Treatment of nonmelanotic hyperpigmentation with the Q-switched ruby laser
Identifieur interne : 000108 ( Istex/Corpus ); précédent : 000107; suivant : 000109Treatment of nonmelanotic hyperpigmentation with the Q-switched ruby laser
Auteurs : Petra Maria Becker-Wegerich ; Annegret Kuhn ; Lucy Malek ; Percy Lehmann ; Mosaad Megahed ; Thomas RuzickaSource :
- Journal of the American Academy of Dermatology [ 0190-9622 ] ; 2000.
English descriptors
- Teeft :
- Acad, Acad dermatol, Antimalarial, Antimalarial agents, Complete disappearance, Cutaneous, Cutaneous lupus erythematosus, Dermatol, Dermatology, Dermis, Erythematosus, First patient, Fitzpatrick skin type, Herpesvirus sarcoma, Histologic findings, Hyperpigmentation, Laser, Laser applications, Laser systems, Laser therapy, Laser treatment, Lesion, Lupus, Melanin, Original magnification, Pigment deposits, Qsrl, Right forearm, Ruby, Ruby laser, Ruzicka, Sarcoma, Selective photothermolysis, Side effects, Significant improvement, Skin biopsy specimen, Skin lesions.
Abstract
Abstract: Hyperpigmentation of the skin is often refractory to conventional therapies, but has significant cosmetic implications if located on visible areas. Because laser systems are capable of removing pigment deposits caused by selective photothermolysis, we addressed the issue of whether the Q-switched ruby laser could be a useful alternative in the treatment of nonmelanotic hyperpigmented skin lesions. We report the successful treatment of a patient with hyperpigmentation caused by iatrogenic human herpesvirus 8–associated Kaposi’s sarcoma and a patient with hyperpigmentation caused by long-term antimalarial therapy for cutaneous lupus erythematosus. In both patients, clinical lightening of the darkly pigmented lesions was seen after a single treatment, and a significant improvement was observed after 3 laser applications. The patients tolerated the laser therapy well without any short-term side effects and did not experience either scarring or considerable textural skin changes. Histologic examination was performed before and after laser treatment to confirm the reduction of the pigment deposits. Our data indicate that treatment of nonmelanotic skin hyperpigmentation with the Q-switched ruby laser might be a safe and powerful therapeutic method. (J Am Acad Dermatol 2000;43:272-4.)
Url:
DOI: 10.1067/mjd.2000.105555
Links to Exploration step
ISTEX:8AE138AA87C53756F75A1FE963B87FE3EFC60D05Le document en format XML
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laser</term><term>Ruzicka</term><term>Sarcoma</term><term>Selective photothermolysis</term><term>Side effects</term><term>Significant improvement</term><term>Skin biopsy specimen</term><term>Skin lesions</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Hyperpigmentation of the skin is often refractory to conventional therapies, but has significant cosmetic implications if located on visible areas. Because laser systems are capable of removing pigment deposits caused by selective photothermolysis, we addressed the issue of whether the Q-switched ruby laser could be a useful alternative in the treatment of nonmelanotic hyperpigmented skin lesions. We report the successful treatment of a patient with hyperpigmentation caused by iatrogenic human herpesvirus 8–associated Kaposi’s sarcoma and a patient with hyperpigmentation caused by long-term antimalarial therapy for cutaneous lupus erythematosus. In both patients, clinical lightening of the darkly pigmented lesions was seen after a single treatment, and a significant improvement was observed after 3 laser applications. The patients tolerated the laser therapy well without any short-term side effects and did not experience either scarring or considerable textural skin changes. Histologic examination was performed before and after laser treatment to confirm the reduction of the pigment deposits. Our data indicate that treatment of nonmelanotic skin hyperpigmentation with the Q-switched ruby laser might be a safe and powerful therapeutic method. 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Because laser systems are capable of removing pigment deposits caused by selective photothermolysis, we addressed the issue of whether the Q-switched ruby laser could be a useful alternative in the treatment of nonmelanotic hyperpigmented skin lesions. We report the successful treatment of a patient with hyperpigmentation caused by iatrogenic human herpesvirus 8–associated Kaposi’s sarcoma and a patient with hyperpigmentation caused by long-term antimalarial therapy for cutaneous lupus erythematosus. In both patients, clinical lightening of the darkly pigmented lesions was seen after a single treatment, and a significant improvement was observed after 3 laser applications. The patients tolerated the laser therapy well without any short-term side effects and did not experience either scarring or considerable textural skin changes. Histologic examination was performed before and after laser treatment to confirm the reduction of the pigment deposits. Our data indicate that treatment of nonmelanotic skin hyperpigmentation with the Q-switched ruby laser might be a safe and powerful therapeutic method. 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scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©2000 American Academy of Dermatology, Inc</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>2000</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Reprint requests: Petra Becker-Wegerich, MD, Department of Dermatology, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.</note><note type="content">Section title: Laser Surgery</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Treatment of nonmelanotic hyperpigmentation with the Q-switched ruby laser</title><author xml:id="author-0000"><persName><forename type="first">Petra Maria</forename><surname>Becker-Wegerich</surname></persName><roleName type="degree">MD</roleName><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Annegret</forename><surname>Kuhn</surname></persName><roleName type="degree">MD</roleName><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Lucy</forename><surname>Malek</surname></persName><roleName type="degree">MD</roleName><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Percy</forename><surname>Lehmann</surname></persName><roleName type="degree">MD</roleName><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Mosaad</forename><surname>Megahed</surname></persName><roleName type="degree">MD</roleName><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Thomas</forename><surname>Ruzicka</surname></persName><roleName type="degree">MD</roleName><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation></author><idno type="istex">8AE138AA87C53756F75A1FE963B87FE3EFC60D05</idno><idno type="ark">ark:/67375/6H6-F38KXP21-4</idno><idno type="DOI">10.1067/mjd.2000.105555</idno><idno type="PII">S0190-9622(00)08497-8</idno><idno type="article-id">08497</idno></analytic><monogr><title level="j">Journal of the American Academy of Dermatology</title><title level="j" type="abbrev">YMJD</title><idno type="pISSN">0190-9622</idno><idno type="PII">S0190-9622(00)X0002-3</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000"></date><biblScope unit="volume">43</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="supplement">P1</biblScope><biblScope unit="page" from="272">272</biblScope><biblScope unit="page" to="274">274</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Hyperpigmentation of the skin is often refractory to conventional therapies, but has significant cosmetic implications if located on visible areas. Because laser systems are capable of removing pigment deposits caused by selective photothermolysis, we addressed the issue of whether the Q-switched ruby laser could be a useful alternative in the treatment of nonmelanotic hyperpigmented skin lesions. We report the successful treatment of a patient with hyperpigmentation caused by iatrogenic human herpesvirus 8–associated Kaposi’s sarcoma and a patient with hyperpigmentation caused by long-term antimalarial therapy for cutaneous lupus erythematosus. In both patients, clinical lightening of the darkly pigmented lesions was seen after a single treatment, and a significant improvement was observed after 3 laser applications. The patients tolerated the laser therapy well without any short-term side effects and did not experience either scarring or considerable textural skin changes. Histologic examination was performed before and after laser treatment to confirm the reduction of the pigment deposits. Our data indicate that treatment of nonmelanotic skin hyperpigmentation with the Q-switched ruby laser might be a safe and powerful therapeutic method. (J Am Acad Dermatol 2000;43:272-4.)</p></abstract></profileDesc><revisionDesc><change when="2000">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-F38KXP21-4/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="gr2"></istex:entity><istex:entity SYSTEM="gr3" NDATA="IMAGE" name="gr3"></istex:entity><istex:entity SYSTEM="gr4" NDATA="IMAGE" name="gr4"></istex:entity></istex:docType><istex:document><article docsubtype="fla" xml:lang="en" version="5.0"><item-info><jid>YMJD</jid><aid>08497</aid><ce:pii>S0190-9622(00)08497-8</ce:pii><ce:doi>10.1067/mjd.2000.105555</ce:doi><ce:copyright type="other" year="2000">American Academy of Dermatology, Inc</ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>Reprint requests: Petra Becker-Wegerich, MD, Department of Dermatology, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Laser Surgery</ce:textfn></ce:dochead><ce:title>Treatment of nonmelanotic hyperpigmentation with the Q-switched ruby laser</ce:title><ce:author-group><ce:author><ce:given-name>Petra Maria</ce:given-name><ce:surname>Becker-Wegerich</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>Annegret</ce:given-name><ce:surname>Kuhn</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>Lucy</ce:given-name><ce:surname>Malek</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>Percy</ce:given-name><ce:surname>Lehmann</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>Mosaad</ce:given-name><ce:surname>Megahed</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>Thomas</ce:given-name><ce:surname>Ruzicka</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:affiliation><ce:textfn>Düsseldorf, Germany</ce:textfn></ce:affiliation><ce:affiliation><ce:textfn>From the Department of Dermatology, Heinrich-Heine-University Düsseldorf</ce:textfn></ce:affiliation></ce:author-group><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">Hyperpigmentation of the skin is often refractory to conventional therapies, but has significant cosmetic implications if located on visible areas. Because laser systems are capable of removing pigment deposits caused by selective photothermolysis, we addressed the issue of whether the Q-switched ruby laser could be a useful alternative in the treatment of nonmelanotic hyperpigmented skin lesions. We report the successful treatment of a patient with hyperpigmentation caused by iatrogenic human herpesvirus 8–associated Kaposi’s sarcoma and a patient with hyperpigmentation caused by long-term antimalarial therapy for cutaneous lupus erythematosus. In both patients, clinical lightening of the darkly pigmented lesions was seen after a single treatment, and a significant improvement was observed after 3 laser applications. The patients tolerated the laser therapy well without any short-term side effects and did not experience either scarring or considerable textural skin changes. Histologic examination was performed before and after laser treatment to confirm the reduction of the pigment deposits. Our data indicate that treatment of nonmelanotic skin hyperpigmentation with the Q-switched ruby laser might be a safe and powerful therapeutic method. (J Am Acad Dermatol 2000;43:272-4.)</ce:simple-para></ce:abstract-sec></ce:abstract></head><body view="all"><ce:sections><ce:para view="all" id="para.0010">Many skin conditions caused by infectious, medication-related, genetic, acquired, and postinflammatory factors are common causes for pigmentary abnormalities.<ce:cross-refs refid="bib1 bib2 bib3"><ce:sup loc="post">1-3</ce:sup></ce:cross-refs> It is important to evaluate the distribution, arrangement, and intensity of the color change for early diagnosis and sufficient therapy. Various therapeutic modalities can be used to treat hyperpigmented skin lesions such as surgical excision, discontinuation of triggering factors, lightening with azelaic acid or hydroquinone creams, camouflaging, or chemical peeling. Because selective photothermolysis with laser systems such as Q-switched ruby (QSRL), alexandrite, neodymium:YAG, and pulsed-dye green light laser is capable of selectively removing pigment deposits,<ce:cross-refs refid="bib4 bib5"><ce:sup loc="post">4,5</ce:sup></ce:cross-refs> we evaluated QSRL treatment as a useful alternative therapy in the management of hyperpigmentation caused by iatrogenic human herpesvirus 8–associated Kaposi’s sarcoma (HHV8-KS) or antimalarial agents.<ce:cross-refs refid="bib6 bib7"><ce:sup loc="post">6,7</ce:sup></ce:cross-refs> The QSRL emits light in the red portion of the visible spectrum at a wavelength of 694 nm, which as been shown to be effective in the treatment of epidermal and dermal cutaneous lesions.<ce:cross-ref refid="bib8"><ce:sup loc="post">8</ce:sup></ce:cross-ref></ce:para><ce:para view="all" id="para.0015">The first patient was a 52-year-old Turkish woman (Fitzpatrick skin type III) with an 18-month history widespread HHV8-KS after systemic glucocorticoid therapy for sarcoidosis of the lung.<ce:cross-ref refid="bib9"><ce:sup loc="post">9</ce:sup></ce:cross-ref> During the immunosuppression she experienced red-brown, livid hyperpigmented patches and tumors on the face, arms, back of the hands, fingers, and legs. After 5 monthly intravenous injections of liposomal doxorubicin (20 mg/cycle), only the facial patches disappeared completely; the tumors on the extremities cleared, leaving strong residual hyperpigmentation (Fig 1, <ce:italic>A</ce:italic> ).
<ce:display><ce:figure id="fig1"><ce:label>Fig. 1</ce:label><ce:caption><ce:simple-para view="all" id="simple-para.0015"><ce:bold>A,</ce:bold> Hyperpigmentation of 52-year-old patient with iatrogenic HHV8-associated Kaposi’s sarcoma. <ce:bold>B,</ce:bold> Almost complete remission 6 weeks after 3 treatments with QSRL.</ce:simple-para></ce:caption><ce:link locator="gr1"></ce:link></ce:figure></ce:display>Skin lesions on the back of the hands were treated 3 times at 6-week intervals with the QSRL (RubyStar, Aesculap-Meditec GmbH, Heroldsberg, Germany; 694 nm, 20 ns, 4 mm) at a fluence of 8 J/cm<ce:sup loc="post">2</ce:sup>. Multiple overlapping pulses were delivered to cover the lesions. Clinical lightening of the darkly pigmented skin lesions was perceived 6 weeks after the first treatment, and significant improvement was observed after 2 additional laser applications (<ce:cross-ref refid="fig1">Fig 1, <ce:italic>B</ce:italic></ce:cross-ref> ). Histologic findings of specimens from the right forearm revealed extensive basal melanin pigmentation as well as widespread deposition of hemosiderin in the mid and reticular dermis, which were both significantly reduced after treatment (Figs 2 and 3).
<ce:display><ce:figure id="figure.0010"><ce:label>Fig. 2</ce:label><ce:caption><ce:simple-para view="all" id="simple-para.0020">Photomicrograph of skin biopsy specimen taken from right forearm of first patient. (Masson-Hampel argentaffin stain; original magnification ×200.) <ce:bold>A,</ce:bold> Before laser treatment extensive melanin pigmentation in basal layer of epidermis and in papillary dermis. <ce:bold>B,</ce:bold> After laser treatment almost complete disappearance of pigmentation.</ce:simple-para></ce:caption><ce:link locator="gr2"></ce:link></ce:figure></ce:display><ce:display><ce:figure id="figure.0015"><ce:label>Fig. 3</ce:label><ce:caption><ce:simple-para view="all" id="simple-para.0025">Photomicrograph of skin biopsy specimen taken from right forearm of first patient. (Iron stain; original magnification ×200.) <ce:bold>A,</ce:bold> Widespread hemosiderin deposits in dermis before laser treatment. <ce:bold>B,</ce:bold> Complete disappearance of deposits after laser treatment.</ce:simple-para></ce:caption><ce:link locator="gr3"></ce:link></ce:figure></ce:display>Interestingly, both chromophores, melanin and hemosiderin, showed absorption by the same wavelength and fluence.</ce:para><ce:para view="all" id="para.0020">The second patient was a 65-year-old white man (Fitzpatrick skin type II) with a 5-year history of lupus erythematosus tumidus, a chronic form of cutaneous lupus erythematosus.<ce:cross-ref refid="bib10"><ce:sup loc="post">10</ce:sup></ce:cross-ref> Although antimalarial agents (chloroquine [Resochin] 250 mg/day for 1 year and hydroxychloroquine [Quensyl] 400 mg/day for an additional 2 years) had led to a complete clearing of the lupus erythematosus tumidus lesions on the face, he experienced dark gray–bluish hyperpigmentation during the therapy (Fig 4, <ce:italic>A</ce:italic> ).
<ce:display><ce:figure id="fig4"><ce:label>Fig. 4</ce:label><ce:caption><ce:simple-para view="all" id="simple-para.0030"><ce:bold>A,</ce:bold> Hyperpigmentation induced by antimalarial agents in 65-year-old patient with cutaneous lupus erythematosus. <ce:bold>B,</ce:bold> Significant improvement 6 weeks after 3 treatments with QSRL.</ce:simple-para></ce:caption><ce:link locator="gr4"></ce:link></ce:figure></ce:display>The pigmented skin lesions were treated 3 times with the QSRL (RubyStar) at a fluence of 8 J/cm<ce:sup loc="post">2</ce:sup>. Each single treated lesion on the face was successfully lightened, and 6 weeks after the last laser application the hyperpigmentation was hardly visible (<ce:cross-ref refid="fig4">Fig 4, <ce:italic>B</ce:italic></ce:cross-ref> ). Before treatment, histologic findings of skin biopsy specimens taken from a pigmented lesion of the left cheek displayed extensive hemosiderin and melanin deposits in the papillary and mid dermis, which were greatly reduced after the therapy. Both patients tolerated the laser applications well without any short-term side effects, and neither experienced scarring or considerable textural changes of the skin.</ce:para><ce:para view="all" id="para.0025">Hyperpigmentation after chemotherapy of HHV8-KS or resulting from antimalarial agents is harmless, but the disfigurement it causes may be psychologically devastating to the affected patient.<ce:cross-ref refid="bib11"><ce:sup loc="post">11</ce:sup></ce:cross-ref> Our data indicate that the QSRL appears to be an appropriate method for the treatment of such hyperpigmentation of the skin; however, a correct diagnosis of the pigmented lesions before treatment is still absolutely necessary.<ce:cross-ref refid="bib12"><ce:sup loc="post">12</ce:sup></ce:cross-ref></ce:para></ce:sections></body><tail view="all"><ce:bibliography view="all" id="bibliography.0010"><ce:section-title>References</ce:section-title><ce:bibliography-sec id="bibliography-sec.0010"><ce:bib-reference id="bib1"><ce:label>1</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>NY</ce:given-name><ce:surname>Kim</ce:surname></sb:author><sb:author><ce:given-name>AG</ce:given-name><ce:surname>Pandya</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Pigmentary diseases</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Med Clin North Am</sb:maintitle></sb:title><sb:volume-nr>82</sb:volume-nr></sb:series><sb:date>1998</sb:date></sb:issue><sb:pages><sb:first-page>1185</sb:first-page><sb:last-page>1207</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib2"><ce:label>2</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>A</ce:given-name><ce:surname>Krebs</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Changes in skin color caused by drugs</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Schweiz Apoth Ztg</sb:maintitle></sb:title><sb:volume-nr>126</sb:volume-nr></sb:series><sb:date>1988</sb:date></sb:issue><sb:pages><sb:first-page>245</sb:first-page><sb:last-page>252</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib3"><ce:label>3</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>L</ce:given-name><ce:surname>Tannenbaum</ce:surname></sb:author><sb:author><ce:given-name>DL</ce:given-name><ce:surname>Tuffanelli</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Antimalarial agents: chloroquine, hydroxychloroquine, quinacrine</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch Dermatol</sb:maintitle></sb:title><sb:volume-nr>116</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>587</sb:first-page><sb:last-page>591</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib4"><ce:label>4</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>S</ce:given-name><ce:surname>Hellwig</ce:surname></sb:author><sb:author><ce:given-name>D</ce:given-name><ce:surname>Petzold</ce:surname></sb:author><sb:author><ce:given-name>K</ce:given-name><ce:surname>König</ce:surname></sb:author><sb:author><ce:given-name>C</ce:given-name><ce:surname>Raulin</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Current status of laser therapy in dermatology</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Hautarzt</sb:maintitle></sb:title><sb:volume-nr>49</sb:volume-nr></sb:series><sb:date>1998</sb:date></sb:issue><sb:pages><sb:first-page>690</sb:first-page><sb:last-page>704</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib5"><ce:label>5</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>MS</ce:given-name><ce:surname>Spicer</ce:surname></sb:author><sb:author><ce:given-name>DJ</ce:given-name><ce:surname>Goldberg</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Lasers in dermatology</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J Am Acad Dermatol</sb:maintitle></sb:title><sb:volume-nr>34</sb:volume-nr></sb:series><sb:date>1996</sb:date></sb:issue><sb:pages><sb:first-page>1</sb:first-page><sb:last-page>25</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib6"><ce:label>6</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>R</ce:given-name><ce:surname>Rüdlinger</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Ruby laser treatment for hyperpigmentation after cytotoxic therapy for AIDS-related Kaposi’s sarcoma</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Br J Dermatol</sb:maintitle></sb:title><sb:volume-nr>138</sb:volume-nr></sb:series><sb:date>1998</sb:date></sb:issue><sb:pages><sb:first-page>924</sb:first-page><sb:last-page>927</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib7"><ce:label>7</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>DJ</ce:given-name><ce:surname>Wallace</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Antimalarial agents and lupus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Rheum Dis Clin North Am</sb:maintitle></sb:title><sb:volume-nr>20</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>243</sb:first-page><sb:last-page>263</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib8"><ce:label>8</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>DJ</ce:given-name><ce:surname>Goldberg</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Benign pigmented lesions of the skin: treatment with the Q-switched ruby laser</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J Dermatol Surg Oncol</sb:maintitle></sb:title><sb:volume-nr>19</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>376</sb:first-page><sb:last-page>379</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib9"><ce:label>9</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>L</ce:given-name><ce:surname>Malek</ce:surname></sb:author><sb:author><ce:given-name>A</ce:given-name><ce:surname>Rönnau</ce:surname></sb:author><sb:author><ce:given-name>M</ce:given-name><ce:surname>Megahed</ce:surname></sb:author><sb:author><ce:given-name>T</ce:given-name><ce:surname>Ruzicka</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>HHV8-assoziierte Kaposi-Sarkome</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Z Hautkr</sb:maintitle></sb:title><sb:volume-nr>74</sb:volume-nr></sb:series><sb:date>1999</sb:date></sb:issue><sb:pages><sb:first-page>374</sb:first-page><sb:last-page>375</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib10"><ce:label>10</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>A</ce:given-name><ce:surname>Kuhn</ce:surname></sb:author><sb:author><ce:given-name>HC</ce:given-name><ce:surname>Schuppe</ce:surname></sb:author><sb:author><ce:given-name>P</ce:given-name><ce:surname>Lehmann</ce:surname></sb:author><sb:author><ce:given-name>G</ce:given-name><ce:surname>Goerz</ce:surname></sb:author><sb:author><ce:given-name>T</ce:given-name><ce:surname>Ruzicka</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Cutaneous manifestations of lupus erythematosus: what is important for rheumatologists?</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Rheumatol Eur</sb:maintitle></sb:title><sb:volume-nr>27</sb:volume-nr></sb:series><sb:date>1998</sb:date></sb:issue><sb:pages><sb:first-page>95</sb:first-page><sb:last-page>101</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib11"><ce:label>11</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>U</ce:given-name><ce:surname>Hohenleutner</ce:surname></sb:author><sb:author><ce:given-name>S</ce:given-name><ce:surname>Michel</ce:surname></sb:author><sb:author><ce:given-name>M</ce:given-name><ce:surname>Landthaler</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Rubinlaser: Medizin oder Kosmetik?</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Z Hautkr</sb:maintitle></sb:title><sb:volume-nr>12</sb:volume-nr></sb:series><sb:date>1995</sb:date></sb:issue><sb:pages><sb:first-page>875</sb:first-page><sb:last-page>876</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib12"><ce:label>12</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:given-name>PM</ce:given-name><ce:surname>Becker-Wegerich</ce:surname></sb:author><sb:author><ce:given-name>K</ce:given-name><ce:surname>Schulte</ce:surname></sb:author><sb:author><ce:given-name>M</ce:given-name><ce:surname>Megahed</ce:surname></sb:author><sb:author><ce:given-name>P</ce:given-name><ce:surname>Lehmann</ce:surname></sb:author><sb:author><ce:given-name>C</ce:given-name><ce:surname>Fritsch</ce:surname></sb:author><sb:author><ce:given-name>T</ce:given-name><ce:surname>Ruzicka</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Laser treatment of melanocytic skin lesions</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Münch Med Wochenschr</sb:maintitle></sb:title><sb:volume-nr>22</sb:volume-nr></sb:series><sb:date>1998</sb:date></sb:issue><sb:pages><sb:first-page>328</sb:first-page><sb:last-page>330</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Treatment of nonmelanotic hyperpigmentation with the Q-switched ruby laser</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Treatment of nonmelanotic hyperpigmentation with the Q-switched ruby laser</title></titleInfo><name type="personal"><namePart type="given">Petra Maria</namePart><namePart type="family">Becker-Wegerich</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Annegret</namePart><namePart type="family">Kuhn</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lucy</namePart><namePart type="family">Malek</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Percy</namePart><namePart type="family">Lehmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mosaad</namePart><namePart type="family">Megahed</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas</namePart><namePart type="family">Ruzicka</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Düsseldorf, GermanyFrom the Department of Dermatology, Heinrich-Heine-University Düsseldorf</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Hyperpigmentation of the skin is often refractory to conventional therapies, but has significant cosmetic implications if located on visible areas. Because laser systems are capable of removing pigment deposits caused by selective photothermolysis, we addressed the issue of whether the Q-switched ruby laser could be a useful alternative in the treatment of nonmelanotic hyperpigmented skin lesions. We report the successful treatment of a patient with hyperpigmentation caused by iatrogenic human herpesvirus 8–associated Kaposi’s sarcoma and a patient with hyperpigmentation caused by long-term antimalarial therapy for cutaneous lupus erythematosus. In both patients, clinical lightening of the darkly pigmented lesions was seen after a single treatment, and a significant improvement was observed after 3 laser applications. The patients tolerated the laser therapy well without any short-term side effects and did not experience either scarring or considerable textural skin changes. Histologic examination was performed before and after laser treatment to confirm the reduction of the pigment deposits. Our data indicate that treatment of nonmelanotic skin hyperpigmentation with the Q-switched ruby laser might be a safe and powerful therapeutic method. (J Am Acad Dermatol 2000;43:272-4.)</abstract><note>Reprint requests: Petra Becker-Wegerich, MD, Department of Dermatology, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.</note><note type="content">Section title: Laser Surgery</note><relatedItem type="host"><titleInfo><title>Journal of the American Academy of Dermatology</title></titleInfo><titleInfo type="abbreviated"><title>YMJD</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued></originInfo><identifier type="ISSN">0190-9622</identifier><identifier type="PII">S0190-9622(00)X0002-3</identifier><part><date>2000</date><detail type="volume"><number>43</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><detail type="supplement"><number>P1</number><caption>Suppl.</caption></detail><extent unit="issue-pages"><start>167</start><end>326</end></extent><extent unit="pages"><start>272</start><end>274</end></extent></part></relatedItem><identifier type="istex">8AE138AA87C53756F75A1FE963B87FE3EFC60D05</identifier><identifier type="ark">ark:/67375/6H6-F38KXP21-4</identifier><identifier type="DOI">10.1067/mjd.2000.105555</identifier><identifier type="PII">S0190-9622(00)08497-8</identifier><identifier type="ArticleID">08497</identifier><accessCondition type="use and reproduction" contentType="copyright">©2000 American Academy of Dermatology, Inc</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>American Academy of Dermatology, Inc, ©2000</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-F38KXP21-4/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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