Childhood onset systemic lupus erythematosus: how is it different from adult SLE?
Identifieur interne : 000387 ( Istex/Corpus ); précédent : 000386; suivant : 000388Childhood onset systemic lupus erythematosus: how is it different from adult SLE?
Auteurs : Amita Aggarwal ; Puja SrivastavaSource :
- International Journal of Rheumatic Diseases [ 1756-1841 ] ; 2015-02.
Abstract
About 20% of systemic lupus erythematosus (SLE) starts in childhood and children have less gender bias in favor of females as compared to adults. Systemic manifestations, nephritis, neuro‐psychiatric disease and cytopenias are more common in children at presentation than adults. Since most children develop lupus in their early adolescence, dealing with the diagnosis of an unpredictable lifelong disease during this phase of life is challenging. Physicians must recognise specific medical and social needs of this age group, for optimal long‐term outcome. Steroids and immunosuppressive drugs are the cornerstone for treatment in children as with adults with lupus. The outcome has improved considerably with these drugs and 10‐year survival is nearly 90%. Due to longer life spans more damage accrues in children as compared to adults. Most of the drugs are associated with significant toxicity and the goal of having a drug which reduces disease activity and damage without hampering normal growth, development and fertility is still an elusive one. The current review focuses on clinical and immunological aspects of childhood SLE and how it differs from adulthood SLE.
Url:
DOI: 10.1111/1756-185X.12419
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Srivastava</title></titleGroup><creators><creator affiliationRef="#apl12419-aff-0001" corresponding="yes" creatorRole="author" xml:id="apl12419-cr-0001"><personName><givenNames>Amita</givenNames> <familyName>Aggarwal</familyName></personName></creator><creator affiliationRef="#apl12419-aff-0001" creatorRole="author" xml:id="apl12419-cr-0002"><personName><givenNames>Puja</givenNames> <familyName>Srivastava</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="IN" type="organization" xml:id="apl12419-aff-0001"><orgDiv>Department of Clinical Immunology</orgDiv><orgName>Sanjay Gandhi Postgraduate Institute of Medical Sciences</orgName> <address><city>Lucknow</city> <country>India</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="apl12419-kwd-0001">autoantibodies</keyword><keyword xml:id="apl12419-kwd-0002">complications</keyword><keyword xml:id="apl12419-kwd-0003">nephritis</keyword><keyword xml:id="apl12419-kwd-0004">neuropsychiatric</keyword><keyword xml:id="apl12419-kwd-0005">pediatric</keyword><keyword xml:id="apl12419-kwd-0006">systemic lupus erythematosus</keyword></keywordGroup><abstractGroup><abstract type="main" xml:id="apl12419-abs-0001"><title type="main">Abstract</title><p>About 20% of systemic lupus erythematosus (<fc>SLE</fc>) starts in childhood and children have less gender bias in favor of females as compared to adults. Systemic manifestations, nephritis, neuro‐psychiatric disease and cytopenias are more common in children at presentation than adults. Since most children develop lupus in their early adolescence, dealing with the diagnosis of an unpredictable lifelong disease during this phase of life is challenging. Physicians must recognise specific medical and social needs of this age group, for optimal long‐term outcome. Steroids and immunosuppressive drugs are the cornerstone for treatment in children as with adults with lupus. The outcome has improved considerably with these drugs and 10‐year survival is nearly 90%. Due to longer life spans more damage accrues in children as compared to adults. Most of the drugs are associated with significant toxicity and the goal of having a drug which reduces disease activity and damage without hampering normal growth, development and fertility is still an elusive one. The current review focuses on clinical and immunological aspects of childhood <fc>SLE</fc> and how it differs from adulthood <fc>SLE</fc>.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Childhood onset systemic lupus erythematosus: how is it different from adult SLE?</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Childhood onset systemic lupus erythematosus: how is it different from adult SLE?</title></titleInfo><name type="personal"><namePart type="given">Amita</namePart><namePart type="family">Aggarwal</namePart><affiliation>Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India</affiliation><affiliation>: Dr Amita Aggarwal, Professor, Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical sciences, Lucknow, India 226014.Emails: ;</affiliation><affiliation>E-mail: aa.amita@gmail.comamita@sgpgi.ac.in</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Puja</namePart><namePart type="family">Srivastava</namePart><affiliation>Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2015-02</dateIssued><dateCreated encoding="w3cdtf">2014-05-27</dateCreated><copyrightDate encoding="w3cdtf">2015</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>About 20% of systemic lupus erythematosus (SLE) starts in childhood and children have less gender bias in favor of females as compared to adults. Systemic manifestations, nephritis, neuro‐psychiatric disease and cytopenias are more common in children at presentation than adults. Since most children develop lupus in their early adolescence, dealing with the diagnosis of an unpredictable lifelong disease during this phase of life is challenging. Physicians must recognise specific medical and social needs of this age group, for optimal long‐term outcome. Steroids and immunosuppressive drugs are the cornerstone for treatment in children as with adults with lupus. The outcome has improved considerably with these drugs and 10‐year survival is nearly 90%. Due to longer life spans more damage accrues in children as compared to adults. Most of the drugs are associated with significant toxicity and the goal of having a drug which reduces disease activity and damage without hampering normal growth, development and fertility is still an elusive one. The current review focuses on clinical and immunological aspects of childhood SLE and how it differs from adulthood SLE.</abstract><subject><genre>keywords</genre><topic>autoantibodies</topic><topic>complications</topic><topic>nephritis</topic><topic>neuropsychiatric</topic><topic>pediatric</topic><topic>systemic lupus erythematosus</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Rheumatic Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Int J Rheum Dis</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Special Issue on Lupus in Asia‐Pacific Region</topic><topic>Clinical Science</topic></subject><identifier type="ISSN">1756-1841</identifier><identifier type="eISSN">1756-185X</identifier><identifier type="DOI">10.1111/(ISSN)1756-185X</identifier><identifier type="PublisherID">APL</identifier><part><date>2015</date><detail type="title"><title>Special issue on LUPUS in the Asia‐Pacific region</title></detail><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>182</start><end>191</end><total>10</total></extent></part></relatedItem><relatedItem type="references" displayLabel="apl12419-cit-0001"><titleInfo><title>Prevalence and burden of pediatric‐onset systemic lupus erythematosus</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kamphuis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ED</namePart><namePart type="family">Silverman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kamphuis S, Silverman ED (2010) Prevalence and burden of pediatric‐onset systemic lupus erythematosus. 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