Cardiotoxicity after low-dose chloroquine antimalarial therapy
Identifieur interne : 000011 ( Istex/Corpus ); précédent : 000010; suivant : 000012Cardiotoxicity after low-dose chloroquine antimalarial therapy
Auteurs : Gabriele Fragasso ; Francesca Sanvito ; Francesca Baratto ; Sabina Martinenghi ; Claudio Doglioni ; Alberto MargonatoSource :
- Heart and Vessels [ 0910-8327 ] ; 2009-09-01.
English descriptors
Abstract
Abstract: Previous reports on antimalarial toxicity have only been related to long-term continuous treatments for nonmalarial indications, which require prolonged use of large doses, up to 1000 g or more every year. We describe a patient with recurrent malaria, prophylactically treated with low-dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction. The right ventricle endomyocardial biopsy was suggestive of chloroquine toxicity. The heart failure improved after drug withdrawal. As a consequence, the potential for reversibility and the severity in undiagnosed cases of these toxic cardiomyopathies emphasize the importance of recognizing early signs of toxicity in order to withdraw antimalarials before the occurrence of life-threatening cardiac toxicity.
Url:
DOI: 10.1007/s00380-008-1144-8
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ISTEX:2B566B16C5719EEAE0CCFC9097BA4763D2823629Le document en format XML
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Margonato</name><affiliation><mods:affiliation>Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132, Milan, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2B566B16C5719EEAE0CCFC9097BA4763D2823629</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1007/s00380-008-1144-8</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-13BZ3GGK-G/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000011</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000011</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cardiotoxicity after low-dose chloroquine antimalarial therapy</title><author><name sortKey="Fragasso, Gabriele" sort="Fragasso, Gabriele" uniqKey="Fragasso G" first="Gabriele" last="Fragasso">Gabriele Fragasso</name><affiliation><mods:affiliation>Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132, Milan, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: gabriele.fragasso@hsr.it</mods:affiliation></affiliation></author><author><name sortKey="Sanvito, Francesca" sort="Sanvito, Francesca" uniqKey="Sanvito F" first="Francesca" last="Sanvito">Francesca Sanvito</name><affiliation><mods:affiliation>Department of Pathology, Istituto Scientifico San Raffaele, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Baratto, Francesca" sort="Baratto, Francesca" uniqKey="Baratto F" first="Francesca" last="Baratto">Francesca Baratto</name><affiliation><mods:affiliation>Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Martinenghi, Sabina" sort="Martinenghi, Sabina" uniqKey="Martinenghi S" first="Sabina" last="Martinenghi">Sabina Martinenghi</name><affiliation><mods:affiliation>Department of Metabolic Medicine, Istituto Scientifico San Raffaele, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Doglioni, Claudio" sort="Doglioni, Claudio" uniqKey="Doglioni C" first="Claudio" last="Doglioni">Claudio Doglioni</name><affiliation><mods:affiliation>Department of Pathology, Istituto Scientifico San Raffaele, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Margonato, Alberto" sort="Margonato, Alberto" uniqKey="Margonato A" first="Alberto" last="Margonato">Alberto Margonato</name><affiliation><mods:affiliation>Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132, Milan, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Heart and Vessels</title><title level="j" type="abbrev">Heart Vessels</title><idno type="ISSN">0910-8327</idno><idno type="eISSN">1615-2573</idno><imprint><publisher>Springer Japan</publisher><pubPlace>Japan</pubPlace><date type="published" when="2009-09-01">2009-09-01</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="385">385</biblScope><biblScope unit="page" to="387">387</biblScope></imprint><idno type="ISSN">0910-8327</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0910-8327</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiomyopathy</term><term>Chloroquine</term><term>Endomyocardial biopsy</term><term>Heart failure</term><term>Toxicity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Previous reports on antimalarial toxicity have only been related to long-term continuous treatments for nonmalarial indications, which require prolonged use of large doses, up to 1000 g or more every year. We describe a patient with recurrent malaria, prophylactically treated with low-dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction. The right ventricle endomyocardial biopsy was suggestive of chloroquine toxicity. The heart failure improved after drug withdrawal. As a consequence, the potential for reversibility and the severity in undiagnosed cases of these toxic cardiomyopathies emphasize the importance of recognizing early signs of toxicity in order to withdraw antimalarials before the occurrence of life-threatening cardiac toxicity.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Gabriele Fragasso</name><affiliations><json:string>Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132, Milan, Italy</json:string><json:string>E-mail: gabriele.fragasso@hsr.it</json:string></affiliations></json:item><json:item><name>Francesca Sanvito</name><affiliations><json:string>Department of Pathology, Istituto Scientifico San Raffaele, Milan, Italy</json:string></affiliations></json:item><json:item><name>Francesca Baratto</name><affiliations><json:string>Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132, Milan, Italy</json:string></affiliations></json:item><json:item><name>Sabina Martinenghi</name><affiliations><json:string>Department of Metabolic Medicine, Istituto Scientifico San Raffaele, Milan, Italy</json:string></affiliations></json:item><json:item><name>Claudio Doglioni</name><affiliations><json:string>Department of Pathology, Istituto Scientifico San Raffaele, Milan, Italy</json:string></affiliations></json:item><json:item><name>Alberto Margonato</name><affiliations><json:string>Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132, Milan, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Chloroquine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cardiomyopathy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Heart failure</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Toxicity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Endomyocardial biopsy</value></json:item></subject><articleId><json:string>1144</json:string><json:string>s00380-008-1144-8</json:string></articleId><arkIstex>ark:/67375/VQC-13BZ3GGK-G</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Previous reports on antimalarial toxicity have only been related to long-term continuous treatments for nonmalarial indications, which require prolonged use of large doses, up to 1000 g or more every year. We describe a patient with recurrent malaria, prophylactically treated with low-dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction. The right ventricle endomyocardial biopsy was suggestive of chloroquine toxicity. The heart failure improved after drug withdrawal. 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We describe a patient with recurrent malaria, prophylactically treated with low-dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction. The right ventricle endomyocardial biopsy was suggestive of chloroquine toxicity. The heart failure improved after drug withdrawal. 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Report</ArticleCategory><ArticleFirstPage>385</ArticleFirstPage><ArticleLastPage>387</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2008</Year><Month>9</Month><Day>23</Day></RegistrationDate><Received><Year>2008</Year><Month>7</Month><Day>2</Day></Received><Accepted><Year>2008</Year><Month>12</Month><Day>26</Day></Accepted><OnlineDate><Year>2009</Year><Month>9</Month><Day>27</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer Japan</CopyrightHolderName><CopyrightYear>2009</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Gabriele</GivenName><FamilyName>Fragasso</FamilyName></AuthorName><Contact><Phone>+39-02-2643-7395</Phone><Fax>+39-02-2643-7395</Fax><Email>gabriele.fragasso@hsr.it</Email></Contact></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Francesca</GivenName><FamilyName>Sanvito</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Francesca</GivenName><FamilyName>Baratto</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Sabina</GivenName><FamilyName>Martinenghi</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Claudio</GivenName><FamilyName>Doglioni</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Alberto</GivenName><FamilyName>Margonato</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Clinical Cardiology, Heart Failure Clinic</OrgDivision><OrgName>Istituto Scientifico San Raffaele</OrgName><OrgAddress><Street>Via Olgettina 60</Street><Postcode>20132</Postcode><City>Milan</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Pathology</OrgDivision><OrgName>Istituto Scientifico San Raffaele</OrgName><OrgAddress><City>Milan</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Department of Metabolic Medicine</OrgDivision><OrgName>Istituto Scientifico San Raffaele</OrgName><OrgAddress><City>Milan</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Previous reports on antimalarial toxicity have only been related to long-term continuous treatments for nonmalarial indications, which require prolonged use of large doses, up to 1000 g or more every year. We describe a patient with recurrent malaria, prophylactically treated with low-dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction. The right ventricle endomyocardial biopsy was suggestive of chloroquine toxicity. The heart failure improved after drug withdrawal. As a consequence, the potential for reversibility and the severity in undiagnosed cases of these toxic cardiomyopathies emphasize the importance of recognizing early signs of toxicity in order to withdraw antimalarials before the occurrence of life-threatening cardiac toxicity.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Chloroquine</Keyword><Keyword>Cardiomyopathy</Keyword><Keyword>Heart failure</Keyword><Keyword>Toxicity</Keyword><Keyword>Endomyocardial biopsy</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cardiotoxicity after low-dose chloroquine antimalarial therapy</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Cardiotoxicity after low-dose chloroquine antimalarial therapy</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Gabriele</namePart><namePart type="family">Fragasso</namePart><affiliation>Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132, Milan, Italy</affiliation><affiliation>E-mail: gabriele.fragasso@hsr.it</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesca</namePart><namePart type="family">Sanvito</namePart><affiliation>Department of Pathology, Istituto Scientifico San Raffaele, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesca</namePart><namePart type="family">Baratto</namePart><affiliation>Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sabina</namePart><namePart type="family">Martinenghi</namePart><affiliation>Department of Metabolic Medicine, Istituto Scientifico San Raffaele, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claudio</namePart><namePart type="family">Doglioni</namePart><affiliation>Department of Pathology, Istituto Scientifico San Raffaele, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alberto</namePart><namePart type="family">Margonato</namePart><affiliation>Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer Japan</publisher><place><placeTerm type="text">Japan</placeTerm></place><dateCreated encoding="w3cdtf">2008-07-02</dateCreated><dateIssued encoding="w3cdtf">2009-09-01</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Previous reports on antimalarial toxicity have only been related to long-term continuous treatments for nonmalarial indications, which require prolonged use of large doses, up to 1000 g or more every year. We describe a patient with recurrent malaria, prophylactically treated with low-dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction. The right ventricle endomyocardial biopsy was suggestive of chloroquine toxicity. The heart failure improved after drug withdrawal. As a consequence, the potential for reversibility and the severity in undiagnosed cases of these toxic cardiomyopathies emphasize the importance of recognizing early signs of toxicity in order to withdraw antimalarials before the occurrence of life-threatening cardiac toxicity.</abstract><note>Case Report</note><subject lang="en"><genre>Key words</genre><topic>Chloroquine</topic><topic>Cardiomyopathy</topic><topic>Heart failure</topic><topic>Toxicity</topic><topic>Endomyocardial biopsy</topic></subject><relatedItem type="host"><titleInfo><title>Heart and Vessels</title></titleInfo><titleInfo type="abbreviated"><title>Heart Vessels</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2009-09-27</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Ultrasound</topic><topic>Interventional Radiology</topic><topic>Biomedical Engineering</topic><topic>Vascular Surgery</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic></subject><identifier type="ISSN">0910-8327</identifier><identifier type="eISSN">1615-2573</identifier><identifier type="JournalID">380</identifier><identifier type="IssueArticleCount">14</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>2009</date><detail type="volume"><number>24</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="pages"><start>385</start><end>387</end></extent></part><recordInfo><recordOrigin>Springer Japan, 2009</recordOrigin></recordInfo></relatedItem><identifier type="istex">2B566B16C5719EEAE0CCFC9097BA4763D2823629</identifier><identifier type="ark">ark:/67375/VQC-13BZ3GGK-G</identifier><identifier type="DOI">10.1007/s00380-008-1144-8</identifier><identifier type="ArticleID">1144</identifier><identifier type="ArticleID">s00380-008-1144-8</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer Japan, 2009</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer Japan, 2009</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-13BZ3GGK-G/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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