Cutaneous lesions of dermatomyositis are improved by hydroxychloroquine
Identifieur interne : 000182 ( Istex/Corpus ); précédent : 000181; suivant : 000183Cutaneous lesions of dermatomyositis are improved by hydroxychloroquine
Auteurs : Thomas Y. Woo ; Jeffrey P. Callen ; John J. Voorhees ; David R. Bickers ; Ruth Hanno ; Curtis HawkinsSource :
- Journal of the American Academy of Dermatology [ 0190-9622 ] ; 1984.
English descriptors
- Teeft :
- Acrodermatitis enteropathica, American academyof dermatology, Antibody level, Antimalarial, Arch dermatol, Arthralgia, Barium enema, Bibasilar rales, Biopsy, Black woman, Chest examination, Corticosteroid, Creatinine clearance, Cutaneous, Cutaneous disease, Cutaneous lesions, Cuticular overgrowth, Dermatologic evaluation, Dermatology, Dermatomyositis, Direct immunofluorescent biopsy, Dorsal surfaces, Erythema, Facial erythema, Heliotrope, Homogeneous pattern, Hydroxychloroquine, Insertional irritability, Intravenous pyelogram, Joint symptoms, Laboratory evaluation, Lesion, Mayo clinic, Methotrexate, Muscle biopsy, Muscle disease, Muscle enzymes, Muscle strength, Muscle weakness, Myositis, Normal limits, Olmsted syndrome, Open study, Oral corticosteroids, Oral prednisone, Papule, Periorbital, Periorbital heliotrope, Periungual, Periungual telangiectasias, Pertinent laboratory findings, Physical examination, Poikiloderma, Prednisone, Primary idiopathic, Prominent periungual telangiectasias, Proximal, Proximal muscle weakness, Proximal muscles, Pulmonary function tests, Rash, Side effects, Skin biopsy, Skin disease, Skin erosions, Skin lesions, Skin rash, Speckled pattern, Spontaneous fibrillations, Telangiectasias, Total resolution, Typical rash, Unremarkable, Upper portion, White woman.
Abstract
Detmatomyositis (DM) is a collagen vascular disease with prominent cutaneous findings. Although the myositis often responds to therapy with corticosteroids and/or immunosuppressives, the cutaneous disease may not respond. Seven patients with cutaneous lesions of DM that had not responded to therapy were treated with hydroxychloroquine in an open study. Three patients had idiopathic DM, one had DM without myositis, one had DM with malignancy, and one had adolescent DM. The response to the addition of hydroxychloroquine was good in all of the patients, and three had total resolution of their skin lesions. In two patients the corticosteroid dosage could be tapered. Therapy with hydroxychloroquine did not appear to have any beneficial effect on the myositis. We conclude that hydroxychloroquine may have a role as an adjuvant to the therapy of patients with cutaneous lesions of DM. (J AM ACAD DERMATOL 10:592-600, 1984.)
Url:
DOI: 10.1016/S0190-9622(84)80263-7
Links to Exploration step
ISTEX:D837DBF4B04BE2BD217577BBA58F1199BA9ACB5CLe document en format XML
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Callen, 554 Medical Towers South, Louisville, KY 40202.</mods:affiliation></affiliation></author><author><name sortKey="Voorhees, John J" sort="Voorhees, John J" uniqKey="Voorhees J" first="John J." last="Voorhees">John J. Voorhees</name><affiliation><mods:affiliation>Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI</mods:affiliation></affiliation></author><author><name sortKey="Bickers, David R" sort="Bickers, David R" uniqKey="Bickers D" first="David R." last="Bickers">David R. 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Woo</name><affiliation><mods:affiliation>Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI</mods:affiliation></affiliation></author><author><name sortKey="Callen, Jeffrey P" sort="Callen, Jeffrey P" uniqKey="Callen J" first="Jeffrey P." last="Callen">Jeffrey P. Callen</name><affiliation><mods:affiliation>Division of Dermatology, University of Louisville Schoot of Medicine, Louisville, KI</mods:affiliation></affiliation><affiliation><mods:affiliation>Reprint requests to: Dr. Jeffrey P. Callen, 554 Medical Towers South, Louisville, KY 40202.</mods:affiliation></affiliation></author><author><name sortKey="Voorhees, John J" sort="Voorhees, John J" uniqKey="Voorhees J" first="John J." last="Voorhees">John J. 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Although the myositis often responds to therapy with corticosteroids and/or immunosuppressives, the cutaneous disease may not respond. Seven patients with cutaneous lesions of DM that had not responded to therapy were treated with hydroxychloroquine in an open study. Three patients had idiopathic DM, one had DM without myositis, one had DM with malignancy, and one had adolescent DM. The response to the addition of hydroxychloroquine was good in all of the patients, and three had total resolution of their skin lesions. In two patients the corticosteroid dosage could be tapered. Therapy with hydroxychloroquine did not appear to have any beneficial effect on the myositis. We conclude that hydroxychloroquine may have a role as an adjuvant to the therapy of patients with cutaneous lesions of DM. 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Woo M.D.</name><affiliations><json:string>Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI</json:string></affiliations></json:item><json:item><name>Jeffrey P. Callen M.D.</name><affiliations><json:string>Division of Dermatology, University of Louisville Schoot of Medicine, Louisville, KI</json:string><json:string>Reprint requests to: Dr. Jeffrey P. Callen, 554 Medical Towers South, Louisville, KY 40202.</json:string></affiliations></json:item><json:item><name>John J. Voorhees M.D.</name><affiliations><json:string>Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI</json:string></affiliations></json:item><json:item><name>David R. Bickers M.D.</name><affiliations><json:string>Department of Dermatology, Case Western Reserve School of Medicine, Cleveland</json:string></affiliations></json:item><json:item><name>Ruth Hanno M.D.</name><affiliations><json:string>Department of Dermatology, Henry Ford Hospital, Detroit, MI</json:string></affiliations></json:item><json:item><name>Curtis Hawkins M.D.</name><affiliations><json:string>Department of Dermatology, Case Western Reserve School of Medicine, Cleveland</json:string></affiliations></json:item></author><articleId><json:string>80263</json:string></articleId><arkIstex>ark:/67375/6H6-GJFS9PQ7-C</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Detmatomyositis (DM) is a collagen vascular disease with prominent cutaneous findings. Although the myositis often responds to therapy with corticosteroids and/or immunosuppressives, the cutaneous disease may not respond. Seven patients with cutaneous lesions of DM that had not responded to therapy were treated with hydroxychloroquine in an open study. Three patients had idiopathic DM, one had DM without myositis, one had DM with malignancy, and one had adolescent DM. The response to the addition of hydroxychloroquine was good in all of the patients, and three had total resolution of their skin lesions. In two patients the corticosteroid dosage could be tapered. Therapy with hydroxychloroquine did not appear to have any beneficial effect on the myositis. We conclude that hydroxychloroquine may have a role as an adjuvant to the therapy of patients with cutaneous lesions of DM. 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Callen, 554 Medical Towers South, Louisville, KY 40202.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">John J.</forename><surname>Voorhees</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI</affiliation></author><author xml:id="author-0003"><persName><forename type="first">David R.</forename><surname>Bickers</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Department of Dermatology, Case Western Reserve School of Medicine, Cleveland</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Ruth</forename><surname>Hanno</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Department of Dermatology, Henry Ford Hospital, Detroit, MI</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Curtis</forename><surname>Hawkins</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Department of Dermatology, Case Western Reserve School of Medicine, Cleveland</affiliation></author><idno type="istex">D837DBF4B04BE2BD217577BBA58F1199BA9ACB5C</idno><idno type="ark">ark:/67375/6H6-GJFS9PQ7-C</idno><idno type="DOI">10.1016/S0190-9622(84)80263-7</idno><idno type="PII">S0190-9622(84)80263-7</idno><idno type="article-id">80263</idno></analytic><monogr><title level="j">Journal of the American Academy of Dermatology</title><title level="j" type="abbrev">YMJD</title><idno type="pISSN">0190-9622</idno><idno type="PII">S0190-9622(84)X8259-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984"></date><biblScope unit="volume">10</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="592">592</biblScope><biblScope unit="page" to="600">600</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1984</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Detmatomyositis (DM) is a collagen vascular disease with prominent cutaneous findings. Although the myositis often responds to therapy with corticosteroids and/or immunosuppressives, the cutaneous disease may not respond. Seven patients with cutaneous lesions of DM that had not responded to therapy were treated with hydroxychloroquine in an open study. Three patients had idiopathic DM, one had DM without myositis, one had DM with malignancy, and one had adolescent DM. The response to the addition of hydroxychloroquine was good in all of the patients, and three had total resolution of their skin lesions. In two patients the corticosteroid dosage could be tapered. Therapy with hydroxychloroquine did not appear to have any beneficial effect on the myositis. We conclude that hydroxychloroquine may have a role as an adjuvant to the therapy of patients with cutaneous lesions of DM. (J AM ACAD DERMATOL 10:592-600, 1984.)</p></abstract></profileDesc><revisionDesc><change when="1984">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-GJFS9PQ7-C/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>YMJD</jid><aid>80263</aid><ce:pii>S0190-9622(84)80263-7</ce:pii><ce:doi>10.1016/S0190-9622(84)80263-7</ce:doi><ce:copyright type="unknown" year="1984">American Academy of Dermatology, Inc.</ce:copyright></item-info><head><ce:title>Cutaneous lesions of dermatomyositis are improved by hydroxychloroquine</ce:title><ce:author-group><ce:author><ce:given-name>Thomas Y.</ce:given-name><ce:surname>Woo</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="aff1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jeffrey P.</ce:given-name><ce:surname>Callen</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="aff2"><ce:sup>**</ce:sup></ce:cross-ref><ce:cross-ref refid="cor1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>John J.</ce:given-name><ce:surname>Voorhees</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="aff1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>David R.</ce:given-name><ce:surname>Bickers</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="aff3"><ce:sup>***</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Ruth</ce:given-name><ce:surname>Hanno</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="aff4"><ce:sup>****</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Curtis</ce:given-name><ce:surname>Hawkins</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="aff3"><ce:sup>***</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>*</ce:label><ce:textfn>Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>**</ce:label><ce:textfn>Division of Dermatology, University of Louisville Schoot of Medicine, Louisville, KI</ce:textfn></ce:affiliation><ce:affiliation id="aff3"><ce:label>***</ce:label><ce:textfn>Department of Dermatology, Case Western Reserve School of Medicine, Cleveland</ce:textfn></ce:affiliation><ce:affiliation id="aff4"><ce:label>****</ce:label><ce:textfn>Department of Dermatology, Henry Ford Hospital, Detroit, MI</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>a</ce:label><ce:text>Reprint requests to: Dr. Jeffrey P. Callen, 554 Medical Towers South, Louisville, KY 40202.</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="21" month="9" year="1983"></ce:date-accepted><ce:abstract id="ab1"><ce:abstract-sec><ce:simple-para>Detmatomyositis (DM) is a collagen vascular disease with prominent cutaneous findings. Although the myositis often responds to therapy with corticosteroids and/or immunosuppressives, the cutaneous disease may not respond. Seven patients with cutaneous lesions of DM that had not responded to therapy were treated with hydroxychloroquine in an open study. Three patients had idiopathic DM, one had DM without myositis, one had DM with malignancy, and one had adolescent DM. The response to the addition of hydroxychloroquine was good in all of the patients, and three had total resolution of their skin lesions. In two patients the corticosteroid dosage could be tapered. Therapy with hydroxychloroquine did not appear to have any beneficial effect on the myositis. We conclude that hydroxychloroquine may have a role as an adjuvant to the therapy of patients with cutaneous lesions of DM. 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Callen, 554 Medical Towers South, Louisville, KY 40202.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John J.</namePart><namePart type="family">Voorhees</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David R.</namePart><namePart type="family">Bickers</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Department of Dermatology, Case Western Reserve School of Medicine, Cleveland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ruth</namePart><namePart type="family">Hanno</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Department of Dermatology, Henry Ford Hospital, Detroit, MI</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Curtis</namePart><namePart type="family">Hawkins</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Department of Dermatology, Case Western Reserve School of Medicine, Cleveland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1984</dateIssued><copyrightDate encoding="w3cdtf">1984</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract>Detmatomyositis (DM) is a collagen vascular disease with prominent cutaneous findings. Although the myositis often responds to therapy with corticosteroids and/or immunosuppressives, the cutaneous disease may not respond. Seven patients with cutaneous lesions of DM that had not responded to therapy were treated with hydroxychloroquine in an open study. Three patients had idiopathic DM, one had DM without myositis, one had DM with malignancy, and one had adolescent DM. The response to the addition of hydroxychloroquine was good in all of the patients, and three had total resolution of their skin lesions. In two patients the corticosteroid dosage could be tapered. Therapy with hydroxychloroquine did not appear to have any beneficial effect on the myositis. We conclude that hydroxychloroquine may have a role as an adjuvant to the therapy of patients with cutaneous lesions of DM. 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