Electrocardiographic monitoring in severe falciparum malaria
Identifieur interne : 000B01 ( Istex/Corpus ); précédent : 000B00; suivant : 000B02Electrocardiographic monitoring in severe falciparum malaria
Auteurs : Delia B. Bethell ; Pham Tung Phuong ; Cao Xuan Thanh Phuong ; François Nosten ; Deborah Waller ; Timothy M. E. Davis ; Nicholas P. J. Day ; Jane Crawley ; David Brewster ; Sasithon Pukrittayakamee ; Nicholas J. WhiteSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1996.
English descriptors
- Teeft :
- Abnormality, Admission parasitaemia, Agonal rhythm, American journal, Antimalarial, Antimalarial drug, Antimalarial drugs, Antimalarial treatment, Artemisinin derivatives, Bygbjerg lanng, Cardiac, Cardiac arrest, Cardiac arrhythmia, Cardiac arrhythmias, Cardiac index, Cerebral malaria, Children chloroquine, Chloroquine, Clinical details, Clinical pharmacology, Complex width, Confidence interval, Continuous electrocardiographic monitoring, Convulsion, Electrocardiographic, Electrocardiographic findings, Electrocardiographic monitoring, Electrocardiographic recording, Falciparum, Falciparum malaria, Fourth patient, Frequent convulsions, Gambian girl, Heart rate, High doses, Hypoglycaemia, Idioventricular rhythm, Intramuscular chloroquine, Jaundice, John radcliffe hospital, Malaria, Minh city, Monitoring period, Multiorgan failure, Organ dysfunction, Orthostatic hypotension, Oxford instruments, Parenteral quinine, Prospective studies, Quinine, Respiratory arrest, Royal society, Severe malaria, Sinus bradycardia, Sinus tachycardia, Square brackets, Tachycardia, Tropical diseases, Tropical medicine, Unpublished observations, Ventricular, Ventricular tachycardia, Vietnamese girl.
Abstract
Abstract: Electrocardiographic monitoring over 24 h was performed with 53 patients with severe Plasmodium falciparum malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated P. falciparum malaria is questionable.
Url:
DOI: 10.1016/S0035-9203(96)90241-2
Links to Exploration step
ISTEX:67D0E8EE5465697FFEC9B372E6433FC7CEDEFE41Le document en format XML
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Bethell</name><affiliation><mods:affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</mods:affiliation></affiliation></author><author><name sortKey="Phuong, Pham Tung" sort="Phuong, Pham Tung" uniqKey="Phuong P" first="Pham Tung" last="Phuong">Pham Tung Phuong</name><affiliation><mods:affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</mods:affiliation></affiliation></author><author><name sortKey="Phuong, Cao Xuan Thanh" sort="Phuong, Cao Xuan Thanh" uniqKey="Phuong C" first="Cao Xuan Thanh" last="Phuong">Cao Xuan Thanh Phuong</name><affiliation><mods:affiliation>Dong Nai Paediatric Centre, Bien Hoa, Viet Nam</mods:affiliation></affiliation></author><author><name sortKey="Nosten, Francois" sort="Nosten, Francois" uniqKey="Nosten F" first="François" last="Nosten">François Nosten</name><affiliation><mods:affiliation>Shoklo Malaria Research Unit, Mae Sot, Thailand</mods:affiliation></affiliation></author><author><name sortKey="Waller, Deborah" sort="Waller, Deborah" uniqKey="Waller D" first="Deborah" last="Waller">Deborah Waller</name><affiliation><mods:affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</mods:affiliation></affiliation></author><author><name sortKey="Davis, Timothy M E" sort="Davis, Timothy M E" uniqKey="Davis T" first="Timothy M. 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Bethell</name><affiliation><mods:affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</mods:affiliation></affiliation></author><author><name sortKey="Phuong, Pham Tung" sort="Phuong, Pham Tung" uniqKey="Phuong P" first="Pham Tung" last="Phuong">Pham Tung Phuong</name><affiliation><mods:affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</mods:affiliation></affiliation></author><author><name sortKey="Phuong, Cao Xuan Thanh" sort="Phuong, Cao Xuan Thanh" uniqKey="Phuong C" first="Cao Xuan Thanh" last="Phuong">Cao Xuan Thanh Phuong</name><affiliation><mods:affiliation>Dong Nai Paediatric Centre, Bien Hoa, Viet Nam</mods:affiliation></affiliation></author><author><name sortKey="Nosten, Francois" sort="Nosten, Francois" uniqKey="Nosten F" first="François" last="Nosten">François Nosten</name><affiliation><mods:affiliation>Shoklo Malaria Research Unit, Mae Sot, Thailand</mods:affiliation></affiliation></author><author><name sortKey="Waller, Deborah" sort="Waller, Deborah" uniqKey="Waller D" first="Deborah" last="Waller">Deborah Waller</name><affiliation><mods:affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</mods:affiliation></affiliation></author><author><name sortKey="Davis, Timothy M E" sort="Davis, Timothy M E" uniqKey="Davis T" first="Timothy M. E." last="Davis">Timothy M. E. Davis</name><affiliation><mods:affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</mods:affiliation></affiliation></author><author><name sortKey="Day, Nicholas P J" sort="Day, Nicholas P J" uniqKey="Day N" first="Nicholas P. J." last="Day">Nicholas P. J. Day</name><affiliation><mods:affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</mods:affiliation></affiliation></author><author><name sortKey="Crawley, Jane" sort="Crawley, Jane" uniqKey="Crawley J" first="Jane" last="Crawley">Jane Crawley</name><affiliation><mods:affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</mods:affiliation></affiliation></author><author><name sortKey="Brewster, David" sort="Brewster, David" uniqKey="Brewster D" first="David" last="Brewster">David Brewster</name><affiliation><mods:affiliation>Royal Victoria Hospital, Banjul, The Gambia</mods:affiliation></affiliation></author><author><name sortKey="Pukrittayakamee, Sasithon" sort="Pukrittayakamee, Sasithon" uniqKey="Pukrittayakamee S" first="Sasithon" last="Pukrittayakamee">Sasithon Pukrittayakamee</name><affiliation><mods:affiliation>Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</mods:affiliation></affiliation></author><author><name sortKey="White, Nicholas J" sort="White, Nicholas J" uniqKey="White N" first="Nicholas J." last="White">Nicholas J. White</name><affiliation><mods:affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="ISSN">0035-9203</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">90</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="266">266</biblScope><biblScope unit="page" to="269">269</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abnormality</term><term>Admission parasitaemia</term><term>Agonal rhythm</term><term>American journal</term><term>Antimalarial</term><term>Antimalarial drug</term><term>Antimalarial drugs</term><term>Antimalarial treatment</term><term>Artemisinin derivatives</term><term>Bygbjerg lanng</term><term>Cardiac</term><term>Cardiac arrest</term><term>Cardiac arrhythmia</term><term>Cardiac arrhythmias</term><term>Cardiac index</term><term>Cerebral malaria</term><term>Children chloroquine</term><term>Chloroquine</term><term>Clinical details</term><term>Clinical pharmacology</term><term>Complex width</term><term>Confidence interval</term><term>Continuous electrocardiographic monitoring</term><term>Convulsion</term><term>Electrocardiographic</term><term>Electrocardiographic findings</term><term>Electrocardiographic monitoring</term><term>Electrocardiographic recording</term><term>Falciparum</term><term>Falciparum malaria</term><term>Fourth patient</term><term>Frequent convulsions</term><term>Gambian girl</term><term>Heart rate</term><term>High doses</term><term>Hypoglycaemia</term><term>Idioventricular rhythm</term><term>Intramuscular chloroquine</term><term>Jaundice</term><term>John radcliffe hospital</term><term>Malaria</term><term>Minh city</term><term>Monitoring period</term><term>Multiorgan failure</term><term>Organ dysfunction</term><term>Orthostatic hypotension</term><term>Oxford instruments</term><term>Parenteral quinine</term><term>Prospective studies</term><term>Quinine</term><term>Respiratory arrest</term><term>Royal society</term><term>Severe malaria</term><term>Sinus bradycardia</term><term>Sinus tachycardia</term><term>Square brackets</term><term>Tachycardia</term><term>Tropical diseases</term><term>Tropical medicine</term><term>Unpublished observations</term><term>Ventricular</term><term>Ventricular tachycardia</term><term>Vietnamese girl</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Electrocardiographic monitoring over 24 h was performed with 53 patients with severe Plasmodium falciparum malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated P. falciparum malaria is questionable.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>electrocardiographic</json:string><json:string>antimalarial</json:string><json:string>quinine</json:string><json:string>abnormality</json:string><json:string>tachycardia</json:string><json:string>severe malaria</json:string><json:string>falciparum</json:string><json:string>tropical medicine</json:string><json:string>chloroquine</json:string><json:string>ventricular</json:string><json:string>hypoglycaemia</json:string><json:string>malaria</json:string><json:string>cardiac</json:string><json:string>heart rate</json:string><json:string>convulsion</json:string><json:string>jaundice</json:string><json:string>electrocardiographic monitoring</json:string><json:string>falciparum malaria</json:string><json:string>cerebral malaria</json:string><json:string>monitoring period</json:string><json:string>intramuscular chloroquine</json:string><json:string>respiratory arrest</json:string><json:string>idioventricular rhythm</json:string><json:string>sinus tachycardia</json:string><json:string>antimalarial treatment</json:string><json:string>confidence interval</json:string><json:string>square brackets</json:string><json:string>antimalarial drugs</json:string><json:string>ventricular tachycardia</json:string><json:string>minh city</json:string><json:string>electrocardiographic recording</json:string><json:string>cardiac arrhythmias</json:string><json:string>complex width</json:string><json:string>orthostatic hypotension</json:string><json:string>artemisinin derivatives</json:string><json:string>bygbjerg lanng</json:string><json:string>admission parasitaemia</json:string><json:string>john radcliffe hospital</json:string><json:string>prospective studies</json:string><json:string>continuous electrocardiographic monitoring</json:string><json:string>clinical details</json:string><json:string>tropical diseases</json:string><json:string>oxford instruments</json:string><json:string>organ dysfunction</json:string><json:string>electrocardiographic findings</json:string><json:string>sinus bradycardia</json:string><json:string>agonal rhythm</json:string><json:string>parenteral quinine</json:string><json:string>multiorgan failure</json:string><json:string>cardiac arrhythmia</json:string><json:string>gambian girl</json:string><json:string>children chloroquine</json:string><json:string>fourth patient</json:string><json:string>vietnamese girl</json:string><json:string>antimalarial drug</json:string><json:string>frequent convulsions</json:string><json:string>cardiac arrest</json:string><json:string>cardiac index</json:string><json:string>unpublished observations</json:string><json:string>high doses</json:string><json:string>royal society</json:string><json:string>american journal</json:string><json:string>clinical pharmacology</json:string></teeft></keywords><author><json:item><name>Delia B. Bethell</name><affiliations><json:string>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</json:string></affiliations></json:item><json:item><name>Pham Tung Phuong</name><affiliations><json:string>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</json:string></affiliations></json:item><json:item><name>Cao Xuan Thanh Phuong</name><affiliations><json:string>Dong Nai Paediatric Centre, Bien Hoa, Viet Nam</json:string></affiliations></json:item><json:item><name>François Nosten</name><affiliations><json:string>Shoklo Malaria Research Unit, Mae Sot, Thailand</json:string></affiliations></json:item><json:item><name>Deborah Waller</name><affiliations><json:string>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</json:string></affiliations></json:item><json:item><name>Timothy M.E. Davis</name><affiliations><json:string>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</json:string></affiliations></json:item><json:item><name>Nicholas P.J. Day</name><affiliations><json:string>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</json:string></affiliations></json:item><json:item><name>Jane Crawley</name><affiliations><json:string>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</json:string></affiliations></json:item><json:item><name>David Brewster</name><affiliations><json:string>Royal Victoria Hospital, Banjul, The Gambia</json:string></affiliations></json:item><json:item><name>Sasithon Pukrittayakamee</name><affiliations><json:string>Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</json:string></affiliations></json:item><json:item><name>Nicholas J. White</name><affiliations><json:string>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Clinical studies and pathology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>malaria</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Plasmodium falciparum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>electrocardiography</value></json:item></subject><arkIstex>ark:/67375/6H6-STMGD07M-Z</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Electrocardiographic monitoring over 24 h was performed with 53 patients with severe Plasmodium falciparum malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated P. falciparum malaria is questionable.</abstract><qualityIndicators><score>7.366</score><pdfWordCount>3470</pdfWordCount><pdfCharCount>23351</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>4</pdfPageCount><pdfPageSize>576 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>158</abstractWordCount><abstractCharCount>1059</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Electrocardiographic monitoring in severe falciparum malaria</title><pmid><json:string>8758072</json:string></pmid><pii><json:string>S0035-9203(96)90241-2</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><language><json:string>unknown</json:string></language><publicationDate>1996</publicationDate><issn><json:string>0035-9203</json:string></issn><pii><json:string>S0035-9203(00)X0066-1</json:string></pii><volume>90</volume><issue>3</issue><pages><first>266</first><last>269</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1940s</json:string><json:string>1996</json:string></date><geogName></geogName><orgName><json:string>Paediatric Department, Royal Darwin Hospital</json:string><json:string>Nufield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</json:string><json:string>Gambia, Thailand and Viet Nam</json:string><json:string>Mahidol University</json:string><json:string>Oxford Instruments</json:string><json:string>Wellcome Trust Laboratories</json:string><json:string>Oxford Instruments, UK</json:string><json:string>Medical Research Council Laboratories, Fajara, The Gambia</json:string><json:string>Victoria Hospital, Banjul, The Gambia</json:string><json:string>University of Western Australia, Dept of Medicine, Fremantle Hospital, Fremantle, Australia</json:string><json:string>John Radcliffe Hospital, Oxford, OX</json:string><json:string>Royal Victoria Hospital, Banjul, The Gambia</json:string><json:string>Paholpolpayuhasena Hospital, Kanchanaburi, Thailand</json:string><json:string>Shoklo Malaria Research Unit, Mae Sot, Thailand</json:string><json:string>World Health Organization</json:string><json:string>Thailand Abstract Electrocardiographic</json:string><json:string>Wellcome Trust of Great Britain</json:string></orgName><orgName_funder><json:string>Wellcome Trust of Great Britain</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Drug</json:string><json:string>P.O. Box</json:string><json:string>Viet Nam</json:string><json:string>David Brewster</json:string><json:string>Deborah Waller</json:string><json:string>M. E. Davis</json:string><json:string>Xuan Thanh</json:string><json:string>Nicholas J. White</json:string><json:string>P. J. Day</json:string><json:string>Nai Province</json:string><json:string>N. Day</json:string><json:string>David BrewsteP</json:string><json:string>Delia Bethell</json:string><json:string>N. J. White</json:string><json:string>Jane Crawley</json:string></persName><placeName><json:string>Ho Chi Minh City</json:string><json:string>Thailand</json:string><json:string>Australia</json:string><json:string>UK</json:string><json:string>Kenya</json:string><json:string>Gambia</json:string><json:string>Oxford</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>JAMES,1985</json:string><json:string>WHITE & HO, 1992</json:string><json:string>BYGBJERG & LANNG, 1982</json:string><json:string>[119-135]</json:string><json:string>WHO, 1990</json:string><json:string>WHITE et al:, 1983</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-STMGD07M-Z</json:string></ark><categories><wos><json:string>1 - social science</json:string><json:string>2 - public, environmental & occupational health</json:string><json:string>1 - science</json:string><json:string>2 - tropical medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - tropical medicine</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Public Health, Environmental and Occupational Health</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - General Medicine</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Parasitology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - cardiologie. appareil circulatoire</json:string></inist></categories><publicationDate>1996</publicationDate><copyrightDate>1996</copyrightDate><doi><json:string>10.1016/S0035-9203(96)90241-2</json:string></doi><id>67D0E8EE5465697FFEC9B372E6433FC7CEDEFE41</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-STMGD07M-Z/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-STMGD07M-Z/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-STMGD07M-Z/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Electrocardiographic monitoring in severe falciparum malaria</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1996</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Electrocardiographic monitoring in severe falciparum malaria</title><author xml:id="author-0000"><persName><forename type="first">Delia B.</forename><surname>Bethell</surname></persName><affiliation>Address for correspondence: Delia Bethell, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Level 7, John Radcliffe Hospital, Oxford, OX3 9DU, UK.</affiliation><affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Pham Tung</forename><surname>Phuong</surname></persName><affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Cao Xuan Thanh</forename><surname>Phuong</surname></persName><affiliation>Dong Nai Paediatric Centre, Bien Hoa, Viet Nam</affiliation></author><author xml:id="author-0003"><persName><forename type="first">François</forename><surname>Nosten</surname></persName><affiliation>Shoklo Malaria Research Unit, Mae Sot, Thailand</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Deborah</forename><surname>Waller</surname></persName><affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Timothy M.E.</forename><surname>Davis</surname></persName><note type="biography">Current address: Timothy M. E. Davis, University of Western Australia, Dept of Medicine, Fremantle Hospital, Fremantle, Australia.</note><affiliation>Current address: Timothy M. E. Davis, University of Western Australia, Dept of Medicine, Fremantle Hospital, Fremantle, Australia.</affiliation><affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</affiliation></author><author xml:id="author-0006"><persName><forename type="first">Nicholas P.J.</forename><surname>Day</surname></persName><affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation></author><author xml:id="author-0007"><persName><forename type="first">Jane</forename><surname>Crawley</surname></persName><note type="biography">Current address: Jane Crawley, Wellcome Trust Laboratories, P.O. Box 230, Kilifi, Kenya.</note><affiliation>Current address: Jane Crawley, Wellcome Trust Laboratories, P.O. Box 230, Kilifi, Kenya.</affiliation><affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</affiliation></author><author xml:id="author-0008"><persName><forename type="first">David</forename><surname>Brewster</surname></persName><note type="biography">Current address: David Brewster, Paediatric Department, Royal Darwin Hospital, P.O. Box 41326, Casuarina, NT 0811, Australia.</note><affiliation>Current address: David Brewster, Paediatric Department, Royal Darwin Hospital, P.O. Box 41326, Casuarina, NT 0811, Australia.</affiliation><affiliation>Royal Victoria Hospital, Banjul, The Gambia</affiliation></author><author xml:id="author-0009"><persName><forename type="first">Sasithon</forename><surname>Pukrittayakamee</surname></persName><affiliation>Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</affiliation></author><author xml:id="author-0010"><persName><forename type="first">Nicholas J.</forename><surname>White</surname></persName><affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation></author><idno type="istex">67D0E8EE5465697FFEC9B372E6433FC7CEDEFE41</idno><idno type="ark">ark:/67375/6H6-STMGD07M-Z</idno><idno type="DOI">10.1016/S0035-9203(96)90241-2</idno><idno type="PII">S0035-9203(96)90241-2</idno></analytic><monogr><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="pISSN">0035-9203</idno><idno type="PII">S0035-9203(00)X0066-1</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996"></date><biblScope unit="volume">90</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="266">266</biblScope><biblScope unit="page" to="269">269</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Electrocardiographic monitoring over 24 h was performed with 53 patients with severe Plasmodium falciparum malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated P. falciparum malaria is questionable.</p></abstract><textClass><keywords scheme="keyword"><list><head>article-category</head><item><term>Clinical studies and pathology</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>malaria</term></item><item><term>Plasmodium falciparum</term></item><item><term>electrocardiography</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996-01-03">Modified</change><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-STMGD07M-Z/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TRSTMH</jid><aid>96902412</aid><ce:pii>S0035-9203(96)90241-2</ce:pii><ce:doi>10.1016/S0035-9203(96)90241-2</ce:doi><ce:copyright type="unknown" year="1996"></ce:copyright><ce:doctopics><ce:doctopic><ce:text>Clinical studies and pathology</ce:text></ce:doctopic></ce:doctopics></item-info><head><ce:title>Electrocardiographic monitoring in severe falciparum malaria</ce:title><ce:author-group><ce:author><ce:given-name>Delia B.</ce:given-name><ce:surname>Bethell</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Pham Tung</ce:given-name><ce:surname>Phuong</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Cao Xuan Thanh</ce:given-name><ce:surname>Phuong</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>François</ce:given-name><ce:surname>Nosten</ce:surname><ce:cross-ref refid="AFF4"><ce:sup>4</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Deborah</ce:given-name><ce:surname>Waller</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Timothy M.E.</ce:given-name><ce:surname>Davis</ce:surname><ce:cross-ref refid="AFF5"><ce:sup>5</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>∗1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Nicholas P.J.</ce:given-name><ce:surname>Day</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jane</ce:given-name><ce:surname>Crawley</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref><ce:cross-ref refid="FN2"><ce:sup>∗2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>David</ce:given-name><ce:surname>Brewster</ce:surname><ce:cross-ref refid="AFF5"><ce:sup>5</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF6"><ce:sup>6</ce:sup></ce:cross-ref><ce:cross-ref refid="FN3"><ce:sup>∗3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Sasithon</ce:given-name><ce:surname>Pukrittayakamee</ce:surname><ce:cross-ref refid="AFF7"><ce:sup>7</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Nicholas J.</ce:given-name><ce:surname>White</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF7"><ce:sup>7</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Dong Nai Paediatric Centre, Bien Hoa, Viet Nam</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>d</ce:label><ce:textfn>Shoklo Malaria Research Unit, Mae Sot, Thailand</ce:textfn></ce:affiliation><ce:affiliation id="AFF5"><ce:label>e</ce:label><ce:textfn>Royal Victoria Hospital, Banjul, The Gambia</ce:textfn></ce:affiliation><ce:affiliation id="AFF6"><ce:label>f</ce:label><ce:textfn>Medical Research Council Laboratories, Fajara, The Gambia</ce:textfn></ce:affiliation><ce:affiliation id="AFF7"><ce:label>g</ce:label><ce:textfn>Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address for correspondence: Delia Bethell, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Level 7, John Radcliffe Hospital, Oxford, OX3 9DU, UK.</ce:text></ce:correspondence><ce:footnote id="FN1"><ce:label>∗1</ce:label><ce:note-para>Current address: Timothy M. E. Davis, University of Western Australia, Dept of Medicine, Fremantle Hospital, Fremantle, Australia.</ce:note-para></ce:footnote><ce:footnote id="FN2"><ce:label>∗2</ce:label><ce:note-para>Current address: Jane Crawley, Wellcome Trust Laboratories, P.O. Box 230, Kilifi, Kenya.</ce:note-para></ce:footnote><ce:footnote id="FN3"><ce:label>∗3</ce:label><ce:note-para>Current address: David Brewster, Paediatric Department, Royal Darwin Hospital, P.O. Box 41326, Casuarina, NT 0811, Australia.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="18" month="12" year="1995"></ce:date-received><ce:date-revised day="3" month="1" year="1996"></ce:date-revised><ce:date-accepted day="4" month="1" year="1996"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Electrocardiographic monitoring over 24 h was performed with 53 patients with severe <ce:italic>Plasmodium falciparum</ce:italic> malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated <ce:italic>P. falciparum</ce:italic> malaria is questionable.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>malaria</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>Plasmodium falciparum</ce:italic></ce:text></ce:keyword><ce:keyword><ce:text>electrocardiography</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Electrocardiographic monitoring in severe falciparum malaria</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Electrocardiographic monitoring in severe falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">Delia B.</namePart><namePart type="family">Bethell</namePart><affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation><description>Address for correspondence: Delia Bethell, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Level 7, John Radcliffe Hospital, Oxford, OX3 9DU, UK.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pham Tung</namePart><namePart type="family">Phuong</namePart><affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cao Xuan Thanh</namePart><namePart type="family">Phuong</namePart><affiliation>Dong Nai Paediatric Centre, Bien Hoa, Viet Nam</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">François</namePart><namePart type="family">Nosten</namePart><affiliation>Shoklo Malaria Research Unit, Mae Sot, Thailand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Deborah</namePart><namePart type="family">Waller</namePart><affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Timothy M.E.</namePart><namePart type="family">Davis</namePart><affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</affiliation><description>Current address: Timothy M. E. Davis, University of Western Australia, Dept of Medicine, Fremantle Hospital, Fremantle, Australia.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicholas P.J.</namePart><namePart type="family">Day</namePart><affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jane</namePart><namePart type="family">Crawley</namePart><affiliation>Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK</affiliation><description>Current address: Jane Crawley, Wellcome Trust Laboratories, P.O. Box 230, Kilifi, Kenya.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Brewster</namePart><affiliation>Royal Victoria Hospital, Banjul, The Gambia</affiliation><description>Current address: David Brewster, Paediatric Department, Royal Darwin Hospital, P.O. Box 41326, Casuarina, NT 0811, Australia.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sasithon</namePart><namePart type="family">Pukrittayakamee</namePart><affiliation>Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicholas J.</namePart><namePart type="family">White</namePart><affiliation>Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Viet Nam</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><dateModified encoding="w3cdtf">1996-01-03</dateModified><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Electrocardiographic monitoring over 24 h was performed with 53 patients with severe Plasmodium falciparum malaria (11 adults and 42 children) to assess the frequency of unrecognized cardiac arrhythmias. Nine patients (17%) died, 5 during the monitoring period and 4 afterwards. Pauses lasting 2–3 s were observed in 3 children, a single couplet in one, and a further child experienced frequent supraventricular ectopic beats which had not been detected clinically. In none of the patients who died could death be attributed to cardiac arrhythmia. Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. The need for routine cardiac monitoring of patients with severe and complicated P. falciparum malaria is questionable.</abstract><subject><genre>article-category</genre><topic>Clinical studies and pathology</topic></subject><subject><genre>Keywords</genre><topic>malaria</topic><topic>Plasmodium falciparum</topic><topic>electrocardiography</topic></subject><relatedItem type="host"><titleInfo><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>TRSTMH</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued></originInfo><identifier type="ISSN">0035-9203</identifier><identifier type="PII">S0035-9203(00)X0066-1</identifier><part><date>1996</date><detail type="volume"><number>90</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue-pages"><start>209</start><end>335</end></extent><extent unit="pages"><start>266</start><end>269</end></extent></part></relatedItem><identifier type="istex">67D0E8EE5465697FFEC9B372E6433FC7CEDEFE41</identifier><identifier type="ark">ark:/67375/6H6-STMGD07M-Z</identifier><identifier type="DOI">10.1016/S0035-9203(96)90241-2</identifier><identifier type="PII">S0035-9203(96)90241-2</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-STMGD07M-Z/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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