Hydroxychloroquine and postoperative thromboembolism after total hip replacement
Identifieur interne : 000071 ( Istex/Corpus ); précédent : 000070; suivant : 000072Hydroxychloroquine and postoperative thromboembolism after total hip replacement
Auteurs : James R. LoudonSource :
- The American Journal of Medicine [ 0002-9343 ] ; 1988.
English descriptors
- Teeft :
- American journal, Arthroplasty, Charnley, Clin orthop, Deep infection, Deep vein thrombosis, Dose heparin, Embolism, Fibrinogen, Fibrinogen uptake test, Heparin, Hydroxychloroquine, John charnley, Lancet, Loudon, Medicine volume, Patient intolerance, Patient tolerance, Prophylaxis, Pulmonary embolism, Surg, Surgical patients, Thromboembolism, Thrombosis, Venous, Wound healing, Wrightington, Wrightington hospital.
Abstract
Abstract: Evidence for the usefulness of hydroxychloroquine as prophylaxis against thromboembolism after total hip replacement is examined. This agent causes reduction in red blood cell aggregation without prolonging the bleeding time in humans and, experimentally, reduces the size of the thrombus. There is a variably demonstrable reduction in platelet aggregation and blood viscosity in humans. After hip replacement, the venographic incidence of deep vein thrombosis is not influenced by hydroxychloroquine. The incidence of fatal pulmonary embolism appears to be reduced, but a controlled trial against placebo does not exist. There are no serious or irreversible side effects, and wound healing is not affected by the administration of this drug. Hydroxychloroquine remains the prophylaxis of choice in use at the Hip Center, Wrightington Hospital, England, 13 years after its introduction.
Url:
DOI: 10.1016/0002-9343(88)90364-6
Links to Exploration step
ISTEX:55EED8586CCA2E3C97198B4B3BB6C137CD6C659FLe document en format XML
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Loudon</name><affiliation><mods:affiliation>Department of Orthopedic Surgery, Victoria Infirmary, Langside, Glasgow, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">The American Journal of Medicine</title><title level="j" type="abbrev">AJM</title><idno type="ISSN">0002-9343</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">85</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="supplement">S1</biblScope><biblScope unit="page" from="57">57</biblScope><biblScope unit="page" to="61">61</biblScope></imprint><idno type="ISSN">0002-9343</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9343</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>American journal</term><term>Arthroplasty</term><term>Charnley</term><term>Clin orthop</term><term>Deep infection</term><term>Deep vein thrombosis</term><term>Dose heparin</term><term>Embolism</term><term>Fibrinogen</term><term>Fibrinogen uptake test</term><term>Heparin</term><term>Hydroxychloroquine</term><term>John charnley</term><term>Lancet</term><term>Loudon</term><term>Medicine volume</term><term>Patient intolerance</term><term>Patient tolerance</term><term>Prophylaxis</term><term>Pulmonary embolism</term><term>Surg</term><term>Surgical patients</term><term>Thromboembolism</term><term>Thrombosis</term><term>Venous</term><term>Wound healing</term><term>Wrightington</term><term>Wrightington hospital</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Evidence for the usefulness of hydroxychloroquine as prophylaxis against thromboembolism after total hip replacement is examined. This agent causes reduction in red blood cell aggregation without prolonging the bleeding time in humans and, experimentally, reduces the size of the thrombus. There is a variably demonstrable reduction in platelet aggregation and blood viscosity in humans. After hip replacement, the venographic incidence of deep vein thrombosis is not influenced by hydroxychloroquine. The incidence of fatal pulmonary embolism appears to be reduced, but a controlled trial against placebo does not exist. There are no serious or irreversible side effects, and wound healing is not affected by the administration of this drug. 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The incidence of fatal pulmonary embolism appears to be reduced, but a controlled trial against placebo does not exist. There are no serious or irreversible side effects, and wound healing is not affected by the administration of this drug. 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Loudon, Department of Orthopedic Surgery, Victoria Infirmary, Langside, Glasgow, United Kingdom G42 9TY.</note><affiliation>Requests for reprints should be addressed to Dr. James R. Loudon, Department of Orthopedic Surgery, Victoria Infirmary, Langside, Glasgow, United Kingdom G42 9TY.</affiliation><affiliation>Department of Orthopedic Surgery, Victoria Infirmary, Langside, Glasgow, United Kingdom</affiliation></author><idno type="istex">55EED8586CCA2E3C97198B4B3BB6C137CD6C659F</idno><idno type="ark">ark:/67375/6H6-KNNSR5WJ-2</idno><idno type="DOI">10.1016/0002-9343(88)90364-6</idno><idno type="PII">0002-9343(88)90364-6</idno><idno type="article-id">88903646</idno></analytic><monogr><title level="j">The American Journal of Medicine</title><title level="j" type="abbrev">AJM</title><idno type="pISSN">0002-9343</idno><idno type="PII">S0002-9343(00)X0914-X</idno><meeting><addName>Update in Rheumatology: Focus on Hydroxychloroquine, Hyatt Regency Cerromar Beach, Dorado, Puerto Rico</addName><date>19871210</date><date>19871211</date></meeting><editor xml:id="book-author-0000"><persName>Nathan J. Zvaifler</persName></editor><editor xml:id="book-author-0001"><persName>M.D.</persName></editor><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988"></date><biblScope unit="volume">85</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="supplement">S1</biblScope><biblScope unit="page" from="57">57</biblScope><biblScope unit="page" to="61">61</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1988</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Evidence for the usefulness of hydroxychloroquine as prophylaxis against thromboembolism after total hip replacement is examined. This agent causes reduction in red blood cell aggregation without prolonging the bleeding time in humans and, experimentally, reduces the size of the thrombus. There is a variably demonstrable reduction in platelet aggregation and blood viscosity in humans. After hip replacement, the venographic incidence of deep vein thrombosis is not influenced by hydroxychloroquine. The incidence of fatal pulmonary embolism appears to be reduced, but a controlled trial against placebo does not exist. There are no serious or irreversible side effects, and wound healing is not affected by the administration of this drug. Hydroxychloroquine remains the prophylaxis of choice in use at the Hip Center, Wrightington Hospital, England, 13 years after its introduction.</p></abstract></profileDesc><revisionDesc><change when="1988">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-KNNSR5WJ-2/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>AJM</jid><aid>88903646</aid><ce:pii>0002-9343(88)90364-6</ce:pii><ce:doi>10.1016/0002-9343(88)90364-6</ce:doi><ce:copyright type="unknown" year="1988"></ce:copyright></item-info><head><ce:title>Hydroxychloroquine and postoperative thromboembolism after total hip replacement</ce:title><ce:author-group><ce:author><ce:given-name>James R.</ce:given-name><ce:surname>Loudon</ce:surname><ce:degrees>M.B., Ch.B., F.R.C.S.</ce:degrees><ce:cross-ref refid="COR1"><ce:sup loc="post">∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Department of Orthopedic Surgery, Victoria Infirmary, Langside, Glasgow, United Kingdom</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Requests for reprints should be addressed to Dr. James R. Loudon, Department of Orthopedic Surgery, Victoria Infirmary, Langside, Glasgow, United Kingdom G42 9TY.</ce:text></ce:correspondence></ce:author-group><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">Evidence for the usefulness of hydroxychloroquine as prophylaxis against thromboembolism after total hip replacement is examined. This agent causes reduction in red blood cell aggregation without prolonging the bleeding time in humans and, experimentally, reduces the size of the thrombus. There is a variably demonstrable reduction in platelet aggregation and blood viscosity in humans. After hip replacement, the venographic incidence of deep vein thrombosis is not influenced by hydroxychloroquine. The incidence of fatal pulmonary embolism appears to be reduced, but a controlled trial against placebo does not exist. There are no serious or irreversible side effects, and wound healing is not affected by the administration of this drug. Hydroxychloroquine remains the prophylaxis of choice in use at the Hip Center, Wrightington Hospital, England, 13 years after its introduction.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Hydroxychloroquine and postoperative thromboembolism after total hip replacement</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Hydroxychloroquine and postoperative thromboembolism after total hip replacement</title></titleInfo><name type="personal"><namePart type="given">James R.</namePart><namePart type="family">Loudon</namePart><namePart type="termsOfAddress">M.B., Ch.B., F.R.C.S.</namePart><affiliation>Department of Orthopedic Surgery, Victoria Infirmary, Langside, Glasgow, United Kingdom</affiliation><description>Requests for reprints should be addressed to Dr. James R. Loudon, Department of Orthopedic Surgery, Victoria Infirmary, Langside, Glasgow, United Kingdom G42 9TY.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1988</dateIssued><copyrightDate encoding="w3cdtf">1988</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Evidence for the usefulness of hydroxychloroquine as prophylaxis against thromboembolism after total hip replacement is examined. This agent causes reduction in red blood cell aggregation without prolonging the bleeding time in humans and, experimentally, reduces the size of the thrombus. There is a variably demonstrable reduction in platelet aggregation and blood viscosity in humans. After hip replacement, the venographic incidence of deep vein thrombosis is not influenced by hydroxychloroquine. The incidence of fatal pulmonary embolism appears to be reduced, but a controlled trial against placebo does not exist. There are no serious or irreversible side effects, and wound healing is not affected by the administration of this drug. Hydroxychloroquine remains the prophylaxis of choice in use at the Hip Center, Wrightington Hospital, England, 13 years after its introduction.</abstract><relatedItem type="host"><titleInfo><title>The American Journal of Medicine</title></titleInfo><titleInfo type="abbreviated"><title>AJM</title></titleInfo><name type="conference"><namePart>Update in Rheumatology: Focus on Hydroxychloroquine, Hyatt Regency Cerromar Beach, Dorado, Puerto Rico</namePart><namePart type="date">19871210</namePart><namePart type="date">19871211</namePart></name><name type="personal"><namePart>Nathan J. 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