ChloroquineV1, Istex, Corpus, bibRecord, 000185

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

Identifieur interne : 000185 ( Istex/Corpus ); précédent : 000184; suivant : 000186

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

Auteurs : Dong Hoon Suh ; Mi-Kyung Kim ; Hee Seung Kim ; Hyun Hoon Chung ; Yong Sang Song

Source :

Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2012-10.

RBID : ISTEX:8793D12DCDEC3A8743A164DE89DAFD3EC7D7D3F9

English descriptors

Teeft :
- Acad, Anticancer, Apoptosis, Apoptotic, Atf4, Atf6, Autophagic cell death, Autophagosome formation, Autophagy, Autophagy inhibition, Beclin1, Biol, Bortezomib, Cancer biol, Cancer cells, Carcinoma, Cell death, Cell survival, Cellular stress responses, Deacetylase, Endoplasmic, Endoplasmic reticulum, Endoplasmic reticulum stress, Glucose deprivation, Hdac, Hdac inhibitors, Heat shock protein, Histone, Inducer, Inhibitor, Intrinsic pathway, Ire1, Kinase, Lymphoma, Mammalian target, Misfolded proteins, Mtor, Myeloma, Nature reviews, Normal cells, Pancreatic, Pathway, Perk, Phosphorylation, Prostate, Protease, Protease inhibitors, Proteasome, Proteasome inhibitors, Protein response, Protein synthesis, Reticulum, Seoul, Stress response, Stress response pathways, Stress responses, Tumor cells, Tumor growth, Xbp1, York academy.

Abstract

The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high metabolic demand. With the limited protein‐folding capacity of the ER, tumor cells often suffer from more ER stress than do normal cells. Thus, cellular stress responses to cope with ER stress, such as the unfolded protein response (UPR) and autophagy, might be more activated in cancer cells than in normal cells. The complex signaling pathways from the UPR to autophagy provide promising druggable targets; a number of UPR/autophagy‐targeted anticancer agents are currently in development in preclinical and clinical studies. In this short review we will discuss the potential anticancer efficacy of modulators of cellular stress responses, especially UPR and autophagy, on the basis of their signaling pathways. In addition, the current developmental status of the UPR/autophagy‐targeted agents will be discussed.

Url:

https://api.istex.fr/ark:/67375/WNG-JSLNVZP5-W/fulltext.pdf

DOI: 10.1111/j.1749-6632.2012.06739.x

Links to Exploration step

ISTEX:8793D12DCDEC3A8743A164DE89DAFD3EC7D7D3F9

Le document en format XML

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Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

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