Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases
Identifieur interne : 000032 ( Istex/Corpus ); précédent : 000031; suivant : 000033Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases
Auteurs : Sarah Braun ; Marion Ferner ; Kai Kronfeld ; Matthias GrieseSource :
- Pediatric Pulmonology [ 8755-6863 ] ; 2015-04.
Abstract
Hydroxychloroquine (HCQ) is one of the drugs frequently used for the treatment of interstitial lung disease (ILD) in children (chILD). This use is off‐label and studies to analyze the effect and safety of HCQ in chILD are lacking. Therefore, a literature research on the usage of chloroquine (CQ) and HCQ in these conditions was done. Eighty‐five case reports and small series in the period from 1984 to 2013 were identified in which children with different diagnoses of ILD were treated with CQ or HCQ, sometimes in combination with other medication including steroids. A favorable response to HCQ or CQ was reported in 35 cases, whereas in the other cases the effect was negative or not clear. The dose of HCQ used was between 5 and 10 mg/kg body weight/day (bw/d). No pharmacokinetic studies have been done. The side effect profile in children seemed to be similar to that in adults. Most often gastrointestinal symptoms were reported. Three patients were found developing retinal changes during the treatment with CQ, whereas in none of the patients treated with HCQ retinal changes were reported. Based on retrospective case reports and small series likely to be reported with bias, the use of HCQ in chILD might be classified as safe. As no prospective data on efficacy and safety of HCQ in chILD are available, systematic collection is necessary. This may be achieved by web‐based registers like the European Management Platform for Childhood Interstitial Lung Diseases. Prospective and controlled investigations of HCQ in patients with chILD are mandatory. Pediatr Pulmonol. 2015; 50:410–419. © 2014 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/ppul.23133
Links to Exploration step
ISTEX:F34AA8E58D1C0E23BBC7ED4F1B0CE8BFCC153EE3Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases</title><author><name sortKey="Braun, Sarah" sort="Braun, Sarah" uniqKey="Braun S" first="Sarah" last="Braun">Sarah Braun</name><affiliation><mods:affiliation>Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University, Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>German Center for Lung Research (DZL), Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence to: Prof. Dr Matthias Griese, Hauner Children's Hospital, University of Munich, Lindwurmstr. 4, 80337 München, Germany. E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: matthias.griese@med.uni-muenchen.de</mods:affiliation></affiliation></author><author><name sortKey="Ferner, Marion" sort="Ferner, Marion" uniqKey="Ferner M" first="Marion" last="Ferner">Marion Ferner</name><affiliation><mods:affiliation>Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz), University Medical Centre, Johannes Gutenberg‐University, Mainz, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kronfeld, Kai" sort="Kronfeld, Kai" uniqKey="Kronfeld K" first="Kai" last="Kronfeld">Kai Kronfeld</name><affiliation><mods:affiliation>Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz), University Medical Centre, Johannes Gutenberg‐University, Mainz, Germany</mods:affiliation></affiliation></author><author><name sortKey="Griese, Matthias" sort="Griese, Matthias" uniqKey="Griese M" first="Matthias" last="Griese">Matthias Griese</name><affiliation><mods:affiliation>Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University, Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>German Center for Lung Research (DZL), Munich, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F34AA8E58D1C0E23BBC7ED4F1B0CE8BFCC153EE3</idno><date when="2015" year="2015">2015</date><idno type="doi">10.1002/ppul.23133</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-DFB7GSN5-V/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000032</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000032</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases</title><author><name sortKey="Braun, Sarah" sort="Braun, Sarah" uniqKey="Braun S" first="Sarah" last="Braun">Sarah Braun</name><affiliation><mods:affiliation>Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University, Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>German Center for Lung Research (DZL), Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence to: Prof. Dr Matthias Griese, Hauner Children's Hospital, University of Munich, Lindwurmstr. 4, 80337 München, Germany. E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: matthias.griese@med.uni-muenchen.de</mods:affiliation></affiliation></author><author><name sortKey="Ferner, Marion" sort="Ferner, Marion" uniqKey="Ferner M" first="Marion" last="Ferner">Marion Ferner</name><affiliation><mods:affiliation>Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz), University Medical Centre, Johannes Gutenberg‐University, Mainz, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kronfeld, Kai" sort="Kronfeld, Kai" uniqKey="Kronfeld K" first="Kai" last="Kronfeld">Kai Kronfeld</name><affiliation><mods:affiliation>Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz), University Medical Centre, Johannes Gutenberg‐University, Mainz, Germany</mods:affiliation></affiliation></author><author><name sortKey="Griese, Matthias" sort="Griese, Matthias" uniqKey="Griese M" first="Matthias" last="Griese">Matthias Griese</name><affiliation><mods:affiliation>Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University, Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>German Center for Lung Research (DZL), Munich, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pediatric Pulmonology</title><title level="j" type="alt">PEDIATRIC PULMONOLOGY</title><idno type="ISSN">8755-6863</idno><idno type="eISSN">1099-0496</idno><imprint><biblScope unit="vol">50</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="410">410</biblScope><biblScope unit="page" to="419">419</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2015-04">2015-04</date></imprint><idno type="ISSN">8755-6863</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">8755-6863</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hydroxychloroquine (HCQ) is one of the drugs frequently used for the treatment of interstitial lung disease (ILD) in children (chILD). This use is off‐label and studies to analyze the effect and safety of HCQ in chILD are lacking. Therefore, a literature research on the usage of chloroquine (CQ) and HCQ in these conditions was done. Eighty‐five case reports and small series in the period from 1984 to 2013 were identified in which children with different diagnoses of ILD were treated with CQ or HCQ, sometimes in combination with other medication including steroids. A favorable response to HCQ or CQ was reported in 35 cases, whereas in the other cases the effect was negative or not clear. The dose of HCQ used was between 5 and 10 mg/kg body weight/day (bw/d). No pharmacokinetic studies have been done. The side effect profile in children seemed to be similar to that in adults. Most often gastrointestinal symptoms were reported. Three patients were found developing retinal changes during the treatment with CQ, whereas in none of the patients treated with HCQ retinal changes were reported. Based on retrospective case reports and small series likely to be reported with bias, the use of HCQ in chILD might be classified as safe. As no prospective data on efficacy and safety of HCQ in chILD are available, systematic collection is necessary. This may be achieved by web‐based registers like the European Management Platform for Childhood Interstitial Lung Diseases. Prospective and controlled investigations of HCQ in patients with chILD are mandatory. Pediatr Pulmonol. 2015; 50:410–419. © 2014 Wiley Periodicals, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Sarah Braun MD</name><affiliations><json:string>Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University, Munich, Germany</json:string><json:string>German Center for Lung Research (DZL), Munich, Germany</json:string><json:string>Correspondence to: Prof. Dr Matthias Griese, Hauner Children's Hospital, University of Munich, Lindwurmstr. 4, 80337 München, Germany. E‐mail:</json:string><json:string>E-mail: matthias.griese@med.uni-muenchen.de</json:string></affiliations></json:item><json:item><name>Marion Ferner MD</name><affiliations><json:string>Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz), University Medical Centre, Johannes Gutenberg‐University, Mainz, Germany</json:string></affiliations></json:item><json:item><name>Kai Kronfeld PhD</name><affiliations><json:string>Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz), University Medical Centre, Johannes Gutenberg‐University, Mainz, Germany</json:string></affiliations></json:item><json:item><name>Matthias Griese MD</name><affiliations><json:string>Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University, Munich, Germany</json:string><json:string>German Center for Lung Research (DZL), Munich, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>antimalarials</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chILD</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chloroquine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hydroxychloroquine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>diffuse parenchymal lung disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Quensyl</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Plaquenil</value></json:item></subject><articleId><json:string>PPUL23133</json:string></articleId><arkIstex>ark:/67375/WNG-DFB7GSN5-V</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>reviewArticle</json:string></originalGenre><abstract>Hydroxychloroquine (HCQ) is one of the drugs frequently used for the treatment of interstitial lung disease (ILD) in children (chILD). This use is off‐label and studies to analyze the effect and safety of HCQ in chILD are lacking. Therefore, a literature research on the usage of chloroquine (CQ) and HCQ in these conditions was done. Eighty‐five case reports and small series in the period from 1984 to 2013 were identified in which children with different diagnoses of ILD were treated with CQ or HCQ, sometimes in combination with other medication including steroids. A favorable response to HCQ or CQ was reported in 35 cases, whereas in the other cases the effect was negative or not clear. The dose of HCQ used was between 5 and 10 mg/kg body weight/day (bw/d). No pharmacokinetic studies have been done. The side effect profile in children seemed to be similar to that in adults. Most often gastrointestinal symptoms were reported. Three patients were found developing retinal changes during the treatment with CQ, whereas in none of the patients treated with HCQ retinal changes were reported. Based on retrospective case reports and small series likely to be reported with bias, the use of HCQ in chILD might be classified as safe. As no prospective data on efficacy and safety of HCQ in chILD are available, systematic collection is necessary. This may be achieved by web‐based registers like the European Management Platform for Childhood Interstitial Lung Diseases. Prospective and controlled investigations of HCQ in patients with chILD are mandatory. Pediatr Pulmonol. 2015; 50:410–419. © 2014 Wiley Periodicals, Inc.</abstract><qualityIndicators><score>10</score><pdfWordCount>6585</pdfWordCount><pdfCharCount>44002</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>593.972 x 792 pts</pdfPageSize><pdfWordsPerPage>659</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>261</abstractWordCount><abstractCharCount>1631</abstractCharCount><keywordCount>7</keywordCount></qualityIndicators><title>Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases</title><genre><json:string>review-article</json:string></genre><host><title>Pediatric Pulmonology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1099-0496</json:string></doi><issn><json:string>8755-6863</json:string></issn><eissn><json:string>1099-0496</json:string></eissn><publisherId><json:string>PPUL</json:string></publisherId><volume>50</volume><issue>4</issue><pages><first>410</first><last>419</last><total>10</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Review</value></json:item><json:item><value>Reviews</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-DFB7GSN5-V</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - respiratory system</json:string><json:string>2 - pediatrics</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - respiratory system</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pulmonary and Respiratory Medicine</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pediatrics, Perinatology, and Child Health</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2015</publicationDate><copyrightDate>2015</copyrightDate><doi><json:string>10.1002/ppul.23133</json:string></doi><id>F34AA8E58D1C0E23BBC7ED4F1B0CE8BFCC153EE3</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-DFB7GSN5-V/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-DFB7GSN5-V/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-DFB7GSN5-V/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases</title><title level="a" type="short">Hydroxychloroquine for chILD</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-QW5Q88H5-V">Wiley Publishing Ltd</publisher><availability><licence>© 2014 Wiley Periodicals, Inc.</licence></availability><date type="published" when="2015-04"></date></publicationStmt><notesStmt><note type="content-type" subtype="review-article" source="reviewArticle" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="review-article"><analytic><title level="a" type="main">Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases</title><title level="a" type="short">Hydroxychloroquine for chILD</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Sarah</forename><surname>Braun</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName type="institution">Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University</orgName><address><settlement>Munich</settlement><country key="DE" xml:lang="en">GERMANY</country></address></affiliation><affiliation><orgName type="institution">German Center for Lung Research (DZL)</orgName><address><settlement>Munich</settlement><country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Marion</forename><surname>Ferner</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName type="division">Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz)</orgName><orgName type="division">University Medical Centre</orgName><orgName type="institution">Johannes Gutenberg‐University</orgName><address><settlement>Mainz</settlement><country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Kai</forename><surname>Kronfeld</surname><roleName type="degree">PhD</roleName></persName><affiliation><orgName type="division">Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz)</orgName><orgName type="division">University Medical Centre</orgName><orgName type="institution">Johannes Gutenberg‐University</orgName><address><settlement>Mainz</settlement><country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Matthias</forename><surname>Griese</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName type="institution">Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University</orgName><address><settlement>Munich</settlement><country key="DE" xml:lang="en">GERMANY</country></address></affiliation><affiliation><orgName type="institution">German Center for Lung Research (DZL)</orgName><address><settlement>Munich</settlement><country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><idno type="istex">F34AA8E58D1C0E23BBC7ED4F1B0CE8BFCC153EE3</idno><idno type="ark">ark:/67375/WNG-DFB7GSN5-V</idno><idno type="DOI">10.1002/ppul.23133</idno><idno type="unit">PPUL23133</idno><idno type="toTypesetVersion">file:PPUL.PPUL23133.pdf</idno></analytic><monogr><title level="j" type="main">Pediatric Pulmonology</title><title level="j" type="alt">PEDIATRIC PULMONOLOGY</title><idno type="pISSN">8755-6863</idno><idno type="eISSN">1099-0496</idno><idno type="book-DOI">10.1002/(ISSN)1099-0496</idno><idno type="book-part-DOI">10.1002/ppul.v50.4</idno><idno type="product">PPUL</idno><imprint><biblScope unit="vol">50</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="410">410</biblScope><biblScope unit="page" to="419">419</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2015-04"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Summary</head><p>Hydroxychloroquine (HCQ) is one of the drugs frequently used for the treatment of interstitial lung disease (ILD) in children (chILD). This use is off‐label and studies to analyze the effect and safety of HCQ in chILD are lacking. Therefore, a literature research on the usage of chloroquine (CQ) and HCQ in these conditions was done.</p><p>Eighty‐five case reports and small series in the period from 1984 to 2013 were identified in which children with different diagnoses of ILD were treated with CQ or HCQ, sometimes in combination with other medication including steroids. A favorable response to HCQ or CQ was reported in 35 cases, whereas in the other cases the effect was negative or not clear. The dose of HCQ used was between 5 and 10 mg/kg body weight/day (bw/d). No pharmacokinetic studies have been done.</p><p>The side effect profile in children seemed to be similar to that in adults. Most often gastrointestinal symptoms were reported. Three patients were found developing retinal changes during the treatment with CQ, whereas in none of the patients treated with HCQ retinal changes were reported.</p><p>Based on retrospective case reports and small series likely to be reported with bias, the use of HCQ in chILD might be classified as safe. As no prospective data on efficacy and safety of HCQ in chILD are available, systematic collection is necessary. This may be achieved by web‐based registers like the European Management Platform for Childhood Interstitial Lung Diseases. Prospective and controlled investigations of HCQ in patients with chILD are mandatory. <hi rend="bold">Pediatr Pulmonol. 2015; 50:410–419.</hi> © 2014 Wiley Periodicals, Inc.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="ppul23133-kwd-0001">antimalarials</term><term xml:id="ppul23133-kwd-0002">chILD</term><term xml:id="ppul23133-kwd-0003">chloroquine</term><term xml:id="ppul23133-kwd-0004">hydroxychloroquine</term><term xml:id="ppul23133-kwd-0005">diffuse parenchymal lung disease</term><term xml:id="ppul23133-kwd-0006">Quensyl</term><term xml:id="ppul23133-kwd-0007">Plaquenil</term></keywords><keywords rend="articleCategory"><term>Review</term></keywords><keywords rend="tocHeading1"><term>Reviews</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-DFB7GSN5-V/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" xml:lang="en" type="serialArticle" xml:id="ppul23133"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1099-0496</doi><issn type="print">8755-6863</issn><issn type="electronic">1099-0496</issn><idGroup><id type="product" value="PPUL"></id></idGroup><titleGroup><title type="main" sort="PEDIATRIC PULMONOLOGY">Pediatric Pulmonology</title><title type="short">Pediatr Pulmonol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi registered="yes">10.1002/ppul.v50.4</doi><copyright ownership="publisher">© 2015 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering type="journalVolume" number="50">50</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="2015-04">April 2015</coverDate></publicationMeta><publicationMeta level="unit" position="130" type="reviewArticle" status="forIssue"><doi>10.1002/ppul.23133</doi><idGroup><id type="unit" value="PPUL23133"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Review</title><title type="tocHeading1">Reviews</title></titleGroup><copyright ownership="publisher">© 2014 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2014-03-29"></event><event type="manuscriptRevised" date="2014-09-20"></event><event type="manuscriptAccepted" date="2014-09-28"></event><event type="xmlCreated" agent="Thomson Digital" date="2014-12-03"></event><event type="publishedOnlineEarlyUnpaginated" date="2014-12-09"></event><event type="firstOnline" date="2014-12-09"></event><event type="publishedOnlineFinalForm" date="2015-03-23"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.7.2 mode:FullText" date="2016-01-05"></event></eventGroup><numberingGroup><numbering type="pageFirst">410</numbering><numbering type="pageLast">419</numbering></numberingGroup><correspondenceTo><lineatedText><line>Correspondence to: Prof. Dr Matthias Griese, Hauner Children's Hospital, University of Munich, Lindwurmstr. 4, 80337 München, Germany. E‐mail:
<email>matthias.griese@med.uni-muenchen.de</email></line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:PPUL.PPUL23133.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases</title><title type="short">Hydroxychloroquine for chILD</title><title type="shortAuthors">Braun et al</title></titleGroup><creators><creator xml:id="ppul23133-cr-0001" creatorRole="author" affiliationRef="#ppul23133-aff-0001 #ppul23133-aff-0002" corresponding="yes"><personName><givenNames>Sarah</givenNames> <familyName>Braun</familyName><degrees>MD</degrees></personName></creator><creator xml:id="ppul23133-cr-0002" creatorRole="author" affiliationRef="#ppul23133-aff-0003"><personName><givenNames>Marion</givenNames> <familyName>Ferner</familyName><degrees>MD</degrees></personName></creator><creator xml:id="ppul23133-cr-0003" creatorRole="author" affiliationRef="#ppul23133-aff-0003"><personName><givenNames>Kai</givenNames> <familyName>Kronfeld</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="ppul23133-cr-0004" creatorRole="author" affiliationRef="#ppul23133-aff-0001 #ppul23133-aff-0002"><personName><givenNames>Matthias</givenNames> <familyName>Griese</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="ppul23133-aff-0001" countryCode="DE"><orgName>Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University</orgName><address><city>Munich</city><country>Germany</country></address></affiliation><affiliation xml:id="ppul23133-aff-0002" countryCode="DE"><orgName>German Center for Lung Research (DZL)</orgName><address><city>Munich</city><country>Germany</country></address></affiliation><affiliation xml:id="ppul23133-aff-0003" countryCode="DE"><orgDiv>Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz)</orgDiv><orgDiv>University Medical Centre</orgDiv><orgName>Johannes Gutenberg‐University</orgName><address><city>Mainz</city><country>Germany</country></address></affiliation></affiliationGroup><keywordGroup type="author" xml:lang="en"><keyword xml:id="ppul23133-kwd-0001">antimalarials</keyword><keyword xml:id="ppul23133-kwd-0002">chILD</keyword><keyword xml:id="ppul23133-kwd-0003">chloroquine</keyword><keyword xml:id="ppul23133-kwd-0004">hydroxychloroquine</keyword><keyword xml:id="ppul23133-kwd-0005">diffuse parenchymal lung disease</keyword><keyword xml:id="ppul23133-kwd-0006">Quensyl</keyword><keyword xml:id="ppul23133-kwd-0007">Plaquenil</keyword></keywordGroup><fundingInfo><fundingAgency>The European Union's Seventh Framework Program</fundingAgency><fundingNumber>305653</fundingNumber></fundingInfo><supportingInformation><p>Additional supporting information may be found in the online version of this article at the publisher's web‐site.</p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:87556863:media:ppul23133:ppul23133-sup-0001-SuppFig_S1"></mediaResource><caption><p><b>Figure S1</b>: 2D‐structures of (a) chloroquine and (b) hydroxychloroquine (PubChem Compound).</p></caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:87556863:media:ppul23133:ppul23133-sup-0001-SuppTab_S1"></mediaResource><caption><p><b>Table S1</b>: Frequency of Potential Adverse Effects Associated With Antimalarial Agents (modified from Lee et al. 2011 [14])</p></caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:87556863:media:ppul23133:ppul23133-sup-0001-SuppTab_S2"></mediaResource><caption><p><b>Table S2</b>: Most Important Drug Interactions of HCQ [14]</p></caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:87556863:media:ppul23133:ppul23133-sup-0001-SuppTab_S3"></mediaResource><caption><p><b>Table S3a</b>: List of Reviewed Case Reports and Small Series Between 1984 and 2013, part 1</p><p><b>Table S3b</b>: List of Reviewed Case Reports and Small Series Between 1984 and 2013, part 2</p></caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><section xml:id="ppul23133-sec-0001"><p>Hydroxychloroquine (HCQ) is one of the drugs frequently used for the treatment of interstitial lung disease (ILD) in children (chILD). This use is off‐label and studies to analyze the effect and safety of HCQ in chILD are lacking. Therefore, a literature research on the usage of chloroquine (CQ) and HCQ in these conditions was done.</p><p>Eighty‐five case reports and small series in the period from 1984 to 2013 were identified in which children with different diagnoses of ILD were treated with CQ or HCQ, sometimes in combination with other medication including steroids. A favorable response to HCQ or CQ was reported in 35 cases, whereas in the other cases the effect was negative or not clear. The dose of HCQ used was between 5 and 10 mg/kg body weight/day (bw/d). No pharmacokinetic studies have been done.</p><p>The side effect profile in children seemed to be similar to that in adults. Most often gastrointestinal symptoms were reported. Three patients were found developing retinal changes during the treatment with CQ, whereas in none of the patients treated with HCQ retinal changes were reported.</p><p>Based on retrospective case reports and small series likely to be reported with bias, the use of HCQ in chILD might be classified as safe. As no prospective data on efficacy and safety of HCQ in chILD are available, systematic collection is necessary. This may be achieved by web‐based registers like the European Management Platform for Childhood Interstitial Lung Diseases. Prospective and controlled investigations of HCQ in patients with chILD are mandatory. <b>Pediatr Pulmonol. 2015; 50:410–419.</b> © 2014 Wiley Periodicals, Inc.</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="ppul23133-note-0002" numbered="no">Conflict of interest: none.</note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Hydroxychloroquine for chILD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases</title></titleInfo><name type="personal"><namePart type="given">Sarah</namePart><namePart type="family">Braun</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University, Munich, Germany</affiliation><affiliation>German Center for Lung Research (DZL), Munich, Germany</affiliation><affiliation>Correspondence to: Prof. Dr Matthias Griese, Hauner Children's Hospital, University of Munich, Lindwurmstr. 4, 80337 München, Germany. E‐mail:</affiliation><affiliation>E-mail: matthias.griese@med.uni-muenchen.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marion</namePart><namePart type="family">Ferner</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz), University Medical Centre, Johannes Gutenberg‐University, Mainz, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kai</namePart><namePart type="family">Kronfeld</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Interdisciplinary Centre for Clinical Trials Mainz (IZKS Mainz), University Medical Centre, Johannes Gutenberg‐University, Mainz, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthias</namePart><namePart type="family">Griese</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dr. von Hauner Children's University Hospital, Ludwig‐Maximilians University, Munich, Germany</affiliation><affiliation>German Center for Lung Research (DZL), Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2015-04</dateIssued><dateCreated encoding="w3cdtf">2014-12-03</dateCreated><dateCaptured encoding="w3cdtf">2014-03-29</dateCaptured><dateValid encoding="w3cdtf">2014-09-28</dateValid><copyrightDate encoding="w3cdtf">2015</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Hydroxychloroquine (HCQ) is one of the drugs frequently used for the treatment of interstitial lung disease (ILD) in children (chILD). This use is off‐label and studies to analyze the effect and safety of HCQ in chILD are lacking. Therefore, a literature research on the usage of chloroquine (CQ) and HCQ in these conditions was done. Eighty‐five case reports and small series in the period from 1984 to 2013 were identified in which children with different diagnoses of ILD were treated with CQ or HCQ, sometimes in combination with other medication including steroids. A favorable response to HCQ or CQ was reported in 35 cases, whereas in the other cases the effect was negative or not clear. The dose of HCQ used was between 5 and 10 mg/kg body weight/day (bw/d). No pharmacokinetic studies have been done. The side effect profile in children seemed to be similar to that in adults. Most often gastrointestinal symptoms were reported. Three patients were found developing retinal changes during the treatment with CQ, whereas in none of the patients treated with HCQ retinal changes were reported. Based on retrospective case reports and small series likely to be reported with bias, the use of HCQ in chILD might be classified as safe. As no prospective data on efficacy and safety of HCQ in chILD are available, systematic collection is necessary. This may be achieved by web‐based registers like the European Management Platform for Childhood Interstitial Lung Diseases. Prospective and controlled investigations of HCQ in patients with chILD are mandatory. Pediatr Pulmonol. 2015; 50:410–419. © 2014 Wiley Periodicals, Inc.</abstract><note type="funding">The European Union's Seventh Framework Program - No. 305653; </note><subject lang="en"><genre>keywords</genre><topic>antimalarials</topic><topic>chILD</topic><topic>chloroquine</topic><topic>hydroxychloroquine</topic><topic>diffuse parenchymal lung disease</topic><topic>Quensyl</topic><topic>Plaquenil</topic></subject><relatedItem type="host"><titleInfo><title>Pediatric Pulmonology</title></titleInfo><titleInfo type="abbreviated"><title>Pediatr Pulmonol.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><note type="content"> Additional supporting information may be found in the online version of this article at the publisher's web‐site.Supporting Info Item: Figure S1: 2D‐structures of (a) chloroquine and (b) hydroxychloroquine (PubChem Compound). - Table S1: Frequency of Potential Adverse Effects Associated With Antimalarial Agents (modified from Lee et al. 2011 [14]) - Table S2: Most Important Drug Interactions of HCQ [14] - Table S3a: List of Reviewed Case Reports and Small Series Between 1984 and 2013, part 1 Table S3b: List of Reviewed Case Reports and Small Series Between 1984 and 2013, part 2 - </note><subject><genre>article-category</genre><topic>Review</topic><topic>Reviews</topic></subject><identifier type="ISSN">8755-6863</identifier><identifier type="eISSN">1099-0496</identifier><identifier type="DOI">10.1002/(ISSN)1099-0496</identifier><identifier type="PublisherID">PPUL</identifier><part><date>2015</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>410</start><end>419</end><total>10</total></extent></part></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0001"><titleInfo><title>ch ILDc. Research in progress: put the orphanage out of business</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bush</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Anthony</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Barbato</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Cunningham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Clement</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Epaud</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Gilbert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Goldbeck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kronfeld</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AG</namePart><namePart type="family">Nicholson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bush A, Anthony G, Barbato A, Cunningham S, Clement A, Epaud R, Gilbert C, Goldbeck L, Kronfeld K, Nicholson AG, et al. ch ILDc. Research in progress: put the orphanage out of business. Thorax 2013; 68:971–973.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>971</start><end>973</end></extent></part><relatedItem type="host"><titleInfo><title>Thorax</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>971</start><end>973</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0002"><titleInfo><title>Incidence and classification of pediatric diffuse parenchymal lung diseases in Germany</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Griese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Haug</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Brasch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Freihorst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Lohse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">von Kries</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Zimmermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Hartl</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Griese M, Haug M, Brasch F, Freihorst A, Lohse P, von Kries R, Zimmermann T, Hartl D. Incidence and classification of pediatric diffuse parenchymal lung diseases in Germany. Orphanet J Rare Dis 2009; 4:26.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>26</start></extent></part><relatedItem type="host"><titleInfo><title>Orphanet J Rare Dis</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>26</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0003"><titleInfo><title>An official American Thoracic Society clinical practice guideline: classification, evaluation, and management of childhood interstitial lung disease in infancy</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Kurland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RR</namePart><namePart type="family">Deterding</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Hagood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LR</namePart><namePart type="family">Young</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AS</namePart><namePart type="family">Brody</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RG</namePart><namePart type="family">Castile</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Dell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LL</namePart><namePart type="family">Fan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hamvas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BC</namePart><namePart type="family">Hilman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Langston</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LM</namePart><namePart type="family">Nogee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">Redding</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thoracic</namePart><namePart type="family">American</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Committee</namePart><namePart type="family">Society</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Childhood</namePart><namePart type="family">on</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lung</namePart><namePart type="family">Interstitial</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kurland G, Deterding RR, Hagood JS, Young LR, Brody AS, Castile RG, Dell S, Fan LL, Hamvas A, Hilman BC, Langston C, Nogee LM, Redding GJ, American Thoracic, Society Committee, on Childhood, Interstitial Lung. An official American Thoracic Society clinical practice guideline: classification, evaluation, and management of childhood interstitial lung disease in infancy. Am J Res Crit Care Med 2013; 188:376–394.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>188</number></detail><extent unit="pages"><start>376</start><end>394</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Res Crit Care Med</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>188</number></detail><extent unit="pages"><start>376</start><end>394</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0004"><titleInfo><title>Interstitial lung diseases in children</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Clement</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Nathan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Epaud</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Fauroux</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Corvol</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Clement A, Nathan N, Epaud R, Fauroux B, Corvol H. Interstitial lung diseases in children. Orphanet J Rare Dis 2010; 5:22.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>22</start></extent></part><relatedItem type="host"><titleInfo><title>Orphanet J Rare Dis</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>22</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0005"><titleInfo><title>Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax</title></titleInfo><name type="personal"><namePart type="given">HS</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Im</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JY</namePart><namePart type="family">Cho</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KS</namePart><namePart type="family">Bae</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TA</namePart><namePart type="family">Klein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Yeom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TS</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Choi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IJ</namePart><namePart type="family">Jang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JW</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lim HS, Im JS, Cho JY, Bae KS, Klein TA, Yeom JS, Kim TS, Choi JS, Jang IJ, Park JW. Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax. Antimicrob Agents Chemother 2009; 53:1468–1475.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>1468</start><end>1475</end></extent></part><relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>1468</start><end>1475</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0006"><titleInfo><title>New insights into mechanisms of therapeutic effects of antimalarial agents in SLE</title></titleInfo><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Wallace</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VS</namePart><namePart type="family">Gudsoorkar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MH</namePart><namePart type="family">Weisman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Venuturupalli</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wallace DJ, Gudsoorkar VS, Weisman MH, Venuturupalli SR. New insights into mechanisms of therapeutic effects of antimalarial agents in SLE. Nat Rev Rheumat 2012; 8:522–533.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>522</start><end>533</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Rev Rheumat</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>522</start><end>533</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0007"><titleInfo><title>Treatment of interstitial lung disease in children</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Dinwiddie</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dinwiddie R. Treatment of interstitial lung disease in children. Paediatr Respir Rev 2004; 5:108–115.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>108</start><end>115</end></extent></part><relatedItem type="host"><titleInfo><title>Paediatr Respir Rev</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>108</start><end>115</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0008"><titleInfo><title>Chronic interstitial lung disease in children</title></titleInfo><name type="personal"><namePart type="given">LL</namePart><namePart type="family">Fan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Langston</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Fan LL, Langston C. Chronic interstitial lung disease in children. Pediatr Pulmonol 1993; 16:184–196.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>184</start><end>196</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Pulmonol</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>184</start><end>196</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0009"><titleInfo><title>Antimalarial medications in dermatology. A review</title></titleInfo><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Weiss</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Weiss JS. Antimalarial medications in dermatology. A review. Dermatol Clin 1991; 9:377–385.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>377</start><end>385</end></extent></part><relatedItem type="host"><titleInfo><title>Dermatol Clin</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>377</start><end>385</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0010"><titleInfo><title>Anti‐malarials in dermatology</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Isaacson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Elgart</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Turner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Isaacson D, Elgart M, Turner ML. Anti‐malarials in dermatology. Int J Dermatol 1982; 21:379–395.</note><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>379</start><end>395</end></extent></part><relatedItem type="host"><titleInfo><title>Int J Dermatol</title></titleInfo><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>379</start><end>395</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0011"><titleInfo><title>Antimalarials in the management of discoid and systemic lupus erythematosus</title></titleInfo><name type="personal"><namePart type="given">EL</namePart><namePart type="family">Dubois</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dubois EL. Antimalarials in the management of discoid and systemic lupus erythematosus. Semin Arthritis Rheum 1978; 8:33–51.</note><part><date>1978</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>33</start><end>51</end></extent></part><relatedItem type="host"><titleInfo><title>Semin Arthritis Rheum</title></titleInfo><part><date>1978</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>33</start><end>51</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0012"><titleInfo><title>A dose‐ranging study of the pharmacokinetics of hydroxychloroquine following intravenous administration to healthy‐ volunteers</title></titleInfo><name type="personal"><namePart type="given">SE</namePart><namePart type="family">Tett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Cutler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RO</namePart><namePart type="family">Day</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KF</namePart><namePart type="family">Brown</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tett SE, Cutler DJ, Day RO, Brown KF. A dose‐ranging study of the pharmacokinetics of hydroxychloroquine following intravenous administration to healthy‐ volunteers. Br J Clin Pharmacol 1988; 26:303–313.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>303</start><end>313</end></extent></part><relatedItem type="host"><titleInfo><title>Br J Clin Pharmacol</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>303</start><end>313</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0013"><titleInfo><title>Population pharmacokinetics of hydroxychloroquine in patients with rheumatoid arthritis</title></titleInfo><name type="personal"><namePart type="given">SJ</namePart><namePart type="family">Carmichael</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Charles</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SE</namePart><namePart type="family">Tett</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Carmichael SJ, Charles B, Tett SE. Population pharmacokinetics of hydroxychloroquine in patients with rheumatoid arthritis. Ther Drug Monit 2003; 25:671–681.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>671</start><end>681</end></extent></part><relatedItem type="host"><titleInfo><title>Ther Drug Monit</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>671</start><end>681</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0014"><titleInfo><title>. Fachinformation Quensyl®., Sanofi‐Aventis Deutschland GmbH 2013.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0015"><titleInfo><title>Hydroxychloroquine is much less active than chloroquine against chloroquine‐resistant Plasmodium falciparum, in agreement with its physicochemical properties</title></titleInfo><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Warhurst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Steele</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IS</namePart><namePart type="family">Adagu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Craig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Cullander</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Warhurst DC, Steele JC, Adagu IS, Craig JC, Cullander C. Hydroxychloroquine is much less active than chloroquine against chloroquine‐resistant Plasmodium falciparum, in agreement with its physicochemical properties. J Antimicrob Chemother 2003; 52:188–193.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>188</start><end>193</end></extent></part><relatedItem type="host"><titleInfo><title>J Antimicrob Chemother</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>188</start><end>193</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0016"><titleInfo><title>The role of antimalarial agents in the treatment of SLE and lupus nephritis</title></titleInfo><name type="personal"><namePart type="given">SJ</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Silverman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Bargman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lee SJ, Silverman E, Bargman JM. The role of antimalarial agents in the treatment of SLE and lupus nephritis. Nat Rev Nephrol 2011; 7:718–729.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>718</start><end>729</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Rev Nephrol</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>718</start><end>729</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0017"><titleInfo><title>Hydroxychloroquine: from malaria to autoimmunity</title></titleInfo><name type="personal"><namePart type="given">I</namePart><namePart type="family">Ben‐Zvi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kivity</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Langevitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Shoenfeld</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ben‐Zvi I, Kivity S, Langevitz P, Shoenfeld Y. Hydroxychloroquine: from malaria to autoimmunity. Clin Rev Allergy Immunol 2012; 42:145–153.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>145</start><end>153</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Rev Allergy Immunol</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>145</start><end>153</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0018"><titleInfo><title>Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells</title></titleInfo><name type="personal"><namePart type="given">HK</namePart><namePart type="family">Ziegler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ER</namePart><namePart type="family">Unanue</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ziegler HK, Unanue ER. Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells. Proc Nat Acad Sci USA 1982; 79:175–178.</note><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>175</start><end>178</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Nat Acad Sci USA</title></titleInfo><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>175</start><end>178</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0019"><titleInfo><title>Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL‐1‐ alpha) and IL‐6 in human monocytes and T cells</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Sperber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Quraishi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TH</namePart><namePart type="family">Kalb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Panja</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Stecher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Mayer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sperber K, Quraishi H, Kalb TH, Panja A, Stecher V, Mayer L. Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL‐1‐ alpha) and IL‐6 in human monocytes and T cells. J Rheumatol 1993; 20:803–808.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>803</start><end>808</end></extent></part><relatedItem type="host"><titleInfo><title>J Rheumatol</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>803</start><end>808</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0020"><titleInfo><title>Effects of antimalarial drugs on phospholipase A and lysophospholipase activities in plasma membrane, mitochondrial, microsomal and cytosolic subcellular fractions of rat liver</title></titleInfo><name type="personal"><namePart type="given">BM</namePart><namePart type="family">Loffler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Bohn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Hesse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kunze</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Loffler BM, Bohn E, Hesse B, Kunze H. Effects of antimalarial drugs on phospholipase A and lysophospholipase activities in plasma membrane, mitochondrial, microsomal and cytosolic subcellular fractions of rat liver. Biochim Biophys Acta 1985; 835:448–455.</note><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>835</number></detail><extent unit="pages"><start>448</start><end>455</end></extent></part><relatedItem type="host"><titleInfo><title>Biochim Biophys Acta</title></titleInfo><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>835</number></detail><extent unit="pages"><start>448</start><end>455</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0021"><titleInfo><title>Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties</title></titleInfo><name type="personal"><namePart type="given">FD</namePart><namePart type="family">Goldman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Gilman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Hollenback</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Kato</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BA</namePart><namePart type="family">Premack</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Rawlings</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Goldman FD, Gilman AL, Hollenback C, Kato RM, Premack BA, Rawlings DJ. Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties. Blood 2000; 95:3460–3466.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><extent unit="pages"><start>3460</start><end>3466</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><extent unit="pages"><start>3460</start><end>3466</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0022"><titleInfo><title>Effect of chloroquine phosphate treatment on serum MMP‐9 and TIMP‐1 levels in patients with systemic lupus erythematosus</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Lesiak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Narbutt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Sysa‐Jedrzejowska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Lukamowicz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DP</namePart><namePart type="family">McCauliffe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Wozniacka</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lesiak A, Narbutt J, Sysa‐Jedrzejowska A, Lukamowicz J, McCauliffe DP, Wozniacka A. Effect of chloroquine phosphate treatment on serum MMP‐9 and TIMP‐1 levels in patients with systemic lupus erythematosus. Lupus 2010; 19:683–688.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>683</start><end>688</end></extent></part><relatedItem type="host"><titleInfo><title>Lupus</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>683</start><end>688</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0023"><titleInfo><title>Mode of action of hydroxychloroquine in RA‐evidence of an inhibitory effect on toll‐like receptor signaling</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Kyburz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Brentano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Gay</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kyburz D, Brentano F, Gay S. Mode of action of hydroxychloroquine in RA‐evidence of an inhibitory effect on toll‐like receptor signaling. Nat Clin Pract Rheumatol 2006; 2:458–459.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>458</start><end>459</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Clin Pract Rheumatol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>458</start><end>459</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0024"><titleInfo><title>Hydroxychloroquine decreases Th17‐related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients</title></titleInfo><name type="personal"><namePart type="given">JC</namePart><namePart type="family">da Silva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HA</namePart><namePart type="family">Mariz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LF</namePart><namePart type="family">da Rocha Jr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PS</namePart><namePart type="family">de Oliveira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AT</namePart><namePart type="family">Dantas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Duarte</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ida</namePart><namePart type="family">Pitta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Galdino</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Pitta</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">da Silva JC, Mariz HA, da Rocha LF Jr, de Oliveira PS, Dantas AT, Duarte AL, Pitta Ida, Galdino R, Pitta SL. Hydroxychloroquine decreases Th17‐related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients. Clinics 2013; 68:766–771.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>766</start><end>771</end></extent></part><relatedItem type="host"><titleInfo><title>Clinics</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>766</start><end>771</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0025"><titleInfo><title>European Society for Clinical M, Infectious Diseases Study Group on Clinical P.Management of imported malaria in Europe</title></titleInfo><name type="personal"><namePart type="given">HH</namePart><namePart type="family">Askling</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Bruneel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Burchard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Castelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PL</namePart><namePart type="family">Chiodini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MP</namePart><namePart type="family">Grobusch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Lopez‐Velez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Paul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Petersen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Popescu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ramharter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Schlagenhauf</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Askling HH, Bruneel F, Burchard G, Castelli F, Chiodini PL, Grobusch MP, Lopez‐Velez R, Paul M, Petersen E, Popescu C, Ramharter M, Schlagenhauf P. European Society for Clinical M, Infectious Diseases Study Group on Clinical P.Management of imported malaria in Europe. Malar J 2012; 11:328.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>328</start></extent></part><relatedItem type="host"><titleInfo><title>Malar J</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>328</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0026"><titleInfo><title>Arguin PM, Tan KR. 2014. Malaria. CDC health information for international travel (Yellow Book). Centers for Disease Control and Prevention.</title></titleInfo><note type="citation/reference">Arguin PM, Tan KR. 2014. Malaria. CDC health information for international travel (Yellow Book). Centers for Disease Control and Prevention.</note><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Arguin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KR</namePart><namePart type="family">Tan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Centers for Disease Control and Prevention</publisher></originInfo><part><date>2014</date></part></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0027"><titleInfo><title>Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Ruiz‐Irastorza</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ramos‐Casals</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Brito‐Zeron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Khamashta</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ruiz‐Irastorza G, Ramos‐Casals M, Brito‐Zeron P, Khamashta MA. Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review. Ann Rheumatol Dis 2010; 69:20–28.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><extent unit="pages"><start>20</start><end>28</end></extent></part><relatedItem type="host"><titleInfo><title>Ann Rheumatol Dis</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><extent unit="pages"><start>20</start><end>28</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0028"><titleInfo><title>Joint European League Against Rheumatism and European Renal Association‐European Dialysis and Transplant Association (EULAR/ERA‐EDTA) recommendations for the management of adult and paediatric lupus nephritis</title></titleInfo><name type="personal"><namePart type="given">GK</namePart><namePart type="family">Bertsias</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Tektonidou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Amoura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Aringer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Bajema</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Berden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Boletis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Cervera</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Dorner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Doria</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bertsias GK, Tektonidou M, Amoura Z, Aringer M, Bajema I, Berden JH, Boletis J, Cervera R, Dorner T, Doria A, et al. Joint European League Against Rheumatism and European Renal Association‐European Dialysis and Transplant Association (EULAR/ERA‐EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheumatol Dis 2012; 71:1771–1782.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>71</number></detail><extent unit="pages"><start>1771</start><end>1782</end></extent></part><relatedItem type="host"><titleInfo><title>Ann Rheumatol Dis</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>71</number></detail><extent unit="pages"><start>1771</start><end>1782</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0029"><titleInfo><title>Product Monograph Plaquenil®. Sanofi‐Aventis Canada Inc 2013.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0030"><titleInfo><title>Dosage of antimalarial drugs for children with juvenile rheumatoid arthritis and systemic lupus erythematosus. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine</title></titleInfo><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Laaksonen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Koskiahde</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Juva</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Laaksonen AL, Koskiahde V, Juva K. Dosage of antimalarial drugs for children with juvenile rheumatoid arthritis and systemic lupus erythematosus. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine. Scand J Rheumatol 1974; 3:103–108.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>103</start><end>108</end></extent></part><relatedItem type="host"><titleInfo><title>Scand J Rheumatol</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>103</start><end>108</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0031"><titleInfo><title>Penicillamine and hydroxychloroquine in the treatment of severe juvenile rheumatoid arthritis. Results of the U.S.A.‐U.S.S.R. double‐blind placebo‐controlled trial</title></titleInfo><name type="personal"><namePart type="given">EJ</namePart><namePart type="family">Brewer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EH</namePart><namePart type="family">Giannini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Kuzmina</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Alekseev</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brewer EJ, Giannini EH, Kuzmina N, Alekseev L. Penicillamine and hydroxychloroquine in the treatment of severe juvenile rheumatoid arthritis. Results of the U.S.A.‐U.S.S.R. double‐blind placebo‐controlled trial. N Engl J Med 1986; 314:1269–1276.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>314</number></detail><extent unit="pages"><start>1269</start><end>1276</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>314</number></detail><extent unit="pages"><start>1269</start><end>1276</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0032"><titleInfo><title>Antimalarials for children: indications, toxicities, and guidelines</title></titleInfo><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Ziering</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LG</namePart><namePart type="family">Rabinowitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NB</namePart><namePart type="family">Esterly</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ziering CL, Rabinowitz LG, Esterly NB. Antimalarials for children: indications, toxicities, and guidelines. J Am Acad Dermatol 1993; 28:764–770.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>764</start><end>770</end></extent></part><relatedItem type="host"><titleInfo><title>J Am Acad Dermatol</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>764</start><end>770</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0033"><titleInfo><title>Dosage of hydroxychloroquine should be based on ideal body weight: comment on the letter by Alarcon</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Easterbrook</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Easterbrook M. Dosage of hydroxychloroquine should be based on ideal body weight: comment on the letter by Alarcon. Arthritis Rheum 2003; 48:863–864; author reply.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>863</start><end>864; author reply</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis Rheum</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>863</start><end>864; author reply</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0034"><titleInfo><title>Antimalarials–are they safe to use in children</title></titleInfo><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Rasmussen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rasmussen JE. Antimalarials–are they safe to use in children. Pediatr Dermatol 1983; 1:89–91.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>89</start><end>91</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Dermatol</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>89</start><end>91</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0035"><titleInfo><title>Lupus profundus in children: treatment with hydroxychloroquine</title></titleInfo><name type="personal"><namePart type="given">JN</namePart><namePart type="family">Fox</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MH</namePart><namePart type="family">Klapman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Rowe</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Fox JN, Klapman MH, Rowe L. Lupus profundus in children: treatment with hydroxychloroquine. J Am Acad Dermatol 1987; 16:839–844.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>839</start><end>844</end></extent></part><relatedItem type="host"><titleInfo><title>J Am Acad Dermatol</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>839</start><end>844</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0036"><titleInfo><title>Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy</title></titleInfo><name type="personal"><namePart type="given">MF</namePart><namePart type="family">Marmor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Kellner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TY</namePart><namePart type="family">Lai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Lyons</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WF</namePart><namePart type="family">Mieler</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Marmor MF, Kellner U, Lai TY, Lyons JS, Mieler WF, American Academy of O. Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy. Ophthalmology 2011; 118:415–422.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>118</number></detail><extent unit="pages"><start>415</start><end>422</end></extent></part><relatedItem type="host"><titleInfo><title>Ophthalmology</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>118</number></detail><extent unit="pages"><start>415</start><end>422</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0037"><titleInfo><title>Position statement: Screening for hydroxychloroquine retinopathy. American College of Rheumatology; 2011.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0038"><titleInfo><title>Hydroxychloroquine in Pediatric Rheumatology. The British Society for Paediatric and Adolescent Rheumatology; 2010.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0039"><titleInfo><title>Chloroquine cardiomyopathy ‐ a review of the literature</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Tonnesmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Kandolf</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Lewalter</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tonnesmann E, Kandolf R, Lewalter T. Chloroquine cardiomyopathy ‐ a review of the literature. Immunopharmacol Immunotoxicol 2013; 35:434–442.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>434</start><end>442</end></extent></part><relatedItem type="host"><titleInfo><title>Immunopharmacol Immunotoxicol</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>434</start><end>442</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0040"><titleInfo><title>Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia</title></titleInfo><name type="personal"><namePart type="given">CY</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FL</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen CY, Wang FL, Lin CC. Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia. Clin Toxicol 2006; 44:173–175.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>173</start><end>175</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Toxicol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>173</start><end>175</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0041"><titleInfo><title>Are 1–2 dangerous? Chloroquine and hydroxychloroquine exposure in toddlers</title></titleInfo><name type="personal"><namePart type="given">ER</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Klein‐Schwartz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Smith ER, Klein‐Schwartz W. Are 1–2 dangerous? Chloroquine and hydroxychloroquine exposure in toddlers. J Emerg Med 2005; 28:437–443.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>437</start><end>443</end></extent></part><relatedItem type="host"><titleInfo><title>J Emerg Med</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>437</start><end>443</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0042"><titleInfo><title>Mühlendahl K, Chloroquin. Vergiftungen im Kindesalter, 4 edition. Stuttgart: Thieme; 2003. pp 144–145.</title></titleInfo><note type="citation/reference">Mühlendahl K, Chloroquin. Vergiftungen im Kindesalter, 4 edition. Stuttgart: Thieme; 2003. pp 144–145.</note><name type="personal"><namePart type="given">K</namePart><namePart type="family">Mühlendahl</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Thieme</publisher><place><placeTerm type="text">Stuttgart</placeTerm></place></originInfo><part><date>2003</date><extent unit="pages"><start>144–145</start></extent></part></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0043"><titleInfo><title>Evidence of transplacental passage of hydroxychloroquine in humans</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Costedoat‐Chalumeau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Amoura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Aymard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wechsler</namePart><namePart type="family">Le TH</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Vauthier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ME</namePart><namePart type="family">Dermer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Darbois</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Piette</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Costedoat‐Chalumeau N, Amoura Z, Aymard G, Le TH Wechsler, Vauthier D, Dermer ME, Darbois Y, Piette JC. Evidence of transplacental passage of hydroxychloroquine in humans. Arthritis Rheum 2002; 46:1123–1124.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>1123</start><end>1124</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis Rheum</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>1123</start><end>1124</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0044"><titleInfo><title>Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: a study of one hundred thirty‐three cases compared with a control group</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Costedoat‐Chalumeau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Amoura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Duhaut</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DL</namePart><namePart type="family">Huong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Sebbough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Wechsler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Vauthier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Denjoy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Lupoglazoff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Piette</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Costedoat‐Chalumeau N, Amoura Z, Duhaut P, Huong DL, Sebbough D, Wechsler B, Vauthier D, Denjoy I, Lupoglazoff JM, Piette JC. Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: a study of one hundred thirty‐three cases compared with a control group. Arthritis Rheum 2003; 48:3207–3211.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>3207</start><end>3211</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis Rheum</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>3207</start><end>3211</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0045"><titleInfo><title>Pregnancy outcome following in utero exposure to hydroxychloroquine: a prospective comparative observational study</title></titleInfo><name type="personal"><namePart type="given">O</namePart><namePart type="family">Diav‐Citrin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Blyakhman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Shechtman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ornoy</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Diav‐Citrin O, Blyakhman S, Shechtman S, Ornoy A. Pregnancy outcome following in utero exposure to hydroxychloroquine: a prospective comparative observational study. Reprod Toxicol 2013; 39:58–62.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>58</start><end>62</end></extent></part><relatedItem type="host"><titleInfo><title>Reprod Toxicol</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>58</start><end>62</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0046"><titleInfo><title>Hydroxychloroquine during pregnancy: a review of retinal toxicity in the newborns</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Tarfaoui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Autret‐Leca</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Mazjoub</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Cissoko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AP</namePart><namePart type="family">Jonville‐Bera</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tarfaoui N, Autret‐Leca E, Mazjoub S, Cissoko H, Jonville‐Bera AP. Hydroxychloroquine during pregnancy: a review of retinal toxicity in the newborns. Therapie 2013; 68:43–47.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>43</start><end>47</end></extent></part><relatedItem type="host"><titleInfo><title>Therapie</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>43</start><end>47</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0047"><titleInfo><title>Ocular toxicity in children exposed in utero to antimalarial drugs: review of the literature</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Osadchy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Ratnapalan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Koren</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Osadchy A, Ratnapalan T, Koren G. Ocular toxicity in children exposed in utero to antimalarial drugs: review of the literature. J Rheumatol 2011; 38:2504–2508.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>2504</start><end>2508</end></extent></part><relatedItem type="host"><titleInfo><title>J Rheumatol</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>2504</start><end>2508</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0048"><titleInfo><title>Treatment of malaria (Guidelines For Clinicians). Centers for disease control and prevention (CDC); 2013.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0049"><titleInfo><title>Multifaceted effects of hydroxychloroquine in human disease</title></titleInfo><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">Olsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Schleich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DR</namePart><namePart type="family">Karp</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Olsen NJ, Schleich MA, Karp DR. Multifaceted effects of hydroxychloroquine in human disease. Semin Arthritis Rheum 2013.</note><part><date>2013</date></part><relatedItem type="host"><titleInfo><title>Semin Arthritis Rheum</title></titleInfo><part><date>2013</date></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0050"><titleInfo><title>Aktories K, Förstermann U, Hofmann FB, Starke K. 2009. Allgemeine und spezielle Pharmakologie und Toxikologie. Munich: Elsevier GmbH.</title></titleInfo><note type="citation/reference">Aktories K, Förstermann U, Hofmann FB, Starke K. 2009. Allgemeine und spezielle Pharmakologie und Toxikologie. Munich: Elsevier GmbH.</note><name type="personal"><namePart type="given">K</namePart><namePart type="family">Aktories</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Förstermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FB</namePart><namePart type="family">Hofmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Starke</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Elsevier</publisher><place><placeTerm type="text">Munich</placeTerm></place></originInfo><part><date>2009</date></part></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0051"><titleInfo><title>Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations</title></titleInfo><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KD</namePart><namePart type="family">Miller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FC</namePart><namePart type="family">Churchill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Berry</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Brown</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SB</namePart><namePart type="family">Williams</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BM</namePart><namePart type="family">Greenwood</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">White NJ, Miller KD, Churchill FC, Berry C, Brown J, Williams SB, Greenwood BM. Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations. N Engl J Med 1988; 319:1493–1500.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>319</number></detail><extent unit="pages"><start>1493</start><end>1500</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>319</number></detail><extent unit="pages"><start>1493</start><end>1500</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0052"><titleInfo><title>Dermatomyositis</title></titleInfo><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Callen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Callen JP. Dermatomyositis. Lancet 2000; 355:53–57.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>355</number></detail><extent unit="pages"><start>53</start><end>57</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>355</number></detail><extent unit="pages"><start>53</start><end>57</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0053"><titleInfo><title>Lupus erythematosus panniculitis in children: report of three cases and review of previously reported cases</title></titleInfo><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Weingartner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Zedek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CN</namePart><namePart type="family">Burkhart</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DS</namePart><namePart type="family">Morrell</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Weingartner JS, Zedek DC, Burkhart CN, Morrell DS. Lupus erythematosus panniculitis in children: report of three cases and review of previously reported cases. Pediatr Dermatol 2012; 29:169–176.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>169</start><end>176</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Dermatol</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>169</start><end>176</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0054"><titleInfo><title>Childhood discoid, lupus erythematosus, antimalarials</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Meurer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Meurer M, Childhood discoid, lupus erythematosus, antimalarials. Dermatology 2003; 207:133.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>207</number></detail><extent unit="pages"><start>133</start></extent></part><relatedItem type="host"><titleInfo><title>Dermatology</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>207</number></detail><extent unit="pages"><start>133</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0055"><titleInfo><title>Slow‐acting antirheumatic drugs in chronic arthritis of childhood</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Grondin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Malleson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RE</namePart><namePart type="family">Petty</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Grondin C, Malleson P, Petty RE. Slow‐acting antirheumatic drugs in chronic arthritis of childhood. Semin Arthritis Rheum 1988; 18:38–47.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>38</start><end>47</end></extent></part><relatedItem type="host"><titleInfo><title>Semin Arthritis Rheum</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>38</start><end>47</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0056"><titleInfo><title>Guidelines for monitoring drug therapy in rheumatoid arthritis. American College of Rheumatology Ad Hoc Committee on Clinical Guidelines. Arthritis Rheum 1996;39:723–731.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0057"><titleInfo><title>Perceptions and realities of testing for alcohol and other drugs in trauma patients</title></titleInfo><name type="personal"><namePart type="given">DB</namePart><namePart type="family">Rootman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Mustard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Kalia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Ahmed</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rootman DB, Mustard R, Kalia V, Ahmed N. Perceptions and realities of testing for alcohol and other drugs in trauma patients. J Trauma 2007; 63:1370–1373.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>1370</start><end>1373</end></extent></part><relatedItem type="host"><titleInfo><title>J Trauma</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>1370</start><end>1373</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0058"><titleInfo><title>Evidence‐based therapy for cutaneous sarcoidosis</title></titleInfo><name type="personal"><namePart type="given">RP</namePart><namePart type="family">Baughman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EE</namePart><namePart type="family">Lower</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Baughman RP, Lower EE. Evidence‐based therapy for cutaneous sarcoidosis. Clin Dermatol 2007; 25:334–340.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>334</start><end>340</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Dermatol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>334</start><end>340</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0059"><titleInfo><title>Randomized trial of prolonged chloroquine therapy in advanced pulmonary sarcoidosis</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Baltzan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Mehta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TH</namePart><namePart type="family">Kirkham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MG</namePart><namePart type="family">Cosio</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Baltzan M, Mehta S, Kirkham TH, Cosio MG. Randomized trial of prolonged chloroquine therapy in advanced pulmonary sarcoidosis. Am J Respir Crit Care Med 1999; 160:192–197.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>160</number></detail><extent unit="pages"><start>192</start><end>197</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Respir Crit Care Med</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>160</number></detail><extent unit="pages"><start>192</start><end>197</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0060"><titleInfo><title>Fatal desquamative interstitial pneumonia in three infants siblings</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Tal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Maor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Bar‐Ziv</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Gorodischer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tal A, Maor E, Bar‐Ziv J, Gorodischer R. Fatal desquamative interstitial pneumonia in three infants siblings. J Pediatr 1984; 104:873–876.</note><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>104</number></detail><extent unit="pages"><start>873</start><end>876</end></extent></part><relatedItem type="host"><titleInfo><title>J Pediatr</title></titleInfo><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>104</number></detail><extent unit="pages"><start>873</start><end>876</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0061"><titleInfo><title>Desquamative interstitial pneumonia responsive to chloroquine</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Leahy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Pasterkamp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Tal</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Leahy F, Pasterkamp H, Tal A. Desquamative interstitial pneumonia responsive to chloroquine. Clin Pediatr 1985; 24:230–232.</note><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>230</start><end>232</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Pediatr</title></titleInfo><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>230</start><end>232</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0062"><titleInfo><title>Familial lung disease associated with proliferation and desquamation of type II pneumonocytes</title></titleInfo><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Farrell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EF</namePart><namePart type="family">Gilbert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JJ</namePart><namePart type="family">Zimmerman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TF</namePart><namePart type="family">Warner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TN</namePart><namePart type="family">Saari</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Farrell PM, Gilbert EF, Zimmerman JJ, Warner TF, Saari TN. Familial lung disease associated with proliferation and desquamation of type II pneumonocytes. Am J Dis Child 1986; 140:262–266.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>140</number></detail><extent unit="pages"><start>262</start><end>266</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Dis Child</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>140</number></detail><extent unit="pages"><start>262</start><end>266</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0063"><titleInfo><title>Familial desquamative interstitial pneumonitis occurring in infants</title></titleInfo><name type="personal"><namePart type="given">JJ</namePart><namePart type="family">Buchino</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WJ</namePart><namePart type="family">Keenan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JT</namePart><namePart type="family">Algren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KE</namePart><namePart type="family">Bove</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Buchino JJ, Keenan WJ, Algren JT, Bove KE. Familial desquamative interstitial pneumonitis occurring in infants. Am J Med Genet Suppl 1987; 3:285–291.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>285</start><end>291</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Med Genet Suppl</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>285</start><end>291</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0064"><titleInfo><title>Sequential pulmonary function measurements during treatment of infantile chronic interstitial pneumonitis</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Kerem</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Bentur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">England</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Reisman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">O'Brodovich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AC</namePart><namePart type="family">Bryan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Levison</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kerem E, Bentur L, England S, Reisman J, O'Brodovich H, Bryan AC, Levison H. Sequential pulmonary function measurements during treatment of infantile chronic interstitial pneumonitis. J Pediatr 1990; 116:61–67.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>116</number></detail><extent unit="pages"><start>61</start><end>67</end></extent></part><relatedItem type="host"><titleInfo><title>J Pediatr</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>116</number></detail><extent unit="pages"><start>61</start><end>67</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0065"><titleInfo><title>A case of fibrosing alveolitis in childhood</title></titleInfo><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Spencer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Price</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Spencer DA, Price JF. A case of fibrosing alveolitis in childhood. J R Soc Med 1991; 84:234–235.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>234</start><end>235</end></extent></part><relatedItem type="host"><titleInfo><title>J R Soc Med</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>234</start><end>235</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0066"><titleInfo><title>Successful chloroquine therapy in a child with lymphoid interstitial pneumonitis</title></titleInfo><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Waters</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Bale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Isaacs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Mellis</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Waters KA, Bale P, Isaacs D, Mellis C. Successful chloroquine therapy in a child with lymphoid interstitial pneumonitis. J Pediatr 1991; 119:989–991.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>989</start><end>991</end></extent></part><relatedItem type="host"><titleInfo><title>J Pediatr</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>989</start><end>991</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0067"><titleInfo><title>Cellular interstitial pneumonitis in infants. A clinicopathologic study</title></titleInfo><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Schroeder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Shannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EJ</namePart><namePart type="family">Mark</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Schroeder SA, Shannon DC, Mark EJ. Cellular interstitial pneumonitis in infants. A clinicopathologic study. Chest 1992; 101:1065–1069.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>101</number></detail><extent unit="pages"><start>1065</start><end>1069</end></extent></part><relatedItem type="host"><titleInfo><title>Chest</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>101</number></detail><extent unit="pages"><start>1065</start><end>1069</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0068"><titleInfo><title>Chloroquine in idiopathic pulmonary haemosiderosis</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bush</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MN</namePart><namePart type="family">Sheppard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JO</namePart><namePart type="family">Warner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bush A, Sheppard MN, Warner JO. Chloroquine in idiopathic pulmonary haemosiderosis. Arch Dis Child 1992; 67:625–627.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>67</number></detail><extent unit="pages"><start>625</start><end>627</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Dis Child</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>67</number></detail><extent unit="pages"><start>625</start><end>627</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0069"><titleInfo><title>Clinical spectrum of chronic interstitial lung disease in children</title></titleInfo><name type="personal"><namePart type="given">LL</namePart><namePart type="family">Fan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Mullen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Brugman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Inscore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DP</namePart><namePart type="family">Parks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CW</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Fan LL, Mullen AL, Brugman SM, Inscore SC, Parks DP, White CW. Clinical spectrum of chronic interstitial lung disease in children. J Pediatr 1992; 121:867–872.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>121</number></detail><extent unit="pages"><start>867</start><end>872</end></extent></part><relatedItem type="host"><titleInfo><title>J Pediatr</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>121</number></detail><extent unit="pages"><start>867</start><end>872</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0070"><titleInfo><title>Treatment of lymphoid interstitial pneumonia with chloroquine</title></titleInfo><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Campos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Simonetti</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Campos JM, Simonetti JP. Treatment of lymphoid interstitial pneumonia with chloroquine. J Pediatr 1993; 122:503.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><extent unit="pages"><start>503</start></extent></part><relatedItem type="host"><titleInfo><title>J Pediatr</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><extent unit="pages"><start>503</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0071"><titleInfo><title>Chloroquine treatment of interstitial lung disease in children</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Avital</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Godfrey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Maayan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Diamant</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Springer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Avital A, Godfrey S, Maayan C, Diamant Y, Springer C. Chloroquine treatment of interstitial lung disease in children. Pediatr Pulmonol 1994; 18:356–360.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>356</start><end>360</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Pulmonol</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>356</start><end>360</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0072"><titleInfo><title>Fibrosing alveolitis and desquamative interstitial pneumonitis</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Sharief</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">OF</namePart><namePart type="family">Crawford</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Dinwiddie</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sharief N, Crawford OF, Dinwiddie R. Fibrosing alveolitis and desquamative interstitial pneumonitis. Pediatr Pulmonol 1994; 17:359–365.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>359</start><end>365</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Pulmonol</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>359</start><end>365</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0073"><titleInfo><title>Familial interstitial lung disease in children: response to chloroquine treatment in one sibling with desquamative interstitial pneumonitis</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Balasubramanyan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Murphy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">O'Sullivan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EJ</namePart><namePart type="family">O'Connell</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Balasubramanyan N, Murphy A, O'Sullivan J, O'Connell EJ. Familial interstitial lung disease in children: response to chloroquine treatment in one sibling with desquamative interstitial pneumonitis. Pediatr Pulmonol 1997; 23:55–61.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>55</start><end>61</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Pulmonol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>55</start><end>61</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0074"><titleInfo><title>Fatal desquamative interstitial pneumonia associated with proven CMV infection in an 8‐month‐old boy</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Schroten</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Manz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kohler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Wolf</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Brockmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Riedel</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Schroten H, Manz S, Kohler H, Wolf U, Brockmann M, Riedel F. Fatal desquamative interstitial pneumonia associated with proven CMV infection in an 8‐month‐old boy. Pediatr Pulmonol 1998; 25:345–347.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>345</start><end>347</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Pulmonol</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>345</start><end>347</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0075"><titleInfo><title>A four‐month‐old girl with chronic cyanosis and diffuse pulmonary infiltrates. Cellular Interstitial pneumonitis</title></titleInfo><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Boyce</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EJ</namePart><namePart type="family">Mark</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RT</namePart><namePart type="family">Bramson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Shannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Youth</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Boyce JA, Mark EJ, Bramson RT, Shannon DC, Youth B. A four‐month‐old girl with chronic cyanosis and diffuse pulmonary infiltrates. Cellular Interstitial pneumonitis. N Engl J Med 1999; 341:2075–2083.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>341</number></detail><extent unit="pages"><start>2075</start><end>2083</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>341</number></detail><extent unit="pages"><start>2075</start><end>2083</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0076"><titleInfo><title>Idiopathic pulmonary fibrosis in infants: good prognosis with conservative management</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Hacking</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Smyth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Shaw</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Kokia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Carty</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Heaf</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hacking D, Smyth R, Shaw N, Kokia G, Carty H, Heaf D. Idiopathic pulmonary fibrosis in infants: good prognosis with conservative management. Arch Dis Child 2000; 83:152–157.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>152</start><end>157</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Dis Child</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>152</start><end>157</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0077"><titleInfo><title>Idiopathic interstitial pneumonitis in children: a national survey in the United Kingdom and Ireland</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Dinwiddie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Sharief</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Crawford</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dinwiddie R, Sharief N, Crawford O. Idiopathic interstitial pneumonitis in children: a national survey in the United Kingdom and Ireland. Pediatr Pulmonol 2002; 34:23–29.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>23</start><end>29</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Pulmonol</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>23</start><end>29</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0078"><titleInfo><title>Cellular interstitial pneumonitis in children: response to hydroxychloroquine treatment in two Cases</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Nikolaidou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Charocopos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Anagnostopoulos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Lazopoulou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kairis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Lourida</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Tzoumakas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Tsiligiannis</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nikolaidou P, Charocopos E, Anagnostopoulos G, Lazopoulou D, Kairis M, Lourida A, Tzoumakas K, Tsiligiannis T. Cellular interstitial pneumonitis in children: response to hydroxychloroquine treatment in two Cases. Pediatr Asthma Allergy Immunol 2003; 16:45–51.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>45</start><end>51</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Asthma Allergy Immunol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>45</start><end>51</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0079"><titleInfo><title>Hydroxychloroquine and surfactant protein C deficiency</title></titleInfo><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Rosen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Waltz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rosen DM, Waltz DA. Hydroxychloroquine and surfactant protein C deficiency. N Engl J Med 2005; 352:207–208.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>352</number></detail><extent unit="pages"><start>207</start><end>208</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>352</number></detail><extent unit="pages"><start>207</start><end>208</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0080"><titleInfo><title>Familial interstitial lung disease in two young Korean sisters</title></titleInfo><name type="personal"><namePart type="given">HB</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SY</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JY</namePart><namePart type="family">Jang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Huh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SJ</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SJ</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kim HB, Lee SY, Kim JH, Jang JY, Huh J, Park SJ, Hong SJ. Familial interstitial lung disease in two young Korean sisters. J Korean Med Sci 2005; 20:1066–1069.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>1066</start><end>1069</end></extent></part><relatedItem type="host"><titleInfo><title>J Korean Med Sci</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>1066</start><end>1069</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0081"><titleInfo><title>Familial interstitial disease with I73T mutation: a mid‐ and long‐term study</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Abou Taam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Jaubert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Emond</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Le Bourgeois</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Epaud</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Karila</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Feldmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Scheinmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">de Blic</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Abou Taam R, Jaubert F, Emond S, Le Bourgeois M, Epaud R, Karila C, Feldmann D, Scheinmann P, de Blic J. Familial interstitial disease with I73T mutation: a mid‐ and long‐term study. Pediatr Pulmonol 2009; 44:167–175.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>167</start><end>175</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Pulmonol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>167</start><end>175</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0082"><titleInfo><title>Characteristics of disorders associated with genetic mutations of surfactant protein C</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Thouvenin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Taam</namePart><namePart type="family">Abou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Flamein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Guillot</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Le Bourgeois</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Reix</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Fayon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Counil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Depontbriand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Feldmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Pointe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HD</namePart><namePart type="family">de Blic</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Clement</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Epaud</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Thouvenin G, Abou Taam, Flamein R, Guillot F, Le Bourgeois L, Reix M, Fayon P, Counil M, Depontbriand F, Feldmann U, Pointe D, de Blic HD, Clement J, Epaud A. Characteristics of disorders associated with genetic mutations of surfactant protein C. Arch Dis Child 2010; 95:449–454.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><extent unit="pages"><start>449</start><end>454</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Dis Child</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><extent unit="pages"><start>449</start><end>454</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0083"><titleInfo><title>A combination of intravenous immunoglobulin and pulse methylprednisolone extended survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: a case report</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Jirarattanasopa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Tantikul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Vichyanond</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Pacharn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Visitsunthorn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Suttinont</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Jirapongsananuruk</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jirarattanasopa N, Tantikul C, Vichyanond P, Pacharn P, Visitsunthorn N, Suttinont P, Jirapongsananuruk O. A combination of intravenous immunoglobulin and pulse methylprednisolone extended survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: a case report. Asian Pac J Allergy Immunol 2010; 28:200–205.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>200</start><end>205</end></extent></part><relatedItem type="host"><titleInfo><title>Asian Pac J Allergy Immunol</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>200</start><end>205</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0084"><titleInfo><title>ABCA3 transporter deficiency</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Hayes Jr.</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EA</namePart><namePart type="family">Lloyd</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Fitch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bush</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hayes D Jr., Lloyd EA, Fitch JA, Bush A. ABCA3 transporter deficiency. Am J Respir Crit Care Med 2012; 186:807.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>186</number></detail><extent unit="pages"><start>807</start></extent></part><relatedItem type="host"><titleInfo><title>Am J Respir Crit Care Med</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>186</number></detail><extent unit="pages"><start>807</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0085"><titleInfo><title>Interstitial lung disease in two brothers with novel compound heterozygous ABCA3 mutations</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kitazawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Moriya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Niizuma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kawano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Saito‐Nanjo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Uchiyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Rikiishi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Sasahara</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Sakamoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Setoguchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kure</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kitazawa H, Moriya K, Niizuma H, Kawano K, Saito‐Nanjo Y, Uchiyama T, Rikiishi T, Sasahara Y, Sakamoto O, Setoguchi Y, Kure S. Interstitial lung disease in two brothers with novel compound heterozygous ABCA3 mutations. Eur J Pediatr 2013; 172:953–957.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>953</start><end>957</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Pediatr</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>953</start><end>957</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0086"><titleInfo><title>Is treatment with hydroxychloroquine effective in surfactant protein C deficiency</title></titleInfo><name type="personal"><namePart type="given">I</namePart><namePart type="family">Rabach</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Poli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Zennaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Germani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ventura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Barbi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rabach I, Poli F, Zennaro F, Germani C, Ventura A, Barbi E. Is treatment with hydroxychloroquine effective in surfactant protein C deficiency. Arch Bronconeumol 2013; 49:213–215.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>213</start><end>215</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Bronconeumol</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>213</start><end>215</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0087"><titleInfo><title>Successful treatment of neonatal respiratory failure caused by a novel surfactant protein C p. Cys121Gly mutation with hydroxychloroquine</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Hepping</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Griese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Lohse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Garbe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Lange</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hepping N, Griese M, Lohse P, Garbe W, Lange L. Successful treatment of neonatal respiratory failure caused by a novel surfactant protein C p. Cys121Gly mutation with hydroxychloroquine. J Perinatol 2013; 33:492–494.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>492</start><end>494</end></extent></part><relatedItem type="host"><titleInfo><title>J Perinatol</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>492</start><end>494</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0088"><titleInfo><title>Ten‐year follow up of hydroxychloroquine treatment for ABCA3 deficiency</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Williamson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Wallis</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Williamson M, Wallis C. Ten‐year follow up of hydroxychloroquine treatment for ABCA3 deficiency. Pediatr Pulmonol 2014; 49:299–301.</note><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>299</start><end>301</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Pulmonol</title></titleInfo><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>299</start><end>301</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0089"><titleInfo><title>Natural history of five children with surfactant protein C mutations and interstitial lung disease</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Avital</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hevroni</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Godfrey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Cohen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Maayan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Nusair</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LM</namePart><namePart type="family">Nogee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Springer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Avital A, Hevroni A, Godfrey S, Cohen S, Maayan C, Nusair S, Nogee LM, Springer C. Natural history of five children with surfactant protein C mutations and interstitial lung disease. Pediatr Pulmonol 2014; 49:1097–1105.</note><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>1097</start><end>1105</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Pulmonol</title></titleInfo><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>1097</start><end>1105</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0090"><titleInfo><title>Chloroquine treatment in desquamative interstitial pneumonia</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Springer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Maayan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Katzir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Ariel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Godfrey</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Springer C, Maayan C, Katzir Z, Ariel I, Godfrey S. Chloroquine treatment in desquamative interstitial pneumonia. Arch Dis Child 1987; 62:76–77.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>62</number></detail><extent unit="pages"><start>76</start><end>77</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Dis Child</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>62</number></detail><extent unit="pages"><start>76</start><end>77</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ppul23133-cit-0091"><titleInfo><title>Survival of an infant with homozygous surfactant protein C (SFTPC) mutation</title></titleInfo><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Arikan‐Ayyildiz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Caglayan‐Sozmen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Isik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Deterding</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MK</namePart><namePart type="family">Dishop</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Couderc</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Epaud</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Louha</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Uzuner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Arikan‐Ayyildiz Z, Caglayan‐Sozmen S, Isik S, Deterding R, Dishop MK, Couderc R, Epaud R, Louha M, Uzuner N. Survival of an infant with homozygous surfactant protein C (SFTPC) mutation. Pediatr Pulmonol 2014; 49:E112–E115.</note><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>E112</start><end>E115</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Pulmonol</title></titleInfo><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>E112</start><end>E115</end></extent></part></relatedItem></relatedItem><identifier type="istex">F34AA8E58D1C0E23BBC7ED4F1B0CE8BFCC153EE3</identifier><identifier type="ark">ark:/67375/WNG-DFB7GSN5-V</identifier><identifier type="DOI">10.1002/ppul.23133</identifier><identifier type="ArticleID">PPUL23133</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2015 Wiley Periodicals, Inc.© 2014 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-16</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-DFB7GSN5-V/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000032 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000032 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:F34AA8E58D1C0E23BBC7ED4F1B0CE8BFCC153EE3
|texte= Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases
}}
| This area was generated with Dilib version V0.6.33. |  |