Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants
Identifieur interne : 000673 ( Istex/Corpus ); précédent : 000672; suivant : 000674Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants
Auteurs : Renate Lüllmann-RauchSource :
- Acta Neuropathologica [ 0001-6322 ] ; 1976-03-01.
English descriptors
- KwdEn :
- Teeft :
- Abnormal, Abnormal cytoplasmic inclusions, Abnormal inclusions, Acta, Acta neuropath, Adrenal glands, Albino, Albino rats, Amphiphilic, Amphiphilic drugs, Antidepressant, Apical, Apical portion, Apical villous processes, Araldite section, Arrowheads point, Arrows point, Cell biol, Chemical composition, Chloroquine, Chlorphentermine, Control albino, Crystalloid, Crystalloid bodies, Crystalloid inclusions, Crystalloid pattern, Crystalloid variety, Cytoplasmic, Direct continuity, Disc saccules, Drug treatment, Enzymatic degradation, Epithelial, Epithelial cells, Epithelium, Fine structure, Foam cell reaction, Functional implications, Further treatment, Ganglion, Ganglion cells, Identical conditions, Inclusion, Lamellated, Liillmann, Lipid, Lipid material, Lipidosis, Molecular basis, Neuroretina, Opaque cytoplasmic bodies, Other cell types, Outer segment fragment, Outer segment membranes, Outer segments, Pars optica, Periodic pentalaminar pattern, Phagocytosed, Phospholipid, Phospholipid pattern, Photoreceptor, Pigment epithelial cell, Pigment epithelial cells, Pigment epithelium, Retinal, Retinal ganglion cells, Retinal lipidosis, Retinal pigment epithelium, Segment fragment, Segment fragments, Segment membranes, Several weeks, Syrian hamsters, Tricyclic, Tricyclic antidepressants, Virchows arch, Visual cell, Wassermann.
Abstract
Summary: Retinal pigment epithelium is known to be engaged in continuous phagocytosis and digestion of old discs of visual cell outer segments, which have a high phospholipid content. The present ultrastructural study was focused mainly on the effects, upon pigment epithelium, of several drugs that are thought to interfere with the enzymatic degradation of phospholipids. Albino rats received high oral doses of chlorphentermine, iprindole, l-chloroamitriptyline, imipramine, or clomipramine. After treatment for several weeks the pigment epithelial cells were doubled in height due to deposition of excessive amounts of abnormal cytoplasmic inclusions which had a crystalloid substructure. Such inclusions which are known from previous studies to be associated with drug-induced phospholipid storage are suggested to contain non-digestible phospholipids, which in pigment epithelium originate mainly from phagocytosed outer segment discs. The alterations were reversible by withdrawal of the drugs. The functional implications of the epithelial alterations remain to be elucidated. Additional examination of the neuroretina revealed numerous abnormal inclusions, mainly of multilamellated structure. Ganglion cells were affected most. The neuroretinal alterations were reminiscent of those described in human cases of inherited lipidoses.
Url:
DOI: 10.1007/BF00688943
Links to Exploration step
ISTEX:74ED03247D99AC9BE254A3A2D41F0949E1186806Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants</title><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><affiliation><mods:affiliation>Department of Anatomy, University of Kiel, Olshausenstr. 40-60, D-2300, Kiel, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:74ED03247D99AC9BE254A3A2D41F0949E1186806</idno><date when="1976" year="1976">1976</date><idno type="doi">10.1007/BF00688943</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-ST15LSZ9-4/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000673</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000673</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants</title><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><affiliation><mods:affiliation>Department of Anatomy, University of Kiel, Olshausenstr. 40-60, D-2300, Kiel, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1976-03-01">1976-03-01</date><biblScope unit="volume">35</biblScope><biblScope unit="issue">1</biblScope><biblScope 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biol</term><term>Chemical composition</term><term>Chloroquine</term><term>Chlorphentermine</term><term>Control albino</term><term>Crystalloid</term><term>Crystalloid bodies</term><term>Crystalloid inclusions</term><term>Crystalloid pattern</term><term>Crystalloid variety</term><term>Cytoplasmic</term><term>Direct continuity</term><term>Disc saccules</term><term>Drug treatment</term><term>Enzymatic degradation</term><term>Epithelial</term><term>Epithelial cells</term><term>Epithelium</term><term>Fine structure</term><term>Foam cell reaction</term><term>Functional implications</term><term>Further treatment</term><term>Ganglion</term><term>Ganglion cells</term><term>Identical conditions</term><term>Inclusion</term><term>Lamellated</term><term>Liillmann</term><term>Lipid</term><term>Lipid material</term><term>Lipidosis</term><term>Molecular basis</term><term>Neuroretina</term><term>Opaque cytoplasmic bodies</term><term>Other cell types</term><term>Outer segment fragment</term><term>Outer 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cell outer segments, which have a high phospholipid content. The present ultrastructural study was focused mainly on the effects, upon pigment epithelium, of several drugs that are thought to interfere with the enzymatic degradation of phospholipids. Albino rats received high oral doses of chlorphentermine, iprindole, l-chloroamitriptyline, imipramine, or clomipramine. After treatment for several weeks the pigment epithelial cells were doubled in height due to deposition of excessive amounts of abnormal cytoplasmic inclusions which had a crystalloid substructure. Such inclusions which are known from previous studies to be associated with drug-induced phospholipid storage are suggested to contain non-digestible phospholipids, which in pigment epithelium originate mainly from phagocytosed outer segment discs. The alterations were reversible by withdrawal of the drugs. The functional implications of the epithelial alterations remain to be elucidated. Additional examination of the neuroretina revealed numerous abnormal inclusions, mainly of multilamellated structure. Ganglion cells were affected most. 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The present ultrastructural study was focused mainly on the effects, upon pigment epithelium, of several drugs that are thought to interfere with the enzymatic degradation of phospholipids. Albino rats received high oral doses of chlorphentermine, iprindole, l-chloroamitriptyline, imipramine, or clomipramine. After treatment for several weeks the pigment epithelial cells were doubled in height due to deposition of excessive amounts of abnormal cytoplasmic inclusions which had a crystalloid substructure. Such inclusions which are known from previous studies to be associated with drug-induced phospholipid storage are suggested to contain non-digestible phospholipids, which in pigment epithelium originate mainly from phagocytosed outer segment discs. The alterations were reversible by withdrawal of the drugs. The functional implications of the epithelial alterations remain to be elucidated. Additional examination of the neuroretina revealed numerous abnormal inclusions, mainly of multilamellated structure. Ganglion cells were affected most. 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The present ultrastructural study was focused mainly on the effects, upon pigment epithelium, of several drugs that are thought to interfere with the enzymatic degradation of phospholipids. Albino rats received high oral doses of chlorphentermine, iprindole, l-chloroamitriptyline, imipramine, or clomipramine. After treatment for several weeks the pigment epithelial cells were doubled in height due to deposition of excessive amounts of abnormal cytoplasmic inclusions which had a crystalloid substructure. Such inclusions which are known from previous studies to be associated with drug-induced phospholipid storage are suggested to contain non-digestible phospholipids, which in pigment epithelium originate mainly from phagocytosed outer segment discs. The alterations were reversible by withdrawal of the drugs. The functional implications of the epithelial alterations remain to be elucidated. Additional examination of the neuroretina revealed numerous abnormal inclusions, mainly of multilamellated structure. Ganglion cells were affected most. The neuroretinal alterations were reminiscent of those described in human cases of inherited lipidoses.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Pigment epithelium</term></item><item><term>Albino rat</term></item><item><term>Neuroretina</term></item><item><term>Phospholipid storage</term></item><item><term>Chlorphentermine</term></item><item><term>Tricyclic antidepressants</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Pathology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1975-11-04">Created</change><change when="1976-03-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-ST15LSZ9-4/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>401</JournalID><JournalPrintISSN>0001-6322</JournalPrintISSN><JournalElectronicISSN>1432-0533</JournalElectronicISSN><JournalTitle>Acta Neuropathologica</JournalTitle><JournalAbbreviatedTitle>Acta Neuropathol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Pathology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>35</VolumeIDStart><VolumeIDEnd>35</VolumeIDEnd><VolumeIssueCount>2</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd><IssueArticleCount>9</IssueArticleCount><IssueHistory><CoverDate><DateString>1976</DateString><Year>1976</Year><Month>3</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1976</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art5"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00688943</ArticleID><ArticleDOI>10.1007/BF00688943</ArticleDOI><ArticleSequenceNumber>5</ArticleSequenceNumber><ArticleTitle Language="En">Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants</ArticleTitle><ArticleCategory>Original Investigations</ArticleCategory><ArticleFirstPage>55</ArticleFirstPage><ArticleLastPage>67</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>11</Month><Day>8</Day></RegistrationDate><Received><Year>1975</Year><Month>11</Month><Day>4</Day></Received><Accepted><Year>1976</Year><Month>1</Month><Day>12</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1976</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>401</JournalID><VolumeIDStart>35</VolumeIDStart><VolumeIDEnd>35</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Renate</GivenName><FamilyName>Lüllmann-Rauch</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Anatomy</OrgDivision><OrgName>University of Kiel</OrgName><OrgAddress><Street>Olshausenstr. 40-60</Street><Postcode>D-2300</Postcode><City>Kiel</City><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>Retinal pigment epithelium is known to be engaged in continuous phagocytosis and digestion of old discs of visual cell outer segments, which have a high phospholipid content. The present ultrastructural study was focused mainly on the effects, upon pigment epithelium, of several drugs that are thought to interfere with the enzymatic degradation of phospholipids.</Para><Para>Albino rats received high oral doses of chlorphentermine, iprindole, l-chloroamitriptyline, imipramine, or clomipramine. After treatment for several weeks the pigment epithelial cells were doubled in height due to deposition of excessive amounts of abnormal cytoplasmic inclusions which had a crystalloid substructure. Such inclusions which are known from previous studies to be associated with drug-induced phospholipid storage are suggested to contain non-digestible phospholipids, which in pigment epithelium originate mainly from phagocytosed outer segment discs. The alterations were reversible by withdrawal of the drugs. The functional implications of the epithelial alterations remain to be elucidated.</Para><Para>Additional examination of the neuroretina revealed numerous abnormal inclusions, mainly of multilamellated structure. Ganglion cells were affected most. The neuroretinal alterations were reminiscent of those described in human cases of inherited lipidoses.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Pigment epithelium</Keyword><Keyword>Albino rat</Keyword><Keyword>Neuroretina</Keyword><Keyword>Phospholipid storage</Keyword><Keyword>Chlorphentermine</Keyword><Keyword>Tricyclic antidepressants</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants</title></titleInfo><name type="personal"><namePart type="given">Renate</namePart><namePart type="family">Lüllmann-Rauch</namePart><affiliation>Department of Anatomy, University of Kiel, Olshausenstr. 40-60, D-2300, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1975-11-04</dateCreated><dateIssued encoding="w3cdtf">1976-03-01</dateIssued><copyrightDate encoding="w3cdtf">1976</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: Retinal pigment epithelium is known to be engaged in continuous phagocytosis and digestion of old discs of visual cell outer segments, which have a high phospholipid content. The present ultrastructural study was focused mainly on the effects, upon pigment epithelium, of several drugs that are thought to interfere with the enzymatic degradation of phospholipids. Albino rats received high oral doses of chlorphentermine, iprindole, l-chloroamitriptyline, imipramine, or clomipramine. After treatment for several weeks the pigment epithelial cells were doubled in height due to deposition of excessive amounts of abnormal cytoplasmic inclusions which had a crystalloid substructure. Such inclusions which are known from previous studies to be associated with drug-induced phospholipid storage are suggested to contain non-digestible phospholipids, which in pigment epithelium originate mainly from phagocytosed outer segment discs. The alterations were reversible by withdrawal of the drugs. The functional implications of the epithelial alterations remain to be elucidated. Additional examination of the neuroretina revealed numerous abnormal inclusions, mainly of multilamellated structure. Ganglion cells were affected most. The neuroretinal alterations were reminiscent of those described in human cases of inherited lipidoses.</abstract><note>Original Investigations</note><subject lang="en"><genre>Key words</genre><topic>Pigment epithelium</topic><topic>Albino rat</topic><topic>Neuroretina</topic><topic>Phospholipid storage</topic><topic>Chlorphentermine</topic><topic>Tricyclic antidepressants</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neuropathologica</title></titleInfo><titleInfo type="abbreviated"><title>Acta Neuropathol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1976-03-01</dateIssued><copyrightDate encoding="w3cdtf">1976</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pathology</topic></subject><identifier type="ISSN">0001-6322</identifier><identifier type="eISSN">1432-0533</identifier><identifier type="JournalID">401</identifier><identifier type="IssueArticleCount">9</identifier><identifier type="VolumeIssueCount">2</identifier><part><date>1976</date><detail type="volume"><number>35</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>55</start><end>67</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1976</recordOrigin></recordInfo></relatedItem><identifier type="istex">74ED03247D99AC9BE254A3A2D41F0949E1186806</identifier><identifier type="ark">ark:/67375/1BB-ST15LSZ9-4</identifier><identifier type="DOI">10.1007/BF00688943</identifier><identifier type="ArticleID">BF00688943</identifier><identifier type="ArticleID">Art5</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1976</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1976</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-ST15LSZ9-4/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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