The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation
Identifieur interne : 000236 ( Istex/Corpus ); précédent : 000235; suivant : 000237The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation
Auteurs : L. Binderup ; E. Bramm ; E. Arrigoni-MartelliSource :
- International Journal of Immunopharmacology [ 0192-0561 ] ; 1982.
English descriptors
- Teeft :
- Acetylsalicylic, Acetylsalicylic acid, Adherent, Adherent cells, Adjuvant, Adjuvant arthritis, Adjuvant disease, Antirheumatic, Antirheumatic drugs, Arthritic, Arthritic lewis rats, Arthritic rats, Arthritis, Arthritis rheum, Aurothiomalate, Binderup, Bramm, Ceils, Cell suspensions, Cell viability, Chloroquine, Chronic inflammation, Concanavalin, Control rats, Corresponding values, Days treatment, Immunological, Immunological reactivity, Immunological responsiveness, Indomethacin, Inflammation, Inhibitory effects, Levamisole, Lewis rats, Lymphocyte, Lymphocyte responsiveness, Macrophage, Mitogen, Myocrisin, Nonadherent, Nonadherent cells, Nonarthritic, Nonarthritic rats, Noninjected, Open bars, Plastic petri dishes, Polyarthritic lesions, Present experiments, Pyritinol, Rat, Rats nonarthritic nonarthritic, Rheumatoid, Rheumatoid arthritis, Separate experiments, Sodium aurothiomalate, Spleen, Spleen cell responsiveness, Spleen cell suspensions, Spleen cells, Suppressive, Suppressive activity, Suppressive macrophages, Suppressor, Suppressor cells, Unseparated, Unseparated spleen cells, Untreated, Untreated rats.
Abstract
Abstract: During the course of adjuvant arthritis in rats adherent spleen cells inhibited the response of spleen lymphocytes to the T-cell mitogen concanavalin A (Con A). The effects of 14 days treatment with various antirheumatic drugs on spleen cell responsiveness to Con A were investigated. Two nonsteroidal anti-inflammatory drugs, indomethacin (1 mg/kg/day p.o.) and acetylsalicylic acid (200 mg/kg/day p.o.) did not modify the spleen cell response, whereas treatment with chloroquine (50 mg/kg/day p.o.) or levamisole (5 mg/kg/day p.o.) further increased the inhibitory effects of the adherent suppressive spleen cells. On the contrary, treatment with sodium aurothiomalate (10 mg/kg/day i.m.), D-penicillamine (50 mg/kg/day p.o.) or pyritinol (50 mg/kg/day p.o.) significantly enhanced the response of th e lymphocytes to Con A. In addition to the effects on spleen cell responsiveness, the ability of the various drug treatments to modify the polyarthritic lesions of the disease was investigated. It is suggested that this model may provide a valuable approach for evaluating the effects of antirheumatic drugs in vivo on immunological responsiveness during chronic inflammatory disease.
Url:
DOI: 10.1016/0192-0561(82)90009-1
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ISTEX:2334F36942BEDD3399167C6C42B280F8623FD75CLe document en format XML
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The effects of 14 days treatment with various antirheumatic drugs on spleen cell responsiveness to Con A were investigated. Two nonsteroidal anti-inflammatory drugs, indomethacin (1 mg/kg/day p.o.) and acetylsalicylic acid (200 mg/kg/day p.o.) did not modify the spleen cell response, whereas treatment with chloroquine (50 mg/kg/day p.o.) or levamisole (5 mg/kg/day p.o.) further increased the inhibitory effects of the adherent suppressive spleen cells. On the contrary, treatment with sodium aurothiomalate (10 mg/kg/day i.m.), D-penicillamine (50 mg/kg/day p.o.) or pyritinol (50 mg/kg/day p.o.) significantly enhanced the response of th e lymphocytes to Con A. In addition to the effects on spleen cell responsiveness, the ability of the various drug treatments to modify the polyarthritic lesions of the disease was investigated. 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Binderup</name><affiliations><json:string>Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup, Denmark</json:string></affiliations></json:item><json:item><name>E. Bramm</name><affiliations><json:string>Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup, Denmark</json:string></affiliations></json:item><json:item><name>E. Arrigoni-Martelli</name><affiliations><json:string>Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup, Denmark</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-J080RBC5-K</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: During the course of adjuvant arthritis in rats adherent spleen cells inhibited the response of spleen lymphocytes to the T-cell mitogen concanavalin A (Con A). The effects of 14 days treatment with various antirheumatic drugs on spleen cell responsiveness to Con A were investigated. Two nonsteroidal anti-inflammatory drugs, indomethacin (1 mg/kg/day p.o.) and acetylsalicylic acid (200 mg/kg/day p.o.) did not modify the spleen cell response, whereas treatment with chloroquine (50 mg/kg/day p.o.) or levamisole (5 mg/kg/day p.o.) further increased the inhibitory effects of the adherent suppressive spleen cells. On the contrary, treatment with sodium aurothiomalate (10 mg/kg/day i.m.), D-penicillamine (50 mg/kg/day p.o.) or pyritinol (50 mg/kg/day p.o.) significantly enhanced the response of th e lymphocytes to Con A. In addition to the effects on spleen cell responsiveness, the ability of the various drug treatments to modify the polyarthritic lesions of the disease was investigated. It is suggested that this model may provide a valuable approach for evaluating the effects of antirheumatic drugs in vivo on immunological responsiveness during chronic inflammatory disease.</abstract><qualityIndicators><score>9.064</score><pdfWordCount>5347</pdfWordCount><pdfCharCount>32987</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>522 x 702 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>172</abstractWordCount><abstractCharCount>1197</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation</title><pmid><json:string>6806203</json:string></pmid><pii><json:string>0192-0561(82)90009-1</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Proc. Soc. exp. biol. Med.</title><language><json:string>unknown</json:string></language><volume>145</volume><pages><first>625</first><last>630</last></pages></serie><host><title>International Journal of Immunopharmacology</title><language><json:string>unknown</json:string></language><publicationDate>1982</publicationDate><issn><json:string>0192-0561</json:string></issn><pii><json:string>S0192-0561(00)X0078-1</json:string></pii><volume>4</volume><issue>1</issue><pages><first>57</first><last>66</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1982</json:string></date><geogName></geogName><orgName><json:string>Sigma Chemical Company</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>B. Rumler</json:string><json:string>B. Hasselriis</json:string><json:string>A. Chloroquine</json:string><json:string>J. P. Camus</json:string><json:string>Ms</json:string></persName><placeName><json:string>Paris</json:string><json:string>Denmark</json:string><json:string>France</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Hillinger & Herzig, 1978</json:string><json:string>Katz & Piliero, 1969</json:string><json:string>Arrigoni-Martelli, Bramm & Binderup, 1978</json:string><json:string>Camus et al., 1978</json:string><json:string>Jerrels, Dean, McCoy, Richardson & Herberman, 1978</json:string><json:string>Hadler, 1976</json:string><json:string>Gabourel, 1963</json:string><json:string>see review by Hill, 1979</json:string><json:string>Lance & Knight, 1974</json:string><json:string>Baumgarmer, Beck, Lorber, Pearson & Whitehouse, 1974</json:string><json:string>Ryzewska, 1967</json:string><json:string>Jayawardena & Waksman, 1977</json:string><json:string>Lipsky & Ziff, 1977</json:string><json:string>Silverman, Johnson, Vaughan & McGlamory, 1976</json:string><json:string>reviewed by Symoens & Rosenthal, 1977</json:string><json:string>Adda, Beraud & Depieds, 1977</json:string><json:string>Sampson & Lui, 1976</json:string><json:string>Wamick, 1975</json:string><json:string>Kahn, 1975</json:string><json:string>Lockshin, Eisenhauer, Kohn, Weksler, Block & Mushlin, 1975</json:string><json:string>Cooke, Hutchings & Playfair, 1978</json:string><json:string>Binderup, Bramm & Arrigoni-Martelli, 1980b</json:string><json:string>Wibo & Poole, 1974</json:string><json:string>Zembala, Mytar, Popiela & Asherson, 1977</json:string><json:string>review by Nelson, 1976</json:string><json:string>Binderup et al., 1980a</json:string><json:string>Binderup, Bramm & Arrigoni-Martelli, 1977</json:string><json:string>Binderup, Bramm & Arrigoni-Martelli, 1980a</json:string><json:string>Camus, Jaffe, Crouzet, Prier, Mercier & Dubois, 1978</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-J080RBC5-K</json:string></ark><categories><wos></wos><scienceMetrix><json:string>1 - 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The effects of 14 days treatment with various antirheumatic drugs on spleen cell responsiveness to Con A were investigated. Two nonsteroidal anti-inflammatory drugs, indomethacin (1 mg/kg/day p.o.) and acetylsalicylic acid (200 mg/kg/day p.o.) did not modify the spleen cell response, whereas treatment with chloroquine (50 mg/kg/day p.o.) or levamisole (5 mg/kg/day p.o.) further increased the inhibitory effects of the adherent suppressive spleen cells. On the contrary, treatment with sodium aurothiomalate (10 mg/kg/day i.m.), D-penicillamine (50 mg/kg/day p.o.) or pyritinol (50 mg/kg/day p.o.) significantly enhanced the response of th e lymphocytes to Con A. In addition to the effects on spleen cell responsiveness, the ability of the various drug treatments to modify the polyarthritic lesions of the disease was investigated. It is suggested that this model may provide a valuable approach for evaluating the effects of antirheumatic drugs in vivo on immunological responsiveness during chronic inflammatory disease.</p></abstract></profileDesc><revisionDesc><change when="1981-06-23">Modified</change><change when="1982">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-J080RBC5-K/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>IMMP</jid><aid>82900091</aid><ce:pii>0192-0561(82)90009-1</ce:pii><ce:doi>10.1016/0192-0561(82)90009-1</ce:doi><ce:copyright type="unknown" year="1982"></ce:copyright></item-info><head><ce:title>The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation</ce:title><ce:author-group><ce:author><ce:given-name>L.</ce:given-name><ce:surname>Binderup</ce:surname></ce:author><ce:author><ce:given-name>E.</ce:given-name><ce:surname>Bramm</ce:surname></ce:author><ce:author><ce:given-name>E.</ce:given-name><ce:surname>Arrigoni-Martelli</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup, Denmark</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="16" month="4" year="1981"></ce:date-received><ce:date-revised day="23" month="6" year="1981"></ce:date-revised><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>During the course of adjuvant arthritis in rats adherent spleen cells inhibited the response of spleen lymphocytes to the T-cell mitogen concanavalin A (Con A). The effects of 14 days treatment with various antirheumatic drugs on spleen cell responsiveness to Con A were investigated. Two nonsteroidal anti-inflammatory drugs, indomethacin (1 mg/kg/day p.o.) and acetylsalicylic acid (200 mg/kg/day p.o.) did not modify the spleen cell response, whereas treatment with chloroquine (50 mg/kg/day p.o.) or levamisole (5 mg/kg/day p.o.) further increased the inhibitory effects of the adherent suppressive spleen cells. On the contrary, treatment with sodium aurothiomalate (10 mg/kg/day i.m.), D-penicillamine (50 mg/kg/day p.o.) or pyritinol (50 mg/kg/day p.o.) significantly enhanced the response of th e lymphocytes to Con A. In addition to the effects on spleen cell responsiveness, the ability of the various drug treatments to modify the polyarthritic lesions of the disease was investigated. It is suggested that this model may provide a valuable approach for evaluating the effects of antirheumatic drugs <ce:italic>in vivo</ce:italic> on immunological responsiveness during chronic inflammatory disease.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation</title></titleInfo><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Binderup</namePart><affiliation>Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Bramm</namePart><affiliation>Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Arrigoni-Martelli</namePart><affiliation>Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1982</dateIssued><dateModified encoding="w3cdtf">1981-06-23</dateModified><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: During the course of adjuvant arthritis in rats adherent spleen cells inhibited the response of spleen lymphocytes to the T-cell mitogen concanavalin A (Con A). The effects of 14 days treatment with various antirheumatic drugs on spleen cell responsiveness to Con A were investigated. Two nonsteroidal anti-inflammatory drugs, indomethacin (1 mg/kg/day p.o.) and acetylsalicylic acid (200 mg/kg/day p.o.) did not modify the spleen cell response, whereas treatment with chloroquine (50 mg/kg/day p.o.) or levamisole (5 mg/kg/day p.o.) further increased the inhibitory effects of the adherent suppressive spleen cells. On the contrary, treatment with sodium aurothiomalate (10 mg/kg/day i.m.), D-penicillamine (50 mg/kg/day p.o.) or pyritinol (50 mg/kg/day p.o.) significantly enhanced the response of th e lymphocytes to Con A. In addition to the effects on spleen cell responsiveness, the ability of the various drug treatments to modify the polyarthritic lesions of the disease was investigated. It is suggested that this model may provide a valuable approach for evaluating the effects of antirheumatic drugs in vivo on immunological responsiveness during chronic inflammatory disease.</abstract><relatedItem type="host"><titleInfo><title>International Journal of Immunopharmacology</title></titleInfo><titleInfo type="abbreviated"><title>IMMP</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1982</dateIssued></originInfo><identifier type="ISSN">0192-0561</identifier><identifier type="PII">S0192-0561(00)X0078-1</identifier><part><date>1982</date><detail type="volume"><number>4</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>80</end></extent><extent unit="pages"><start>57</start><end>66</end></extent></part></relatedItem><identifier type="istex">2334F36942BEDD3399167C6C42B280F8623FD75C</identifier><identifier type="ark">ark:/67375/6H6-J080RBC5-K</identifier><identifier type="DOI">10.1016/0192-0561(82)90009-1</identifier><identifier type="PII">0192-0561(82)90009-1</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-J080RBC5-K/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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