Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide
Identifieur interne : 000101 ( Istex/Corpus ); précédent : 000100; suivant : 000102Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide
Auteurs : Frances Flanagan ; Louisa Glackin ; Dubhfeasa M. SlatterySource :
- Pediatric Pulmonology [ 8755-6863 ] ; 2013-03.
Abstract
Idiopathic pulmonary hemosiderosis (IPH), a subtype of diffuse alveolar hemorrhage is a rare condition, first described by Virchow in 1864. Historically, it manifests in children in the first decade of life with the combination of hemoptysis, iron deficiency anemia, and alveolar infiltrates on chest radiograph. More recently, diffuse alveolar hemorrhage has been classified by the absence or presence of pulmonary capillaritis (PC), the latter carrying a potential for a poorer outcome. While systemic corticosteroids remain the first line treatment option, other immune modulators have been trailed including hydroxychloroquine, azathioprine, 6‐mercaptopurine, and cyclophosphamide with varying results. Our case demonstrates for the first time, the successful use of intravenous cyclophosphamide in the management of chronic idiopathic PC. Pediatr Pulmonol. 2013; 48:303–305. © 2012 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/ppul.22583
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ISTEX:42BD8BE56D88E616415C3A12F3B018304FC5E1DBLe document en format XML
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Historically, it manifests in children in the first decade of life with the combination of hemoptysis, iron deficiency anemia, and alveolar infiltrates on chest radiograph. More recently, diffuse alveolar hemorrhage has been classified by the absence or presence of pulmonary capillaritis (PC), the latter carrying a potential for a poorer outcome. While systemic corticosteroids remain the first line treatment option, other immune modulators have been trailed including hydroxychloroquine, azathioprine, 6‐mercaptopurine, and cyclophosphamide with varying results. Our case demonstrates for the first time, the successful use of intravenous cyclophosphamide in the management of chronic idiopathic PC. Pediatr Pulmonol. 2013; 48:303–305. © 2012 Wiley Periodicals, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Conflict of interest: None.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Treatment of Chronic Idiopathic PC</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide</title></titleInfo><name type="personal"><namePart type="given">Frances</namePart><namePart type="family">Flanagan</namePart><namePart type="termsOfAddress">MB, BCh</namePart><affiliation>Department of Respiratory Medicine, Children's University Hospital, Dublin, Ireland</affiliation><affiliation>E-mail: fraflanagan@gmail.com</affiliation><affiliation>Correspondence address: Department of Respiratory Medicine, Children's University Hospital, Temple Street, Dublin 1, Ireland.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Louisa</namePart><namePart type="family">Glackin</namePart><namePart type="termsOfAddress">MRCPCH</namePart><affiliation>Department of Respiratory Medicine, Children's University Hospital, Dublin, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dubhfeasa M.</namePart><namePart type="family">Slattery</namePart><namePart type="termsOfAddress">FRCPCH</namePart><affiliation>Department of Respiratory Medicine, Children's University Hospital, Dublin, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="case-report" displayLabel="caseStudy" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2013-03</dateIssued><dateCaptured encoding="w3cdtf">2011-10-25</dateCaptured><dateValid encoding="w3cdtf">2012-04-04</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">1</extent><extent unit="references">16</extent><extent unit="words">1489</extent></physicalDescription><abstract lang="en">Idiopathic pulmonary hemosiderosis (IPH), a subtype of diffuse alveolar hemorrhage is a rare condition, first described by Virchow in 1864. Historically, it manifests in children in the first decade of life with the combination of hemoptysis, iron deficiency anemia, and alveolar infiltrates on chest radiograph. More recently, diffuse alveolar hemorrhage has been classified by the absence or presence of pulmonary capillaritis (PC), the latter carrying a potential for a poorer outcome. While systemic corticosteroids remain the first line treatment option, other immune modulators have been trailed including hydroxychloroquine, azathioprine, 6‐mercaptopurine, and cyclophosphamide with varying results. Our case demonstrates for the first time, the successful use of intravenous cyclophosphamide in the management of chronic idiopathic PC. Pediatr Pulmonol. 2013; 48:303–305. © 2012 Wiley Periodicals, Inc.</abstract><note type="content">*Conflict of interest: None.</note><note type="funding">none reported</note><subject lang="en"><genre>keywords</genre><topic>idiopathic</topic><topic>pulmonary</topic><topic>capillaritis</topic><topic>cyclophosphamide</topic></subject><relatedItem type="host"><titleInfo><title>Pediatric Pulmonology</title></titleInfo><titleInfo type="abbreviated"><title>Pediatr. 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Chest 1992; 102: 959– 960.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>102</number></detail><extent unit="pages"><start>959</start><end>960</end></extent></part><relatedItem type="host"><titleInfo><title>Chest</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>102</number></detail><extent unit="pages"><start>959</start><end>960</end></extent></part></relatedItem></relatedItem><identifier type="istex">42BD8BE56D88E616415C3A12F3B018304FC5E1DB</identifier><identifier type="ark">ark:/67375/WNG-GZK5CB9R-T</identifier><identifier type="DOI">10.1002/ppul.22583</identifier><identifier type="ArticleID">PPUL22583</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-16</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-GZK5CB9R-T/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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