Clinical spectrum of chronic interstitial lung disease in children
Identifieur interne : 000157 ( Istex/Corpus ); précédent : 000156; suivant : 000158Clinical spectrum of chronic interstitial lung disease in children
Auteurs : Leland L. Fan ; Ann L. W. Mullen ; Susan M. Brugman ; Stephen C. Inscore ; David P. Parks ; Carl W. WhiteSource :
- The Journal of Pediatrics [ 0022-3476 ] ; 1992.
English descriptors
- Teeft :
- Alveolar infiltrates, Alveolar proteinosis, Background data, Beneficial response, Biopsy, Bronchoalveolar lavage, Cardiac catheterization, Chloroquine, Chronic lung disease, Clinical findings, Clinical spectrum, Considerable number, Cryptogenic fibrosing alveolitis, Desquamative, Disorder, Exclusion criteria, Expiratory flow, Fatal desquamative, Fibrosing alveolitis, Growth failure, Heterogeneous group, Hypersensitivity pneumonitis, Idiopathic, Initial evaluation, Interstitial, Interstitial lung disease, Interstitial lung diseases, Interstitial pneumonitis, Lung disease, Lung function, Lymphocyte infiltrative disorders, Lymphoid, Mortality rate, Mortality rates, National jewish center, Normal values, Open lung biopsy, Other patients, Peak expiratory flow, Pediatr, Pediatric, Pediatrics, Pediatrics december, Pneumonia, Pneumonitis, Pulmonary fibrosis, Pulmonary hemangiomatosis, Pulmonary hemosiderosis, Pulmonary hypertension, Pulmonary lymphangiomatosis, Pulmonary lymphoid hyperplasia, Rare disorders, Recombinant interferon, Respiratory medicine, Restrictive lung disease, Restrictive pattern, Specific diagnosis, Specific therapy, Teaching hospital, Total lung capacity, Typical findings, Vital capacity maneuvers.
Abstract
To describe the clinical spectrum of interstitial lung disease in children, we reviewed our experience with 48 patients during a 12-year period. Most patients initially had typical findings of restrictive lung disease and hypoxemia. Growth failure or pulmonary hypertension or both were found in more than one third. Specific diagnosis, made in 35 patients (70%), most often required invasive studies, particularly open lung biopsy. Although the diagnostic yield from open lung biopsy was high, the diagnosis of many patients remained uncertain. Many different disorders were encountered. The response to corticosteroids, bronchodilators, and chloroquine was inconsistent. Six patients died, five within 1 year after the initial evaluation. The spectrum of pediatric interstitial lung disease includes a large, heterogeneous group of rare disorders associated with high morbidity and mortallty rates.
Url:
DOI: 10.1016/S0022-3476(05)80330-0
Links to Exploration step
ISTEX:22214B84479BCC51693FADC09723EDA4919EB750Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical spectrum of chronic interstitial lung disease in children</title><author><name sortKey="Fan, Leland L" sort="Fan, Leland L" uniqKey="Fan L" first="Leland L." last="Fan">Leland L. Fan</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Reprint requests: Leland L. Fan, MD, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson, Denver, CO 80206.</mods:affiliation></affiliation></author><author><name sortKey="Mullen, Ann L W" sort="Mullen, Ann L W" uniqKey="Mullen A" first="Ann L. W." last="Mullen">Ann L. W. Mullen</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation></author><author><name sortKey="Brugman, Susan M" sort="Brugman, Susan M" uniqKey="Brugman S" first="Susan M." last="Brugman">Susan M. Brugman</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation></author><author><name sortKey="Inscore, Stephen C" sort="Inscore, Stephen C" uniqKey="Inscore S" first="Stephen C." last="Inscore">Stephen C. Inscore</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation></author><author><name sortKey="Parks, David P" sort="Parks, David P" uniqKey="Parks D" first="David P." last="Parks">David P. Parks</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation></author><author><name sortKey="White, Carl W" sort="White, Carl W" uniqKey="White C" first="Carl W." last="White">Carl W. White</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation><affiliation><mods:affiliation>*Supported in part (Dr. White) by a Grant-in-Aid and an Established Investigator Award from the American Heart Association National Center, and National Institutes of Health SCOR I P50 L 46481-01.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:22214B84479BCC51693FADC09723EDA4919EB750</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/S0022-3476(05)80330-0</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-ZFD0JTGP-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000157</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000157</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Clinical spectrum of chronic interstitial lung disease in children</title><author><name sortKey="Fan, Leland L" sort="Fan, Leland L" uniqKey="Fan L" first="Leland L." last="Fan">Leland L. Fan</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Reprint requests: Leland L. Fan, MD, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson, Denver, CO 80206.</mods:affiliation></affiliation></author><author><name sortKey="Mullen, Ann L W" sort="Mullen, Ann L W" uniqKey="Mullen A" first="Ann L. W." last="Mullen">Ann L. W. Mullen</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation></author><author><name sortKey="Brugman, Susan M" sort="Brugman, Susan M" uniqKey="Brugman S" first="Susan M." last="Brugman">Susan M. Brugman</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation></author><author><name sortKey="Inscore, Stephen C" sort="Inscore, Stephen C" uniqKey="Inscore S" first="Stephen C." last="Inscore">Stephen C. Inscore</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation></author><author><name sortKey="Parks, David P" sort="Parks, David P" uniqKey="Parks D" first="David P." last="Parks">David P. Parks</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation></author><author><name sortKey="White, Carl W" sort="White, Carl W" uniqKey="White C" first="Carl W." last="White">Carl W. White</name><affiliation><mods:affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</mods:affiliation></affiliation><affiliation><mods:affiliation>*Supported in part (Dr. White) by a Grant-in-Aid and an Established Investigator Award from the American Heart Association National Center, and National Institutes of Health SCOR I P50 L 46481-01.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Pediatrics</title><title level="j" type="abbrev">YMPD</title><idno type="ISSN">0022-3476</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">121</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="867">867</biblScope><biblScope unit="page" to="872">872</biblScope></imprint><idno type="ISSN">0022-3476</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3476</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Alveolar infiltrates</term><term>Alveolar proteinosis</term><term>Background data</term><term>Beneficial response</term><term>Biopsy</term><term>Bronchoalveolar lavage</term><term>Cardiac catheterization</term><term>Chloroquine</term><term>Chronic lung disease</term><term>Clinical findings</term><term>Clinical spectrum</term><term>Considerable number</term><term>Cryptogenic fibrosing alveolitis</term><term>Desquamative</term><term>Disorder</term><term>Exclusion criteria</term><term>Expiratory flow</term><term>Fatal desquamative</term><term>Fibrosing alveolitis</term><term>Growth failure</term><term>Heterogeneous group</term><term>Hypersensitivity pneumonitis</term><term>Idiopathic</term><term>Initial evaluation</term><term>Interstitial</term><term>Interstitial lung disease</term><term>Interstitial lung diseases</term><term>Interstitial pneumonitis</term><term>Lung disease</term><term>Lung function</term><term>Lymphocyte infiltrative disorders</term><term>Lymphoid</term><term>Mortality rate</term><term>Mortality rates</term><term>National jewish center</term><term>Normal values</term><term>Open lung biopsy</term><term>Other patients</term><term>Peak expiratory flow</term><term>Pediatr</term><term>Pediatric</term><term>Pediatrics</term><term>Pediatrics december</term><term>Pneumonia</term><term>Pneumonitis</term><term>Pulmonary fibrosis</term><term>Pulmonary hemangiomatosis</term><term>Pulmonary hemosiderosis</term><term>Pulmonary hypertension</term><term>Pulmonary lymphangiomatosis</term><term>Pulmonary lymphoid hyperplasia</term><term>Rare disorders</term><term>Recombinant interferon</term><term>Respiratory medicine</term><term>Restrictive lung disease</term><term>Restrictive pattern</term><term>Specific diagnosis</term><term>Specific therapy</term><term>Teaching hospital</term><term>Total lung capacity</term><term>Typical findings</term><term>Vital capacity maneuvers</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To describe the clinical spectrum of interstitial lung disease in children, we reviewed our experience with 48 patients during a 12-year period. Most patients initially had typical findings of restrictive lung disease and hypoxemia. Growth failure or pulmonary hypertension or both were found in more than one third. Specific diagnosis, made in 35 patients (70%), most often required invasive studies, particularly open lung biopsy. Although the diagnostic yield from open lung biopsy was high, the diagnosis of many patients remained uncertain. Many different disorders were encountered. The response to corticosteroids, bronchodilators, and chloroquine was inconsistent. Six patients died, five within 1 year after the initial evaluation. The spectrum of pediatric interstitial lung disease includes a large, heterogeneous group of rare disorders associated with high morbidity and mortallty rates.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>pneumonitis</json:string><json:string>desquamative</json:string><json:string>initial evaluation</json:string><json:string>pediatr</json:string><json:string>pediatric</json:string><json:string>lymphoid</json:string><json:string>lung disease</json:string><json:string>idiopathic</json:string><json:string>pediatrics</json:string><json:string>chloroquine</json:string><json:string>open lung biopsy</json:string><json:string>specific diagnosis</json:string><json:string>pulmonary hemangiomatosis</json:string><json:string>interstitial pneumonitis</json:string><json:string>pulmonary lymphoid hyperplasia</json:string><json:string>pulmonary fibrosis</json:string><json:string>national jewish center</json:string><json:string>lymphocyte infiltrative disorders</json:string><json:string>clinical spectrum</json:string><json:string>pediatrics december</json:string><json:string>respiratory medicine</json:string><json:string>chronic lung disease</json:string><json:string>hypersensitivity pneumonitis</json:string><json:string>interstitial lung diseases</json:string><json:string>interstitial</json:string><json:string>lung function</json:string><json:string>clinical findings</json:string><json:string>typical findings</json:string><json:string>background data</json:string><json:string>exclusion criteria</json:string><json:string>specific therapy</json:string><json:string>restrictive lung disease</json:string><json:string>vital capacity maneuvers</json:string><json:string>peak expiratory flow</json:string><json:string>expiratory flow</json:string><json:string>total lung capacity</json:string><json:string>alveolar infiltrates</json:string><json:string>restrictive pattern</json:string><json:string>normal values</json:string><json:string>cardiac catheterization</json:string><json:string>bronchoalveolar lavage</json:string><json:string>alveolar proteinosis</json:string><json:string>growth failure</json:string><json:string>heterogeneous group</json:string><json:string>rare disorders</json:string><json:string>mortality rates</json:string><json:string>pulmonary hypertension</json:string><json:string>fibrosing alveolitis</json:string><json:string>cryptogenic fibrosing alveolitis</json:string><json:string>other patients</json:string><json:string>pulmonary hemosiderosis</json:string><json:string>pulmonary lymphangiomatosis</json:string><json:string>beneficial response</json:string><json:string>teaching hospital</json:string><json:string>fatal desquamative</json:string><json:string>mortality rate</json:string><json:string>interstitial lung disease</json:string><json:string>recombinant interferon</json:string><json:string>considerable number</json:string><json:string>pneumonia</json:string><json:string>biopsy</json:string><json:string>disorder</json:string></teeft></keywords><author><json:item><name>Leland L. Fan MD</name><affiliations><json:string>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</json:string><json:string>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</json:string><json:string>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</json:string><json:string>Reprint requests: Leland L. Fan, MD, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson, Denver, CO 80206.</json:string></affiliations></json:item><json:item><name>Ann L.W. Mullen RN, MS</name><affiliations><json:string>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</json:string><json:string>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</json:string><json:string>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</json:string></affiliations></json:item><json:item><name>Susan M. Brugman MD</name><affiliations><json:string>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</json:string><json:string>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</json:string><json:string>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</json:string></affiliations></json:item><json:item><name>Stephen C. Inscore MD</name><affiliations><json:string>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</json:string><json:string>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</json:string><json:string>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</json:string></affiliations></json:item><json:item><name>David P. Parks MD</name><affiliations><json:string>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</json:string><json:string>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</json:string><json:string>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</json:string></affiliations></json:item><json:item><name>Carl W. White MD</name><affiliations><json:string>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</json:string><json:string>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</json:string><json:string>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</json:string><json:string>*Supported in part (Dr. White) by a Grant-in-Aid and an Established Investigator Award from the American Heart Association National Center, and National Institutes of Health SCOR I P50 L 46481-01.</json:string></affiliations></json:item></author><articleId><json:string>05803300</json:string></articleId><arkIstex>ark:/67375/6H6-ZFD0JTGP-8</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>To describe the clinical spectrum of interstitial lung disease in children, we reviewed our experience with 48 patients during a 12-year period. Most patients initially had typical findings of restrictive lung disease and hypoxemia. Growth failure or pulmonary hypertension or both were found in more than one third. Specific diagnosis, made in 35 patients (70%), most often required invasive studies, particularly open lung biopsy. Although the diagnostic yield from open lung biopsy was high, the diagnosis of many patients remained uncertain. Many different disorders were encountered. The response to corticosteroids, bronchodilators, and chloroquine was inconsistent. Six patients died, five within 1 year after the initial evaluation. The spectrum of pediatric interstitial lung disease includes a large, heterogeneous group of rare disorders associated with high morbidity and mortallty rates.</abstract><qualityIndicators><score>6.567</score><pdfWordCount>3031</pdfWordCount><pdfCharCount>20214</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>554.28 x 770.28 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>128</abstractWordCount><abstractCharCount>900</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Clinical spectrum of chronic interstitial lung disease in children</title><pmid><json:string>1447647</json:string></pmid><pii><json:string>S0022-3476(05)80330-0</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>The Journal of Pediatrics</title><language><json:string>unknown</json:string></language><publicationDate>1992</publicationDate><issn><json:string>0022-3476</json:string></issn><pii><json:string>S0022-3476(92)X8056-X</json:string></pii><volume>121</volume><issue>6</issue><pages><first>867</first><last>872</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1992</json:string><json:string>from 1980 through 1991</json:string></date><geogName></geogName><orgName><json:string>National Jewish Center for Immunology and Respiratory Medicine</json:string><json:string>University Hospital, Children</json:string><json:string>National Jewish Center</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Susan M. Brugman</json:string><json:string>C. Inscore</json:string><json:string>Steven Abman</json:string><json:string>Gary Larsen</json:string><json:string>Their</json:string><json:string>Frank Accurso</json:string><json:string>Talmadge King</json:string><json:string>Derek Uchida</json:string><json:string>P. Parks</json:string><json:string>To</json:string><json:string>Carl W. White</json:string><json:string>L. W. Mullen</json:string></persName><placeName><json:string>Denver</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Fan et al.</json:string><json:string>Gaultier et al.</json:string><json:string>Stillwell et al.</json:string><json:string>Fernald et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-ZFD0JTGP-8</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - pediatrics</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - pediatrics</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pediatrics, Perinatology, and Child Health</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1992</publicationDate><copyrightDate>1992</copyrightDate><doi><json:string>10.1016/S0022-3476(05)80330-0</json:string></doi><id>22214B84479BCC51693FADC09723EDA4919EB750</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-ZFD0JTGP-8/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-ZFD0JTGP-8/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-ZFD0JTGP-8/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Clinical spectrum of chronic interstitial lung disease in children</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©1992 Mosby-Year Book, Inc.</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1992</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Section title: Original article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Clinical spectrum of chronic interstitial lung disease in children</title><author xml:id="author-0000"><persName><forename type="first">Leland L.</forename><surname>Fan</surname></persName><roleName type="degree">MD</roleName><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation><affiliation>Reprint requests: Leland L. Fan, MD, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson, Denver, CO 80206.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Ann L.W.</forename><surname>Mullen</surname></persName><roleName type="degree">RN, MS</roleName><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Susan M.</forename><surname>Brugman</surname></persName><roleName type="degree">MD</roleName><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Stephen C.</forename><surname>Inscore</surname></persName><roleName type="degree">MD</roleName><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation></author><author xml:id="author-0004"><persName><forename type="first">David P.</forename><surname>Parks</surname></persName><roleName type="degree">MD</roleName><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Carl W.</forename><surname>White</surname></persName><roleName type="degree">MD</roleName><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation><affiliation>*Supported in part (Dr. White) by a Grant-in-Aid and an Established Investigator Award from the American Heart Association National Center, and National Institutes of Health SCOR I P50 L 46481-01.</affiliation></author><idno type="istex">22214B84479BCC51693FADC09723EDA4919EB750</idno><idno type="ark">ark:/67375/6H6-ZFD0JTGP-8</idno><idno type="DOI">10.1016/S0022-3476(05)80330-0</idno><idno type="PII">S0022-3476(05)80330-0</idno><idno type="article-id">05803300</idno></analytic><monogr><title level="j">The Journal of Pediatrics</title><title level="j" type="abbrev">YMPD</title><idno type="pISSN">0022-3476</idno><idno type="PII">S0022-3476(92)X8056-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992"></date><biblScope unit="volume">121</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="867">867</biblScope><biblScope unit="page" to="872">872</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1992</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>To describe the clinical spectrum of interstitial lung disease in children, we reviewed our experience with 48 patients during a 12-year period. Most patients initially had typical findings of restrictive lung disease and hypoxemia. Growth failure or pulmonary hypertension or both were found in more than one third. Specific diagnosis, made in 35 patients (70%), most often required invasive studies, particularly open lung biopsy. Although the diagnostic yield from open lung biopsy was high, the diagnosis of many patients remained uncertain. Many different disorders were encountered. The response to corticosteroids, bronchodilators, and chloroquine was inconsistent. Six patients died, five within 1 year after the initial evaluation. The spectrum of pediatric interstitial lung disease includes a large, heterogeneous group of rare disorders associated with high morbidity and mortallty rates.</p></abstract></profileDesc><revisionDesc><change when="1992">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-ZFD0JTGP-8/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>YMPD</jid><aid>05803300</aid><ce:pii>S0022-3476(05)80330-0</ce:pii><ce:doi>10.1016/S0022-3476(05)80330-0</ce:doi><ce:copyright type="unknown" year="1992">Mosby-Year Book, Inc.</ce:copyright></item-info><head><ce:dochead><ce:textfn>Original article</ce:textfn></ce:dochead><ce:title>Clinical spectrum of chronic interstitial lung disease in children</ce:title><ce:author-group><ce:author><ce:degrees>MD</ce:degrees><ce:given-name>Leland L.</ce:given-name><ce:surname>Fan</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="aff3"><ce:sup>c</ce:sup></ce:cross-ref><ce:cross-ref refid="cor1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:author><ce:degrees>RN, MS</ce:degrees><ce:given-name>Ann L.W.</ce:given-name><ce:surname>Mullen</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="aff3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:degrees>MD</ce:degrees><ce:given-name>Susan M.</ce:given-name><ce:surname>Brugman</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="aff3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:degrees>MD</ce:degrees><ce:given-name>Stephen C.</ce:given-name><ce:surname>Inscore</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="aff3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:degrees>MD</ce:degrees><ce:given-name>David P.</ce:given-name><ce:surname>Parks</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="aff3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:degrees>MD</ce:degrees><ce:given-name>Carl W.</ce:given-name><ce:surname>White</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="aff3"><ce:sup>c</ce:sup></ce:cross-ref><ce:cross-ref refid="fn1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>a</ce:label><ce:textfn>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>b</ce:label><ce:textfn>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</ce:textfn></ce:affiliation><ce:affiliation id="aff3"><ce:label>c</ce:label><ce:textfn>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>**</ce:label><ce:text>Reprint requests: Leland L. Fan, MD, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson, Denver, CO 80206.</ce:text></ce:correspondence><ce:footnote id="fn1"><ce:label>*</ce:label><ce:note-para>Supported in part (Dr. White) by a Grant-in-Aid and an Established Investigator Award from the American Heart Association National Center, and National Institutes of Health SCOR I P50 L 46481-01.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="30" month="12" year="1991"></ce:date-received><ce:date-accepted day="28" month="7" year="1992"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="en"><ce:abstract-sec><ce:simple-para>To describe the clinical spectrum of interstitial lung disease in children, we reviewed our experience with 48 patients during a 12-year period. Most patients initially had typical findings of restrictive lung disease and hypoxemia. Growth failure or pulmonary hypertension or both were found in more than one third. Specific diagnosis, made in 35 patients (70%), most often required invasive studies, particularly open lung biopsy. Although the diagnostic yield from open lung biopsy was high, the diagnosis of many patients remained uncertain. Many different disorders were encountered. The response to corticosteroids, bronchodilators, and chloroquine was inconsistent. Six patients died, five within 1 year after the initial evaluation. The spectrum of pediatric interstitial lung disease includes a large, heterogeneous group of rare disorders associated with high morbidity and mortallty rates.</ce:simple-para></ce:abstract-sec></ce:abstract></head><tail><ce:bibliography><ce:section-title>References</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Crystal</ce:surname><ce:given-name>RG</ce:given-name></sb:author><sb:author><ce:surname>Bitterman</ce:surname><ce:given-name>PB</ce:given-name></sb:author><sb:author><ce:surname>Rennard</ce:surname><ce:given-name>SI</ce:given-name></sb:author><sb:author><ce:surname>Hance</ce:surname><ce:given-name>AJ</ce:given-name></sb:author><sb:author><ce:surname>Keogh</ce:surname><ce:given-name>BA</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Interstitial lung diseases of unknown cause: disorders characterized by chronic inflammation of the lower respiratory tract</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>N Engl J Med</sb:maintitle></sb:title><sb:volume-nr>310</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>154</sb:first-page><sb:last-page>166</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib2"><ce:label>2.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Carrington</ce:surname><ce:given-name>CB</ce:given-name></sb:author><sb:author><ce:surname>Gaensler</ce:surname><ce:given-name>EA</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Clinical-pathologic approach to diffuse infiltrative lung disease</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Thurlbeck</ce:surname><ce:given-name>WM</ce:given-name></sb:editor><sb:editor><ce:surname>Abell</ce:surname><ce:given-name>MR</ce:given-name></sb:editor></sb:editors><sb:title><sb:maintitle>The lung: structure, function and disease</sb:maintitle></sb:title><sb:date>1978</sb:date><sb:publisher><sb:name>Williams & Wilkins</sb:name><sb:location>Baltimore</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>58</sb:first-page><sb:last-page>87</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib3"><ce:label>3.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Patchefsky</ce:surname><ce:given-name>AS</ce:given-name></sb:author><sb:author><ce:surname>Israel</ce:surname><ce:given-name>HL</ce:given-name></sb:author><sb:author><ce:surname>Hoch</ce:surname><ce:given-name>WS</ce:given-name></sb:author><sb:author><ce:surname>Gordon</ce:surname><ce:given-name>G</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Desquamative interstitial pneumonia: relationship to interstitial fibrosis</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Thorax</sb:maintitle></sb:title><sb:volume-nr>28</sb:volume-nr></sb:series><sb:date>1973</sb:date></sb:issue><sb:pages><sb:first-page>680</sb:first-page><sb:last-page>693</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib4"><ce:label>4.</ce:label><sb:reference><sb:comment>pt 1</sb:comment><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Crouch</ce:surname><ce:given-name>E</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Pathobiology of pulmonary fibrosis</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am J Physiol</sb:maintitle></sb:title><sb:volume-nr>259</sb:volume-nr></sb:series><sb:issue-nr>4</sb:issue-nr><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>L159</sb:first-page><sb:last-page>L184</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib5"><ce:label>5.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Cherniack</ce:surname><ce:given-name>RM</ce:given-name></sb:author><sb:author><ce:surname>Crystal</ce:surname><ce:given-name>RG</ce:given-name></sb:author><sb:author><ce:surname>Kalica</ce:surname><ce:given-name>AR</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Current concepts in idiopathic pulmonary fibrosis: a road map for the future</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am Rev Respir Dis</sb:maintitle></sb:title><sb:volume-nr>143</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>680</sb:first-page><sb:last-page>683</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib6"><ce:label>6.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>King</ce:surname><ce:given-name>TE</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Diagnostic advances in idiopathic pulmonary fibrosis</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Chest</sb:maintitle></sb:title><sb:volume-nr>100</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>238</sb:first-page><sb:last-page>241</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib7"><ce:label>7.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Diaz</ce:surname><ce:given-name>RP</ce:given-name></sb:author><sb:author><ce:surname>Bowman</ce:surname><ce:given-name>CM</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Childhood interstitial lung disease</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Semin Respir Med</sb:maintitle></sb:title><sb:volume-nr>11</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>253</sb:first-page><sb:last-page>268</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib8"><ce:label>8.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Laraya-Cuasay</ce:surname><ce:given-name>LR</ce:given-name></sb:author><sb:author><ce:surname>Hughes</ce:surname><ce:given-name>WT</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Interstitial lung diseases in children</sb:maintitle></sb:title></sb:contribution><sb:host><sb:book><sb:date>1988</sb:date><sb:publisher><sb:name>CRC Press</sb:name><sb:location>Boca Raton, Florida</sb:location></sb:publisher></sb:book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib9"><ce:label>9.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Kradin</ce:surname><ce:given-name>RL</ce:given-name></sb:author><sb:author><ce:surname>Mark</ce:surname><ce:given-name>EJ</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Benign lymphoid disorders of the lung, with a theory ragarding their development</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Hum Pathol</sb:maintitle></sb:title><sb:volume-nr>14</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>857</sb:first-page><sb:last-page>867</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib10"><ce:label>10.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>White</ce:surname><ce:given-name>CW</ce:given-name></sb:author><sb:author><ce:surname>Sondheimer</ce:surname><ce:given-name>HM</ce:given-name></sb:author><sb:author><ce:surname>Crouch</ce:surname><ce:given-name>EC</ce:given-name></sb:author><sb:author><ce:surname>Wilson</ce:surname><ce:given-name>H</ce:given-name></sb:author><sb:author><ce:surname>Fan</ce:surname><ce:given-name>LL</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Treatment of pulmonary hemangiomatosis with recombinant interferon alfa-2a</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>N Engl J Med</sb:maintitle></sb:title><sb:volume-nr>320</sb:volume-nr></sb:series><sb:date>1989</sb:date></sb:issue><sb:pages><sb:first-page>1197</sb:first-page><sb:last-page>1200</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib11"><ce:label>11.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>White</ce:surname><ce:given-name>CW</ce:given-name></sb:author><sb:author><ce:surname>Wolf</ce:surname><ce:given-name>SJ</ce:given-name></sb:author><sb:author><ce:surname>Korones</ce:surname><ce:given-name>D</ce:given-name></sb:author><sb:author><ce:surname>Sondheimer</ce:surname><ce:given-name>HM</ce:given-name></sb:author><sb:author><ce:surname>Tosi</ce:surname><ce:given-name>MF</ce:given-name></sb:author><sb:author><ce:surname>Yu</ce:surname><ce:given-name>A</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Treatment of childhood angiomatous diseases with recombinant interferon alfa-2a</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J Pediatr</sb:maintitle></sb:title><sb:volume-nr>118</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>59</sb:first-page><sb:last-page>66</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib12"><ce:label>12.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Fernald</ce:surname><ce:given-name>GW</ce:given-name></sb:author><sb:author><ce:surname>Denny</ce:surname><ce:given-name>FW</ce:given-name></sb:author><sb:author><ce:surname>Fairclough</ce:surname><ce:given-name>DL</ce:given-name></sb:author><sb:author><ce:surname>Helms</ce:surname><ce:given-name>RW</ce:given-name></sb:author><sb:author><ce:surname>Volberg</ce:surname><ce:given-name>FM</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Chronic lung disease in children referred to a teaching hospital</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pediatr Pulmonol</sb:maintitle></sb:title><sb:volume-nr>2</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>27</sb:first-page><sb:last-page>34</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib13"><ce:label>13.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Gaultier</ce:surname><ce:given-name>CI</ce:given-name></sb:author><sb:author><ce:surname>Chaussain</ce:surname><ce:given-name>M</ce:given-name></sb:author><sb:author><ce:surname>Boulé</ce:surname><ce:given-name>M</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Lung function in interstitial lung diseases in children</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Bull Eur Physiopathal Respir</sb:maintitle></sb:title><sb:volume-nr>16</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>57</sb:first-page><sb:last-page>66</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib14"><ce:label>14.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Tal</ce:surname><ce:given-name>A</ce:given-name></sb:author><sb:author><ce:surname>Maor</ce:surname><ce:given-name>E</ce:given-name></sb:author><sb:author><ce:surname>Bar-Ziv</ce:surname><ce:given-name>J</ce:given-name></sb:author><sb:author><ce:surname>Gorodischer</ce:surname><ce:given-name>R</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Fatal desquamative interstitial pneumonia in three infants siblings</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J Pediatr</sb:maintitle></sb:title><sb:volume-nr>104</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>873</sb:first-page><sb:last-page>876</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib15"><ce:label>15.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Farrell</ce:surname><ce:given-name>PM</ce:given-name></sb:author><sb:author><ce:surname>Gilbert</ce:surname><ce:given-name>EF</ce:given-name></sb:author><sb:author><ce:surname>Zimmerman</ce:surname><ce:given-name>JJ</ce:given-name></sb:author><sb:author><ce:surname>Warner</ce:surname><ce:given-name>TF</ce:given-name></sb:author><sb:author><ce:surname>Saari</ce:surname><ce:given-name>TN</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Familial lung disease associated with proliferation and desquamation of type II pneumonocytes</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am J Dis Child</sb:maintitle></sb:title><sb:volume-nr>140</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>262</sb:first-page><sb:last-page>266</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib16"><ce:label>16.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Wigger</ce:surname><ce:given-name>HJ</ce:given-name></sb:author><sb:author><ce:surname>Berdon</ce:surname><ce:given-name>WE</ce:given-name></sb:author><sb:author><ce:surname>Ores</ce:surname><ce:given-name>CN</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Fatal desquamative interstitial pneumonia in an infant</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch Pathol Lab Med</sb:maintitle></sb:title><sb:volume-nr>101</sb:volume-nr></sb:series><sb:date>1977</sb:date></sb:issue><sb:pages><sb:first-page>129</sb:first-page><sb:last-page>132</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib17"><ce:label>17.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Barnes</ce:surname><ce:given-name>SE</ce:given-name></sb:author><sb:author><ce:surname>Godfrey</ce:surname><ce:given-name>S</ce:given-name></sb:author><sb:author><ce:surname>Millward-Sadler</ce:surname><ce:given-name>GH</ce:given-name></sb:author><sb:author><ce:surname>Roberton</ce:surname><ce:given-name>NRC</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Desquamative fibrosing alveolitis unresponsive to steroid or cytoxic therapy</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch Dis Child</sb:maintitle></sb:title><sb:volume-nr>50</sb:volume-nr></sb:series><sb:date>1975</sb:date></sb:issue><sb:pages><sb:first-page>324</sb:first-page><sb:last-page>327</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib18"><ce:label>18.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Howatt</ce:surname><ce:given-name>WF</ce:given-name></sb:author><sb:author><ce:surname>Heidelberger</ce:surname><ce:given-name>KP</ce:given-name></sb:author><sb:author><ce:surname>LeGlovan</ce:surname><ce:given-name>DP</ce:given-name></sb:author><sb:author><ce:surname>Schnitzer</ce:surname><ce:given-name>B</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Desquamative interstitial pneumonia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am J Dis Child</sb:maintitle></sb:title><sb:volume-nr>126</sb:volume-nr></sb:series><sb:date>1973</sb:date></sb:issue><sb:pages><sb:first-page>346</sb:first-page><sb:last-page>348</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib19"><ce:label>19.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Buchta</ce:surname><ce:given-name>RM</ce:given-name></sb:author><sb:author><ce:surname>Park</ce:surname><ce:given-name>S</ce:given-name></sb:author><sb:author><ce:surname>Giammona</ce:surname><ce:given-name>ST</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Desquamative interstitial pneumonia in a 7-week-old infant</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am J Dis Child</sb:maintitle></sb:title><sb:volume-nr>120</sb:volume-nr></sb:series><sb:date>1970</sb:date></sb:issue><sb:pages><sb:first-page>341</sb:first-page><sb:last-page>343</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib20"><ce:label>20.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Boner</ce:surname><ce:given-name>A</ce:given-name></sb:author><sb:author><ce:surname>Wilmott</ce:surname><ce:given-name>RW</ce:given-name></sb:author><sb:author><ce:surname>Dinwiddie</ce:surname><ce:given-name>R</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Desquamative interstitial pneumonia and antigen-antibody complexes in two infants with congenital rubella</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pediatrics</sb:maintitle></sb:title><sb:volume-nr>72</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>835</sb:first-page><sb:last-page>839</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib21"><ce:label>21.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Rosenow</ce:surname><ce:given-name>EC</ce:given-name></sb:author><sb:author><ce:surname>O'Connell</ce:surname><ce:given-name>EJ</ce:given-name></sb:author><sb:author><ce:surname>Harrison</ce:surname><ce:given-name>EG</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Desquamative interstitial pneumonia in children</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am J Dis Child</sb:maintitle></sb:title><sb:volume-nr>120</sb:volume-nr></sb:series><sb:date>1970</sb:date></sb:issue><sb:pages><sb:first-page>344</sb:first-page><sb:last-page>348</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib22"><ce:label>22.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Springer</ce:surname><ce:given-name>C</ce:given-name></sb:author><sb:author><ce:surname>Maayan</ce:surname><ce:given-name>C</ce:given-name></sb:author><sb:author><ce:surname>Katzir</ce:surname><ce:given-name>Z</ce:given-name></sb:author><sb:author><ce:surname>Ariel</ce:surname><ce:given-name>I</ce:given-name></sb:author><sb:author><ce:surname>Godfrey</ce:surname><ce:given-name>S</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Chloroquine treatment in desquamative interstitial pneumonia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch Dis Child</sb:maintitle></sb:title><sb:volume-nr>62</sb:volume-nr></sb:series><sb:date>1987</sb:date></sb:issue><sb:pages><sb:first-page>76</sb:first-page><sb:last-page>77</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib23"><ce:label>23.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Leahy</ce:surname><ce:given-name>F</ce:given-name></sb:author><sb:author><ce:surname>Pasterkamp</ce:surname><ce:given-name>H</ce:given-name></sb:author><sb:author><ce:surname>Tal</ce:surname><ce:given-name>A</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Desquamative interstitial pneumonia responsive to chloroquine</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Clin Pediatr</sb:maintitle></sb:title><sb:volume-nr>24</sb:volume-nr></sb:series><sb:date>1985</sb:date></sb:issue><sb:pages><sb:first-page>230</sb:first-page><sb:last-page>232</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib24"><ce:label>24.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Stillwell</ce:surname><ce:given-name>PC</ce:given-name></sb:author><sb:author><ce:surname>Norris</ce:surname><ce:given-name>DG</ce:given-name></sb:author><sb:author><ce:surname>O'Connel</ce:surname><ce:given-name>EJ</ce:given-name></sb:author><sb:author><ce:surname>Rosenow</ce:surname><ce:given-name>EC</ce:given-name></sb:author><sb:author><ce:surname>Weiland</ce:surname><ce:given-name>LH</ce:given-name></sb:author><sb:author><ce:surname>Harrison</ce:surname><ce:given-name>EG</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Desquamative interstitial pneumonitis in children</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Chest</sb:maintitle></sb:title><sb:volume-nr>77</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>165</sb:first-page><sb:last-page>171</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib25"><ce:label>25.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Hewitt</ce:surname><ce:given-name>CJ</ce:given-name></sb:author><sb:author><ce:surname>Hull</ce:surname><ce:given-name>D</ce:given-name></sb:author><sb:author><ce:surname>Keeling</ce:surname><ce:given-name>JW</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Fibrosing alveolitis in infancy and childhood</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch Dis Child</sb:maintitle></sb:title><sb:volume-nr>52</sb:volume-nr></sb:series><sb:date>1977</sb:date></sb:issue><sb:pages><sb:first-page>22</sb:first-page><sb:last-page>37</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib26"><ce:label>26.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Zapletal</ce:surname><ce:given-name>A</ce:given-name></sb:author><sb:author><ce:surname>Houstek</ce:surname><ce:given-name>J</ce:given-name></sb:author><sb:author><ce:surname>Samanek</ce:surname><ce:given-name>M</ce:given-name></sb:author><sb:author><ce:surname>Copova</ce:surname><ce:given-name>M</ce:given-name></sb:author><sb:author><ce:surname>Paul</ce:surname><ce:given-name>T</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Lung function in children and adolescents with idiopathic interstitial pulmonary fibrosis</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pediatr Pulmonol</sb:maintitle></sb:title><sb:volume-nr>1</sb:volume-nr></sb:series><sb:date>1985</sb:date></sb:issue><sb:pages><sb:first-page>154</sb:first-page><sb:last-page>166</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib27"><ce:label>27.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Chetty</ce:surname><ce:given-name>A</ce:given-name></sb:author><sb:author><ce:surname>Bhuyan</ce:surname><ce:given-name>UN</ce:given-name></sb:author><sb:author><ce:surname>Mitra</ce:surname><ce:given-name>DK</ce:given-name></sb:author><sb:author><ce:surname>Roy</ce:surname><ce:given-name>S</ce:given-name></sb:author><sb:author><ce:surname>Deorari</ce:surname><ce:given-name>A</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Cryptogenic fibrosing alveolitis in children</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Ann Allergy</sb:maintitle></sb:title><sb:volume-nr>58</sb:volume-nr></sb:series><sb:date>1987</sb:date></sb:issue><sb:pages><sb:first-page>336</sb:first-page><sb:last-page>340</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib28"><ce:label>28.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Steinkamp</ce:surname><ce:given-name>G</ce:given-name></sb:author><sb:author><ce:surname>Müller</ce:surname><ce:given-name>KM</ce:given-name></sb:author><sb:author><ce:surname>Schirg</ce:surname><ce:given-name>E</ce:given-name></sb:author><sb:author><ce:surname>Von Der Hardt</ce:surname><ce:given-name>H</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Fibrosing alveolitis in childhood</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Acta Paediatr Scand</sb:maintitle></sb:title><sb:volume-nr>79</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>823</sb:first-page><sb:last-page>831</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib29"><ce:label>29.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>O'Brodovich</ce:surname><ce:given-name>HM</ce:given-name></sb:author><sb:author><ce:surname>Moser</ce:surname><ce:given-name>MM</ce:given-name></sb:author><sb:author><ce:surname>Lu</ce:surname><ce:given-name>L</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Familial lymphoid interstitial pneumonia: a long-term follow-up</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pediatrics</sb:maintitle></sb:title><sb:volume-nr>65</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>523</sb:first-page><sb:last-page>528</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib30"><ce:label>30.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Rubinstein</ce:surname><ce:given-name>A</ce:given-name></sb:author><sb:author><ce:surname>Morecki</ce:surname><ce:given-name>R</ce:given-name></sb:author><sb:author><ce:surname>Silverman</ce:surname><ce:given-name>B</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Pulmonary disease in children with acquire immune deficiency syndrome and AIDS-related complex</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J Pediatr</sb:maintitle></sb:title><sb:volume-nr>108</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>498</sb:first-page><sb:last-page>503</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib31"><ce:label>31.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Lovell</ce:surname><ce:given-name>D</ce:given-name></sb:author><sb:author><ce:surname>Lindsley</ce:surname><ce:given-name>C</ce:given-name></sb:author><sb:author><ce:surname>Langston</ce:surname><ce:given-name>C</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Lymphoid interstitial pneumonia in juvenile rheumatoid arthritis</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J Pediatr</sb:maintitle></sb:title><sb:volume-nr>105</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>947</sb:first-page><sb:last-page>950</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib32"><ce:label>32.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Kerem</ce:surname><ce:given-name>E</ce:given-name></sb:author><sb:author><ce:surname>Bentur</ce:surname><ce:given-name>L</ce:given-name></sb:author><sb:author><ce:surname>England</ce:surname><ce:given-name>S</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Sequential pulmonary function measurements during treatment of infantile chronic interstitial pneumonitis</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J Pediatr</sb:maintitle></sb:title><sb:volume-nr>116</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>61</sb:first-page><sb:last-page>67</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib33"><ce:label>33.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Waters</ce:surname><ce:given-name>KA</ce:given-name></sb:author><sb:author><ce:surname>Bale</ce:surname><ce:given-name>P</ce:given-name></sb:author><sb:author><ce:surname>Isaacs</ce:surname><ce:given-name>D</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Successful chloroquine therapy in a child with lymphoid interstitial pneumonitis</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J Pediatr</sb:maintitle></sb:title><sb:volume-nr>119</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>989</sb:first-page><sb:last-page>991</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Clinical spectrum of chronic interstitial lung disease in children</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Clinical spectrum of chronic interstitial lung disease in children</title></titleInfo><name type="personal"><namePart type="given">Leland L.</namePart><namePart type="family">Fan</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation><affiliation>Reprint requests: Leland L. Fan, MD, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson, Denver, CO 80206.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ann L.W.</namePart><namePart type="family">Mullen</namePart><namePart type="termsOfAddress">RN, MS</namePart><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susan M.</namePart><namePart type="family">Brugman</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephen C.</namePart><namePart type="family">Inscore</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David P.</namePart><namePart type="family">Parks</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carl W.</namePart><namePart type="family">White</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Pediatric Pulmonology Natiohal Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA</affiliation><affiliation>Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA</affiliation><affiliation>Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas USA</affiliation><affiliation>*Supported in part (Dr. White) by a Grant-in-Aid and an Established Investigator Award from the American Heart Association National Center, and National Institutes of Health SCOR I P50 L 46481-01.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">To describe the clinical spectrum of interstitial lung disease in children, we reviewed our experience with 48 patients during a 12-year period. Most patients initially had typical findings of restrictive lung disease and hypoxemia. Growth failure or pulmonary hypertension or both were found in more than one third. Specific diagnosis, made in 35 patients (70%), most often required invasive studies, particularly open lung biopsy. Although the diagnostic yield from open lung biopsy was high, the diagnosis of many patients remained uncertain. Many different disorders were encountered. The response to corticosteroids, bronchodilators, and chloroquine was inconsistent. Six patients died, five within 1 year after the initial evaluation. The spectrum of pediatric interstitial lung disease includes a large, heterogeneous group of rare disorders associated with high morbidity and mortallty rates.</abstract><note type="content">Section title: Original article</note><relatedItem type="host"><titleInfo><title>The Journal of Pediatrics</title></titleInfo><titleInfo type="abbreviated"><title>YMPD</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued></originInfo><identifier type="ISSN">0022-3476</identifier><identifier type="PII">S0022-3476(92)X8056-X</identifier><part><date>1992</date><detail type="volume"><number>121</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="issue-pages"><start>839</start><end>1032</end></extent><extent unit="pages"><start>867</start><end>872</end></extent></part></relatedItem><identifier type="istex">22214B84479BCC51693FADC09723EDA4919EB750</identifier><identifier type="ark">ark:/67375/6H6-ZFD0JTGP-8</identifier><identifier type="DOI">10.1016/S0022-3476(05)80330-0</identifier><identifier type="PII">S0022-3476(05)80330-0</identifier><identifier type="ArticleID">05803300</identifier><accessCondition type="use and reproduction" contentType="copyright">©1992 Mosby-Year Book, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Mosby-Year Book, Inc., ©1992</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-ZFD0JTGP-8/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000157 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000157 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:22214B84479BCC51693FADC09723EDA4919EB750
|texte= Clinical spectrum of chronic interstitial lung disease in children
}}
| This area was generated with Dilib version V0.6.33. |  |