Hydroxychloroquine: From Malaria to Autoimmunity
Identifieur interne : 000001 ( Istex/Corpus ); précédent : 000000; suivant : 000002Hydroxychloroquine: From Malaria to Autoimmunity
Auteurs : Ilan Ben-Zvi ; Shaye Kivity ; Pnina Langevitz ; Yehuda ShoenfeldSource :
- Clinical Reviews in Allergy & Immunology [ 1080-0549 ] ; 2012-04-01.
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- KwdEn :
Abstract
Abstract: Quinine was first recognized as a potent antimalarial agent hundreds of years ago. Since then, the beneficial effects of quinine and its more advanced synthetic forms, chloroquine and hydroxychloroquine, have been increasingly recognized in a myriad of other diseases in addition to malaria. In recent years, antimalarials were shown to have various immunomodulatory effects, and currently have an established role in the management of rheumatic diseases, such as systemic lupus erythematosus and rheumatoid arthritis, skin diseases, and in the treatment of chronic Q fever. Lately, additional metabolic, cardiovascular, antithrombotic, and antineoplastic effects of antimalarials were shown. In this review, we discuss the known various immunomodulatory mechanisms of antimalarials and the current evidence for their beneficial effects in various diseases and in potential novel applications.
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DOI: 10.1007/s12016-010-8243-x
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ISTEX:3A14B734D06C0A8779CF74756A86D8DC8781C6D6Le document en format XML
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Since then, the beneficial effects of quinine and its more advanced synthetic forms, chloroquine and hydroxychloroquine, have been increasingly recognized in a myriad of other diseases in addition to malaria. In recent years, antimalarials were shown to have various immunomodulatory effects, and currently have an established role in the management of rheumatic diseases, such as systemic lupus erythematosus and rheumatoid arthritis, skin diseases, and in the treatment of chronic Q fever. Lately, additional metabolic, cardiovascular, antithrombotic, and antineoplastic effects of antimalarials were shown. 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DisplayOrder="Western"><GivenName>Ilan</GivenName><FamilyName>Ben-Zvi</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Shaye</GivenName><FamilyName>Kivity</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Pnina</GivenName><FamilyName>Langevitz</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff4" CorrespondingAffiliationID="Aff4"><AuthorName DisplayOrder="Western"><GivenName>Yehuda</GivenName><FamilyName>Shoenfeld</FamilyName></AuthorName><Contact><Email>shoenfel@post.tau.ac.il</Email></Contact></Author><Affiliation ID="Aff1"><OrgDivision>Rheumatology Unit, Zabludowicz Center for Autoimmune Diseases and Department of Internal Medicine F</OrgDivision><OrgName>Sheba Medical Center</OrgName><OrgAddress><City>Tel-Hashomer</City><Postcode>52621</Postcode><Country Code="IL">Israel</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Rheumatology Unit, Zabludowicz Center for Autoimmune Diseases and Department of Internal Medicine A and C</OrgDivision><OrgName>Sheba Medical Center</OrgName><OrgAddress><City>Tel-Hashomer</City><Postcode>52621</Postcode><Country Code="IL">Israel</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Rheumatology Unit, Zabludowicz Center for Autoimmune Diseases</OrgDivision><OrgName>Sheba Medical Center</OrgName><OrgAddress><City>Tel-Hashomer</City><Postcode>52621</Postcode><Country Code="IL">Israel</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgDivision>Zabludowicz Center for Autoimmune Diseases and Department of Internal Medicine B</OrgDivision><OrgName>Sheba Medical Center</OrgName><OrgAddress><City>Tel-Hashomer</City><Postcode>52621</Postcode><Country Code="IL">Israel</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para>Quinine was first recognized as a potent antimalarial agent hundreds of years ago. Since then, the beneficial effects of quinine and its more advanced synthetic forms, chloroquine and hydroxychloroquine, have been increasingly recognized in a myriad of other diseases in addition to malaria. In recent years, antimalarials were shown to have various immunomodulatory effects, and currently have an established role in the management of rheumatic diseases, such as systemic lupus erythematosus and rheumatoid arthritis, skin diseases, and in the treatment of chronic Q fever. Lately, additional metabolic, cardiovascular, antithrombotic, and antineoplastic effects of antimalarials were shown. In this review, we discuss the known various immunomodulatory mechanisms of antimalarials and the current evidence for their beneficial effects in various diseases and in potential novel applications.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Chloroquine</Keyword><Keyword>Hydroxychloroquine</Keyword><Keyword>Antimalarial</Keyword><Keyword>Novel</Keyword><Keyword>Therapy</Keyword><Keyword>Lupus</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Hydroxychloroquine: From Malaria to Autoimmunity</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Hydroxychloroquine: From Malaria to Autoimmunity</title></titleInfo><name type="personal"><namePart type="given">Ilan</namePart><namePart type="family">Ben-Zvi</namePart><affiliation>Rheumatology Unit, Zabludowicz Center for Autoimmune Diseases and Department of Internal Medicine F, Sheba Medical Center, 52621, Tel-Hashomer, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shaye</namePart><namePart type="family">Kivity</namePart><affiliation>Rheumatology Unit, Zabludowicz Center for Autoimmune Diseases and Department of Internal Medicine A and C, Sheba Medical Center, 52621, Tel-Hashomer, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pnina</namePart><namePart type="family">Langevitz</namePart><affiliation>Rheumatology Unit, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, 52621, Tel-Hashomer, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Yehuda</namePart><namePart type="family">Shoenfeld</namePart><affiliation>Zabludowicz Center for Autoimmune Diseases and Department of Internal Medicine B, Sheba Medical Center, 52621, Tel-Hashomer, Israel</affiliation><affiliation>E-mail: shoenfel@post.tau.ac.il</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="ReviewPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Humana Press Inc</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2012-04-01</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Quinine was first recognized as a potent antimalarial agent hundreds of years ago. Since then, the beneficial effects of quinine and its more advanced synthetic forms, chloroquine and hydroxychloroquine, have been increasingly recognized in a myriad of other diseases in addition to malaria. In recent years, antimalarials were shown to have various immunomodulatory effects, and currently have an established role in the management of rheumatic diseases, such as systemic lupus erythematosus and rheumatoid arthritis, skin diseases, and in the treatment of chronic Q fever. Lately, additional metabolic, cardiovascular, antithrombotic, and antineoplastic effects of antimalarials were shown. In this review, we discuss the known various immunomodulatory mechanisms of antimalarials and the current evidence for their beneficial effects in various diseases and in potential novel applications.</abstract><subject lang="en"><genre>Keywords</genre><topic>Chloroquine</topic><topic>Hydroxychloroquine</topic><topic>Antimalarial</topic><topic>Novel</topic><topic>Therapy</topic><topic>Lupus</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Reviews in Allergy & Immunology</title></titleInfo><titleInfo type="abbreviated"><title>Clinic Rev Allerg Immunol</title></titleInfo><name type="personal"><namePart type="given">Yehuda</namePart><namePart type="family">Shoenfeld</namePart><role><roleTerm type="text">editor</roleTerm></role></name><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2012-03-14</dateIssued><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Allergology</topic></subject><identifier type="ISSN">1080-0549</identifier><identifier type="eISSN">1559-0267</identifier><identifier type="JournalID">12016</identifier><identifier type="IssueArticleCount">15</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>2012</date><detail type="issue"><title>Novel Concepts in Autoimmunity</title></detail><detail type="volume"><number>42</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="pages"><start>145</start><end>153</end></extent></part><recordInfo><recordOrigin>Springer Science+Business Media, LLC, 2012</recordOrigin></recordInfo></relatedItem><identifier type="istex">3A14B734D06C0A8779CF74756A86D8DC8781C6D6</identifier><identifier type="ark">ark:/67375/VQC-WHGN0CDL-Z</identifier><identifier type="DOI">10.1007/s12016-010-8243-x</identifier><identifier type="ArticleID">8243</identifier><identifier type="ArticleID">s12016-010-8243-x</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer Science+Business Media, LLC, 2011</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer Science+Business Media, LLC, 2011</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-WHGN0CDL-Z/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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