Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells
Identifieur interne : 000060 ( Istex/Corpus ); précédent : 000059; suivant : 000061Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells
Auteurs : Elizabeth A. Perkett ; Wojciech Ornatowski ; Jens F. Poschet ; Vojo DereticSource :
- Pediatric Pulmonology [ 8755-6863 ] ; 2006-08.
English descriptors
- Teeft :
- Assay, Beta, Biol, Breath condensate, Bronchial epithelial cells, Brosis, Cell line, Cell lines, Cell number, Cftr, Cftr gene, Chloroquine, Chloroquine normalizes, Chloroquine treatment, Control cells, Control levels, Cystic, Cystic fibrosis foundation, Epithelial, Epithelial cell line, Epithelial cells, Extracellular, Extracellular microenvironment, Extracellular milieu, Furin, Grant sponsor, Growth factor beta, Individual isoforms, Luciferase, Luciferase activity, Luciferase assay, Lung development, Lung disease, Mexico health sciences center, Mlec, Mlec cells, More acidic, Normal cells, Open bars control cells, Pcep, Pediatr pulmonol, Perkett, Proc natl acad, Pulmonary hypertension, Respir, Respir cell, Responsive promoter, Rheumatoid arthritis, Separate experiments, Stable transfection, Tgfb activity, Total amount.
Abstract
Cystic fibrosis (CF) remains a fatal progressive disease in spite of the discovery and characterization of the CFTR gene. Transforming growth factor beta (TGF‐β) has been implicated in pathophysiology of CF. Previous reports have shown the trans‐Golgi network (TGN) is hyperacdified in CF epithelial cells in culture and that this hyperacidification can be corrected with the membrane permeant weak base, chloroquine. In this study bioactive TGF‐β produced by CF and normal cells was measured using a reporter cell line with a TGF‐β responsive promoter linked to luciferase. Increased levels of TGF‐β were detected in the conditioned media from CF epithelial cells compared to their matched controls—(IB3‐1 vs. S9; pCEP‐R vs. pCEP, CuFi‐4 vs. NuLi‐1). Levels of TGF‐β were normalized with chloroquine indicating that the hyperacidification of the TGN of CF cells is responsible for the altered TGF‐β levels. Pediatr Pulmonol. 2006; 41: 771–778. © 2006 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ppul.20452
Links to Exploration step
ISTEX:A2849A46DE7DDD029AF6A556308714E9B3453E4ALe document en format XML
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Perkett MD</name><affiliations><json:string>Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</json:string><json:string>Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</json:string><json:string>E-mail: eperkett@salud.unm.edu</json:string><json:string>Correspondence address: Pediatrics Pulmonary, MSC 10‐5590, 1 University of New Mexico, Albuquerque, NM 87131‐0001.</json:string></affiliations></json:item><json:item><name>Wojciech Ornatowski PhD</name><affiliations><json:string>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</json:string></affiliations></json:item><json:item><name>Jens F. Poschet PhD</name><affiliations><json:string>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</json:string></affiliations></json:item><json:item><name>Vojo Deretic PhD</name><affiliations><json:string>Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</json:string><json:string>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>pulmonary</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fibrosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chronic inflammation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>furin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>trans‐Golgi Network</value></json:item></subject><articleId><json:string>PPUL20452</json:string></articleId><arkIstex>ark:/67375/WNG-S3CWTFMW-C</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Cystic fibrosis (CF) remains a fatal progressive disease in spite of the discovery and characterization of the CFTR gene. Transforming growth factor beta (TGF‐β) has been implicated in pathophysiology of CF. Previous reports have shown the trans‐Golgi network (TGN) is hyperacdified in CF epithelial cells in culture and that this hyperacidification can be corrected with the membrane permeant weak base, chloroquine. In this study bioactive TGF‐β produced by CF and normal cells was measured using a reporter cell line with a TGF‐β responsive promoter linked to luciferase. Increased levels of TGF‐β were detected in the conditioned media from CF epithelial cells compared to their matched controls—(IB3‐1 vs. S9; pCEP‐R vs. pCEP, CuFi‐4 vs. NuLi‐1). Levels of TGF‐β were normalized with chloroquine indicating that the hyperacidification of the TGN of CF cells is responsible for the altered TGF‐β levels. 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Perkett</json:string><json:string>Wojciech Ornatowski</json:string><json:string>Dan Rifken</json:string><json:string>Jens F. 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A.</forename><surname>Perkett</surname><roleName type="degree">MD</roleName></persName><email>eperkett@salud.unm.edu</email><affiliation><orgName type="division">Department of Pediatrics</orgName><orgName type="institution">University of New Mexico Health Sciences Center</orgName><address><addrLine>Albuquerque</addrLine><addrLine>New Mexico</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation><affiliation><orgName type="laboratory">Department of Cell Biology and Physiology</orgName><orgName type="institution">University of New Mexico Health Sciences Center</orgName><address><addrLine>Albuquerque</addrLine><addrLine>New Mexico</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Wojciech</forename><surname>Ornatowski</surname><roleName type="degree">PhD</roleName></persName><affiliation><orgName type="department">Department of Molecular Genetics 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>Cystic fibrosis (CF) remains a fatal progressive disease in spite of the discovery and characterization of the <hi rend="italic">CFTR</hi> gene. Transforming growth factor beta (TGF‐β) has been implicated in pathophysiology of CF. Previous reports have shown the <hi rend="italic">trans</hi>‐Golgi network (TGN) is hyperacdified in CF epithelial cells in culture and that this hyperacidification can be corrected with the membrane permeant weak base, chloroquine. In this study bioactive TGF‐β produced by CF and normal cells was measured using a reporter cell line with a TGF‐β responsive promoter linked to luciferase. Increased levels of TGF‐β were detected in the conditioned media from CF epithelial cells compared to their matched controls—(IB3‐1 vs. S9; pCEP‐R vs. pCEP, CuFi‐4 vs. NuLi‐1). Levels of TGF‐β were normalized with chloroquine indicating that the hyperacidification of the TGN of CF cells is responsible for the altered TGF‐β levels. Pediatr Pulmonol. 2006; 41: 771–778. © 2006 Wiley‐Liss, Inc.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">pulmonary</term><term xml:id="kwd2">fibrosis</term><term xml:id="kwd3">chronic inflammation</term><term xml:id="kwd4">furin</term><term xml:id="kwd5"><hi rend="italic">trans</hi>‐Golgi Network</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-S3CWTFMW-C/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1099-0496</doi><issn type="print">8755-6863</issn><issn type="electronic">1099-0496</issn><idGroup><id type="product" value="PPUL"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="PEDIATRIC PULMONOLOGY">Pediatric Pulmonology</title><title type="short">Pediatr. 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Transforming growth factor beta (TGF‐β) has been implicated in pathophysiology of CF. Previous reports have shown the <i>trans</i>‐Golgi network (TGN) is hyperacdified in CF epithelial cells in culture and that this hyperacidification can be corrected with the membrane permeant weak base, chloroquine. In this study bioactive TGF‐β produced by CF and normal cells was measured using a reporter cell line with a TGF‐β responsive promoter linked to luciferase. Increased levels of TGF‐β were detected in the conditioned media from CF epithelial cells compared to their matched controls—(IB3‐1 vs. S9; pCEP‐R vs. pCEP, CuFi‐4 vs. NuLi‐1). Levels of TGF‐β were normalized with chloroquine indicating that the hyperacidification of the TGN of CF cells is responsible for the altered TGF‐β levels. Pediatr Pulmonol. 2006; 41: 771–778. © 2006 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Chloroquine Normalizes TGF‐β in CF</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells</title></titleInfo><name type="personal"><namePart type="given">Elizabeth A.</namePart><namePart type="family">Perkett</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</affiliation><affiliation>Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</affiliation><affiliation>E-mail: eperkett@salud.unm.edu</affiliation><affiliation>Correspondence address: Pediatrics Pulmonary, MSC 10‐5590, 1 University of New Mexico, Albuquerque, NM 87131‐0001.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wojciech</namePart><namePart type="family">Ornatowski</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jens F.</namePart><namePart type="family">Poschet</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vojo</namePart><namePart type="family">Deretic</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</affiliation><affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2006-08</dateIssued><dateCaptured encoding="w3cdtf">2006-01-17</dateCaptured><dateValid encoding="w3cdtf">2006-03-04</dateValid><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">4</extent><extent unit="tables">0</extent><extent unit="references">35</extent><extent unit="words">1290</extent></physicalDescription><abstract lang="en">Cystic fibrosis (CF) remains a fatal progressive disease in spite of the discovery and characterization of the CFTR gene. Transforming growth factor beta (TGF‐β) has been implicated in pathophysiology of CF. Previous reports have shown the trans‐Golgi network (TGN) is hyperacdified in CF epithelial cells in culture and that this hyperacidification can be corrected with the membrane permeant weak base, chloroquine. In this study bioactive TGF‐β produced by CF and normal cells was measured using a reporter cell line with a TGF‐β responsive promoter linked to luciferase. Increased levels of TGF‐β were detected in the conditioned media from CF epithelial cells compared to their matched controls—(IB3‐1 vs. S9; pCEP‐R vs. pCEP, CuFi‐4 vs. NuLi‐1). Levels of TGF‐β were normalized with chloroquine indicating that the hyperacidification of the TGN of CF cells is responsible for the altered TGF‐β levels. Pediatr Pulmonol. 2006; 41: 771–778. © 2006 Wiley‐Liss, Inc.</abstract><note type="funding">NIH - No. AI 50825; No. AI 31139; </note><note type="funding">Phillip Morris USA, Inc.</note><note type="funding">University of New Mexico Pediatric Research Funds</note><note type="funding">Cystic Fibrosis Foundation</note><subject lang="en"><genre>keywords</genre><topic>pulmonary</topic><topic>fibrosis</topic><topic>chronic inflammation</topic><topic>furin</topic><topic>trans‐Golgi Network</topic></subject><relatedItem type="host"><titleInfo><title>Pediatric Pulmonology</title></titleInfo><titleInfo type="abbreviated"><title>Pediatr. 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