The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant
Identifieur interne : 000531 ( Istex/Corpus ); précédent : 000530; suivant : 000532The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant
Auteurs : M. F. Heath ; W. JacobsonSource :
- Lung [ 0341-2040 ] ; 1985-12-01.
English descriptors
- KwdEn :
- Teeft :
- Alveolar macrophages, Ambroxol, Chloroquine, Control activities, Heath, Imipramine, Jacobson, Lung surfactant, Lysosomal, Lysosomal fraction, Lysosomal phospholipase, Lysosomal phospholipases, Lysosome, Macrophage, Phosphatidylcholine, Phospholipase, Phospholipases, Phospholipid, Phospholipidosis, Pulmonary surfactant, Rabbit lung parenchyma, Surfactant.
Abstract
Abstract: Ambroxol inhibits activity against phosphatidylcholine of phospholipase A from the lysosomes of rabbit lung, and in lysates of alveolar macrophages. The inhibition is of the same potency as that of imipramine and chloroquine. The latter are 2 of the many drugs with similar structural features, but very different pharmacologic actions, that can cause phospholipidosis in vivo as a result of the inhibition of lysosomal phospholipases. Since ambroxol shares these structural features, and inhibits the phospholipase A in vitro, we propose that the ability of ambroxol to elevate levels of pulmonary surfactant arises, at least in part, from this inhibitory property.
Url:
DOI: 10.1007/BF02713834
Links to Exploration step
ISTEX:8856E45A58B2FB10200D31DA90850F95F7F06705Le document en format XML
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F." last="Heath">M. F. Heath</name><affiliation><mods:affiliation>Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, CB3 OES, Cambridge, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Paediatrics, University of Cambridge Clinical School, Addenbrooke’s Hospital, Hills Road, CB2 2QQ, Cambridge, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Jacobson, W" sort="Jacobson, W" uniqKey="Jacobson W" first="W." last="Jacobson">W. 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The inhibition is of the same potency as that of imipramine and chloroquine. The latter are 2 of the many drugs with similar structural features, but very different pharmacologic actions, that can cause phospholipidosis in vivo as a result of the inhibition of lysosomal phospholipases. Since ambroxol shares these structural features, and inhibits the phospholipase A in vitro, we propose that the ability of ambroxol to elevate levels of pulmonary surfactant arises, at least in part, from this inhibitory property.</div></front></TEI><istex><corpusName>springer-journals</corpusName><keywords><teeft><json:string>ambroxol</json:string><json:string>lysosomal</json:string><json:string>phospholipase</json:string><json:string>phospholipases</json:string><json:string>macrophage</json:string><json:string>chloroquine</json:string><json:string>phospholipid</json:string><json:string>surfactant</json:string><json:string>phospholipidosis</json:string><json:string>heath</json:string><json:string>jacobson</json:string><json:string>phosphatidylcholine</json:string><json:string>imipramine</json:string><json:string>lysosome</json:string><json:string>lysosomal phospholipases</json:string><json:string>alveolar macrophages</json:string><json:string>lysosomal phospholipase</json:string><json:string>pulmonary surfactant</json:string><json:string>control activities</json:string><json:string>lung surfactant</json:string><json:string>lysosomal fraction</json:string><json:string>rabbit lung parenchyma</json:string></teeft></keywords><author><json:item><name>M. 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AffiliationIDS="Aff1 Aff2" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><GivenName>F.</GivenName><FamilyName>Heath</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><GivenName>W.</GivenName><FamilyName>Jacobson</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Clinical Veterinary Medicine</OrgDivision><OrgName>University of Cambridge</OrgName><OrgAddress><Street>Madingley Road</Street><Postcode>CB3 OES</Postcode><City>Cambridge</City><Country>United Kingdom</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Paediatrics</OrgDivision><OrgName>University of Cambridge Clinical School, Addenbrooke’s Hospital</OrgName><OrgAddress><Street>Hills Road</Street><Postcode>CB2 2QQ</Postcode><City>Cambridge</City><Country>United Kingdom</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Ambroxol inhibits activity against phosphatidylcholine of phospholipase A from the lysosomes of rabbit lung, and in lysates of alveolar macrophages. The inhibition is of the same potency as that of imipramine and chloroquine. The latter are 2 of the many drugs with similar structural features, but very different pharmacologic actions, that can cause phospholipidosis in vivo as a result of the inhibition of lysosomal phospholipases. Since ambroxol shares these structural features, and inhibits the phospholipase A in vitro, we propose that the ability of ambroxol to elevate levels of pulmonary surfactant arises, at least in part, from this inhibitory property.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Phospholipases</Keyword><Keyword>Lysosomes</Keyword><Keyword>Ambroxol</Keyword><Keyword>Pulmonary surfactant</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">M.</namePart><namePart type="given">F.</namePart><namePart type="family">Heath</namePart><affiliation>Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, CB3 OES, Cambridge, United Kingdom</affiliation><affiliation>Department of Paediatrics, University of Cambridge Clinical School, Addenbrooke’s Hospital, Hills Road, CB2 2QQ, Cambridge, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Jacobson</namePart><affiliation>Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, CB3 OES, Cambridge, United Kingdom</affiliation><affiliation>Department of Paediatrics, University of Cambridge Clinical School, Addenbrooke’s Hospital, Hills Road, CB2 2QQ, Cambridge, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1985-12-01</dateIssued><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Ambroxol inhibits activity against phosphatidylcholine of phospholipase A from the lysosomes of rabbit lung, and in lysates of alveolar macrophages. The inhibition is of the same potency as that of imipramine and chloroquine. The latter are 2 of the many drugs with similar structural features, but very different pharmacologic actions, that can cause phospholipidosis in vivo as a result of the inhibition of lysosomal phospholipases. Since ambroxol shares these structural features, and inhibits the phospholipase A in vitro, we propose that the ability of ambroxol to elevate levels of pulmonary surfactant arises, at least in part, from this inhibitory property.</abstract><subject lang="en"><genre>Key words</genre><topic>Phospholipases</topic><topic>Lysosomes</topic><topic>Ambroxol</topic><topic>Pulmonary surfactant</topic></subject><relatedItem type="host"><titleInfo><title>Lung</title><subTitle>An International Journal on Lungs, Airways and Breathing</subTitle></titleInfo><titleInfo type="abbreviated"><title>Lung</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1985-12-01</dateIssued><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><subject><genre>Journal-Subject-Group</genre><topic authority="SpringerSubjectCodes" authorityURI="H">Medicine & Public Health</topic><topic authority="SpringerSubjectCodes" authorityURI="H33134">Pneumology/Respiratory System</topic></subject><identifier type="ISSN">0341-2040</identifier><identifier type="eISSN">1432-1750</identifier><identifier type="JournalID">408</identifier><identifier type="IssueArticleCount">36</identifier><identifier type="VolumeIssueCount">0</identifier><part><date>1985</date><detail type="volume"><number>163</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>337</start><end>344</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1985</recordOrigin></recordInfo></relatedItem><identifier type="istex">8856E45A58B2FB10200D31DA90850F95F7F06705</identifier><identifier type="ark">ark:/67375/1BB-QQLQK2S0-K</identifier><identifier type="DOI">10.1007/BF02713834</identifier><identifier type="ArticleID">BF02713834</identifier><identifier type="ArticleID">Art34</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag New York, Inc, 1985</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag New York, Inc, 1985</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-QQLQK2S0-K/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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