Amiodarone inhibits multiple drug resistance in yeast Saccharomyces cerevisiae
Identifieur interne : 000635 ( Istex/Corpus ); précédent : 000634; suivant : 000636Amiodarone inhibits multiple drug resistance in yeast Saccharomyces cerevisiae
Auteurs : Dmitry A. Knorre ; Tatiana N. Krivonosova ; Olga V. Markova ; Fedor F. SeverinSource :
- Archives of Microbiology [ 0302-8933 ] ; 2009-08-01.
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Abstract
Abstract: Amiodarone is a widely used antiarrhythmic drug. There is also evidence that amiodarone decreases multidrug resistance in human cell lines. In this paper, we have shown that amiodarone has similar effect on yeast, Saccharomyces cerevisiae, decreasing multiple drug resistance. Amiodarone stimulates the accumulation of ethidium bromide by inhibiting its efflux from the cells. The effect of amiodarone is much stronger on wild-type cells compared to the mutant with inactivated ABC-transporters. Interestingly, the action of amiodarone is additive with the one of chloroquine, a known inhibitor of ABC-transporters. We speculate that these findings could help in the development of antifungal drug mixes.
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DOI: 10.1007/s00203-009-0493-8
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Belozersky Institute of Physico-Chemical Biology, Moscow State University, GSP-2, Leninskie Gory, 119992, Moscow, Russia</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Microbiology</title><title level="j" type="abbrev">Arch Microbiol</title><idno type="ISSN">0302-8933</idno><idno type="eISSN">1432-072X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2009-08-01">2009-08-01</date><biblScope unit="volume">191</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="675">675</biblScope><biblScope unit="page" to="679">679</biblScope></imprint><idno type="ISSN">0302-8933</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0302-8933</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amiodarone</term><term>Multidrug resistance</term><term>Pleiotropic drug resistance</term><term>Yeast</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Amiodarone is a widely used antiarrhythmic drug. There is also evidence that amiodarone decreases multidrug resistance in human cell lines. In this paper, we have shown that amiodarone has similar effect on yeast, Saccharomyces cerevisiae, decreasing multiple drug resistance. Amiodarone stimulates the accumulation of ethidium bromide by inhibiting its efflux from the cells. The effect of amiodarone is much stronger on wild-type cells compared to the mutant with inactivated ABC-transporters. Interestingly, the action of amiodarone is additive with the one of chloroquine, a known inhibitor of ABC-transporters. We speculate that these findings could help in the development of antifungal drug mixes.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Dmitry A. Knorre</name><affiliations><json:string>A.N. 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There is also evidence that amiodarone decreases multidrug resistance in human cell lines. In this paper, we have shown that amiodarone has similar effect on yeast, Saccharomyces cerevisiae, decreasing multiple drug resistance. Amiodarone stimulates the accumulation of ethidium bromide by inhibiting its efflux from the cells. The effect of amiodarone is much stronger on wild-type cells compared to the mutant with inactivated ABC-transporters. Interestingly, the action of amiodarone is additive with the one of chloroquine, a known inhibitor of ABC-transporters. We speculate that these findings could help in the development of antifungal drug mixes.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Yeast</term></item><item><term>Amiodarone</term></item><item><term>Pleiotropic drug resistance</term></item><item><term>Multidrug resistance</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>ABC</term><term>ATP-binding cassette</term></item><item><term>MDR</term><term>Multiple drug resitance</term></item><item><term>EB</term><term>Ethidium bromide</term></item><item><term>C12-TPP</term><term>Dodecyltriphenylphosphonium</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Life Sciences</head><item><term>Ecology</term></item><item><term>Biotechnology</term></item><item><term>Biochemistry, general</term></item><item><term>Cell Biology</term></item><item><term>Microbial 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TocLevels="0"><ArticleID>493</ArticleID><ArticleDOI>10.1007/s00203-009-0493-8</ArticleDOI><ArticleSequenceNumber>7</ArticleSequenceNumber><ArticleTitle Language="En" OutputMedium="All">Amiodarone inhibits multiple drug resistance in yeast <Emphasis Type="Italic">Saccharomyces cerevisiae</Emphasis></ArticleTitle><ArticleCategory>Short Communication</ArticleCategory><ArticleFirstPage>675</ArticleFirstPage><ArticleLastPage>679</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2009</Year><Month>6</Month><Day>4</Day></RegistrationDate><Received><Year>2008</Year><Month>11</Month><Day>10</Day></Received><Revised><Year>2009</Year><Month>5</Month><Day>21</Day></Revised><Accepted><Year>2009</Year><Month>6</Month><Day>1</Day></Accepted><OnlineDate><Year>2009</Year><Month>6</Month><Day>18</Day></OnlineDate></ArticleHistory><ArticleEditorialResponsibility>Axel Brakhage</ArticleEditorialResponsibility><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>2009</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Dmitry</GivenName><GivenName>A.</GivenName><FamilyName>Knorre</FamilyName></AuthorName><Contact><Phone>+7-495-9393107</Phone><Fax>+7-495-9393181</Fax><Email>knorre@belozersky.msu.ru</Email></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Tatiana</GivenName><GivenName>N.</GivenName><FamilyName>Krivonosova</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Olga</GivenName><GivenName>V.</GivenName><FamilyName>Markova</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Fedor</GivenName><GivenName>F.</GivenName><FamilyName>Severin</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>A.N. Belozersky Institute of Physico-Chemical Biology</OrgDivision><OrgName>Moscow State University</OrgName><OrgAddress><Street>GSP-2, Leninskie Gory</Street><Postcode>119992</Postcode><City>Moscow</City><Country Code="RU">Russia</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para>Amiodarone is a widely used antiarrhythmic drug. There is also evidence that amiodarone decreases multidrug resistance in human cell lines. In this paper, we have shown that amiodarone has similar effect on yeast, <Emphasis Type="Italic">Saccharomyces cerevisiae</Emphasis>, decreasing multiple drug resistance. Amiodarone stimulates the accumulation of ethidium bromide by inhibiting its efflux from the cells. The effect of amiodarone is much stronger on wild-type cells compared to the mutant with inactivated ABC-transporters. Interestingly, the action of amiodarone is additive with the one of chloroquine, a known inhibitor of ABC-transporters. We speculate that these findings could help in the development of antifungal drug mixes.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Yeast</Keyword><Keyword>Amiodarone</Keyword><Keyword>Pleiotropic drug resistance</Keyword><Keyword>Multidrug resistance</Keyword></KeywordGroup><AbbreviationGroup><Heading>Abbreviations</Heading><DefinitionList><DefinitionListEntry><Term>ABC</Term><Description><Para>ATP-binding cassette</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>MDR</Term><Description><Para>Multiple drug resitance</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>EB</Term><Description><Para>Ethidium bromide</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>C12-TPP</Term><Description><Para>Dodecyltriphenylphosphonium</Para></Description></DefinitionListEntry></DefinitionList></AbbreviationGroup><ArticleNote Type="CommunicatedBy"><SimplePara>Communicated by Axel Brakhage.</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Amiodarone inhibits multiple drug resistance in yeast Saccharomyces cerevisiae</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Amiodarone inhibits multiple drug resistance in yeast Saccharomyces cerevisiae </title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Dmitry</namePart><namePart type="given">A.</namePart><namePart type="family">Knorre</namePart><affiliation>A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, GSP-2, Leninskie Gory, 119992, Moscow, Russia</affiliation><affiliation>E-mail: knorre@belozersky.msu.ru</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tatiana</namePart><namePart type="given">N.</namePart><namePart type="family">Krivonosova</namePart><affiliation>A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, GSP-2, Leninskie Gory, 119992, Moscow, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Olga</namePart><namePart type="given">V.</namePart><namePart type="family">Markova</namePart><affiliation>A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, GSP-2, Leninskie Gory, 119992, Moscow, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fedor</namePart><namePart type="given">F.</namePart><namePart type="family">Severin</namePart><affiliation>A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, GSP-2, Leninskie Gory, 119992, Moscow, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="BriefCommunication" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">2008-11-10</dateCreated><dateIssued encoding="w3cdtf">2009-08-01</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Amiodarone is a widely used antiarrhythmic drug. There is also evidence that amiodarone decreases multidrug resistance in human cell lines. In this paper, we have shown that amiodarone has similar effect on yeast, Saccharomyces cerevisiae, decreasing multiple drug resistance. Amiodarone stimulates the accumulation of ethidium bromide by inhibiting its efflux from the cells. The effect of amiodarone is much stronger on wild-type cells compared to the mutant with inactivated ABC-transporters. Interestingly, the action of amiodarone is additive with the one of chloroquine, a known inhibitor of ABC-transporters. We speculate that these findings could help in the development of antifungal drug mixes.</abstract><note>Short Communication</note><subject lang="en"><genre>Keywords</genre><topic>Yeast</topic><topic>Amiodarone</topic><topic>Pleiotropic drug resistance</topic><topic>Multidrug resistance</topic></subject><subject><genre>Abbreviations</genre><topic>ABC : ATP-binding cassette</topic><topic>MDR : Multiple drug resitance</topic><topic>EB : Ethidium bromide</topic><topic>C12-TPP : Dodecyltriphenylphosphonium</topic></subject><relatedItem type="host"><titleInfo><title>Archives of Microbiology</title></titleInfo><titleInfo type="abbreviated"><title>Arch Microbiol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2009-07-23</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><subject><genre>Life Sciences</genre><topic>Ecology</topic><topic>Biotechnology</topic><topic>Biochemistry, general</topic><topic>Cell Biology</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic></subject><identifier type="ISSN">0302-8933</identifier><identifier type="eISSN">1432-072X</identifier><identifier type="JournalID">203</identifier><identifier type="IssueArticleCount">7</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>2009</date><detail type="volume"><number>191</number><caption>vol.</caption></detail><detail type="issue"><number>8</number><caption>no.</caption></detail><extent unit="pages"><start>675</start><end>679</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 2009</recordOrigin></recordInfo></relatedItem><identifier type="istex">0021C1E463D36E4FE354F4DD246F2B64536F6897</identifier><identifier type="ark">ark:/67375/VQC-Z252V097-H</identifier><identifier type="DOI">10.1007/s00203-009-0493-8</identifier><identifier type="ArticleID">493</identifier><identifier type="ArticleID">s00203-009-0493-8</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 2009</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 2009</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-Z252V097-H/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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