Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome
Identifieur interne : 000414 ( Istex/Corpus ); précédent : 000413; suivant : 000415Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome
Auteurs : E. Botelho-Nevers ; P.-E. Fournier ; H. Richet ; F. Fenollar ; H. Lepidi ; C. Foucault ; A. Branchereau ; P. Piquet ; M. Maurin ; D. RaoultSource :
- European Journal of Clinical Microbiology & Infectious Diseases [ 0934-9723 ] ; 2007-09-01.
Abstract
Abstract: Q fever is a zoonotic disease caused by Coxiella burnetii. Polymorphic, the disease may present as an acute or chronic infection. Vascular infections are the second most common form of chronic Q fever, following endocarditis. Herein, we studied the outcome of 30 new cases of aortic infection caused by C. burnetii using uni- and multivariate analyses. The outcome of ten cases previously reported by our team was also updated. Of these 40 patients, 32 had a follow-up of ≥3 years. Among them, the overall mortality was of 25% (8/32). Vascular rupture was significantly and independently (multivariate P=0.03) associated with a lethal issue, whereas vascular surgery was significantly associated with recovery (uni- and multivariate P<0.01). Our findings demonstrate the critical importance of surgery in the management of C. burnetii vascular infections.
Url:
DOI: 10.1007/s10096-007-0357-6
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ISTEX:8C2FEF88242B4FEDFD0DDB1D4320C44EAB9EB4C3Le document en format XML
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Botelho-Nevers</name><affiliation><mods:affiliation>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</mods:affiliation></affiliation></author><author><name sortKey="Fournier, P E" sort="Fournier, P E" uniqKey="Fournier P" first="P.-E." last="Fournier">P.-E. Fournier</name><affiliation><mods:affiliation>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: Pierre-Edouard.Fournier@medecine.univ-mrs.fr</mods:affiliation></affiliation></author><author><name sortKey="Richet, H" sort="Richet, H" uniqKey="Richet H" first="H." last="Richet">H. 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Raoult</name><affiliation><mods:affiliation>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Clinical Microbiology & Infectious Diseases</title><title level="j" type="abbrev">Eur J Clin Microbiol Infect Dis</title><idno type="ISSN">0934-9723</idno><idno type="eISSN">1435-4373</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2007-09-01">2007-09-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="635">635</biblScope><biblScope unit="page" to="640">640</biblScope></imprint><idno type="ISSN">0934-9723</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0934-9723</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Q fever is a zoonotic disease caused by Coxiella burnetii. Polymorphic, the disease may present as an acute or chronic infection. Vascular infections are the second most common form of chronic Q fever, following endocarditis. Herein, we studied the outcome of 30 new cases of aortic infection caused by C. burnetii using uni- and multivariate analyses. The outcome of ten cases previously reported by our team was also updated. Of these 40 patients, 32 had a follow-up of ≥3 years. Among them, the overall mortality was of 25% (8/32). Vascular rupture was significantly and independently (multivariate P=0.03) associated with a lethal issue, whereas vascular surgery was significantly associated with recovery (uni- and multivariate P<0.01). Our findings demonstrate the critical importance of surgery in the management of C. burnetii vascular infections.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>E. Botelho-Nevers</name><affiliations><json:string>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</json:string></affiliations></json:item><json:item><name>P.-E. Fournier</name><affiliations><json:string>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</json:string><json:string>E-mail: Pierre-Edouard.Fournier@medecine.univ-mrs.fr</json:string></affiliations></json:item><json:item><name>H. Richet</name><affiliations><json:string>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</json:string></affiliations></json:item><json:item><name>F. 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Polymorphic, the disease may present as an acute or chronic infection. Vascular infections are the second most common form of chronic Q fever, following endocarditis. Herein, we studied the outcome of 30 new cases of aortic infection caused by C. burnetii using uni- and multivariate analyses. The outcome of ten cases previously reported by our team was also updated. Of these 40 patients, 32 had a follow-up of ≥3 years. Among them, the overall mortality was of 25% (8/32). Vascular rupture was significantly and independently (multivariate P=0.03) associated with a lethal issue, whereas vascular surgery was significantly associated with recovery (uni- and multivariate P>0.01). 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Our findings demonstrate the critical importance of surgery in the management of C. burnetii vascular infections.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Internal Medicine</term></item><item><term>Medical Microbiology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-09-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-GDKVKXCR-1/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" 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VolumeType="Regular"><VolumeIDStart>26</VolumeIDStart><VolumeIDEnd>26</VolumeIDEnd><VolumeIssueCount>12</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular" OutputMedium="All"><IssueInfo TocLevels="0"><IssueIDStart>9</IssueIDStart><IssueIDEnd>9</IssueIDEnd><IssueArticleCount>13</IssueArticleCount><IssueHistory><OnlineDate><Year>2007</Year><Month>8</Month><Day>21</Day></OnlineDate><PrintDate><Year>2007</Year><Month>8</Month><Day>21</Day></PrintDate><CoverDate><Year>2007</Year><Month>9</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>2007</CopyrightYear></IssueCopyright></IssueInfo><Article ID="s10096-007-0357-6" OutputMedium="All"><ArticleInfo ArticleType="OriginalPaper" ContainsESM="No" Language="En" NumberingStyle="Unnumbered" TocLevels="0"><ArticleID>357</ArticleID><ArticleDOI>10.1007/s10096-007-0357-6</ArticleDOI><ArticleSequenceNumber>4</ArticleSequenceNumber><ArticleTitle Language="En"><Emphasis Type="Italic">Coxiella burnetii</Emphasis> infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome</ArticleTitle><ArticleCategory>Article</ArticleCategory><ArticleFirstPage>635</ArticleFirstPage><ArticleLastPage>640</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2007</Year><Month>6</Month><Day>22</Day></RegistrationDate><OnlineDate><Year>2007</Year><Month>7</Month><Day>13</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>2007</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>E.</GivenName><FamilyName>Botelho-Nevers</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>P.-E.</GivenName><FamilyName>Fournier</FamilyName></AuthorName><Contact><Phone>+33-491-385517</Phone><Fax>+33-491-387772</Fax><Email>Pierre-Edouard.Fournier@medecine.univ-mrs.fr</Email></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Richet</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>F.</GivenName><FamilyName>Fenollar</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Lepidi</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>C.</GivenName><FamilyName>Foucault</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>A.</GivenName><FamilyName>Branchereau</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>P.</GivenName><FamilyName>Piquet</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff4"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><FamilyName>Maurin</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>D.</GivenName><FamilyName>Raoult</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine</OrgDivision><OrgName>Université de la Méditerranée</OrgName><OrgAddress><Street>27 Blvd Jean Moulin</Street><Postcode>13385</Postcode><City>Marseille Cedex 5</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Service de Chirurgie Vasculaire</OrgDivision><OrgName>Hôpital de la Timone</OrgName><OrgAddress><Postcode>13385</Postcode><City>Marseille</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Service de Chirurgie Vasculaire</OrgDivision><OrgName>Hôpital Sainte-Marguerite</OrgName><OrgAddress><Postcode>13009</Postcode><City>Marseille</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgDivision>Laboratoire de Bactériologie</OrgDivision><OrgName>Hôpital Michallon</OrgName><OrgAddress><Postcode>38043</Postcode><City>Grenoble</City><Country Code="FR">France</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Q fever is a zoonotic disease caused by <Emphasis Type="Italic">Coxiella burnetii</Emphasis>. Polymorphic, the disease may present as an acute or chronic infection. Vascular infections are the second most common form of chronic Q fever, following endocarditis. Herein, we studied the outcome of 30 new cases of aortic infection caused by <Emphasis Type="Italic">C. burnetii</Emphasis> using uni- and multivariate analyses. The outcome of ten cases previously reported by our team was also updated. Of these 40 patients, 32 had a follow-up of ≥3 years. Among them, the overall mortality was of 25% (8/32). Vascular rupture was significantly and independently (multivariate <Emphasis Type="Italic">P</Emphasis>=0.03) associated with a lethal issue, whereas vascular surgery was significantly associated with recovery (uni- and multivariate <Emphasis Type="Italic">P</Emphasis><0.01). Our findings demonstrate the critical importance of surgery in the management of <Emphasis Type="Italic">C. burnetii</Emphasis> vascular infections.</Para></Abstract><ArticleNote Type="Misc"><SimplePara>All authors have read and approved the final version of the manuscript and do not have any conflict of interest related to this research.</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title> Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Botelho-Nevers</namePart><affiliation>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">P.-E.</namePart><namePart type="family">Fournier</namePart><affiliation>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</affiliation><affiliation>E-mail: Pierre-Edouard.Fournier@medecine.univ-mrs.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Richet</namePart><affiliation>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Fenollar</namePart><affiliation>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Lepidi</namePart><affiliation>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Foucault</namePart><affiliation>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Branchereau</namePart><affiliation>Service de Chirurgie Vasculaire, Hôpital de la Timone, 13385, Marseille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Piquet</namePart><affiliation>Service de Chirurgie Vasculaire, Hôpital Sainte-Marguerite, 13009, Marseille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Maurin</namePart><affiliation>Laboratoire de Bactériologie, Hôpital Michallon, 38043, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Raoult</namePart><affiliation>Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Blvd Jean Moulin, 13385, Marseille Cedex 5, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateIssued encoding="w3cdtf">2007-09-01</dateIssued><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Q fever is a zoonotic disease caused by Coxiella burnetii. Polymorphic, the disease may present as an acute or chronic infection. Vascular infections are the second most common form of chronic Q fever, following endocarditis. Herein, we studied the outcome of 30 new cases of aortic infection caused by C. burnetii using uni- and multivariate analyses. The outcome of ten cases previously reported by our team was also updated. Of these 40 patients, 32 had a follow-up of ≥3 years. Among them, the overall mortality was of 25% (8/32). Vascular rupture was significantly and independently (multivariate P=0.03) associated with a lethal issue, whereas vascular surgery was significantly associated with recovery (uni- and multivariate P<0.01). Our findings demonstrate the critical importance of surgery in the management of C. burnetii vascular infections.</abstract><note>Article</note><relatedItem type="host"><titleInfo><title>European Journal of Clinical Microbiology & Infectious Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Eur J Clin Microbiol Infect Dis</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2007-08-21</dateIssued><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Internal Medicine</topic><topic>Medical Microbiology</topic></subject><identifier type="ISSN">0934-9723</identifier><identifier type="eISSN">1435-4373</identifier><identifier type="JournalID">10096</identifier><identifier type="IssueArticleCount">13</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2007</date><detail type="volume"><number>26</number><caption>vol.</caption></detail><detail type="issue"><number>9</number><caption>no.</caption></detail><extent unit="pages"><start>635</start><end>640</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 2007</recordOrigin></recordInfo></relatedItem><identifier type="istex">8C2FEF88242B4FEDFD0DDB1D4320C44EAB9EB4C3</identifier><identifier type="ark">ark:/67375/VQC-GDKVKXCR-1</identifier><identifier type="DOI">10.1007/s10096-007-0357-6</identifier><identifier type="ArticleID">357</identifier><identifier type="ArticleID">s10096-007-0357-6</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 2007</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 2007</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-GDKVKXCR-1/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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