Antimalarial Properties of Imipramine and Amitriptyline
Identifieur interne : 000906 ( Istex/Corpus ); précédent : 000905; suivant : 000907Antimalarial Properties of Imipramine and Amitriptyline
Auteurs : Purabi Dutta ; John Pinto ; Richard RivlinSource :
- The Journal of Protozoology [ 0022-3921 ] ; 1990-01.
English descriptors
- Teeft :
- Amitriptyline, Antidepressant, Antimalarial, Antimalarial agents, Antimalarial drugs, Antimalarial effects, Antimalarial efficacy, Chloroquine, Chlorpromazine, Dietary riboflavin deficiency, Eimeria, Erythrocyte, Erythrocyte membranes, Falciparum, Glutathione, Hemolysis, Hemolytic, Hemolytic response, Host erythrocytes, Human erythrocytes, Imipramine, Malaria, Malarial, Malarial parasites, Metabolism, Oocyst, Oocyst residuum, Oocysts, Parasite, Parasitemia, Plasmodium, Plasmodium falciparum, Residuum, Riboflavin, Riboflavin deficiency, Riboflavin metabolism, Tricyclic, Tricyclic antidepressants, Various concentrations.
Abstract
Dietary riboflavin deficiency is known to diminish malarial parasitemia. In this study, we determined whether imipramine and amitriptyline, drugs which inhibit riboflavin metabolism, have antimalarial efficacy. In addition, we evaluated whether these drugs, like other antimalarial agents, increase the hemolytic response to ferriprotoporphyrin IX (FP). The growth of Plasmodium falciparum (FCR3) in the absence and presence of these drugs (10 to 75 μM) was measured by determining (3H)hypoxanthine uptake by intraerythrocytic parasites for 48 h in RPMI 1640 medium. The uptake of (3H)hypoxanthine was significantly reduced in a dose‐dependent manner by both imipramine and amitriptyline. The IC50 values of imipramine and amitriptyline at 48 h were 56 and 45 μM, respectively. Both drugs enhanced hemolysis induced by FP (10 or 20 μM). No hemolysis by these drugs was detected in the absence of FP. It is concluded that the tricyclic antidepressants, imipramine and amitriptyline, possess substantial antimalarial properties.
Url:
DOI: 10.1111/j.1550-7408.1990.tb01116.x
Links to Exploration step
ISTEX:A8B7EC5E95300504DC87AB436B0D7B67A929F6F1Le document en format XML
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Interactions</json:string><json:string>Steven Meshnick</json:string></persName><placeName><json:string>Summit</json:string><json:string>NJ.</json:string><json:string>Venezuela</json:string><json:string>Papua New Guinea</json:string><json:string>British Honduras</json:string><json:string>NY</json:string><json:string>Brazil</json:string><json:string>York</json:string><json:string>Grand Island</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[4]</json:string><json:string>[34]</json:string><json:string>Rastegaiff, 1930</json:string><json:string>[29]</json:string><json:string>[33]</json:string><json:string>[8]</json:string><json:string>[39]</json:string><json:string>[32]</json:string><json:string>[38]</json:string><json:string>[3]</json:string><json:string>[20]</json:string><json:string>[26]</json:string><json:string>[30]</json:string><json:string>[7]</json:string><json:string>[36]</json:string><json:string>[9]</json:string><json:string>[2]</json:string><json:string>[24]</json:string><json:string>Geary et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-9FPH4V8Z-L</json:string></ark><categories><wos></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - 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The IC<hi rend="subscript">50</hi> values of imipramine and amitriptyline at 48 h were 56 and 45 μM, respectively. Both drugs enhanced hemolysis induced by FP (10 or 20 μM). No hemolysis by these drugs was detected in the absence of FP. It is concluded that the tricyclic antidepressants, imipramine and amitriptyline, possess substantial antimalarial properties.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Glutathione</term><term xml:id="k2">hemolysis</term><term xml:id="k3">hypoxanthine</term><term xml:id="k4">malaria</term><term xml:id="k5"><hi rend="italic">Plasmodium</hi></term><term xml:id="k6">riboflavin</term><term xml:id="k7">tricyclic antidepressants</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-9FPH4V8Z-L/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1550-7408a</doi><issn type="print">0022-3921</issn><issn type="electronic">1550-7408</issn><idGroup><id type="product" value="JEU"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="THE JOURNAL OF PROTOZOOLOGY">The Journal of Protozoology</title></titleGroup></publicationMeta><publicationMeta level="part" position="01101"><doi origin="wiley">10.1111/jeu.1990.37.issue-1</doi><numberingGroup><numbering type="journalVolume" number="37">37</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="1990-01">January 1990</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0005400" status="forIssue"><doi origin="wiley">10.1111/j.1550-7408.1990.tb01116.x</doi><idGroup><id type="unit" value="JEU54"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><eventGroup><event type="firstOnline" date="2007-05-01"></event><event type="publishedOnlineFinalForm" date="2007-05-01"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.2.3 mode:FullText" date="2013-09-03"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-30"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="54">54</numbering><numbering type="pageLast" number="58">58</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:JEU.JEU54.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="referenceTotal" number="39"></count><count type="linksCrossRef" number="5"></count></countGroup><titleGroup><title type="main">Antimalarial Properties of Imipramine and Amitriptyline<link href="#fn1"><sup>1</sup></link><link href="#fn2"><sup>2</sup></link></title><title type="tocForm">Antimalarial Properties of Imipramine and Amitriptyline</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>PURABI</givenNames><familyName>DUTTA</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>JOHN</givenNames><familyName>PINTO</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>RICHARD</givenNames><familyName>RIVLIN</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Memorial Sloan‐Kettering Cancer Center and Cornell University Medical College, New York, New York 10021</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Glutathione</keyword><keyword xml:id="k2">hemolysis</keyword><keyword xml:id="k3">hypoxanthine</keyword><keyword xml:id="k4">malaria</keyword><keyword xml:id="k5"><i>Plasmodium</i></keyword><keyword xml:id="k6">riboflavin</keyword><keyword xml:id="k7">tricyclic antidepressants</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">ABSTRACT</title><p>Dietary riboflavin deficiency is known to diminish malarial parasitemia. In this study, we determined whether imipramine and amitriptyline, drugs which inhibit riboflavin metabolism, have antimalarial efficacy. In addition, we evaluated whether these drugs, like other antimalarial agents, increase the hemolytic response to ferriprotoporphyrin IX (FP). The growth of <i>Plasmodium falciparum</i> (FCR3) in the absence and presence of these drugs (10 to 75 μM) was measured by determining (<sup>3</sup>H)hypoxanthine uptake by intraerythrocytic parasites for 48 h in RPMI 1640 medium. The uptake of (<sup>3</sup>H)hypoxanthine was significantly reduced in a dose‐dependent manner by both imipramine and amitriptyline. The IC<sub>50</sub> values of imipramine and amitriptyline at 48 h were 56 and 45 μM, respectively. Both drugs enhanced hemolysis induced by FP (10 or 20 μM). No hemolysis by these drugs was detected in the absence of FP. It is concluded that the tricyclic antidepressants, imipramine and amitriptyline, possess substantial antimalarial properties.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Preliminary findings were published in an abstract form in <i>Fed. Proc.</i>, <b>45</b>:202, 1986.</p></note><note xml:id="fn2"><p>The research was performed in the Nutrition Research Laboratory of Sloan‐Kettering Institute.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Antimalarial Properties of Imipramine and Amitriptyline</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Antimalarial Properties of Imipramine and Amitriptyline12</title></titleInfo><name type="personal"><namePart type="given">PURABI</namePart><namePart type="family">DUTTA</namePart><affiliation>Memorial Sloan‐Kettering Cancer Center and Cornell University Medical College, New York, New York 10021</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JOHN</namePart><namePart type="family">PINTO</namePart><affiliation>Memorial Sloan‐Kettering Cancer Center and Cornell University Medical College, New York, New York 10021</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RICHARD</namePart><namePart type="family">RIVLIN</namePart><affiliation>Memorial Sloan‐Kettering Cancer Center and Cornell University Medical College, New York, New York 10021</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1990-01</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">39</extent><extent unit="linksCrossRef">5</extent></physicalDescription><abstract lang="en">Dietary riboflavin deficiency is known to diminish malarial parasitemia. In this study, we determined whether imipramine and amitriptyline, drugs which inhibit riboflavin metabolism, have antimalarial efficacy. In addition, we evaluated whether these drugs, like other antimalarial agents, increase the hemolytic response to ferriprotoporphyrin IX (FP). The growth of Plasmodium falciparum (FCR3) in the absence and presence of these drugs (10 to 75 μM) was measured by determining (3H)hypoxanthine uptake by intraerythrocytic parasites for 48 h in RPMI 1640 medium. The uptake of (3H)hypoxanthine was significantly reduced in a dose‐dependent manner by both imipramine and amitriptyline. The IC50 values of imipramine and amitriptyline at 48 h were 56 and 45 μM, respectively. Both drugs enhanced hemolysis induced by FP (10 or 20 μM). No hemolysis by these drugs was detected in the absence of FP. It is concluded that the tricyclic antidepressants, imipramine and amitriptyline, possess substantial antimalarial properties.</abstract><note type="content">*Preliminary findings were published in an abstract form in Fed. Proc., 45:202, 1986.</note><note type="content">*The research was performed in the Nutrition Research Laboratory of Sloan‐Kettering Institute.</note><subject lang="en"><genre>keywords</genre><topic>Glutathione</topic><topic>hemolysis</topic><topic>hypoxanthine</topic><topic>malaria</topic><topic>Plasmodium</topic><topic>riboflavin</topic><topic>tricyclic antidepressants</topic></subject><relatedItem type="host"><titleInfo><title>The Journal of Protozoology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-3921</identifier><identifier type="eISSN">1550-7408</identifier><identifier type="DOI">10.1111/(ISSN)1550-7408a</identifier><identifier type="PublisherID">JEU</identifier><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>54</start><end>58</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Antimalarial effects of riboflavin deficiency</title></titleInfo><name type="personal"><namePart type="given">C. 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