The Effect of Some Anti‐inflammatory Agents on Elastase Release From Neutrophils In‐vitro
Identifieur interne : 000A05 ( Istex/Corpus ); précédent : 000A04; suivant : 000A06The Effect of Some Anti‐inflammatory Agents on Elastase Release From Neutrophils In‐vitro
Auteurs : E. O. Adeyemi ; V. S. Chadwick ; H. J. F. HodgsonSource :
- Journal of Pharmacy and Pharmacology [ 0022-3573 ] ; 1990-07.
English descriptors
- Teeft :
- Acetylsalicylic acid, Adeyemi, Arachidonic acid metabolism, Assay, Connective tissue, Dark bars, Ducane road, Elastase, Elastase assay buffer, Elastase release, Elastase secretion, Enzyme activity, Febs lett, Functional assay, Functional inhibition, Human leucocyte elastase, Indomethacin, Inflammatory, Inflammatory bowel disease, Inhibitory capacity, Klotz maier, Leucocyte, Leucocyte elastase, Lipoxygenase pathway, Maximum elastase activity, Nast leduc, Neutrophil, Neutrophil elastase, Neutrophil elastase release, Pathway, Percentage decrease, Polymorphonuclear leucocytes, Positive control, Prednisolone, Radioimmunometric assay, Radiolabelled protein, Rheumatoid arthritis, Room temperature, Salicylic acid, Short preincubation period, Sigma chemicals, Sodium azide, Sulphosalicylic acid, Supernatant, Tissue damage, Ulcerative colitis, Various concentrations, West germany.
Abstract
Abstract— In view of the potential role of released polymorphonuclear leucocyte elastase in causing tissue damage, the effect of commonly used anti‐inflammatory drugs on elastase release from neutrophils has been studied in‐vitro. Elastase release from neutrophils exposed to the synthetic bacterial cell wall peptide N‐formyl‐L‐methionyl‐L‐leucyl‐L‐phenylalanine (10−6 M) was quantitated using a radiometric immunoassay and a functional assay of elastase. Prednisolone and non‐steroidal anti‐inflammatory drugs inhibited elastase release at concentrations from 0.1 mM‐0.1 nM. No inhibition by sulphosalicylic acid, D‐penicillamine or chloroquine sulphate was observed. The clinical relevance of these findings is discussed.
Url:
DOI: 10.1111/j.2042-7158.1990.tb06601.x
Links to Exploration step
ISTEX:14FBB419C30821D0CD20F289699B230717D988F7Le document en format XML
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Elastase release from neutrophils exposed to the synthetic bacterial cell wall peptide N‐formyl‐L‐methionyl‐L‐leucyl‐L‐phenylalanine (10−6 M) was quantitated using a radiometric immunoassay and a functional assay of elastase. Prednisolone and non‐steroidal anti‐inflammatory drugs inhibited elastase release at concentrations from 0.1 mM‐0.1 nM. No inhibition by sulphosalicylic acid, D‐penicillamine or chloroquine sulphate was observed. 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Prednisolone and non‐steroidal anti‐inflammatory drugs inhibited elastase release at concentrations from 0.1 mM‐0.1 nM. No inhibition by sulphosalicylic acid, D‐penicillamine or chloroquine sulphate was observed. 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The clinical relevance of these findings is discussed.</p></abstract><textClass><keywords rend="tocHeading1"><term>Original Article</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LX3W2N2W-R/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)2042-7158</doi><issn type="print">0022-3573</issn><issn type="electronic">2042-7158</issn><idGroup><id type="product" value="JPHP"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF PHARMACY AND PHARMACOLOGY">Journal of Pharmacy and Pharmacology</title></titleGroup></publicationMeta><publicationMeta level="part" position="07107"><doi origin="wiley">10.1111/jphp.1990.42.issue-7</doi><numberingGroup><numbering type="journalVolume" number="42">42</numbering><numbering type="journalIssue" number="7">7</numbering></numberingGroup><coverDate startDate="1990-07">July 1990</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="7" status="forIssue"><doi origin="wiley">10.1111/j.2042-7158.1990.tb06601.x</doi><idGroup><id type="unit" value="JPHP6601"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="tocHeading1">Original Article</title></titleGroup><copyright>1990 Royal Pharmaceutical Society of Great Britain</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.4.7 mode:FullText" date="2011-03-14"></event><event type="firstOnline" date="2011-04-12"></event><event type="publishedOnlineFinalForm" date="2011-04-12"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="487">487</numbering><numbering type="pageLast" number="490">490</numbering></numberingGroup><correspondenceTo>Dept. of Medicine, Hammersmith Hospital, Ducane Road, London W12 0NN, UK.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JPHP.JPHP6601.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>March 16, 1990</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="25"></count><count type="linksCrossRef" number="4"></count></countGroup><titleGroup><title type="main">The Effect of Some Anti‐inflammatory Agents on Elastase Release From Neutrophils In‐vitro</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>E. O.</givenNames><familyName>ADEYEMI</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>V. S.</givenNames><familyName>CHADWICK</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>H. J. F.</givenNames><familyName>HODGSON</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="GB"><unparsedAffiliation>Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, 150 Ducane Road, London W12 0NN, UK</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Abstract—</b> In view of the potential role of released polymorphonuclear leucocyte elastase in causing tissue damage, the effect of commonly used anti‐inflammatory drugs on elastase release from neutrophils has been studied in‐vitro. Elastase release from neutrophils exposed to the synthetic bacterial cell wall peptide <i>N‐</i>formyl‐L‐methionyl‐L‐leucyl‐L‐phenylalanine (10<sup>−6</sup> M) was quantitated using a radiometric immunoassay and a functional assay of elastase. Prednisolone and non‐steroidal anti‐inflammatory drugs inhibited elastase release at concentrations from 0.1 mM‐0.1 nM. No inhibition by sulphosalicylic acid, D‐penicillamine or chloroquine sulphate was observed. The clinical relevance of these findings is discussed.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The Effect of Some Anti‐inflammatory Agents on Elastase Release From Neutrophils In‐vitro</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The Effect of Some Anti‐inflammatory Agents on Elastase Release From Neutrophils In‐vitro</title></titleInfo><name type="personal"><namePart type="given">E. O.</namePart><namePart type="family">ADEYEMI</namePart><affiliation>Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, 150 Ducane Road, London W12 0NN, UK</affiliation><affiliation>Correspondence address: Dept. of Medicine, Hammersmith Hospital, Ducane Road, London W12 0NN, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. S.</namePart><namePart type="family">CHADWICK</namePart><affiliation>Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, 150 Ducane Road, London W12 0NN, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. J. F.</namePart><namePart type="family">HODGSON</namePart><affiliation>Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, 150 Ducane Road, London W12 0NN, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1990-07</dateIssued><edition>March 16, 1990</edition><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">25</extent><extent unit="linksCrossRef">4</extent></physicalDescription><abstract lang="en">Abstract— In view of the potential role of released polymorphonuclear leucocyte elastase in causing tissue damage, the effect of commonly used anti‐inflammatory drugs on elastase release from neutrophils has been studied in‐vitro. Elastase release from neutrophils exposed to the synthetic bacterial cell wall peptide N‐formyl‐L‐methionyl‐L‐leucyl‐L‐phenylalanine (10−6 M) was quantitated using a radiometric immunoassay and a functional assay of elastase. Prednisolone and non‐steroidal anti‐inflammatory drugs inhibited elastase release at concentrations from 0.1 mM‐0.1 nM. No inhibition by sulphosalicylic acid, D‐penicillamine or chloroquine sulphate was observed. 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H.</namePart><namePart type="family">Nielsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Bukhave</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Elmgreen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Ahnfelt‐Tonne</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nielsen, O. H., Bukhave, K., Elmgreen, J., Ahnfelt‐Tonne, I. (1987) Inhibition of 5‐lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalzine and 5‐amino salicylic acid. 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