Effects of several lipidosis-inducing drugs upon the area postrema and adjacent medullary nuclei of adult rats
Identifieur interne : 000430 ( Istex/Corpus ); précédent : 000429; suivant : 000431Effects of several lipidosis-inducing drugs upon the area postrema and adjacent medullary nuclei of adult rats
Auteurs : Wolf Frisch ; Renate Lüllmann-RauchSource :
- Acta Neuropathologica [ 0001-6322 ] ; 1980-01-01.
English descriptors
- KwdEn :
- Teeft :
- Acta, Acta neuropathol, Adult rats, Area postrema, Berl, Cell tissue, Central neurons, Chloroquine, Chlorphentermine, Chlorphentermine treatment, Circumventricular, Circumventricular organ, Dendrite, Drug distribution, General lipidosis, Generalized lipidosis, Inclusion, Inset, Lipidosis, Lipidotic inclusions, Lysosomal, Lysosomal storage, Lysosome, Medulla oblongata, Nerve cell bodies, Nerve cell perikarya, Nerve cells, Nervi, Neuronal perikarya, Neuropathol, Nucleus dorsalis nervi vagi, Nucleus gracilis, Nucleus nervi hypoglossi, Nucleus tractus solitarii, Perhexiline, Perikarya, Postrema, Present findings, Present study, Quinacrine, Rat, Suzuki.
Abstract
Summary: The present study is concerned with the question of whether or not amphiphilic drugs (chloroquine, quinacrine, perhexiline) that fail to induce general lipidosis in the central nervous system (CNS) of adult rats can produce lipidosis in a circumventricular organ (area postrema) not furnished with a blood-brain barrier. Chlorphentermine known to induce general lipidosis in CNS of adult rats served as reference compound. All drugs, when chronically applied in high oral doses, induced significant perikaryal lipidosis in the area postrema. In the adjacent nuclei (nucleus tractus solitarii, nucleus dorsalis nervi vagi, nucleus nervi hypoglossi, nucleus gracilis), only chlorphentermine caused generalized lipidosis, whereas the other drugs had either limited or no effects. The present findings strongly suggest that the exemption, of most regions of the CNS of adult rats, from lipidosis induced by chloroquine and others is due to hindered drug distribution across the blood-brain barrier, rather than being due to non-susceptibility of central neurons toward the lipidosis-inducing action of the drugs.
Url:
DOI: 10.1007/BF00705806
Links to Exploration step
ISTEX:EF1AACD4B9C8ED804AFC66F534DFF48D769A864DLe document en format XML
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Chlorphentermine known to induce general lipidosis in CNS of adult rats served as reference compound. All drugs, when chronically applied in high oral doses, induced significant perikaryal lipidosis in the area postrema. In the adjacent nuclei (nucleus tractus solitarii, nucleus dorsalis nervi vagi, nucleus nervi hypoglossi, nucleus gracilis), only chlorphentermine caused generalized lipidosis, whereas the other drugs had either limited or no effects. 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Alterations in perikarya and dendrites</title><author xml:id="author-0000"><persName><forename type="first">Wolf</forename><surname>Frisch</surname></persName><affiliation>Department of Anatomy, University of Kiel, Olshausenstr. 40/60, D-2300, Kiel, Germany</affiliation></author><author xml:id="author-0001" corresp="yes"><persName><forename type="first">Renate</forename><surname>Lüllmann-Rauch</surname></persName><affiliation>Department of Anatomy, University of Kiel, Olshausenstr. 40/60, D-2300, Kiel, Germany</affiliation></author><idno type="istex">EF1AACD4B9C8ED804AFC66F534DFF48D769A864D</idno><idno type="ark">ark:/67375/1BB-HXL92T4B-T</idno><idno type="DOI">10.1007/BF00705806</idno><idno type="article-id">BF00705806</idno><idno type="article-id">Art2</idno></analytic><monogr><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="pISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">10</idno><idno type="volume-issue-count">3</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1980-01-01"></date><biblScope unit="volume">52</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="179">179</biblScope><biblScope unit="page" to="187">187</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1980-07-29</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: The present study is concerned with the question of whether or not amphiphilic drugs (chloroquine, quinacrine, perhexiline) that fail to induce general lipidosis in the central nervous system (CNS) of adult rats can produce lipidosis in a circumventricular organ (area postrema) not furnished with a blood-brain barrier. Chlorphentermine known to induce general lipidosis in CNS of adult rats served as reference compound. All drugs, when chronically applied in high oral doses, induced significant perikaryal lipidosis in the area postrema. In the adjacent nuclei (nucleus tractus solitarii, nucleus dorsalis nervi vagi, nucleus nervi hypoglossi, nucleus gracilis), only chlorphentermine caused generalized lipidosis, whereas the other drugs had either limited or no effects. The present findings strongly suggest that the exemption, of most regions of the CNS of adult rats, from lipidosis induced by chloroquine and others is due to hindered drug distribution across the blood-brain barrier, rather than being due to non-susceptibility of central neurons toward the lipidosis-inducing action of the drugs.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Medulla oblongata</term></item><item><term>Rat</term></item><item><term>Chlorophentermine</term></item><item><term>Chloroquine</term></item><item><term>Lipidosis</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Pathology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1980-07-29">Created</change><change when="1980-01-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-HXL92T4B-T/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>401</JournalID><JournalPrintISSN>0001-6322</JournalPrintISSN><JournalElectronicISSN>1432-0533</JournalElectronicISSN><JournalTitle>Acta Neuropathologica</JournalTitle><JournalAbbreviatedTitle>Acta Neuropathol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Pathology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>52</VolumeIDStart><VolumeIDEnd>52</VolumeIDEnd><VolumeIssueCount>3</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>3</IssueIDStart><IssueIDEnd>3</IssueIDEnd><IssueArticleCount>10</IssueArticleCount><IssueHistory><CoverDate><DateString>1980</DateString><Year>1980</Year><Month>1</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1980</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art2"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00705806</ArticleID><ArticleDOI>10.1007/BF00705806</ArticleDOI><ArticleSequenceNumber>2</ArticleSequenceNumber><ArticleTitle Language="En">Effects of several lipidosis-inducing drugs upon the area postrema and adjacent medullary nuclei of adult rats</ArticleTitle><ArticleSubTitle Language="En">I. Alterations in perikarya and dendrites</ArticleSubTitle><ArticleCategory>Original Works</ArticleCategory><ArticleFirstPage>179</ArticleFirstPage><ArticleLastPage>187</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>11</Month><Day>9</Day></RegistrationDate><Received><Year>1980</Year><Month>7</Month><Day>29</Day></Received><Accepted><Year>1980</Year><Month>8</Month><Day>13</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1980</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>401</JournalID><VolumeIDStart>52</VolumeIDStart><VolumeIDEnd>52</VolumeIDEnd><IssueIDStart>3</IssueIDStart><IssueIDEnd>3</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Wolf</GivenName><FamilyName>Frisch</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Renate</GivenName><FamilyName>Lüllmann-Rauch</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Anatomy</OrgDivision><OrgName>University of Kiel</OrgName><OrgAddress><Street>Olshausenstr. 40/60</Street><Postcode>D-2300</Postcode><City>Kiel</City><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>The present study is concerned with the question of whether or not amphiphilic drugs (chloroquine, quinacrine, perhexiline) that fail to induce general lipidosis in the central nervous system (CNS) of adult rats can produce lipidosis in a circumventricular organ (area postrema) not furnished with a blood-brain barrier. Chlorphentermine known to induce general lipidosis in CNS of adult rats served as reference compound. All drugs, when chronically applied in high oral doses, induced significant perikaryal lipidosis in the area postrema. In the adjacent nuclei (nucleus tractus solitarii, nucleus dorsalis nervi vagi, nucleus nervi hypoglossi, nucleus gracilis), only chlorphentermine caused generalized lipidosis, whereas the other drugs had either limited or no effects. The present findings strongly suggest that the exemption, of most regions of the CNS of adult rats, from lipidosis induced by chloroquine and others is due to hindered drug distribution across the blood-brain barrier, rather than being due to non-susceptibility of central neurons toward the lipidosis-inducing action of the drugs.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Medulla oblongata</Keyword><Keyword>Rat</Keyword><Keyword>Chlorophentermine</Keyword><Keyword>Chloroquine</Keyword><Keyword>Lipidosis</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of several lipidosis-inducing drugs upon the area postrema and adjacent medullary nuclei of adult rats</title><subTitle>I. Alterations in perikarya and dendrites</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Effects of several lipidosis-inducing drugs upon the area postrema and adjacent medullary nuclei of adult rats</title></titleInfo><name type="personal"><namePart type="given">Wolf</namePart><namePart type="family">Frisch</namePart><affiliation>Department of Anatomy, University of Kiel, Olshausenstr. 40/60, D-2300, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Renate</namePart><namePart type="family">Lüllmann-Rauch</namePart><affiliation>Department of Anatomy, University of Kiel, Olshausenstr. 40/60, D-2300, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1980-07-29</dateCreated><dateIssued encoding="w3cdtf">1980-01-01</dateIssued><copyrightDate encoding="w3cdtf">1980</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: The present study is concerned with the question of whether or not amphiphilic drugs (chloroquine, quinacrine, perhexiline) that fail to induce general lipidosis in the central nervous system (CNS) of adult rats can produce lipidosis in a circumventricular organ (area postrema) not furnished with a blood-brain barrier. Chlorphentermine known to induce general lipidosis in CNS of adult rats served as reference compound. All drugs, when chronically applied in high oral doses, induced significant perikaryal lipidosis in the area postrema. In the adjacent nuclei (nucleus tractus solitarii, nucleus dorsalis nervi vagi, nucleus nervi hypoglossi, nucleus gracilis), only chlorphentermine caused generalized lipidosis, whereas the other drugs had either limited or no effects. The present findings strongly suggest that the exemption, of most regions of the CNS of adult rats, from lipidosis induced by chloroquine and others is due to hindered drug distribution across the blood-brain barrier, rather than being due to non-susceptibility of central neurons toward the lipidosis-inducing action of the drugs.</abstract><note>Original Works</note><subject lang="en"><genre>Key words</genre><topic>Medulla oblongata</topic><topic>Rat</topic><topic>Chlorophentermine</topic><topic>Chloroquine</topic><topic>Lipidosis</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neuropathologica</title></titleInfo><titleInfo type="abbreviated"><title>Acta Neuropathol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1980-01-01</dateIssued><copyrightDate encoding="w3cdtf">1980</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pathology</topic></subject><identifier type="ISSN">0001-6322</identifier><identifier type="eISSN">1432-0533</identifier><identifier type="JournalID">401</identifier><identifier type="IssueArticleCount">10</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>1980</date><detail type="volume"><number>52</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="pages"><start>179</start><end>187</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1980</recordOrigin></recordInfo></relatedItem><identifier type="istex">EF1AACD4B9C8ED804AFC66F534DFF48D769A864D</identifier><identifier type="ark">ark:/67375/1BB-HXL92T4B-T</identifier><identifier type="DOI">10.1007/BF00705806</identifier><identifier type="ArticleID">BF00705806</identifier><identifier type="ArticleID">Art2</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1980</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1980</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-HXL92T4B-T/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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