Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome
Identifieur interne : 000803 ( Istex/Corpus ); précédent : 000802; suivant : 000804Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome
Auteurs : Y. A. Dalavanga ; P. V. Voulgari ; A. N. Georgiadis ; C. Leontaridi ; S. Katsenos ; M. Vassiliou ; A. A. Drosos ; S. H. ConstantopoulosSource :
- Rheumatology International [ 0172-8172 ] ; 2006-07-01.
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- KwdEn :
Abstract
Abstract: Twelve years ago we reported that lymphocytic alveolitis [or bronchoalveolar lavage (BAL) lymphocytosis] correlates with clinical pulmonary involvement in primary Sjogren’s syndrome (pSS). Our thesis was based οn subtle clinical and functional evidence of interstitial lung disease (ILD) in pSS patients with “high lymphocytic alveolitis” (>15% lymphocytes in BAL). This report is a follow-up study of these patients. Basic clinical and functional re-evaluation of the 22 patients with pSS, studied in 1991, emphasized the differences between those with alveolitis and those without alveolitis. There was no significant functional decline. There were, however, two statistically significant differences between the two groups: (1) only patients with BAL lymphocytosis had to be treated with steroids (5/12 vs. 0/10, P<0.05) and (2) only patients with BAL lymphocytosis had died in the mean time (6/12 vs. 0/10, P<0.01). The causes of death were various. On only two occasions were they related to respiratory infections while there were no deaths from respiratory failure secondary to ILD. BAL lymphocytosis appears to be a surprisingly serious index of dismal prognosis in patients with pSS. We offer no unifying pathophysiologic mechanism for it and, therefore, all we propose is that BAL is performed early, in as many patients with pSS as possible. These patients should then be followed up systematically, in order to evaluate if BAL lymphocytosis has any pathophysiologic importance in the development of clinically serious pSS, which is serious enough to lead to death.
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DOI: 10.1007/s00296-005-0092-1
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Leontaridi</name><affiliation><mods:affiliation>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</mods:affiliation></affiliation></author><author><name sortKey="Katsenos, S" sort="Katsenos, S" uniqKey="Katsenos S" first="S." last="Katsenos">S. Katsenos</name><affiliation><mods:affiliation>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</mods:affiliation></affiliation></author><author><name sortKey="Vassiliou, M" sort="Vassiliou, M" uniqKey="Vassiliou M" first="M." last="Vassiliou">M. Vassiliou</name><affiliation><mods:affiliation>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</mods:affiliation></affiliation></author><author><name sortKey="Drosos, A A" sort="Drosos, A A" uniqKey="Drosos A" first="A. A." last="Drosos">A. A. 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Our thesis was based οn subtle clinical and functional evidence of interstitial lung disease (ILD) in pSS patients with “high lymphocytic alveolitis” (>15% lymphocytes in BAL). This report is a follow-up study of these patients. Basic clinical and functional re-evaluation of the 22 patients with pSS, studied in 1991, emphasized the differences between those with alveolitis and those without alveolitis. There was no significant functional decline. There were, however, two statistically significant differences between the two groups: (1) only patients with BAL lymphocytosis had to be treated with steroids (5/12 vs. 0/10, P<0.05) and (2) only patients with BAL lymphocytosis had died in the mean time (6/12 vs. 0/10, P<0.01). The causes of death were various. On only two occasions were they related to respiratory infections while there were no deaths from respiratory failure secondary to ILD. BAL lymphocytosis appears to be a surprisingly serious index of dismal prognosis in patients with pSS. We offer no unifying pathophysiologic mechanism for it and, therefore, all we propose is that BAL is performed early, in as many patients with pSS as possible. These patients should then be followed up systematically, in order to evaluate if BAL lymphocytosis has any pathophysiologic importance in the development of clinically serious pSS, which is serious enough to lead to death.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Y. A. Dalavanga</name><affiliations><json:string>Department of Anatomy, Medical School, University of Ioannina, 45110, Ioannina, Greece</json:string></affiliations></json:item><json:item><name>P. V. Voulgari</name><affiliations><json:string>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</json:string></affiliations></json:item><json:item><name>A. N. Georgiadis</name><affiliations><json:string>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</json:string></affiliations></json:item><json:item><name>C. Leontaridi</name><affiliations><json:string>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</json:string></affiliations></json:item><json:item><name>S. Katsenos</name><affiliations><json:string>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</json:string></affiliations></json:item><json:item><name>M. Vassiliou</name><affiliations><json:string>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</json:string></affiliations></json:item><json:item><name>A. A. 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Our thesis was based οn subtle clinical and functional evidence of interstitial lung disease (ILD) in pSS patients with “high lymphocytic alveolitis” (>15% lymphocytes in BAL). This report is a follow-up study of these patients. Basic clinical and functional re-evaluation of the 22 patients with pSS, studied in 1991, emphasized the differences between those with alveolitis and those without alveolitis. There was no significant functional decline. There were, however, two statistically significant differences between the two groups: (1) only patients with BAL lymphocytosis had to be treated with steroids (5/12 vs. 0/10, P>0.05) and (2) only patients with BAL lymphocytosis had died in the mean time (6/12 vs. 0/10, P>0.01). The causes of death were various. On only two occasions were they related to respiratory infections while there were no deaths from respiratory failure secondary to ILD. BAL lymphocytosis appears to be a surprisingly serious index of dismal prognosis in patients with pSS. We offer no unifying pathophysiologic mechanism for it and, therefore, all we propose is that BAL is performed early, in as many patients with pSS as possible. These patients should then be followed up systematically, in order to evaluate if BAL lymphocytosis has any pathophysiologic importance in the development of clinically serious pSS, which is serious enough to lead to death.</abstract><qualityIndicators><score>7.422</score><pdfWordCount>2566</pdfWordCount><pdfCharCount>17701</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>595 x 785 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>238</abstractWordCount><abstractCharCount>1586</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome</title><genre><json:string>research-article</json:string></genre><host><title>Rheumatology International</title><language><json:string>unknown</json:string></language><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><issn><json:string>0172-8172</json:string></issn><eissn><json:string>1437-160X</json:string></eissn><journalId><json:string>296</json:string></journalId><volume>26</volume><issue>9</issue><pages><first>799</first><last>804</last></pages><genre><json:string>journal</json:string></genre></host><ark><json:string>ark:/67375/VQC-KVKLF1M8-2</json:string></ark><publicationDate>2006</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1007/s00296-005-0092-1</json:string></doi><id>92070722C099F3FEA3FBC887BF314072F05F2335</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-KVKLF1M8-2/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-KVKLF1M8-2/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/VQC-KVKLF1M8-2/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><licence><p>Springer-Verlag, 2005</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>2005-02-25</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Original Article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome</title><author xml:id="author-0000"><persName><forename type="first">Y. 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Our thesis was based οn subtle clinical and functional evidence of interstitial lung disease (ILD) in pSS patients with “high lymphocytic alveolitis” (>15% lymphocytes in BAL). This report is a follow-up study of these patients. Basic clinical and functional re-evaluation of the 22 patients with pSS, studied in 1991, emphasized the differences between those with alveolitis and those without alveolitis. There was no significant functional decline. There were, however, two statistically significant differences between the two groups: (1) only patients with BAL lymphocytosis had to be treated with steroids (5/12 vs. 0/10, P<0.05) and (2) only patients with BAL lymphocytosis had died in the mean time (6/12 vs. 0/10, P<0.01). The causes of death were various. On only two occasions were they related to respiratory infections while there were no deaths from respiratory failure secondary to ILD. BAL lymphocytosis appears to be a surprisingly serious index of dismal prognosis in patients with pSS. We offer no unifying pathophysiologic mechanism for it and, therefore, all we propose is that BAL is performed early, in as many patients with pSS as possible. These patients should then be followed up systematically, in order to evaluate if BAL lymphocytosis has any pathophysiologic importance in the development of clinically serious pSS, which is serious enough to lead to death.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Bronchoalveolar lavage</term></item><item><term>Primary Sjogren’s syndrome</term></item><item><term>Epitheliitis</term></item><item><term>Lymphocytic alveolitis</term></item><item><term>BAL lymphocytosis</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-02-25">Created</change><change when="2006-07-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-KVKLF1M8-2/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal OutputMedium="All"><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>296</JournalID><JournalPrintISSN>0172-8172</JournalPrintISSN><JournalElectronicISSN>1437-160X</JournalElectronicISSN><JournalTitle>Rheumatology International</JournalTitle><JournalSubTitle>Clinical and Experimental Investigations</JournalSubTitle><JournalAbbreviatedTitle>Rheumatol Int</JournalAbbreviatedTitle></JournalInfo><Volume OutputMedium="All"><VolumeInfo TocLevels="0" VolumeType="Regular"><VolumeIDStart>26</VolumeIDStart><VolumeIDEnd>26</VolumeIDEnd><VolumeIssueCount>12</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular" OutputMedium="All"><IssueInfo TocLevels="0"><IssueIDStart>9</IssueIDStart><IssueIDEnd>9</IssueIDEnd><IssueArticleCount>16</IssueArticleCount><IssueHistory><OnlineDate><Year>2006</Year><Month>5</Month><Day>30</Day></OnlineDate><PrintDate><Year>2006</Year><Month>5</Month><Day>30</Day></PrintDate><CoverDate><Year>2006</Year><Month>7</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>2006</CopyrightYear></IssueCopyright></IssueInfo><Article ID="s00296-005-0092-1" OutputMedium="All"><ArticleInfo ArticleType="OriginalPaper" ContainsESM="No" Language="En" NumberingStyle="Unnumbered" TocLevels="0"><ArticleID>92</ArticleID><ArticleDOI>10.1007/s00296-005-0092-1</ArticleDOI><ArticleSequenceNumber>4</ArticleSequenceNumber><ArticleTitle Language="En">Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome</ArticleTitle><ArticleCategory>Original Article</ArticleCategory><ArticleFirstPage>799</ArticleFirstPage><ArticleLastPage>804</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>11</Month><Day>24</Day></RegistrationDate><Received><Year>2005</Year><Month>2</Month><Day>25</Day></Received><Accepted><Year>2005</Year><Month>11</Month><Day>20</Day></Accepted><OnlineDate><Year>2005</Year><Month>12</Month><Day>13</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>2005</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Y. A.</GivenName><FamilyName>Dalavanga</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>P. V.</GivenName><FamilyName>Voulgari</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>A. N.</GivenName><FamilyName>Georgiadis</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>C.</GivenName><FamilyName>Leontaridi</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>S.</GivenName><FamilyName>Katsenos</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><FamilyName>Vassiliou</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2" CorrespondingAffiliationID="Aff2"><AuthorName DisplayOrder="Western"><GivenName>A. A.</GivenName><FamilyName>Drosos</FamilyName></AuthorName><Contact><Phone>+30-26510-99755</Phone><Fax>+30-26510-97054</Fax><Email>adrosos@cc.uoi.gr</Email></Contact></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>S. H.</GivenName><FamilyName>Constantopoulos</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Anatomy, Medical School</OrgDivision><OrgName>University of Ioannina</OrgName><OrgAddress><Postcode>45110</Postcode><City>Ioannina</City><Country>Greece</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Rheumatology Clinic, Department of Internal Medicine, Medical School</OrgDivision><OrgName>University of Ioannina</OrgName><OrgAddress><Postcode>45110</Postcode><City>Ioannina</City><Country>Greece</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Pneumonology Clinic, Department of Internal Medicine, Medical School</OrgDivision><OrgName>University of Ioannina</OrgName><OrgAddress><Postcode>45110</Postcode><City>Ioannina</City><Country>Greece</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Twelve years ago we reported that lymphocytic alveolitis [or bronchoalveolar lavage (BAL) lymphocytosis] correlates with clinical pulmonary involvement in primary Sjogren’s syndrome (pSS). Our thesis was based οn subtle clinical and functional evidence of interstitial lung disease (ILD) in pSS patients with “high lymphocytic alveolitis” (>15% lymphocytes in BAL). This report is a follow-up study of these patients. Basic clinical and functional re-evaluation of the 22 patients with pSS, studied in 1991, emphasized the differences between those with alveolitis and those without alveolitis. There was no significant functional decline. There were, however, two statistically significant differences between the two groups: (1) only patients with BAL lymphocytosis had to be treated with steroids (5/12 vs. 0/10, <Emphasis Type="Italic">P</Emphasis><0.05) and (2) only patients with BAL lymphocytosis had died in the mean time (6/12 vs. 0/10, <Emphasis Type="Italic">P</Emphasis><0.01). The causes of death were various. On only two occasions were they related to respiratory infections while there were no deaths from respiratory failure secondary to ILD. BAL lymphocytosis appears to be a surprisingly serious index of dismal prognosis in patients with pSS. We offer no unifying pathophysiologic mechanism for it and, therefore, all we propose is that BAL is performed early, in as many patients with pSS as possible. These patients should then be followed up systematically, in order to evaluate if BAL lymphocytosis has any pathophysiologic importance in the development of clinically serious pSS, which is serious enough to lead to death.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>Bronchoalveolar lavage</Keyword><Keyword>Primary Sjogren’s syndrome</Keyword><Keyword>Epitheliitis</Keyword><Keyword>Lymphocytic alveolitis</Keyword><Keyword>BAL lymphocytosis</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Lymphocytic alveolitis: a surprising index of poor prognosis in patients with primary Sjogren’s syndrome</title></titleInfo><name type="personal"><namePart type="given">Y. A.</namePart><namePart type="family">Dalavanga</namePart><affiliation>Department of Anatomy, Medical School, University of Ioannina, 45110, Ioannina, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. V.</namePart><namePart type="family">Voulgari</namePart><affiliation>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. N.</namePart><namePart type="family">Georgiadis</namePart><affiliation>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Leontaridi</namePart><affiliation>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Katsenos</namePart><affiliation>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Vassiliou</namePart><affiliation>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">A. A.</namePart><namePart type="family">Drosos</namePart><affiliation>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</affiliation><affiliation>E-mail: adrosos@cc.uoi.gr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. H.</namePart><namePart type="family">Constantopoulos</namePart><affiliation>Pneumonology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">2005-02-25</dateCreated><dateIssued encoding="w3cdtf">2006-07-01</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Twelve years ago we reported that lymphocytic alveolitis [or bronchoalveolar lavage (BAL) lymphocytosis] correlates with clinical pulmonary involvement in primary Sjogren’s syndrome (pSS). Our thesis was based οn subtle clinical and functional evidence of interstitial lung disease (ILD) in pSS patients with “high lymphocytic alveolitis” (>15% lymphocytes in BAL). This report is a follow-up study of these patients. Basic clinical and functional re-evaluation of the 22 patients with pSS, studied in 1991, emphasized the differences between those with alveolitis and those without alveolitis. There was no significant functional decline. There were, however, two statistically significant differences between the two groups: (1) only patients with BAL lymphocytosis had to be treated with steroids (5/12 vs. 0/10, P<0.05) and (2) only patients with BAL lymphocytosis had died in the mean time (6/12 vs. 0/10, P<0.01). The causes of death were various. On only two occasions were they related to respiratory infections while there were no deaths from respiratory failure secondary to ILD. BAL lymphocytosis appears to be a surprisingly serious index of dismal prognosis in patients with pSS. We offer no unifying pathophysiologic mechanism for it and, therefore, all we propose is that BAL is performed early, in as many patients with pSS as possible. These patients should then be followed up systematically, in order to evaluate if BAL lymphocytosis has any pathophysiologic importance in the development of clinically serious pSS, which is serious enough to lead to death.</abstract><note>Original Article</note><subject lang="en"><genre>Keywords</genre><topic>Bronchoalveolar lavage</topic><topic>Primary Sjogren’s syndrome</topic><topic>Epitheliitis</topic><topic>Lymphocytic alveolitis</topic><topic>BAL lymphocytosis</topic></subject><relatedItem type="host"><titleInfo><title>Rheumatology International</title><subTitle>Clinical and Experimental Investigations</subTitle></titleInfo><titleInfo type="abbreviated"><title>Rheumatol Int</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2006-05-30</dateIssued><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><identifier type="ISSN">0172-8172</identifier><identifier type="eISSN">1437-160X</identifier><identifier type="JournalID">296</identifier><identifier type="IssueArticleCount">16</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2006</date><detail type="volume"><number>26</number><caption>vol.</caption></detail><detail type="issue"><number>9</number><caption>no.</caption></detail><extent unit="pages"><start>799</start><end>804</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 2006</recordOrigin></recordInfo></relatedItem><identifier type="istex">92070722C099F3FEA3FBC887BF314072F05F2335</identifier><identifier type="ark">ark:/67375/VQC-KVKLF1M8-2</identifier><identifier type="DOI">10.1007/s00296-005-0092-1</identifier><identifier type="ArticleID">92</identifier><identifier type="ArticleID">s00296-005-0092-1</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 2005</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 2005</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-KVKLF1M8-2/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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