. © 2013 The Authors. Drug Testing and Analysis published by John Wiley & Sons, Ltd.</div><div type="abstract">Drug concentration distributions were studied in post‐mortem (PM) femoral venous blood from 57 903 Finnish autopsy cases representing all causes of death during an eleven‐year period. Median, mean, and upper percentile (90th, 95th, 97.5th) concentrations were calculated for 129 drugs and a PM blood/plasma relationship was calculated for each drug. These drug concentration distributions provide a helpful reference not only to forensic toxicologists and pathologists but also to clinical pharmacologists in charge of interpreting drug concentrations in PM cases.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Terhi Launiainen</name><affiliations><json:string>University of Helsinki, Hjelt Institute, Department of Forensic Medicine, PO Box 40 (Kytösuontie 11), FI‐00014, Helsinki, Finland</json:string><json:string>Correspondence to: Terhi Launiainen, Hjelt Institute, Department of Forensic Medicine, PO Box 40 (Kytösuontie 11), FI‐00014 University of Helsinki, Finland.E‐mail</json:string><json:string>E-mail: terhi.launiainen@helsinki.fi</json:string></affiliations></json:item><json:item><name>Ilkka Ojanperä</name><affiliations><json:string>University of Helsinki, Hjelt Institute, Department of Forensic Medicine, PO Box 40 (Kytösuontie 11), FI‐00014, Helsinki, Finland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>post‐mortem toxicology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>post‐mortem drug redistribution</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cause of death</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>drug concentration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>blood</value></json:item></subject><articleId><json:string>DTA1507</json:string></articleId><arkIstex>ark:/67375/WNG-HLT5KJNC-W</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Therapeutic drug concentrations measured in plasma are of limited value as reference intervals for interpretation in post‐mortem (PM) toxicology. In this study, drug concentration distributions were studied in PM femoral venous blood from 57 903 Finnish autopsy cases representing all causes of death during an 11‐year period. Cause‐of‐death information was obtained from death certificates issued by forensic pathologists. Median, mean, and upper percentile (90th, 95th, 97.5th) concentrations were calculated for 129 drugs. To illustrate how PM median concentrations relate to established therapeutic ranges in plasma, a PM blood/plasma relationship was calculated for each drug. Males represented 75% of the subjects and showed a lower median age (55 yrs) than females (59 yrs). In 43% of these cases, blood alcohol concentration was higher than 0.2‰, and the median was 1.8‰. Sixty‐one (47%) of the 129 drugs showed a PM blood/plasma relationship of 1. For 22 drugs (17%), the relationship was >1, and for 46 drugs (35%), the relationship was >1. 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<lineatedText><line>Correspondence to: Terhi Launiainen, Hjelt Institute, Department of Forensic Medicine, PO Box 40 (Kytösuontie 11), FI‐00014 University of Helsinki, Finland.</line><line>E‐mail <email>terhi.launiainen@helsinki.fi</email></line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:DTA.DTA1507.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="shortAuthors">T. Launiainen and I. Ojanperä</title><title type="main">Drug concentrations in post‐mortem femoral blood compared with therapeutic concentrations in plasma</title><title type="short">Drug concentrations in post‐mortem femoral blood</title></titleGroup><creators><creator creatorRole="author" xml:id="dta1507-cr-0001" affiliationRef="#dta1507-aff-0001" corresponding="yes"><personName><givenNames>Terhi</givenNames><familyName>Launiainen</familyName></personName></creator><creator creatorRole="author" xml:id="dta1507-cr-0002" affiliationRef="#dta1507-aff-0001"><personName><givenNames>Ilkka</givenNames><familyName>Ojanperä</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="FI" type="organization" xml:id="dta1507-aff-0001"><orgDiv>University of Helsinki, Hjelt Institute</orgDiv><orgName>Department of Forensic Medicine</orgName><address><street>PO Box 40 (Kytösuontie 11)</street><postCode>FI‐00014</postCode><city>Helsinki</city><country>Finland</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="dta1507-kwd-0001">post‐mortem toxicology</keyword><keyword xml:id="dta1507-kwd-0002">post‐mortem drug redistribution</keyword><keyword xml:id="dta1507-kwd-0003">cause of death</keyword><keyword xml:id="dta1507-kwd-0004">drug concentration</keyword><keyword xml:id="dta1507-kwd-0005">blood</keyword></keywordGroup><supportingInformation xml:id="dta1507-supinf-0001"><supportingInfoItem xml:id="dta1507-supitem-0001"><mediaResource alt="supplementary data" mimeType="application/vnd.openxmlformats-officedocument.wordprocessingml.document" rendition="webOriginal" href="urn-x:wiley:19427603:media:dta1507:dta_1507_supplementarymaterial"></mediaResource><caption>Supporting info item</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main"><p>Therapeutic drug concentrations measured in plasma are of limited value as reference intervals for interpretation in post‐mortem (PM) toxicology. In this study, drug concentration distributions were studied in PM femoral venous blood from 57 903 Finnish autopsy cases representing all causes of death during an 11‐year period. Cause‐of‐death information was obtained from death certificates issued by forensic pathologists. Median, mean, and upper percentile (90th, 95th, 97.5th) concentrations were calculated for 129 drugs. To illustrate how PM median concentrations relate to established therapeutic ranges in plasma, a PM blood/plasma relationship was calculated for each drug. Males represented 75% of the subjects and showed a lower median age (55 yrs) than females (59 yrs). In 43% of these cases, blood alcohol concentration was higher than 0.2‰, and the median was 1.8‰. Sixty‐one (47%) of the 129 drugs showed a PM blood/plasma relationship of 1. For 22 drugs (17%), the relationship was <1, and for 46 drugs (35%), the relationship was >1. No marked correlation was found between the PM blood/plasma relationship and the volume of distribution (V<sub>d</sub>). For 36 drugs, more than 10% of cases were fatal poisonings attributed to this drug as the main finding. These drug concentration distributions based on a large database provide a helpful reference not only to forensic toxicologists and pathologists but also to clinical pharmacologists in charge of interpreting drug concentrations in PM cases. © 2013 The Authors. <i>Drug Testing and Analysis</i> published by John Wiley & Sons, Ltd.</p></abstract><abstract type="graphical"><p>Drug concentration distributions were studied in post‐mortem (PM) femoral venous blood from 57 903 Finnish autopsy cases representing all causes of death during an eleven‐year period. Median, mean, and upper percentile (90th, 95th, 97.5th) concentrations were calculated for 129 drugs and a PM blood/plasma relationship was calculated for each drug. These drug concentration distributions provide a helpful reference not only to forensic toxicologists and pathologists but also to clinical pharmacologists in charge of interpreting drug concentrations in PM cases.
<blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" href="urn:x-wiley:19427603:media:dta1507:dta1507-toc-0001"></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Drug concentrations in post‐mortem femoral blood compared with therapeutic concentrations in plasma</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Drug concentrations in post‐mortem femoral blood</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Drug concentrations in post‐mortem femoral blood compared with therapeutic concentrations in plasma</title></titleInfo><name type="personal"><namePart type="given">Terhi</namePart><namePart type="family">Launiainen</namePart><affiliation>University of Helsinki, Hjelt Institute, Department of Forensic Medicine, PO Box 40 (Kytösuontie 11), FI‐00014, Helsinki, Finland</affiliation><affiliation>Correspondence to: Terhi Launiainen, Hjelt Institute, Department of Forensic Medicine, PO Box 40 (Kytösuontie 11), FI‐00014 University of Helsinki, Finland.E‐mail</affiliation><affiliation>E-mail: terhi.launiainen@helsinki.fi</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ilkka</namePart><namePart type="family">Ojanperä</namePart><affiliation>University of Helsinki, Hjelt Institute, Department of Forensic Medicine, PO Box 40 (Kytösuontie 11), FI‐00014, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-04</dateIssued><dateCreated encoding="w3cdtf">2013-06-25</dateCreated><dateCaptured encoding="w3cdtf">2013-03-04</dateCaptured><dateValid encoding="w3cdtf">2013-06-06</dateValid><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Therapeutic drug concentrations measured in plasma are of limited value as reference intervals for interpretation in post‐mortem (PM) toxicology. In this study, drug concentration distributions were studied in PM femoral venous blood from 57 903 Finnish autopsy cases representing all causes of death during an 11‐year period. Cause‐of‐death information was obtained from death certificates issued by forensic pathologists. Median, mean, and upper percentile (90th, 95th, 97.5th) concentrations were calculated for 129 drugs. To illustrate how PM median concentrations relate to established therapeutic ranges in plasma, a PM blood/plasma relationship was calculated for each drug. Males represented 75% of the subjects and showed a lower median age (55 yrs) than females (59 yrs). In 43% of these cases, blood alcohol concentration was higher than 0.2‰, and the median was 1.8‰. Sixty‐one (47%) of the 129 drugs showed a PM blood/plasma relationship of 1. For 22 drugs (17%), the relationship was <1, and for 46 drugs (35%), the relationship was >1. No marked correlation was found between the PM blood/plasma relationship and the volume of distribution (Vd). For 36 drugs, more than 10% of cases were fatal poisonings attributed to this drug as the main finding. These drug concentration distributions based on a large database provide a helpful reference not only to forensic toxicologists and pathologists but also to clinical pharmacologists in charge of interpreting drug concentrations in PM cases. © 2013 The Authors. Drug Testing and Analysis published by John Wiley & Sons, Ltd.</abstract><abstract type="graphical">Drug concentration distributions were studied in post‐mortem (PM) femoral venous blood from 57 903 Finnish autopsy cases representing all causes of death during an eleven‐year period. Median, mean, and upper percentile (90th, 95th, 97.5th) concentrations were calculated for 129 drugs and a PM blood/plasma relationship was calculated for each drug. These drug concentration distributions provide a helpful reference not only to forensic toxicologists and pathologists but also to clinical pharmacologists in charge of interpreting drug concentrations in PM cases.</abstract><note type="additional physical form">Supporting info item</note><subject><genre>keywords</genre><topic>post‐mortem toxicology</topic><topic>post‐mortem drug redistribution</topic><topic>cause of death</topic><topic>drug concentration</topic><topic>blood</topic></subject><relatedItem type="host"><titleInfo><title>Drug Testing and Analysis</title></titleInfo><titleInfo type="abbreviated"><title>Drug Test. Analysis</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research article</topic><topic>Research articles</topic></subject><identifier type="ISSN">1942-7603</identifier><identifier type="eISSN">1942-7611</identifier><identifier type="DOI">10.1002/(ISSN)1942-7611</identifier><identifier type="PublisherID">DTA</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>308</start><end>316</end><total>9</total></extent></part></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0001"><titleInfo><title>Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Schulz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Iwersen‐Bergmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Andresen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Schmoldt</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">M. Schulz, S. Iwersen‐Bergmann, H. Andresen, A. Schmoldt. Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics. Crit. Care 2012, 16, R136.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>R136</start></extent></part><relatedItem type="host"><titleInfo><title>Crit. Care</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>R136</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0002"><titleInfo><title>A. Dasgupta. Therapeutic Drug Monitoring: Newer Drugs and Biomarkers. Academic Press, San Diego, CA, 2012.</title></titleInfo><note type="citation/reference">A. Dasgupta. Therapeutic Drug Monitoring: Newer Drugs and Biomarkers. Academic Press, San Diego, CA, 2012.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Dasgupta</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Academic Press</publisher><place><placeTerm type="text">San Diego, CA</placeTerm></place></originInfo><part><date>2012</date></part></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0003"><titleInfo><title>A Compendium of pharmacological, therapeutic and toxicological data on 136 drugs and chemicals in humans</title></titleInfo><name type="personal"><namePart type="given">M.D.</namePart><namePart type="family">Osselton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">M.D. Osselton. A Compendium of pharmacological, therapeutic and toxicological data on 136 drugs and chemicals in humans. Bull. Int. Assoc. Forensic Toxicol. 1983, 17, 16.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>16</start></extent></part><relatedItem type="host"><titleInfo><title>Bull. Int. Assoc. Forensic Toxicol.</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>16</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0004"><titleInfo><title>B.C. Baselt. Disposition of Toxic Drugs and Chemicals in Man, 9th edition. Biomedical Publications, Seal Beach, CA, 2011.</title></titleInfo><note type="citation/reference">B.C. Baselt. Disposition of Toxic Drugs and Chemicals in Man, 9th edition. Biomedical Publications, Seal Beach, CA, 2011.</note><name type="personal"><namePart type="given">B.C.</namePart><namePart type="family">Baselt</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Biomedical Publications</publisher><place><placeTerm type="text">Seal Beach, CA</placeTerm></place></originInfo><part><date>2011</date></part></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0005"><titleInfo><title>Post‐mortem drug redistribution‐‐a toxicological nightmare</title></titleInfo><name type="personal"><namePart type="given">D.J.</namePart><namePart type="family">Pounder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.R.</namePart><namePart type="family">Jones</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">D.J. Pounder, G.R. Jones. Post‐mortem drug redistribution‐‐a toxicological nightmare. Forensic Sci. Int. 1990, 45, 253.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>253</start></extent></part><relatedItem type="host"><titleInfo><title>Forensic Sci. Int.</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>253</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0006"><titleInfo><title>The forensic science implications of site and temporal influences on postmortem blood‐drug concentrations</title></titleInfo><name type="personal"><namePart type="given">R.W.</namePart><namePart type="family">Prouty</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.H.</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">R.W. Prouty, W.H. Anderson. The forensic science implications of site and temporal influences on postmortem blood‐drug concentrations. J. Forensic Sci. 1990, 35, 243.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>243</start></extent></part><relatedItem type="host"><titleInfo><title>J. Forensic Sci.</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>243</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0007"><titleInfo><title>A comparison of drug concentrations in postmortem cardiac and peripheral blood in 320 cases</title></titleInfo><name type="personal"><namePart type="given">A.L.</namePart><namePart type="family">Dalpe‐Scott</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Degouffe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Garbutt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Drost</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">A.L. Dalpe‐Scott, M. Degouffe, D. Garbutt, M. Drost. A comparison of drug concentrations in postmortem cardiac and peripheral blood in 320 cases. Can. Soc. Forensic Sci. J. 1995, 28, 113.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>113</start></extent></part><relatedItem type="host"><titleInfo><title>Can. Soc. Forensic Sci. J.</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>113</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0008"><titleInfo><title>J. Forensic Sci.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Hilberg, S. Rogde, J. Morland. Postmortem drug redistribution‐‐human cases related to results in experimental animals. J. Forensic Sci. 1999, 44, 3.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Hilberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Rogde</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Morland</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>3</start></extent></part></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0009"><titleInfo><title>The redistribution of selected psychiatric drugs in post‐mortem cases</title></titleInfo><name type="personal"><namePart type="given">K.E.</namePart><namePart type="family">Rodda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.H.</namePart><namePart type="family">Drummer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">K.E. Rodda, O.H. Drummer. The redistribution of selected psychiatric drugs in post‐mortem cases. Forensic Sci. Int. 2006, 164, 235.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>164</number></detail><extent unit="pages"><start>235</start></extent></part><relatedItem type="host"><titleInfo><title>Forensic Sci. Int.</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>164</number></detail><extent unit="pages"><start>235</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0010"><titleInfo><title>Evaluation of postmortem redistribution phenomena for commonly encountered drugs</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Han</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Jeong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">In</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">E. Han, E. Kim, H. Hong, S. Jeong, J. Kim, S. In, et al.Evaluation of postmortem redistribution phenomena for commonly encountered drugs. Forensic Sci. Int. 2012, 219, 265.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>219</number></detail><extent unit="pages"><start>265</start></extent></part><relatedItem type="host"><titleInfo><title>Forensic Sci. Int.</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>219</number></detail><extent unit="pages"><start>265</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0011"><titleInfo><title>The time‐dependant post‐mortem redistribution of antipsychotic drugs</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Saar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Beyer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Gerostamoulos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.H.</namePart><namePart type="family">Drummer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">E. Saar, J. Beyer, D. Gerostamoulos, O.H. Drummer. The time‐dependant post‐mortem redistribution of antipsychotic drugs. Forensic Sci. Int. 2012, 222, 223.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>222</number></detail><extent unit="pages"><start>223</start></extent></part><relatedItem type="host"><titleInfo><title>Forensic Sci. Int.</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>222</number></detail><extent unit="pages"><start>223</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0012"><titleInfo><title>Mechanisms underlying postmortem redistribution of drugs: A review</title></titleInfo><name type="personal"><namePart type="given">A.L.</namePart><namePart type="family">Pelissier‐Alicot</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.M.</namePart><namePart type="family">Gaulier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Champsaur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Marquet</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">A.L. Pelissier‐Alicot, J.M. Gaulier, P. Champsaur, P. Marquet. Mechanisms underlying postmortem redistribution of drugs: A review. J. Anal. Toxicol. 2003, 27, 533.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>533</start></extent></part><relatedItem type="host"><titleInfo><title>J. Anal. Toxicol.</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>533</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0013"><titleInfo><title>Key concepts in postmortem drug redistribution</title></titleInfo><name type="personal"><namePart type="given">M.C.</namePart><namePart type="family">Yarema</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.E.</namePart><namePart type="family">Becker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">M.C. Yarema, C.E. Becker. Key concepts in postmortem drug redistribution. Clin. Toxicol. 2005, 43, 235.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><extent unit="pages"><start>235</start></extent></part><relatedItem type="host"><titleInfo><title>Clin. Toxicol.</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><extent unit="pages"><start>235</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0014"><titleInfo><title>Post‐mortem drug concentrations</title></titleInfo><name type="personal"><namePart type="given">M.C.</namePart><namePart type="family">Kennedy</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">M.C. Kennedy. Post‐mortem drug concentrations. Intern. Med. J. 2010, 40, 183.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>183</start></extent></part><relatedItem type="host"><titleInfo><title>Intern. Med. J.</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>183</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0015"><titleInfo><title>Post‐mortem clinical pharmacology</title></titleInfo><name type="personal"><namePart type="given">R.E.</namePart><namePart type="family">Ferner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">R.E. Ferner. Post‐mortem clinical pharmacology. Brit. J. Clin. Pharmacol. 2008, 66, 430.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>430</start></extent></part><relatedItem type="host"><titleInfo><title>Brit. J. Clin. Pharmacol.</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>430</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0016"><titleInfo><title>Concentration distributions of the drugs most frequently identified in post‐mortem femoral blood representing all causes of death</title></titleInfo><name type="personal"><namePart type="given">A.W.</namePart><namePart type="family">Jones</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Holmgren</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">A.W. Jones, A. Holmgren. Concentration distributions of the drugs most frequently identified in post‐mortem femoral blood representing all causes of death. Med. Sci. Law 2009, 49, 257.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>257</start></extent></part><relatedItem type="host"><titleInfo><title>Med. Sci. Law</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>257</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0017"><titleInfo><title>Postmortem drug concentration intervals for the non‐intoxicated state ‐ A review</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Linnet</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">K. Linnet. Postmortem drug concentration intervals for the non‐intoxicated state ‐ A review. J. Forensic Leg. Med. 2012, 19, 245.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>245</start></extent></part><relatedItem type="host"><titleInfo><title>J. Forensic Leg. Med.</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>245</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0018"><titleInfo><title>Toxicological screening with formula‐based metabolite identification by liquid chromatography/time‐of‐flight mass spectrometry</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Pelander</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Ojanpera</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Laks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Rasanen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vuori</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">A. Pelander, I. Ojanpera, S. Laks, I. Rasanen, E. Vuori. Toxicological screening with formula‐based metabolite identification by liquid chromatography/time‐of‐flight mass spectrometry. Anal. Chem. 2003, 75, 5710.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>5710</start></extent></part><relatedItem type="host"><titleInfo><title>Anal. Chem.</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>5710</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0019"><titleInfo><title>Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time‐of‐flight mass spectrometry</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Ojanpera</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Pelander</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Pelzing</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Krebs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vuori</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Ojanpera</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">S. Ojanpera, A. Pelander, M. Pelzing, I. Krebs, E. Vuori, I. Ojanpera. Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time‐of‐flight mass spectrometry. Rapid Commun. Mass Spectrom. 2006, 20, 1161.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>1161</start></extent></part><relatedItem type="host"><titleInfo><title>Rapid Commun. Mass Spectrom.</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>1161</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0020"><titleInfo><title>Automated quantitative screening for acidic and neutral drugs in whole blood by dual‐column capillary gas chromatography</title></titleInfo><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Ojanpera</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Rasanen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vuori</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">I. Ojanpera, I. Rasanen, E. Vuori. Automated quantitative screening for acidic and neutral drugs in whole blood by dual‐column capillary gas chromatography. J. Anal. Toxicol. 1991, 15, 204.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>204</start></extent></part><relatedItem type="host"><titleInfo><title>J. Anal. Toxicol.</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>204</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0021"><titleInfo><title>Adverse interaction of warfarin and paracetamol: Evidence from a post‐mortem study</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Launiainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Sajantila</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Rasanen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vuori</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Ojanpera</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">T. Launiainen, A. Sajantila, I. Rasanen, E. Vuori, I. Ojanpera. Adverse interaction of warfarin and paracetamol: Evidence from a post‐mortem study. Eur. J. Clin. Pharmacol. 2010, 66, 97.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>97</start></extent></part><relatedItem type="host"><titleInfo><title>Eur. J. Clin. Pharmacol.</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>97</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0022"><titleInfo><title>Quantitative screening for benzodiazepines in blood by dual‐column gas chromatography and comparison of the results with urine immunoassay</title></titleInfo><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Rasanen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Ojanpera</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vuori</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">I. Rasanen, I. Ojanpera, E. Vuori. Quantitative screening for benzodiazepines in blood by dual‐column gas chromatography and comparison of the results with urine immunoassay. J. Anal. Toxicol. 2000, 24, 46.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>46</start></extent></part><relatedItem type="host"><titleInfo><title>J. Anal. Toxicol.</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>46</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0023"><titleInfo><title>Fast gas chromatography‐negative‐ion chemical ionization mass spectrometry with microscale volume sample preparation for the determination of benzodiazepines and alpha‐hydroxy metabolites, zaleplon and zopiclone in whole blood</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Gunnar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Ariniemi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Lillsunde</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">T. Gunnar, K. Ariniemi, P. Lillsunde. Fast gas chromatography‐negative‐ion chemical ionization mass spectrometry with microscale volume sample preparation for the determination of benzodiazepines and alpha‐hydroxy metabolites, zaleplon and zopiclone in whole blood. J. Mass Spectrom. 2006, 41, 741.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>741</start></extent></part><relatedItem type="host"><titleInfo><title>J. Mass Spectrom.</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>741</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0024"><titleInfo><title>Precise gas chromatography with retention time locking in comprehensive toxicological screening for drugs in blood</title></titleInfo><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Rasanen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Kontinen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Nokua</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Ojanpera</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vuori</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">I. Rasanen, I. Kontinen, J. Nokua, I. Ojanpera, E. Vuori. Precise gas chromatography with retention time locking in comprehensive toxicological screening for drugs in blood. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2003, 788, 243.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>788</number></detail><extent unit="pages"><start>243</start></extent></part><relatedItem type="host"><titleInfo><title>J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>788</number></detail><extent unit="pages"><start>243</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0025"><titleInfo><title>Pharmacokinetics of dixyrazine: Low bioavailability, improved by food intake</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Liedholm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Liden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Kroon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Melander</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Wahlin‐Boll</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">H. Liedholm, A. Liden, L. Kroon, A. Melander, E. Wahlin‐Boll. Pharmacokinetics of dixyrazine: Low bioavailability, improved by food intake. Drug Nutr. Interact. 1985, 3, 87.</note><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>87</start></extent></part><relatedItem type="host"><titleInfo><title>Drug Nutr. Interact.</title></titleInfo><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>87</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0026"><titleInfo><title>A compilation of fatal and control concentrations of drugs in postmortem femoral blood</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Druid</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Holmgren</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">H. Druid, P. Holmgren. A compilation of fatal and control concentrations of drugs in postmortem femoral blood. J. Forensic Sci. 1997, 42, 79.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>79</start></extent></part><relatedItem type="host"><titleInfo><title>J. Forensic Sci.</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>79</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0027"><titleInfo><title>Reference concentrations of antidepressants. A compilation of postmortem and therapeutic levels</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Reis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Aamo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Ahlner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Druid</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">M. Reis, T. Aamo, J. Ahlner, H. Druid. Reference concentrations of antidepressants. A compilation of postmortem and therapeutic levels. J. Anal. Toxicol.. 2007, 31, 254.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>254</start></extent></part><relatedItem type="host"><titleInfo><title>J. Anal. Toxicol.</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>254</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0028"><titleInfo><title>Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocrit</title></titleInfo><name type="personal"><namePart type="given">A.W.</namePart><namePart type="family">Jones</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Larsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">A.W. Jones, H. Larsson. Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocrit. Ther. Drug Monit. 2004, 26, 380.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>380</start></extent></part><relatedItem type="host"><titleInfo><title>Ther. Drug Monit.</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>380</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0029"><titleInfo><title>Prevalence of adverse drug combinations in a large post‐mortem toxicology database</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Launiainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vuori</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Ojanpera</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">T. Launiainen, E. Vuori, I. Ojanpera. Prevalence of adverse drug combinations in a large post‐mortem toxicology database. Int. J. Leg. Med. 2009, 123, 109.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>123</number></detail><extent unit="pages"><start>109</start></extent></part><relatedItem type="host"><titleInfo><title>Int. J. Leg. Med.</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>123</number></detail><extent unit="pages"><start>109</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0030"><titleInfo><title>Benzodiazepines and alcohol are associated with cases of fatal buprenorphine poisoning</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hakkinen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Launiainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vuori</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Ojanpera</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">M. Hakkinen, T. Launiainen, E. Vuori, I. Ojanpera. Benzodiazepines and alcohol are associated with cases of fatal buprenorphine poisoning. Eur. J. Clin. Pharmacol. 2012, 68, 301.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>301</start></extent></part><relatedItem type="host"><titleInfo><title>Eur. J. Clin. Pharmacol.</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>301</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0031"><titleInfo><title>Comparison of fatal poisonings by prescription opioids</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hakkinen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Launiainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vuori</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Ojanpera</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">M. Hakkinen, T. Launiainen, E. Vuori, I. Ojanpera. Comparison of fatal poisonings by prescription opioids. Forensic Sci. Int. 2012, 222, 327.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>222</number></detail><extent unit="pages"><start>327</start></extent></part><relatedItem type="host"><titleInfo><title>Forensic Sci. Int.</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>222</number></detail><extent unit="pages"><start>327</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0032"><titleInfo><title>Drug and chemical blood‐level data 2001</title></titleInfo><name type="personal"><namePart type="given">C.L.</namePart><namePart type="family">Winek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.W.</namePart><namePart type="family">Wahba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.L.</namePart><namePart type="family">Winek Jr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.W.</namePart><namePart type="family">Balzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">C.L. Winek, W.W. Wahba, C.L. Winek Jr, T.W. Balzer. Drug and chemical blood‐level data 2001. Forensic Sci. Int. 2001, 122, 107.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><extent unit="pages"><start>107</start></extent></part><relatedItem type="host"><titleInfo><title>Forensic Sci. Int.</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><extent unit="pages"><start>107</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="dta1507-cit-0033"><titleInfo><title>C. Dollery. Therapeutic Drugs, 2nd edition. Churchill Livingstone, Edinborough,1999.</title></titleInfo><note type="citation/reference">C. Dollery. Therapeutic Drugs, 2nd edition. Churchill Livingstone, Edinborough,1999.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Dollery</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Churchill Livingstone</publisher><place><placeTerm type="text">Edinborough</placeTerm></place></originInfo><part><date>1999</date></part></relatedItem><identifier type="istex">40BB8E8C4613EA9FA9DA34DE146CE54BDAC61544</identifier><identifier type="ark">ark:/67375/WNG-HLT5KJNC-W</identifier><identifier type="DOI">10.1002/dta.1507</identifier><identifier type="ArticleID">DTA1507</identifier><accessCondition type="use and reproduction" contentType="creativeCommonsBy-nc-nd">This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-14</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-HLT5KJNC-W/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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