Retinal lesions in rats after treatment with chlorphentermine or with tricyclic antidepressants
Identifieur interne : 000690 ( Istex/Corpus ); précédent : 000689; suivant : 000691Retinal lesions in rats after treatment with chlorphentermine or with tricyclic antidepressants
Auteurs : Renate Lüllmann-RauchSource :
- Virchows Archiv B [ 0340-6075 ] ; 1974-12-01.
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Abstract
Summary: Treatment of rats with the anorectic drug chlorphentermine or with the tricyclic antidepressants iprindole, 1-chlor-amitriptyline, clomipramine and imipramine induced cellular lesions in retinal pigment epithelial cells and in retinal ganglion cells. The ultrastructural findings, which are characterized by the formation of numerous membrane-bound cytoplasmic inclusions with crystalloid or lamellar internal patterns, are interpreted as a manifestation of a drug-induced phospholipidosis.
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DOI: 10.1007/BF02889346
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B Zellpath.</title><idno type="ISSN">0340-6075</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1974-12-01">1974-12-01</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="309">309</biblScope><biblScope unit="page" to="312">312</biblScope></imprint><idno type="ISSN">0340-6075</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-6075</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antidepressant</term><term>Chlorphentermine</term><term>Crystalloid</term><term>Drug treatment</term><term>Ganglion</term><term>Higher magnification</term><term>Lamellated</term><term>Liillmann</term><term>Phospholipidosis</term><term>Reil</term><term>Retinal</term><term>Retinal ganglion cells</term><term>Retinal lesions</term><term>Retinal pigment epithelium</term><term>Tricyclic</term><term>Tricyclic antidepressants</term><term>Ultrastructural</term><term>Virchow</term><term>Virchows arch</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Treatment of rats with the anorectic drug chlorphentermine or with the tricyclic antidepressants iprindole, 1-chlor-amitriptyline, clomipramine and imipramine induced cellular lesions in retinal pigment epithelial cells and in retinal ganglion cells. 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Abt. B Zellpath.</title><idno type="pISSN">0340-6075</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">32</idno><idno type="volume-issue-count">0</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1974-12-01"></date><biblScope unit="volume">15</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="309">309</biblScope><biblScope unit="page" to="312">312</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1974-03-07</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: Treatment of rats with the anorectic drug chlorphentermine or with the tricyclic antidepressants iprindole, 1-chlor-amitriptyline, clomipramine and imipramine induced cellular lesions in retinal pigment epithelial cells and in retinal ganglion cells. 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The ultrastructural findings, which are characterized by the formation of numerous membrane-bound cytoplasmic inclusions with crystalloid or lamellar internal patterns, are interpreted as a manifestation of a drug-induced phospholipidosis.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Retinal lesions in rats after treatment with chlorphentermine or with tricyclic antidepressants</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Retinal lesions in rats after treatment with chlorphentermine or with tricyclic antidepressants</title></titleInfo><name type="personal"><namePart type="given">Renate</namePart><namePart type="family">Lüllmann-Rauch</namePart><affiliation>Department of Anatomy, University of Kiel, West Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1974-03-07</dateCreated><dateIssued encoding="w3cdtf">1974-12-01</dateIssued><copyrightDate encoding="w3cdtf">1974</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: Treatment of rats with the anorectic drug chlorphentermine or with the tricyclic antidepressants iprindole, 1-chlor-amitriptyline, clomipramine and imipramine induced cellular lesions in retinal pigment epithelial cells and in retinal ganglion cells. 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